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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Historical fluxes of metal and metalloids in an aquatic ecosystem affected by land-use change and mining activities in northwestern Mexico

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International Journal of Sediment Research 2023年第5期38卷 724-738页

作者： Ochoa-Contreras Roberto Jara-Marini Martín enrique Ruiz-Fernández Ana Carolina Sanchez-Cabeza Joan Albert Meza-Figueroa Diana Pérez-Bernal Libia Hascibe Posgrado en ciencias Centro de Investigación en Alimentación y Desarrollo Unidad Hermosillo 2. Centro de Investigación en Alimentación y Desarrollo Unidad Hermosillo Unidad Acad emica Mazatlán Instituto de Ciencias del Mar y Limnología Universidad Nacional Autónoma de M exico departamento de Geología División de Ciencias Exactas y Naturales Universidad de Sonora Rosales y Encinas

Freshwater reservoirs are essential owing because of their ecological, economic, and social *** are particularly vulnerable to contamination, as of metal and metalloids, derived from anthropogenic activities like mining. The temporal variations in trace element concentrations(arsenic(As),mercury(Hg), chromium(Cr), copper(Cu), nickel(ni), lead(Pb), and zinc(Zn)), enrichment, fluxes, and possible sources were evaluated by studying two sediment cores from the La Angostura(AnG) Reservoir(northwest Mexico), using210Pb geochronology. The enrichment factors showed from null to minor enrichment for most elements, but moderate to severe enrichment of mercury(Hg). Most trace element concentrations had a detrital origin, and notable Hg concentration increases since the past decade were associated with severe drought periods, likely resulting from wildfires. The observed sediment concentrations of As and Hg can cause adverse effects on biota in the ecosystem since they are above the probable effect level(PEL). development of strategies for metal attenuation in this reservoir is recommended and metals should be controlled until specific ecotoxicological studies are performed.

关键词： Aquatic ecosystems 210Pb geochronology Mining activities Metals Metalloids enrichment factors

Alluvial sedimentation and tectonostratigraphic evolution in a narrow extensional zigzag basin margin (northern Teruel Basin, Spain)

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Journal of Palaeogeography 2019年第4期8卷 368-392页

作者： Lope Ezquerro Aránzazu Luzón José L.Simón Carlos L.Liesa departamento de ciencias de la Tierra Facultad de Ciencias Geotransfer Research Group and Instituto de Investigación en Ciencias Ambientales (IUCA) Universidad de Zaragoza

The northern part of the eastern margin of the extensional neogene Teruel Basin(central-eastern Spain)consists of a non-linear,zigzag fault zone made of alternating ca.2 km long,nnW-SSE trending segments and shorter nnESSW *** outcrop conditions made possible a comprehensive integrated stratigraphic and structural study,especially focused on coarse clastic sediments deposited along the basin ***-exposed stratal relationships with boundary faults,allowed the analysis of tectonic influence on *** deformation includes growth faulting,rollover anticlines,and monoclines and associated onlap stratal terminations,angular unconformities,and other complex growth strata *** of them is the onlap-over-rollover bed arrangement described here for the first time,which reveals the competition between tectonic subsidence and sedimentary ***,the structural inheritance(dense Mesozoic fracture grid)and the dominant,nearly‘multidirectional’(σ1 vertical,σ2≈σ3),Pliocene extensional regime withσ3 close to E-W,are considered to have controlled the margin structure and ***-stratigraphic evolution includes:(i)reactivation of inherited nnW-SSE faults and development of W-SW-directed small alluvial fans(SAF)while nnE-SSW segments acted as gentle relay ramp zones;(ii)progressive activation of nnE-SSW faults and development of nW-directed very small alluvial fans(VSAF);during stages i and ii sediments were trapped close to the margin,avoiding widespread progradation;(iii)linking of nnW-SSE and nnE-SSW structural segments,overall basin sinking and widespread alluvial progradation;(iv)fault activity attenuation and alluvial *** particular structure and kinematic evolution of this margin controlled alluvial system *** of alluvial fans,directly set up at the border faults,was conditioned by the narrowness of the margin,small catchment areas,and proximity between faults,which prevented the development of l

关键词： Extensional basin Alluvial fan Stratal stacking pattern Structural inheritance Fault linkage

design of multilayer hybrid sol-gel coatings with bifunctional barrier-bioactive response on the Elektron 21 magnesium alloy for biomedical applications

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Journal of Magnesium and Alloys 2021年第6期9卷 2097-2112页

作者： K.S.Durán n.Hernández L.M.Rueda C.A.Hernández-Barrios A.E.Coy F.Viejo Grupo de investigación en desarrollo y tecnología de nuevos Materiales(GIMAT) Universidad Industrial de Santander9 Cra.27Colombia Grupo de investigación de las ciencias de las Ingenierías(GICI) Universidad de San BuenaventuraCartagenaCalle Real de TerneraDiagonal 32#30-966Colombia

