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Single-cell technologies:From research to application

The Innovation 2022年第6期3卷 92-108页

作者： Lu Wen Guoqiang Li Tao Huang Wei Geng Hao Pei Jialiang Yang Miao Zhu Pengfei Zhang Rui Hou Geng Tian Wentao Su Jian Chen Dake Zhang Pingan Zhu Wei Zhang Xiuxin Zhang Ning Zhang Yunlong Zhao Xin Cao Guangdun Peng Xianwen Ren Nan Jiang Caihuan Tian Zi-Jiang Chen Biomedical Pioneering Innovation Centre(BIOPIC) Peking UniversityBeijing 100871China Bio-Med Big Data Center CAS Key Laboratory of Computational BiologyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China School of Chemical Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Mozhuo Biotech(Zhejiang)Co. Ltd.TongxiangJiaxing 314500China Geneis(Beijing)Co. Ltd.Beijing 100102China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China School of Food Science and Technology Dalian Polytechnic UniversityDalian 116034China State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China Key Laboratory of Biomechanics and Mechanobiology Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China Department of Mechanical Engineering City University of Hong KongHong Kong 999077China Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China Center of Peony Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesKey Laboratory of Biology and Genetic Improvement of Flower Crops(North China)Key Laboratory of Biology and Genetic Improvement of Horticultural CropsMinistry of Agriculture and Rural AffairsBeijing 100081China Department of Hepatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Advanced Technology Institute University of SurreyGuildfordSurreyGU27XHUK National Physical Laboratory TeddingtonMiddlesex TW110LWUK Institute of Clinical Science Zhongshan HospitalFudan UniversityShanghai 200032China West China School of Basic Medical Sciences&Forensic Medicine Sichuan UniversityChengdu 610041China Jinfeng Laboratory Chongqing 401329China Center for Reproduc

In recent years,more and more single-cell technologies have been developed.A vast amount of single-cell omics data has been generated by large projects,such as the Human Cell Atlas,the Mouse Cell Atlas,the Mouse RNA Atlas,the Mouse ATAC Atlas,and the Plant Cell *** on these single-cell big data,thousands of bioinformatics algorithms for quality control,clustering,cell-type annotation,developmental inference,cell-cell transition,cell-cell interaction,and spatial analysis are *** powerful experimental single-cell technology and state-of-the-art big data analysis methods based on artificial intelligence,the molecular landscape at the single-cell level can be revealed.

关键词： Atlas landscape application

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Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications

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Science China(Life Sciences) 2022年第7期65卷 1342-1356页

作者： Hui Zhao Jianping Zhao Di Wu Zhaolin Sun Yang Hua Min Zheng Yumei Liu Qi Yang Xiahe Huang Yuan Li Yueshan Piao Yingchun Wang Sin Man Lam Huijuan Xu Guanghou Shui Yongjun Wang Haifeng Yao Liangxue Lai Zhuo Du Jidong Mi Enqi Liu Xunming Ji Yong Q.Zhang Key Laboratory of Molecular Developmental Biology and CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute ofGenetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Beijing Sinogene Biotechnology Co.ltd Beijing 102200China Xuanwu Hospital Capital Medical UniversityBeijing 100053China TianTan Hospital Capital Medical UniversityBeijing 100070China Beijing Petsguard Animal Hospital Beijing 100192China Laboratory Animal Center Xi’an Jiaotong University Health Science CenterXi’an 710049China

Atherosclerotic cardiovascular disease resulting from dysregulated lipid metabolism is the leading cause of morbidity and mortality *** E(ApoE)plays a critical role in cholesterol *** in lipid-metabolizing proteins including ApoE in multiple model organisms such as mice and rats exhibiting elevated levels of cholesterol have been widely used for dissecting the pathology of atherosclerosis,but few of these animal models exhibit advanced atherosclerotic plaques leading to ischemia-induced clinical symptoms,limiting their use for translational *** we report hypercholesterolemia and severe atherosclerosis characterized by stenosis and occlusion of arteries,together with clinical manifestations of stroke and gangrene,in ApoE knockout dogs generated by CRISPR/Cas9 and cloned by somatic cell nuclear transfer ***,the hypercholesterolemia and atherosclerotic complications in F0 mutants are recapitulated in their *** the ApoE-associated atherosclerosis and clinical manifestations in mutant dogs are more similar to that in human patients compared with those in other animal models,these mutant dogs will be invaluable in developing and evaluating new therapies,including endovascular procedures,against atherosclerosis and related disorders.

