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Journal of Iron and steel Research International 2022年第9期29卷 1474-1484页

作者： Shuai Tian Zhen-bao Liu Ren-li Fu Xiao-hui Wang Jian-xiong Liang School of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016JiangsuChina instiute for special steel institute Central Iron and Steel Research InstituteBeijing 100081China

The stress corrosion cracking(SCC)behavior of a 1900 MPa-grade ultra-high-strength stainless steel in 3.5 wt.% NaCl solution was investigated by X-ray diffractometer,scanning electron microscopy,electron back-scattered diffraction,X-ray photoelectron spectroscopy,and potentiodynamic polarization *** results showed that USS122G stel has good SCC resistance,and the critical stress intensiy factor(K_(iscc))of USS122G steel was about 68.906 MPa m^(1/2) and Kiscc/K_(ic)=0.76(K_(ic) is plane strain fracture toughness).The existence of film-like austenite along the lath martensite boundary and the protective effect of thecc passivation flm were the main factors for its high *** them,the main components of the passivation film on the surface of USS122G steel were Cr_(2)O_(3),Cr(OH)_(3),FeOOH,and Ni(OH)_(2).The fracture morphology of SCC zone was intergranular and *** the slow and fast scanning rate polarization curve test results,it can be concluded that SCC mechanism of USS122G steel in 3.5 wt.%NaCl solution at the open-circuit potential was a mixed mechanism involving hydrogen embritlement and anodic dissolution.

关键词： Ultra-high-strength stainless steel.Critical stress intensity factor-Film-like austenite Hydrogen embrittlement Anodic dissolution

Neuropeptide cholecystokinin:a key neuromodulator for hippocampal functions

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Neural Regeneration Research 2025年第7期20卷 1991-1992页

作者： Fengwen Huang Stephen Temitayo Bello Department of Neuroscience City University of Hong KongKowloon TongHong Kong Special Administrative RegionChina Center for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong Special Administrative RegionChina

Spatial memory is crucial for survival within external surroundings and wild *** hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and *** neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal ***(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target *** instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety ***,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.

关键词： abundant functions modulator

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

Rolling Contact Fatigue Properties of SAE 8620 steel after Case Carburizing

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Journal of Iron and steel Research International 2016年第7期23卷 711-716页

作者： Yan-guang CAO Le XU Gou-qiang ZHANG Jie SHI Mao-qiu WANG institute of special steels Central Iron and Steel Research Institute

Rolling contact fatigue（RCF）properties of SAE 8620 steel after case carburizing have been investigated under two contact stresses of 4.0and *** show that the RCF life ranges from 2.5×10^6 to 3×10^7 cycles under the contact stress of 5.5GPa,while it can be more than 1×10^8 cycles under the contact stress of *** rated fatigue life L_（10）（lives with the 10%failure）is also drastically shortened from 9.8×10^6 to 5.4×10^5 cycles when the contact stress is increased from 4.0to *** calculations and fractographs show that the maximum shear stress and the contact area increase with increasing the contact stress,making RCF tend to occur earlier.

关键词： case hardening steel carburizing rolling contact fatigue contact stress SAE 8620steel

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Non-equilibrium Grain-boundary Segregation of Phosphorus in an Fe-17Cr Alloy

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Journal of Iron and steel Research International 2014年第12期21卷 1136-1139页

作者： Kai WANG Hong SI Central Iron and steel Research institute Research institute for special steel Dongbei Special Steel Group Co.Ltd.

In order to confirm the segregation characteristic of phosphorus in an Fe-17Cr alloy at grain boundary, the phosphorus segregation was obtained by Auger electron spectroscopy. The results show that a maximum phosphorus segregation appeared at 450 ℃ for all specimens aged for 30 rain at 350, 400, 450, 500, and 600 ℃ after being solution-treated at 1 000 ℃ for 1 h. These results were analyzed by the characteristics of segregation peak temperature of non-equilibrium segregation.

