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Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding

World Journal of Clinical Cases 2018年第13期6卷 611-623页

作者： José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo Servicio de Aparato Digestivo Hospital Universitario Marques? de Valdecilla instituto de investigación Sanitaria Marqués de Valdecilla Centro de investigación Biomédica Red de enfermedades Hepáticas y Digestivas Laboratorio de investigación en Hepatología y Gastroenterología Hospital General Universitario Gregorio Mara?ón-Instituto de Investigación Sanitaria Gregorio Mara?ón

AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(nSBBs) and acute nonresponders received *** Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional nSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic *** Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(nSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). no clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional nSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with *** Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects fo

关键词： Gastrointestinal hemorrhage Propranolol Carvedilol Liver cirrhosis Portal hypertension

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Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

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neural Regeneration Research 2022年第1期17卷 31-37页

作者： Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre Unidad de Evaluación Preclínica Unidad de Biotecnología Médica y FarmacéuticaCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico instituto de neurociencias IdISSCHospital Clínico San CarlosMadridEspaña Biochemistry and Molecular Genetics department University of AlabamaBirminghamAlabama Unidad de Biotecnología Industrial Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Centro Universitario de los Altos Universidad de GuadalajaraGuadalajaraMéxico

The presenilin genes(PSen1 and PSen2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressive disease *** 1 is the catalytic core of theγ-secretase complex that conducts the intramembranous proteolytic excision of multiple transmembrane proteins like the amyloid precursor protein,notch-1,n-and E-cadherin,LRP,Syndecan,delta,Jagged,CD44,ErbB4,and *** 1 plays an essential role in neural progenitor maintenance,neurogenesis,neurite outgrowth,synaptic function,neuronal function,myelination,and ***,an imbalance caused by mutations in presenilin 1/γ-secretase might cause aberrant signaling,synaptic dysfunction,memory impairment,and increased Aβ42/Aβ40 ratio,contributing to neurodegeneration during the initial stages of Alzheimer’s disease *** review focuses on the neuronal differentiation dysregulation mediated by PSen1 mutations in Alzheimer’s ***,we emphasize the importance of Alzheimer’s disease-induced pluripotent stem cells models in analyzing PSen1 mutations implication over the early stages of the Alzheimer’s disease pathogenesis throughout neuronal differentiation impairment.

关键词： familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation notch presenilin 1 PSen1 mutations γ-secretase complex

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A review of recent advances of kesterite thin films based on magnesium,iron and nickel for photovoltaic application:insights into synthesis,characterization and optoelectronic properties

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Clean energy 2024年第2期8卷 217-238页

作者： nelson Mauricio Espinel Pérez enrique Vera López Jairo Alberto Gómez Cuaspud Juan Bautista Carda Castelló Grupo de investigación en Integridad y Evaluación de Materiales(GIEM).instituto para la investigación e Innovación en ciencia y tecnología de Materiales(InCITEMA).Universidad Pedagógica y Tecnológica de Colombia Av.Central del Norte 39-115.Tunja-BoyacáColombia Servicio nacional de Aprendizaje(Sena).Centro Minero.Vereda MorcáSector Batá.Sogamoso-Boyacá Colombia Universidad Jaume I.Grupo de Química Inorgánica y Orgánica.Castellón de la Plana Campus del Riu Sec.Castellón de la PlanaEspaña

This review emphasizes the recent advancements and prospects of thin-film kesterite-based photovoltaic(PV)applications using magnesium,iron and *** quest for novel materials employed in solar cells has resulted in incorporating these elements into the composition of kesterite as substitutes or modifiers(dopants)for *** integration has induced notable repercussions on the structural,optoelectronics and morphological properties,which are *** first section of this paper offers a comprehensive review of the general characteristics of kesterite *** crucial materials exhibit a high absorption coefficient(104 cm-1)and an optical band gap of 1.0-1.8 ***,they are free of critical raw materials,non-toxic and *** second section depicts the substitution or modification of zinc by magnesium in ***,this paper provides a comprehensive review of the quaternary and pentanary systems Cu_(2)MgSn(S,Se)_(4) and Cu_(2)Zn_(1-x)Mg_(x)SnS_(4),highlighting their advantages and *** the last section,a review of the quaternary or pentanary systems is conducted,namely Cu_(2)ZnxFe_(1-x)SnS_(4) and Cu_(2)Znxni_(1-x)SnS_(4),along with their effects on optoelectronic *** conclusion,various methods for obtaining modified or substituted kesterite materials using magnesium,iron and nickel have demonstrated sustainability,scalability for industrial production and potential candidacy as substitutes for conventional PV *** prospects for pentanary materials(Cu_(2)Zn_(1-x)Mg_(x)SnS_(4),Cu_(2)Zn_(1-x)FexSnS_(4) and Cu_(2)Zn_(1-x)nixSnS_(4))are to overcome the efficiency record of kesterite reported in 2014,which was 12.6%for Cu_(2)ZnSn(S,Se)_(4),and to enhance its optoelectronic properties through synthesis conditions that comply with the principles of green chemistry.

