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Asian Pacific Journal of Tropical Biomedicine 2019年第9期9卷 365-372页

作者： Mariano Nicolás Alemán Sara Serafina Sánchez Stella Maris Honoré instituto Superior de investigaciones Biológicas (INSIBIO) Consejo Nacional de Investigaciones Científicas y Técnicas - Universidad Nacional de Tucumán (CONICET-UNT)

Objective: To evaluate the potential of Smallanthus sonchifolius(S. sonchifolius) roots in ameliorating hepatic damage of rats fed with a high fructose ***: The effect of S. sonchifolius roots on energy intake, body weight, fat and liver mass was determined in male rats fed with a high-fructose diet. Plasma glucose, triglycerides, total cholesterol, lipoproteins and aspartate aminotransferase and alanine aminotransferase were analyzed. Histological changes of the livers were evaluated by electronic microscopy and apoptosis was examined using the TUNEL method. The levels of malondialdehyde, reducedglutathione and antioxidant enzymes(catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase) activities were also ***: S. sonchifolius roots significantly decreased energy intake, body weight, fat and liver mass(P < 0.05). S. sonchifolius roots ameliorated liver steatosis and mitochondrial morphology, avoiding cellular apoptosis and normalizing transaminase activity in the liver of rats fed with high fructose. Enzymatic assays revealed that S. sonchifolius roots had a modulatory effect on the oxidative stress induced by fructose-feeding by reducing lipid peroxidation(P < 0.05) and antioxidant enzyme activities(P < 0.05) in ***: S. sonchifolius roots can ameliorate non-alcoholic fatty liver disease by improving oxidative stress and liver injury.

关键词： Smallanthus sonchifolius roots Non-alcoholic fatty liver disease Oxidative stress Apoptosis Liver

Fatty acids in microalgae and cyanobacteria in a changing world:Contrasting temperate and cold environments

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BIOCELL 2022年第3期46卷 607-621页

作者： MARCELO P.HERNANDO IRENE R.SCHLOSS FLORENCIA de LA ROSA MARLEEN de TROCH Comisión Nacional de Energía Atómica(CNEA) Centro Atómico ConstituyentesDepartamento de RadiobiologíaSan MartínBuenos AiresArgentina Red de Investigación de Estresores Marinos-costeros en América Latina y el Caribe(REMARCO) Mar del Plata7602Argentina instituto Antártico Argentino(IAA) San MartínBuenos AiresArgentina Centro Austral de investigaciones científicas(CADIC-CONICET) Ushuaia9410Argentina Universidad Nacional de Tierra del Fuego Ushuaia9410Argentina instituto de Ciencias Básicas y Experimentales(ICBE) Universidad de MorónMorónBuenos AiresArgentina Consejo Nacional de investigaciones científicas y Técnicas(CONICET) Buenos AiresArgentina Ghent University Faculty of SciencesBiology DepartmentMarine BiologyGhent9000Belgium

Under the present changing climate conditions and the observed temperature increase,it is of high importance to understand its effects on aquatic microbial life,and organisms’adaptations at the biochemical *** adjust to temperature or salinity stress and avoid cell damage,organisms alter their degree of fatty acids(FAs)***,temperature is expected to have strong effects on both the quantity and quality of FAs in aquatic *** we review some recent findings about FAs sensitivity to climate change in contrasting ***,heat waves may induce changes in the relative abundance of polyunsaturated FAs(PUFA).However,the impact of the exposure to warming waters is different in temperate and polar *** cold marine waters,high concentration of omega-3(ω3)FAs such as eicosapentaenoic acid(EPA)is promoted due to the activation of the desaturase *** this way,cells have enough energy to produce or activate antioxidant protection mechanisms and avoid oxidative stress due to heat ***,under high irradiance and heat wave conditions in temperate environments,photosystems’protection is achieved by decreasing EPA concentration due to desaturase *** FAs are transferred in aquatic food ***,any alteration in the production of essential FAs by phytoplankton(the main source ofω3)due to climate warming can be transferred to higher trophic levels,with cascading effects for the entire aquatic ecosystem.