关键词： ApoE atherosclerosis hypercholesterolemia gangrene stroke

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The development of a high-performance Ni-superalloy additively manufactured heat pipe

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Advances in Manufacturing 2022年第4期10卷 610-624页

作者： Sheng Li Khamis Essa James Carr States Chiwanga Andrew Norton Moataz M.Attallah School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Engineering University of BirminghamEdgbastonBirmingham B152TTUK Henry Moseley X-ray Imaging Facility Henry Royce Institute for Advanced MaterialsDepartment of MaterialsUniversity of ManchesterManchester M139PLUK European Thermodynamics ltd 8 Priory Business ParkWistow RoadKibworthLeicestershire LE80RXUK Rolls-Royce plc P.O.Box 31Derby DE248BJUK School of Metallurgy and Materials University of BirminghamEdgbastonBirmingham B152TTUK

Additively manufacturing(AM)has been used to manufacture fine structures with structured/engineered porosity in heat management *** this study,laser powder bed fusion(LPBF)was used to manufacture a high-performance Ni-superalloy heat pipe,through tailoring LPBF process parameters to fabricate thin wall and *** using novel laser scanning strategies,wick structure heat pipes with maximised surface-area-to-volume ratio,fine features size around 100µm,and controlled porosity were successfully *** and X-ray microtomography(micro-CT)were used to investigate the 3D structure of the void space within the *** test results showed that most of the heat pipes made by LPBF had better performance than the conventionally manufactured *** study also investigated the influences of the process parameters on the porosity volume fraction and the feature *** results showed that LPBF process could fabricate thin structure due to the change of melt pool contact *** relationship between process parameters and bead size reported in this study could help design and manufacture heat pipe with complex fine structure.

关键词： Laser powder bed fusion(LPBF) Heat pipe Melt pool Microtomography(micro-CT)

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壳牌对未来车用能源多元化发展趋势的思考

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汽车安全与节能学报 2020年第1期11卷 17-35页

作者：贾恬郑彬 Warnecke W Kolbeck A Aradi A Kofod M Clark R Wilbrand K 壳牌(上海)技术有限公司上海201210 Shell Global Solutions(Germany)GmbH Hamburg 21107Germany Shell Global Solutions US Inc Houston 77082-3101USA Shell Global Solutions(UK)ltd London SE17NAUK

面对能源短缺和环境污染的双重挑战,交通领域的转型升级不可避免。本文结合未来车用动力系统的发展趋势,对交通运输领域中应用的多种先进动力系统、清洁能源及替代燃料进行综述和评价,包括目前主要使用的传统液态化石燃料即汽、柴油及... 详细信息

面对能源短缺和环境污染的双重挑战,交通领域的转型升级不可避免。本文结合未来车用动力系统的发展趋势,对交通运输领域中应用的多种先进动力系统、清洁能源及替代燃料进行综述和评价,包括目前主要使用的传统液态化石燃料即汽、柴油及先进内燃机技术,清洁替代燃料(如生物燃料、天然气合成油(GTL)燃料、电转液(PTL)燃料、液化天然气(LNG)等),以及电气化动力系统(包括混合动力、纯电动和燃料电池)等,并着重讨论液体燃料。壳牌认为没有一种单一的解决方案可以解决复杂的能源问题,未来交通能源结构将呈现多种能源并存的特点,并分别适用于不同的场景。该文还介绍了壳牌近期基于不同政治、经济和社会发展程度提出的3种远景(壳牌“高山”、“海洋”和“天空”远景),提出壳牌对未来车用能源领域转型脱碳发展情景的思考。

关键词：清洁替代燃料内燃机技术生物燃料天然气合成油(GTL) 电转液(PTL)燃料液化天然气(LNG) 电气化动力总成远景预测

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Emvirus:An embedding-based neural framework for human-virus proteinprotein interactions prediction

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生物安全与健康(英文) 2023年第3期5卷 152-158页

作者： Pengfei Xie Jujuan Zhuang Geng Tian Jialiang Yang College of Transportation Engineering Dalian Maritime UniversityDalian 116026China School of Science Dalian Maritime UniversityDalian 116026China Geneis Bejing Co. LtdBeijing 100102China Qingdao Geneis Institute of Big Data Mining and Precision Medicine Qingdao 266000China

Human-virus protein-protein interactions(PPIs)play critical roles in viral *** example,the spike protein of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)binds primarily to human angiotensinconverting enzyme 2(ACE2)protein to infect human ***,identifying and blocking these PPIs contribute to controlling and preventing ***,wet-lab experiment-based identification of human-virus PPIs is usually expensive,labor-intensive,and time-consuming,which presents the need for computational *** machine-learning methods have been proposed recently and achieved good results in predicting humanvirus ***,most methods are based on protein sequence features and apply manually extracted features,such as statistical characteristics,phylogenetic profiles,and physicochemical *** this work,we present an embedding-based neural framework with convolutional neural network(CNN)and bi-directional long short-term memory unit(Bi-LSTM)architecture,named Emvirus,to predict human-virus PPIs(including human-SARS-CoV-2 PPIs).In addition,we conduct cross-viral experiments to explore the generalization ability of *** to other feature extraction methods,Emvirus achieves better prediction accuracy.