关键词： kesterite thin film magnesium iron nickel substitutes or modifiers novel materials sustainability

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Ontogeny of rat chondrocyte proliferation:studies in embryo,adult and osteoarthritic (OA) cartilage

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Cell Research 2005年第2期15卷 99-104页

作者： Madaí A GóMEZ-CAMARILLO,Juan B.KOURI departamento de Patología Experimental Centro de investigación y de Estudios Avanzados. instituto Politécnico nacional(CInVESTAV-IPn) México.Centro de investigación en ciencias Biológicas Universidad Autónoma de Tlaxcala México. departamento de Patología Experimental Centro de investigación y de Estudios Avanzados. instituto Politécnico nacional(CInVESTAV-IPn) México

The aim of this work was to study the ontogeny of chondrocyte cell division using embryo, adult and osteoarthritic(OA) cartilage. We searched for mitosis phases and performed a comparative evaluation of mitotic index, basic fibro-blast growth factor b (FGFb), transforming growth factor β1 (TGF-β1) receptors, cyclin dependent kinase (CDK1)and Cyclin-B expression in fetal, neonate, 3, 5, 8 weeks old rats and experimental OA. Our results showed that mitosisphases were observed in all normal cartilage studied, although, we found a decrease in mitotic index in relation to tissuedevelopment. no mitosis was detected in OA cartilage. We also found a statistical significant reduction in cell number inOA cartilage, compared with the normal tissue. Furthermore, FGFb and TGF-β1 receptors diminished in relation totissue development, and were very scarce in experimental OA. Western blot assays showed CDK-1 expression in allcases, including human-OA cartilage. Similar results were observed for Cyclin-B, except for 8 weeks, when it was notexpressed. Our results suggest that cell division seems to be scarce, if not absent within the OA cartilage ***, the existence of factors essential for cell division leaves open the question concerning chondrocyteproliferation in OA cartilage, which is likely to be present in the early stages of the disease.

关键词： proliferation chondrocytes mitotic index growth factors.

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design of multilayer hybrid sol-gel coatings with bifunctional barrier-bioactive response on the Elektron 21 magnesium alloy for biomedical applications

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Journal of Magnesium and Alloys 2021年第6期9卷 2097-2112页

作者： K.S.Durán n.Hernández L.M.Rueda C.A.Hernández-Barrios A.E.Coy F.Viejo Grupo de investigación en desarrollo y tecnología de nuevos Materiales(GIMAT) Universidad Industrial de Santander9 Cra.27Colombia Grupo de investigación de las ciencias de las Ingenierías(GICI) Universidad de San BuenaventuraCartagenaCalle Real de TerneraDiagonal 32#30-966Colombia

The present study aims to develop multilayer barrier-bioactive hybrid sol-gel coatings from a mixture of the silane precursors tetraethylorthosilicate(TEOS)and glycidoxypropyltriethoxysilane(GPTMS)deposited on the Elektron 21 magnesium *** purpose of the inner layer(barrier coating)was to provide corrosion protection to the magnesium alloy,whereas the outer layer(bioactive coating)was doped with different Ca and Mg contents to produce a bioactive *** coatings were characterised using scanning electron microscopy(SEM)and their corrosion behaviour was evaluated by anodic polarisation and electrochemical impedance spectroscopy after immersion in simulated body fluid(SBF)at 37±0.5°*** experimental results showed that the multilayer coatings increased the corrosion resistance of the alloy up to three orders of magnitude during immersion in SBF *** the other hand,the presence of Ca and Mg in the bioactive coating promoted the growth of apatite-like ***,an increment of salt content favoured the formation of porous coatings,which allowed the access of the electrolyte to the substrate leading to their rapid *** the latter,this research endorses the premise that the TEOS-GPTMS hybrid system represents a promising alternative to produce bifunctional barrier-bioactive coatings.