关键词： Antarctic Temperate Essential FAs Increased temperature Microalgae Cyanobacteria

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

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Cellular & Molecular Immunology 2023年第8期20卷 955-968页

作者： Manuel M.Vicente Inês Alves Ângela Fernandes Ana M.Dias Beatriz Santos-Pereira Elena Pérez-Anton Sofia Santos Tao Yang Alexandra Correia Anja Münster-Kühnel Afonso R.M.Almeida Sarina Ravens Gabriel A.Rabinovich Manuel Vilanova Ana E.Sousa SaloméS.Pinho i3S–Institute for Research and Innovation in Health University of PortoPortoPortugal Institute of Biomedical Sciences Abel Salazar(ICBAS) University of PortoPortoPortugal Graduate Program in Areas of Basic and Applied Biology(GABBA) ICBASUniversity of PortoPortoPortugal Faculty of Medicine University of PortoPortoPortugal Nephrology department Centro Hospitalar e Universitário do PortoPortoPortugal Institute of Immunology Hannover Medical SchoolHannoverGermany Institute of Clinical Biochemistry Hannover Medical SchoolHannoverGermany instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Laboratorio de Inmunopatología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Laboratorio de Inmuno-oncología Translacional Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Facultad de Ciencias Exactas y Naturales(FCEyN) Universidad de Buenos AiresCiudad de Buenos AiresArgentina

T-cell development ensures the formation of diverse repertoires of T-cell receptors(TCRs)that recognize a variety of *** is a major posttranslational modification present in virtually all cells,including T-lymphocytes,that regulates activity/*** these structures are known to be involved in TCR-selection in DP thymocytes,it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to ***,we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes,as well as dynamic *** restricting the N-glycosylation profile of thymocytes to high-mannose structures,using specific glycoengineered mice(Rag1CreMgat1fl/fl),we showed remarkable defects in key developmental checkpoints,includingß-selection,regulatory T-cell generation andγδT-cell development,associated with increased susceptibility to colon and kidney inflammation and *** further demonstrated that a single N-glycan antenna(modeled in Rag1CreMgat2fl/fl mice)is the sine-qua-non condition to ensure normal *** conclusion,we revealed that mannosylated thymocytes lead to a dysregulation in T-cell development that is associated with inflammation susceptibility.

关键词： N-glycosylation T-cell development Thymocytes Glycocalyx Inflammation

Non-steroidal anti-inflammatory drugs(NSAIDs) and neuroprotection in the elderly a view from the mitochondria

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Neural Regeneration Research 2015年第9期10卷 1371-1372页

作者： María Calvo-Rodríguez Lucía Nú?ez Carlos Villalobos instituto de Biologíay Genética Molecular (IBGM) Consejo Superior de Investigaciones Científicas (CSIC) and Universidad de Valladolid

The most important risk factor for stroke and neurodegeneration is aging. In fact, survival after stroke diminishes largely with aging. In fact, recovery after brain artery occlusion is dramatically worsened by aging, even normal aging is associated with neuron damage and cognitive decline. Mechanisms involved in aging-related, cognitive decline and susceptibility to neuron damage in stroke and neurode- generation are largely unknown. One of the most important mech- anisms contributing to neural dysfunction and death is excitotox- icity. This process is based on the fact that the excessive glutamate receptor stimulation may lead to neuronal damage. This overstim- ulation may be due to increased concentration of glutamate, or the prolonged activation of receptors.

关键词： NSAIDs Non-steroidal anti-inflammatory drugs and neuroprotection in the elderly a view from the mitochondria view

Excitotoxicity-induced endocytosis as a potential target for stroke neuroprotection

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Neural Regeneration Research 2021年第2期16卷 300-301页

作者： Margarita Díaz-Guerra instituto de investigaciones Biomédicas“Alberto Sols” Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

decreased neuronal survival-signaling and brain damage:Stroke is a leading cause of death worldwide,the major cause of adult disability and second of *** spite of the social and economic importance of this disorder,an... 详细信息

关键词： drugs death damage

Microbiota of a seepage face at the mouth of a subterranean estuary:diversity,distribution and substrate dependence

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海洋学报:英文版 2023年第8期42卷 147-157页

作者： Yueming Wu Yongjun Wei Juan Severino Pino Ibánhez Danqing Sun Kaiqi Lu Qianqian Wang Jian Li Shan Jiang State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China instituto de Investigacións Mariñas Consejo Superior de Investigaciones CientíficasVigo 36208Spain School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China School of Environment and Safety Engineering Jiangsu UniversityZhenjiang 212013China