关键词： grain boundary non-equilibrium segregation ferritic steel

Microstructure Evolution and Precipitation Behavior of 0Cr16Ni5Mo Martensitic Stainless steel during Tempering Process

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Journal of Iron and steel Research International 2016年第4期23卷 401-408页

作者： Wu-hua YUAN Xue-hui GONG Yong-qing SUN Jian-xiong LIANG College of Materials Science and Engineering Hunan University special steel institute Central Iron and Steel Research Institute

The microstructure, morphology of precipitates and retained austenite and the volume fraction of retained austenite in 0Crl6Ni5Mo stainless steel during the tempering process were analyzed using optical microscope （OM）, transmission electron microscope （TEM）, X-ray diffraction （XRD） and scanning transmission electron microscope （STEM）. The results show that the microstructure of the tempered steel is mainly composed of tempered martensite, retained austenite, and delta ferrite. In the case of samples tempered from 500 to 700℃, the precipitates are mainly M23C6, which precipitate along the lath martensite boundaries. The precipitate content increases with the tempering temperature. During the tempering process, the content of retained austenite initially increases and then decreases, the maximum content of retained austenite being 29 vol.% upon tempering at 600℃. TEM analysis of the tested steel reveals two morphology types of retained austenite. One is thin film-like retained austenite that exists along the martensite lath boundary. The other is blocky austenite located on packet at the boundary and the original austenite grain boundary. To further understand the stability of reversed austenite, the Ni content in reversed austenite was measured using STEM. Results show a significant difference in nickel concentrations between reversed austenite and martensite.

关键词： 0Cr16Ni5Mo stainless steel microstructure evolution precipitate reversed austenite thermal stability

Precipitated phases of superaustenitic stainless steel 654SMO

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Journal of Iron and steel Research International 2017年第7期24卷 743-749页

作者： Zhi-gang Song En-xiang Pu special steel institute Central Iron & Steel Research Institute School of Materials Science and Engineering Tsinghua University

The phase diagram of superaustenitic stainless steel 654SMO was calculated by thermodynamic software and the precipitated phases in the specimens aged at 800-1100°C for 1hwere studied by methods of physicochemical phase analysis,scanning electron microscopy and transmission electron *** results showed that the size of precipitated particles increased with increasing the *** amount of second phases reached the maximum value at 900°C,but decreased above 900°*** were about eight kinds of precipitated phases in 654SMO includingσphase,Cr_2N,μphase,χphase,Laves phase,M_（23）C_6,M_6C and M_3C,in which theσphase and Cr_2N were the dominant precipitated phases.

关键词： 654SMO Precipitation Superaustenitic stainless steel Precipitated phase Second phase

Effects of long term aging on microstructure and properties of a tungsten bearing heat resistant alloy

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Journal of Iron and steel Research International 2020年第4期27卷 477-487页

作者： Han-sheng Bao Gang Yang Zheng-zong Chen Zheng-dong Liu institute for special steels Central Iron and Steel Research InstituteBeijing 100081China

The effects of long-term aging at 700 and 750℃ on microstructure and mechanical properties of a new developed tungsten bearing heat-resistant alloy used for advanced ultra-supercritical power plant was investigated both experimentally and *** results showed that the mechanical properties maintained excellent stability after long-term aging at 700℃ for 10,000h,while the impact absorbing energy decreased sharply after 1000-h aging and then kept constant till 10,*** main precipitates after long-term aging at 700 and 750℃ were M23C6,MC and homogeneous γ′-*** mass fraction of M23C6 carbides increased with increasing aging time,and M23C6 carbides precipitated in shape of chains and lamellas on grain *** slight decrease in MC carbides during aging may be due to degradation *** weight fraction of γ′-phase increased with the aging time,and then changed little after 5000h;γ′-phase exhibited excellent microstructure stability and low coarsening rate during long-term aging at 700℃.However,the coarsening rate of γ′-phase was much higher at 750℃.

关键词： Tungsten Long-term aging Heat-resistant alloy gama′-phase Coarsening rate

Development of Chinese duplex stainless steel in recent years

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Journal of Iron and steel Research International 2017年第2期24卷 121-130页

作者： Zhi-gang Song Han Feng Shao-mei Hu institute for special steels Central Iron and Steel Research Institute Beijing 100081 China

The development in research, production, applications, and national standards of Chinese duplex stainless steel （DSS） in recent years was introduced in light of the worldwide development in the field of DSS. The results showed that the output of Chinese DSS increased greatly, and at the same time its grade gradually evolved into a collaborative developing series including the main grade type 2205 and other DSS types in recent years. Economical DSS and super DSS underwent rapid development, especially after 2010. In re- cent years, the application of Chinese DSS has been expanded further not only in traditional application ar- eas such as the petrochemical industry, but also in diverse new fields such as oil and gas transportation, chemical tanker manufacturing, nuclear power plants, and construction. Moreover, due to the increase in output and improvement in quality, as well as applications in Chinese projects, Chinese DSS has also been exported to the Middle East, Eastern Europe, and other regions.

关键词： Duplex stainless steelNitrogen alloyingHot ductilityPrecipitated phase