关键词： Magnesium bioactivity coating sol-gel EIS corrosion

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Postoperative Crohn’s disease recurrence: A practical approach

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World Journal of Gastroenterology 2008年第36期14卷 5540-5548页

作者： Pilar nos Eugeni Domènech Centro de investigación Biomédica en Red de enfermedades Hepáticas y Digestivas (Ciberehd) Spain

Crohn's disease is a chronic inflammatory condition that may involve any segment of the gastrointestinal tract. Although several drugs have proven efficacy in inducing and maintaining disease in remission, resectional surgery remains as a cornerstone in the management of the disease, mainly for the treatment of its stenosing and penetrating complications. However, the occurrence of new mucosal (endoscopic) lesions in the neoterminal ileum early after surgery is almost constant, it is followed in the mid-term by clinical symptoms and, in a proportion of patients, repeated intestinal resections are required. Pathogenesis of postoperative recurrence (POR) is not fully understood, but luminal factors (commensal microbes, dietary antigens) seem to play an important role, and environmental and genetic factors may also have a relevant influence. Many studies tried to identify clinical predictors for POR with heterogeneous results, and only smoking has repeatedly been associated with a higher risk of POR. Ileocolonoscopy remains as the gold standard for the assessment of appearance and severity of POR, although the real usefulness of the available endoscopic score needs to be revisited and alternative techniques are emerging. Several drugs have been evaluated to prevent POR with limited success. Smoking cessation seems to be one of the more beneficial therapeutic measures. Aminosalicylates have only proved to be of marginal benefit, and they are only used in low-risk patients. nitroimidazolic antibiotics, although efficient, are associated with a high rate of intolerance and might induce irreversible side effects when used for a long-term. Thiopurines are not widely used after ileocecal resection, maybe because some concerns in giving immunomodulators in asymptomatic patients still remain. In the era of biological agents and genetic testing, a well-established preventive strategy for POR is still lacking, and larger studies to identify good clinical, serological, and geneti

关键词： Crohn's disease Postoperative recurrence Smoking Aminosalicylates nitroimidazolic antibiotics Thiopurines

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neuroprotective therapy for retinal neurodegenerative diseases by stem cell secretome

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neural Regeneration Research 2021年第1期16卷 117-118页

作者： Ricardo Usategui-Martín Ivan Fernandez-Bueno instituto Universitario de Oftalmobiología Aplicada(IOBA) Retina GroupUniversidad de ValladolidValladolidSpain Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León Red Temática de Investigación Cooperativa en SaludOftaredInstituto de Salud Carlos IIIValladolidSpain

Retinal neurodegenerative diseases like agerelated macular degeneration,glaucoma,diabetic retinopathy or retinitis pigmentosa are the most frequent causes of incurable low vision and blindness *** had been estimated that the prevalence of these diseases varies between 1/750 and 1/5000 depending on the region,the level of consanguinity or ethnicity(na et al.,2017).The functional and structural complexity of the retina makes it susceptible to multiple types of pathogenic damage.

关键词： diseases protective degenerative

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Modelling of phosphorus accumulation in an aeroponic coriander crop

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International Journal of Agricultural and Biological engineering 2022年第6期15卷 73-79页

作者： Alejandro Rincón Santamaría John E.Candelo-Becerra Fredy E.Hoyos Velasco Grupo de investigación en desarrollos Tecnológicos y Ambientales-GIDTA Facultad de Ingeniería y ArquitecturaUniversidad Católica de Manizales170002 ManizalesColombia Grupo de investigación en Microbiología y Biotecnología Agroindustrial-GIMIBAG Instituto de Investigación en Microbiología y Biotecnología AgroindustrialFacultad de Ciencias de la SaludUniversidad Católica de Manizales170002 ManizalesColombia department of Electrical energy and Automation Faculty of MinesUniversidad Nacional de ColombiaSede MedellínMedellín 050041AntioquiaColombia

A model was developed for phosphorus(P)concentration over time in a closed aeroponic coriander *** addition,the setting and starting up of the soilless culture is described,and the measurements of electrical conductivity(EC),pH and concentration of major ions in the mixing tank are *** using mass balance principles,the dynamics of the nutrient concentration in the mixing tank and in the drainage solution are *** series of continuous stirred tank reactors are considered for the flow structure,using a power law relationship to represent the rate of nutrient removal,considering water volume *** concentration measurements were used for model fitting,and the resulting simulation is in good agreement with data.