Subterranean estuaries,i.e.,the mixing zone between terrestrial groundwater and recirculated seawater,host a wide range of ***,field campaigns were conducted at the mouth of the subterranean estuary at the Sanggou Bay(Shandong Province,China)over four consecutive seasons at a seepage face(0−20 cm depth).The diversity of benthic microbiome was characterized via 16S rRNA gene sequencing and metagenomics,combined with physic-chemical parameters,e.g.,organic carbon,total nitrogen and sulfate contents in *** spring,the dominant species were assigned to the phylum *** opportunistic species was assigned to Acidobacteria,Actinobacteria and *** key components were identified to be species of the genera Pseudoalteromonas,Colwellia and Sphingobium,indicating the involvement of sediment microbiota in the degradation of sedimentary organic carbon,particularly that of pelagic origin,e.g.,phytoplankton detritus and bivalve *** spring,the microbial community was statistically similar along the depth profiles and among the three sampled *** spatial distributions were obtained in the remaining *** contrast,the dominant species assemblages varied significantly among seasons,with key genera being Thioprofundum and Nitrosopumilus during summer and autumn and Thioprofundum and Ilumatobacter during *** analysis revealed a seasonal shift in benthic nitrogen and sulfur metabolism associated with these variations in microbial community ***,our findings suggested that macro elements derived from pelagic inputs,particularly detrital phytoplankton,shaped the microbial community compositions at the seepage face,resulting in significant seasonal variations,while the influence of terrestrial materials transported by groundwater on the sediment microbiota at the seepage face found to be minor.

关键词： subterranean estuary microbiota seepage face seasonal variation substrate

缓蚀离子存在条件下阳极氧化提高Ti-6Al-4V合金的耐蚀性

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Transactions of Nonferrous Metals Society of China 2022年第6期32卷 1896-1909页

作者： A.L.MARTINEZ D.O.FLAMINI S.B.SAIDMAN instituto de Ingeniería Electroquímica y Corrosión(INIEC) Departamento de Ingeniería Química(DIQ)Universidad Nacional del Sur(UNS)Argentina Consejo Nacional de investigaciones científicas y Técnicas(CONICET) Bahía BlancaArgentina

通过恒电流阳极氧化在Ti−6Al−4V合金表面制备彩色氧化物薄膜。采用3种不同的含有腐蚀无机缓蚀剂的水溶液(Na_(2)MoO_(4),NaH_(2)PO_(4)和NH_(4)VO_(3))进行阳极化处理,研究缓蚀剂阴离子对合金在Ringer溶液中腐蚀行为的影响。采用开路电... 详细信息

通过恒电流阳极氧化在Ti−6Al−4V合金表面制备彩色氧化物薄膜。采用3种不同的含有腐蚀无机缓蚀剂的水溶液(Na_(2)MoO_(4),NaH_(2)PO_(4)和NH_(4)VO_(3))进行阳极化处理,研究缓蚀剂阴离子对合金在Ringer溶液中腐蚀行为的影响。采用开路电位(OCP)、Tafel极化、线性扫描伏安(LSV)和计时电流(CA)等手段,评估处理后电极的腐蚀性能。通过释放的Mo、V和P,采用ICP-AES技术检测缓蚀剂离子的掺入。利用扫描电子显微镜(SEM)、X射线衍射(XRD)和X射线光电子能谱(XPS)对形成的氧化物进行表征。结果表明,无论采用何种溶液,均获得无孔或裂纹的致密无定形氧化物。在Na_(2)MoO_(4)溶液中阳极氧化样品的腐蚀电流密度最低(0.11μA/cm^(2)),即使在Ringer溶液中浸泡168 h,仍能保护合金,而未检测到裂纹或腐蚀产物。XPS分析结果显示,钼以Mo^(6+)和Mo^(4+)的形式掺入氧化膜中。

关键词： Ti−6Al−4V合金阳极氧化无机缓蚀剂腐蚀防护

3-D crustal-scale gravity model of the San Rafael Block and Payenia volcanic province in Mendoza,Argentina

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Geoscience Frontiers 2018年第1期9卷 239-248页

作者： Daniel Richarte Marianela Lupari Agustina Pesce Silvina Nacif Mario Gimenez instituto Geofísico-Sismológico Volponi Universidad Nacional de San JuanArgentina Consejo Nacional de investigaciones científicas y Técnicas(CONICET) Argentina

