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Adenoma incidence decreases u nder the efect of polypectomy

World Journal of Gastroenterology 2012年第11期18卷 1243-1248页

作者： Isadora Rosa Paulo Fidalgo Jose Soares Susana Vinga Carla Oliveira Joao P Silva Susana M Ferro Paula Chaves Antonio G Oliveira Carlos N Leitao Gastroenterology department Instituto Portu-gues de Oncologia de Lisboa Francisco Gentil EPE 1099-023Lisboa Portugal Faculdade de Ciencias da Safldeda Universidade da Beira Interior 6200-506 Covilha Portugal Jose Soares Gastroenterology Department Hospital de SantoAntonio EPE 4099-001 Porto Portugal instituto de engenharia de sistemas e com-putadores: investigacao e desenvolvimento 1000-029 LisboaPortugal Hospital de Santo Antonio EPE 4099-001Porto Portugal Pathology department Instituto Portugues deOncologia de Lisboa Francisco Gentil EPE 1099-023 LisboaPortugal Biostatistics department Faculdade deCiencias M6dicas 1169-056 Lisboa Portugal

MM:To investigate whether, under the influence of pol ypectomy, the incidence of adenoma decreases with age. MeTHODS:Consecutive patients with colonic adenomas identified at index colonoscopy were retrospectively selected if they had undergone three or more complete colonoscopies, at least 24mo apart. Patients who had any first-degree relative with colorectal cancer were excluded. Data regarding number of adenomas at each colonoscopy, their location, size and histological classification were recorded. The monthly incidence density of adenomas after the index examination was estimated for the study population, by using the person-years method. Baseline adenomas were excluded from incidence calculations but their characteristics were correlated with recurrence at follow-up, using the X^42 test. ReSULTS:One hundred and fifty-six patients were included (109male, mean age at index colonoscopy 56.8±10.3 years), with follow-up that ranged from 48 to 232mo. No significant correlations were observed between the number, the presence of villous component, or the size of adenomas at index colonoscopy and the presence of adenomas at subsequent colonoscopies (P = 0.49, 0.12 and 0.78, respectively). The incidence of colonic adenomas was observed to decay from 1.4% person-months at the beginning of the study to values close to 0%, at 12 years after index colonoscopy. CONCLUSION:Our results suggest the sporadic formation of adenomas occurs within a discrete period and that, when these adenomas are removed, all neoplasia-prone clones may be extinguished.

关键词：卡洛斯菲铁发病率

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