关键词： aeroponic culture hydroponics soilless culture nutrient modelling Coriander sativum

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Immunogenicity and mechanisms impairing the response to vaccines in inflammatory bowel disease

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World Journal of Gastroenterology 2015年第40期21卷 11273-11281页

作者： Alicia C Marín Javier P Gisbert María Chaparro Gastro- enterology Unit Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria PrincesaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas28021 MadridSpain

Inflammatory bowel disease(IBD) is an immunological disorder that is usually treated with immunosuppressive therapy,potentially leading to increases in vulnerability to infections. Although many infections can be pre-vented by vaccination,vaccination coverage in these patients in clinical practice is insufficient. Therefore,the seroprotection condition should be verified,even for routine vaccines,such as hepatitis B or pneu-mococcus. Response to vaccines in IBD patients is thought to be impaired due to the immunological alterations generated by the disease and to the immunomodulatory treatments. The immunogenicity of hepatitis B,influenza,and pneumococcal vaccines is impaired in IBD patients,whereas the response to papillomavirus vaccine seems similar to that observed in the healthy population. On the other hand,data on the immunogenicity of tetanus vaccine in IBD patients are conflicting. Studies assessing the response to measles-mumps-rubella,varicella,and herpes zoster vaccines in IBD patients are scarce. The cellular and molecular mechanisms responsible for the impairment of the response to vaccination in IBD patients are poorly understood. Studies aiming to assess the response to vaccines in IBD patients and to identify the mechanisms involved in their immunogenicity are warranted. A better understanding of the immune response,specifically to vaccines,in patients with immune-mediated diseases(such as IBD),is crucial when developing vaccines that trigger more potent immunologic responses.

关键词： Crohn’s disease Inflammatory bowel disease Tumor n

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Surface Properties of Fe_4n Compounds Layer on AISI 4340 Steel Modified by Pulsed Plasma nitriding

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Journal of Materials Science & Technology 2013年第3期29卷 287-290页

作者： J.C.Díaz-Guillén G.Vargas-Gutiérrez E.E.Granda-Gutiérrez J.S.Zamarripa-Pia S.I.Pérez-Aguilar J.Candelas-Ramírez L.lvarez-Contreras Centro de investigacin en Materiales Avanzados S.C.Miguel de Cervantes 120Complejo Industrial ChihuahuaC.P.31109 ChihuahuaChihuahuaMexico Corporacin Mexicana de investigacin en Materiales S.A.de C.V.Ciencia y Tecnología No 790Fracc.Saltillo 400C.P.25290 SaltilloCoahuilaMexico Centro de investigacin y Estudios Avanzados del IPn Unidad SaltilloCarretera Saltillo Monterrey km 13Apdo.Postal 663C.P.25000 SaltilloCoahuilaMexico

In this work, the effect of nitriding current density on hardness, crystalline phase composition, layer thickness and corrosion rate of AlSl 4340 steel has been studied. X-ray diffraction analysis shows that thin layers formed during nitriding process are constituted of 7-Fe4n for samples processed between 1 and 2.5 mA/cm2. Thickness of nitrided layer increases proportionally to current density （0 μm for 0.5 mA/cm2 to 15 pm for 2.5 mA/cm2）. Plasma nitriding increased the surface hardness from 300 HV50g for untreated sample, to around 800HV5og for nitrided samples at 1 mA/cm2. While the untreated samples exhibited a corrosion rate of 0.153 mm per year, the corrosion performance was improved up to 0.03 mm per year at current densities above 1 mA/cm2, which is about one fifth of the corrosion rate of the untreated sample.

关键词： Plasma nitriding Current density Hardness Corrosion

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