The present study aims to develop multilayer barrier-bioactive hybrid sol-gel coatings from a mixture of the silane precursors tetraethylorthosilicate(TEOS)and glycidoxypropyltriethoxysilane(GPTMS)deposited on the Elektron 21 magnesium *** purpose of the inner layer(barrier coating)was to provide corrosion protection to the magnesium alloy,whereas the outer layer(bioactive coating)was doped with different Ca and Mg contents to produce a bioactive *** coatings were characterised using scanning electron microscopy(SEM)and their corrosion behaviour was evaluated by anodic polarisation and electrochemical impedance spectroscopy after immersion in simulated body fluid(SBF)at 37±0.5°*** experimental results showed that the multilayer coatings increased the corrosion resistance of the alloy up to three orders of magnitude during immersion in SBF *** the other hand,the presence of Ca and Mg in the bioactive coating promoted the growth of apatite-like ***,an increment of salt content favoured the formation of porous coatings,which allowed the access of the electrolyte to the substrate leading to their rapid *** the latter,this research endorses the premise that the TEOS-GPTMS hybrid system represents a promising alternative to produce bifunctional barrier-bioactive coatings.

关键词： Magnesium bioactivity coating sol-gel EIS corrosion

A novel and stretchable carbon-nanotube/ni@TiO_(2):W photocatalytic composite for the complete removal of diclofenac drug from the drinking water

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Journal of environmental Sciences 2023年第4期126卷 575-589页

作者： Ernesto Valadez-Renteria Rafael Perez-Gonzalez Christian Gomez-Solis Luis Armando Diaz-Torres Armando encinas Jorge Oliva Vicente Rodriguez-Gonzalez Consejo nacional de Ciencia y tecnología-División de Materiales Avanzados Instituto Potosino de Investigación Científica y TecnológicaSan Luis Potosí78216México División de ciencias e Ingenierías Universidad de GuanajuatoLeón 37150México Grupo de Espectroscopia de Materiales Avanzados y nanoestructurados(GEMAnA) Centro de Investigaciones enópticaA.C.Lomas Del CampestreLeón 37150México

We present the structural,morphological and photocatalytic properties of stretchable composites made with carbon nanotubes (CnTs),silicon rubber and ni@TiO_(2):W nanoparticles(TiWni nPs) with average size of 37±2 *** images showed that the TiWni nPs decorated the surface of the CnT fibers,which are oriented in a preferential *** nPs presented a mixture of anatase/rutile phases with cubic *** performance of the TiWni powders and stretchable composites was evaluated for the photocatalytic degradation of diclofenac (DCF) anti-inflammatory drug under ultraviolet-visible *** results revealed that the maximum DCF degradation percentages were 34.6%,91.9%,97.1%,98.5%and 100%for the CnT composite (stretched at 0%),TiWni powders,CnT+TiWni(stretched at 0%),CnT+TiWni (stretched at 50%) and CnT+TiWni (stretched at 100%),***,stretching the CnT+TiWni composites was a good strategy to enhance the DCF degradation percentage from 97.1%to 100%,since stretching created additional defects (oxygen vacancies) that acted as electron sink,delaying the electron-hole recombination,and favors the DCF ***/absorbance measurements confirmed the presence of such ***,the reactive oxygen species (ROS) were determined by the scavenger’s experiments and found that the main ROS were the·OH and O_(2)-radicals,which attacked the DCF molecules,causing their *** results of this investigation confirmed that the stretchable CnT/TiWni-based composites are a viable alternative to remove pharmaceutical contaminants from water and can be manually separated from the decontaminated water,which is unviable using photocatalytic powders.

关键词： Diclofenac Pharmaceutical contaminant TiO_(2) Carbon nanotubes Stretchable composite Photocatalysis

Modelling of phosphorus accumulation in an aeroponic coriander crop

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International Journal of Agricultural and Biological engineering 2022年第6期15卷 73-79页

作者： Alejandro Rincón Santamaría John E.Candelo-Becerra Fredy E.Hoyos Velasco Grupo de investigación en desarrollos Tecnológicos y Ambientales-GIDTA Facultad de Ingeniería y ArquitecturaUniversidad Católica de Manizales170002 ManizalesColombia Grupo de investigación en Microbiología y Biotecnología Agroindustrial-GIMIBAG Instituto de Investigación en Microbiología y Biotecnología AgroindustrialFacultad de Ciencias de la SaludUniversidad Católica de Manizales170002 ManizalesColombia department of Electrical energy and Automation Faculty of MinesUniversidad Nacional de ColombiaSede MedellínMedellín 050041AntioquiaColombia

A model was developed for phosphorus(P)concentration over time in a closed aeroponic coriander *** addition,the setting and starting up of the soilless culture is described,and the measurements of electrical conductivity(EC),pH and concentration of major ions in the mixing tank are *** using mass balance principles,the dynamics of the nutrient concentration in the mixing tank and in the drainage solution are *** series of continuous stirred tank reactors are considered for the flow structure,using a power law relationship to represent the rate of nutrient removal,considering water volume *** concentration measurements were used for model fitting,and the resulting simulation is in good agreement with data.