关键词： SARS-CoV-2 human-virus PPI Word embedding Doc2vec Neural networks

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沉井法施工在滨江水厂取水泵房工程中的应用

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中国给水排水 2010年第24期26卷 109-113页

作者：雷晓玲江滔刘宇波刘博骞重庆交通大学河海学院重庆400074 Sino French Water Development〈Macao〉Co.ltd. 澳门中铁十局集团第十工程有限公司江苏无锡214000

以常熟市滨江水厂取水泵房沉井施工为例,主要从沉井下沉和沉井封底两个步骤着手,对下沉过程的两个阶段(干沉和湿沉)和封底过程进行介绍,重点阐述和分析了施工过程中的关键性技术并进行总结,以供参考。

关键词：沉井施工滨江水厂取水泵房应用

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A Study on Conductive Polymer in PCB Manufacturing

A Study on Conductive Polymer in PCB Manufacturing

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作者： Binyun Liu Liang Xiao Yaqi Zhang Meng Wang Xuefeng He Wang Xia Zihong Zhou Liqin Qiu Guangdong Toneset Science & Technology Co. Ltd Guangdong Printed Circuit Chemicals Engineering Technology Center School of Chemistry The Key Laboratory of Low-Carbon Chemistry & Energy Conservation of Guangdong Province Sun Yat-Sen University

Making Hole Conductive is one of the key technologies in Printed Circuit Board manufacture. For a long time, electroless copper was the unique technology of hole metallization process. However, it’s long process, high water consumption and the resulting huge amount of waste water. A large number of toxic and harmful chemicals are also discharged into the environment, causing great harm to the health of workers and the environment. In this paper, the environmentally materialization technology-selective organic conductive coating（SOC） technology was studied. The resource consumption, product quality, and environmental and economic benefits of the traditional PTH and new SOC technology applied in the making hole conductive were compared and analyzed in detail through the investigation of long-term operation examples. The necessity, advantages and practicality of SOC technology were revealed.

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大规模信息网络智能管理的方法和技术的研究

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计算机科学 2001年第9期28卷 38-41页

作者：庄力可杜军平涂序彦赵敏哲北京科技大学信息工程学院北京100083 北京工商大学信息工程学院北京100037 新加坡DONOVAN Pte ltd

Starting from the analysis of system architecture and applying large-scale cybernetics,we explore the combiantion of CORBA,Web,Active Network with SNMP respectively based on the discussions of the status and shortcomings for large-scale information networks. We address the application of mobile Agent in SNMP and the mechanism of information exchange between agents. In order to tackle with the increasingly enlarged and sophisticated heterogeneous network environments ,we presente a design scheme for decreasing the distrbuted management layers and increasing the intelligence of managed objects. We realize a active network management model with a thin architecture.

关键词： Internet 信息网络智能管理体系结构

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新建的和既有的钢筋混凝土结构的阴极防护

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全面腐蚀控制 2009年第7期23卷 65-68页

作者：周欲晓 Atef Cheaitani 圣维可防腐科技有限公司广东广州510530 Savcor Group ltd SydneyAustralia

钢筋混凝土结构的腐蚀是全世界建筑业面临的挑战之一。现在看来,显然所有海洋环境中的构筑物在其寿命期内都会遭受到氯化物的腐蚀导致的劣化。为了实现对既有结构的长期修复和提高新建结构的耐腐蚀性能,至关重要的是要充分认识钢筋腐蚀... 详细信息

钢筋混凝土结构的腐蚀是全世界建筑业面临的挑战之一。现在看来,显然所有海洋环境中的构筑物在其寿命期内都会遭受到氯化物的腐蚀导致的劣化。为了实现对既有结构的长期修复和提高新建结构的耐腐蚀性能,至关重要的是要充分认识钢筋腐蚀的机理,也必须了解最新的技术可用于修复既有的结构和对新建的结构防腐蚀。本文将重点介绍劣化的主要原因和预防钢筋混凝土结构腐蚀,保护及防护的最新技术。

关键词：阴极防护阴极保护钢筋混凝土结构劣化氯化物

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Power Planning Algorithm Considering the Operating Strategy of a Power Sales Company under the Background of New Electricity Reform

Power Planning Algorithm Considering the Operating Strategy ...

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作者： Wei ZHOU Xiao-hu ZHANG Xuan YU Li-jun WANG Jiu GU Da XIE State Grid Corporation East China Branch China Power Engineering Consulting Group East China Electric Power Design Institute Co. Ltd School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University

With the introduction of the open electricity sales side in the new power reform,more and more power sales companies have joined the competition on the power sales side,and various power sales companies have been defined as different names due to different resources *** view of the problem of power supply planning under the background of new power system reform,this paper firstly models the operation of different types of power sales companies,and designs the power planning algorithm considering the impact of the sales company,and then analyzes its operation for load forecasting and power *** impact is finally calculated by simulation to calculate the amount of peak reduction in load forecasting and power planning capacity.

关键词： Power planning Energy service providers Load aggregators Power sales companies Load forecasting

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