The San Rafael Block(SRB)is part of one of the main retroarc volcanic provinces in southern Central Andes in Mendoza,*** block is located in the Andean foothills between the orogenic front and foreland basement uplifts of late Miocene *** order to analyze the geochronological evolution of the Quaternary volcanism in the region,several geologic and geophysical studies have been ***,the crust,where the SRB is located,has not been well characterized *** on gravimetric and magnetic data,together with isostatic and elastic thickness analyses,we modeled the crustal structure of the *** obtained has allowed us to understand the crust where the SRB and the Payenia volcanic province are *** anomalies indicate that the SRB presents higher densities to the North of Cerro Nevado and Moho calculations suggest depths for this block between 40 and 50 *** of elastic thickness would indicate that the crust supporting the San Rafael Block presents values of approximately 10 km,being enough to support the block ***,in the Payenia region,elastic thickness values are close to zero due to the regional temperature increase.

关键词： San Rafael Block Payenia 3-D crustal model Asthenospheric wedge

Validation of kinetic modeling of progesterone release from polymeric membranes

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Asian Journal of Pharmaceutical Sciences 2018年第1期13卷 54-62页

作者： Analia Irma Romero Mercedes Villegas Alicia Graciela Cid Mónica Liliana Parentis Elio Emilio Gonzo José María Bermúdez instituto de investigaciones para la Industria Química Universidad Nacional de Salta – Consejo Nacional de Investigaciones Científicas y Técnicas Facultad de Ingeniería Universidad Nacional de Salta

Mathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to elucidate the physical transport mechanisms involved. In this paper we validate a novel mathematical model that describes progesterone(Prg) controlled release from poly-3-hydroxybutyric acid(PHB) membranes. A statistical analysis was conducted to compare the fitting of our model with six different models and the Akaike information criterion(AIC) was used to find the equation with best-fit. A simple relation between mass and drug released rate was found,which allows predicting the effect of Prg loads on the release behavior. Our proposed model was the one with minimum AIC value, and therefore it was the one that statistically fitted better the experimental data obtained for all the Prg loads tested. Furthermore, the initial release rate was calculated and therefore, the interface mass transfer coefficient estimated and the equilibrium distribution constant of Prg between the PHB and the release medium was also determined. The results lead us to conclude that our proposed model is the one which best fits the experimental data and can be successfully used to describe Prg drug release in PHB membranes.

关键词： Mathematical models Model validation Drug delivery/release Mass transfer coefficient Equilibrium distribution constant

Cysteine and Cysteine-Related SignalingPathways in Arabidopsis thaliana

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Molecular Plant 2014年第2期7卷 264-276页

作者： Luis C. Romero M. Ángeles Aroca Ana M. Laureano-Marín Inmaculada Moreno Irene García Cecilia Gotor instituto de Bioquímica Vegetal y Fotosíntesis Consejo Superior de Investigaciones Científicas and Universidad de Sevilla Avenida Américo Vespucio 49 41092 Sevilla Spain

Cysteine occupies a central position in plant metabolism because it is a reduced sulfur donor moleculeinvolved in the synthesis of essential biomolecules and defense compounds. Moreover, cysteine per se and its deriva-tive molecules play roles in the redox signaling of processes occurring in various cellular compartments. Cysteine issynthesized during the sulfate assimilation pathway via the incorporation of sulfide to O-acetylserine, catalyzed byO-acetylserine（thiol）lyase （OASTL）. Plant cells contain OASTLs in the mitochondria, chloroplasts, and cytosol, resultingin a complex array of isoforms and subcellular cysteine pools, in recent years, significant progress has been made inArabidopsis, in determining the specific roles of the OASTLs and the metabolites produced by them. Thus, the dis-covery of novel enzymatic activities of the less-abundant, like deS1 with L-cysteine desulfhydrase activity and SCSwith S-sulfocysteine synthase activity, has provided new perspectives on their roles, besides their metabolic ***, the research has been demonstrated that cytosolic sulfide and chloroplastic S-sulfocysteine act as signalingmolecules regulating autophagy and protecting the photosystems, respectively. In the cytosol, cysteine plays an essentialrole in plant immunity; in the mitochondria, this molecule plays a central role in the detoxification of cyanide, which isessential for root hair development and plant responses to pathogens.

关键词： β-cyanoalanine synthase cysteine desulfhydrase cyanide O-acetylserine(thiol)lyase plant development plant immunity redox signaling S-sulfocysteine synthase stress sulfide