关键词： aeroponic culture hydroponics soilless culture nutrient modelling Coriander sativum

Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation

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neural Regeneration Research 2019年第10期14卷 1787-1795页

作者： Alan Hinojosa-Godínez Luis F. Jave-Suarez Mario Flores-Soto Alma y. Gálvez-Contreras Sonia Luquín Edith Oregon-Romero Oscar González-Pérez Rocio E. González-Castaneda Laboratorio de Microscopía de Alta Resolución Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Laboratorio de neurociencias Facultad de PsicologíaUniversidad de ColimaColimaMéxico División de Inmunología Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico División de neurociencias Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico instituto de investigación en ciencias Biomédicas (IICB) Departamento de Biología Molecular y GenómicaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Unidad de Atención en neurociencias Departamento de Neurociencias. Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico

Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult ***,this effect has not been observed in long-term sleep *** precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this *** this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword *** results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate *** observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep *** addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(BrdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated *** findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived *** procedures performed in this study were approved by the Animal Ethics Committee of the University of Guadalajara,Mexico(approval ***-16610)on January 2,2016.

关键词： sleep-deprivation melatonin microRnA neurogenesis Sirtuin 1 SIRT1 methyl-CpG-binding protein 2 MECP2 epigenetic text-mining mir-9 let-7b

Interlayer distance effects on absorption coefficient and refraction index change in p-type double-δ-doped GaAs quantum wells

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Chinese Physics B 2019年第12期28卷 186-190页

作者： H noverola-Gamas L M Gaggero-Sager O Oubram instituto de investigaciones en ciencias Básicas y Aplicadas Universidad Autónoma del Estado de Morelos MorelosCuernavaca 62209Mexico Division Academica de Ingeniería y Arquitectura Universidad Juárez Autonoma de TabascoCunduacan 8660Mexico Centro de investigación en Ingeniería y ciencias Aplicadas Universidad Autónoma del Estado de MorelosCuernavaca 62209Mexico Facultad de ciencias Químicas e Ingeniería Universidad Autónoma del Estado de MorelosCuernavaca 62209Mexico

In the framework of the Thomas–Fermi(TF) approach, a model for the p-type double-δ-doped(DDD) system in Ga As is presented. This model, unlike other works in the literature, takes into account that the Poisson equation associated with the system is nonlinear. The electronic structure is calculated for heavy and light holes. The changes in the electronic structure result of the distance d between the doped layers are studied. In particular, the relative absorption coefficient as well as the relative refractive index change is calculated as a function of the incident photon energy for heavy holes. The effect of the interlayer distance exhibits, in the absorption coefficient, a red shift of the peak position and a decrease in amplitude when the distance increases. In addition, the relative refractive index change node has a red shift as well as the interlayer distance increases. The calculations show that the effect of the separation between layers has a greater influence on the linear terms. These results are very important for theoretical calculations and engineering of optical and electronic devices based in δ-doped Ga As.

关键词： double delta-doping p-type GaAs layers electronic structure Thomas–Fermi approach nonlinear optical properties

Coyote(Canis latrans)in South America:potential routes of colonization

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Integrative Zoology 2020年第6期15卷 471-481页

作者： Octavio MOnROy-VILCHIS JoséF.GOnZÁLEZ-MAyA Ángel BALBUenA-SERRAnO Fausto ELVIR Martha M.ZARCO-GOnZÁLEZ Clarita RODRÍGUEZ-SOTO Centro de investigación en ciencias Biológicas Aplicadas Universidad Autónoma del Estado de MéxicoInstituto Literario 100TolucaMéxico50000México instituto de Ecología Universidad Nacional Autónoma de MéxicoCoyoacánMéxico The Sierra to Sea Institute and ProCAT Colombia Las AlturasCoto BrusPuntarenasCosta Rica Fundación investigación en ciencias para el Estudio y Conservación de la Biodiversidad Instituto de Ciencia para el Estudio y Conservación de la Biodiversidadfrente a la Escuela República de JapónTegucigalpaHonduras Facultad de Geografía Universidad Autónoma del Estado de MéxicoInstituto Literario 100TolucaMéxico50000México

During the last century,the coyote(Canis latrans)has increased its distribution in Central *** the 1980s,it had not been recorded in *** records show that coyotes have crossed the Panama Canal,indicating that continues to expand;therefore,there is a possibility that it will reach northern South *** objectives were to identify potential coyote colonization routes to South America,and the variables that favor its *** hypothesized that habitat fragmentation benefits coyote *** applied 7 algorithms to model the potential distribution of the coyote,using 196 presence records and 12 *** models with better performance were used to generate a consensus *** our consensus model and the areas with highest probability of presence,a potential colonization route was generated between Central America and northern South *** route lies through southern Costa Rica,along the Pacific coast of Panama to the south,to the Andean mountains in northern *** variables that explained potential coyote distribution were human population density,altitude,and percentage of crops with positive influence,and tropical broadleaf forests with negative *** results indicate that human activities and deforestation are related to coyote distribution *** can be implemented within the identified route to improve environmental management,in order to avoid the presence of the coyote in the ecosystems of northern South America.

关键词： Canis latrans carnivore distribution expansion invasive management species distribution model