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The Effect of Brain Gym on Global Cognitive Function of Institutionalized Older People

International Journal of Mental Health Promotion 2022年第3期24卷 375-383页

作者： Araceli Cano-Estrada Araceli Jimenez-Mendoza denny Contreras-Guerrero Mario Hernandes-Alejandro Andres Salas-Casas Escuela Superior de Tlahuelilpan Universidad Autónoma del Estado de HidalgoTlahuelilpanHidalgoMéxico Escuela Nacional de Enfermería y Obstetricia.universidad Nacional autónoma de México Mexico CityMéxico departomento de Bioingenieria Unidad Profesional Interdisciplinaria de Biotecnología del Instituto Politecnico Nacional(UPIBIIPN)Mexico CityMexico Instituto de Ciencias de la Salud.Universidad Autónoma del Estado de Hidalgo.Pachuca Hidalgo.México.Scuela Superior de TlahuelilpanUniversidad Autónoma del Estado de HidalgoTlahuelilpanHidalgoMéxico

Cognitive function of older adults is influenced by several factors such as age,sex,education,and physical activity so that it can impact the decrease in progressive cognitive function.It is necessary to implement cognitive training in old people’s care to prevent or delay the onset of age-related cognitive decline.Brain gym is a series of simple motion exercises and is an alternative therapy that stimulates the brain.This study aims to evaluate the effect of brain gym as a cognitive training intervention on global cognitive functioning of institutionalized older population.The study is a non-randomized quasi-experimental one using pre-and post-test control group design.The participants of the study were 65 years old or older who had been part of gerontological centers from a local community.They were divided into two groups:control and intervention,each one with 15 people.Mini-Mental State Examination was applied to the sample before and after the cognitive training.The brain gym training consists of bi-weekly group meeting for 12 weeks,lasting 50 min each.The treated group had a significantly better global cognitive function.Recalling(memory),orientation and language skills were the domains with the most significant changes(pder people lease type your abstract here.Abstract of a research paper is typically 200 to 400 words in length,and 150 to 300 words for a review paper.Abstract shall be running continuously(not structured)and shall not include reference citations.Abbreviations that appear only once in the abstract should be defined in full.If abbreviations appear more than once,the full definitions should be provided first before they can be used elsewhere.

关键词： Cognitive function brain gymnastic older people gerontological center physical activity

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Clinical and microbiological features of vulvovaginitis in Mexican girls

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Open Journal of Obstetrics and Gynecology 2013年第2期3卷 243-248页

作者： Mario I.Ortiz Edna J.Arreola-Bautista Beatriz A.Sánchez-Reyes Georgina Romo-Hernández Marco A.Escamilla-Acosta Area Académica de Medicina del instituto de ciencias de la salud de la universidad autónoma del estado de hidalgo PachucaHidalgoMexico universidad del Futbol y ciencias del deporte San Agustín TlaxiacaHidalgoMexico Hospital del Nino DIF hidalgo PachucaHidalgoMexico

Study Objective: To determine the prevalence of vulvovaginitis, predisposing factors, microbial etiology and therapy in patients treated at the Hospital del Nino DIF, pachuca, hidalgo, Mexico. design. This was an observational and descriptive study from 2006 to 2009. Setting: Hospital del Nino DIF, pachuca, hidalgo, Mexico. Participants. Patients from 0 to 16 years, with vulvovaginitis and/or vaginal discharge were included. Interventions: None. Main Outcome Measures: demographic data, etiology, clinical features, risk factors and therapy were analyzed. Results: Four hundred twenty seven patients with diagnosis of vulvovaginitis were included. The average prevalence to 4 years in the study period was 0.19%. The age group most affected was schoolchildren (225 cases: 52.69%). The main signs and symptoms presented were leucorrhea (99.3%), vaginal hyperemia (32.6%), vulvar itching (32.1%) and erythema (28.8%). Identified risk factors were poor hygiene (15.7%), urinary tract infection (14.7%), intestinal parasites (5.6%) and obesity or overweight (3.3%). The main microorganisms found in vaginal cultures were enterobacteriaceae (Escherichia coli, Klebsiella and Enterococcus faecalis), Staphylococcus spp, and Gardnerella vaginalis. Several inconsistent were found in the drug prescription of the patients. Conclusion: Vulvovaginitis prevalence in Mexican girls is low and this was caused mainly by opportunist microorganisms. The initial treatment of vulvovaginitis must include hygienic measure and an antimicrobial according to the clinical features and microorganism found.

关键词： Vulvovaginitis Prevalence Etiologic Microorganisms Mexican Children and Adolescents

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Effect of dichloromethylene diphosphonate on liver regeneration following thioacetamide-induced necrosis in rats

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World Journal of Hepatology 2013年第7期5卷 379-386页

作者： Mirandeli Bautista María ngeles Gómez del Rio Juana Benedí María Isabel Sánchez-Reus José A Morales-González Ana María Téllez-López Maricela López-Orozco rea Académica de Farmacia Instituto de Ciencias de la Salud Universidad Autónoma del Estado de Hidalgo departamento de Bioquímica y Biología Molecular Facultad de Farmacia Ciudad Universitaria departamento de Farmacología Facultad de Farmacia Ciudad Universitaria Escuela Superior de Medicina Instituto Politécnico Nacional

AIM: To study the effect of dichloromethylene diphos-phonate (DMDP), a selective Kupffer cell toxicant in reference to liver damage and postnecrotic liver regeneration in rats induced by sublethal dose thioacetamide (TA). METHODS: Rats, intravenously (iv ) pre-treated with a single dose of DMDP (10 mg/kg), were intraperitoneally (ip ) injected with TA 6.6 mmol/kg (per 500 mg/kg body weight). Hepatocytes were isolated from rats at 0, 24, 48 and 72 h following TA intoxication and blood and liver samples were obtained. To evaluate the mecha-nisms involved in the postnecrotic regenerative state, DNA distribution and ploidy time course were assayed in isolated hepatocytes. Circulating cytokine tumor necrosis factor-alpha (TNF-α) was assayed in serum and determined by reverse transcriptase-polymerase chain reaction in liver extract. RESULTS: The effect of DMDP induced noticeable changes in postnecrotic regeneration, causing an increased percentage of hepatocytes in the cell cycle S phase. The increase at 24 h in S1 population in rats pretreated with DMDP + TA was significantly (P demonstrate that Kupffer cells are involved in TA-induced liver, as well as in post-necrotic proliferative liver states.

关键词： Dichloromethylene diphosphonate Kupffer cells Thioacetamide Hepatotoxicity Cell cycle

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Molecular isolation and identification of Mycobacterium avium subsp.hominissuis in Didelphis virginiana from hidalgo,Mexico

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Asian Pacific Journal of Tropical Medicine 2020年第3期13卷 131-136页

作者： Nallely Rivero-Perez Juan Ocampo-López Benjamín Valladares-Carranza Fabián R.Gómez de Anda Francisco J.Pena Jiménez Victor M.Martínez Juárez Armando Peláez Acero Jose I.Olave Leyva deyanira Ojeda-Ramírez Adrian Zaragoza-Bastida Area Académica de Medicina Veterinaria y Zootecnia Instituto de Ciencias AgropecuariaUniversidad Autónoma del Estado de HidalgoAv.Universidad Km 1Ex-Hda.de AquetzalpaC.P.43600 TulancingoHidalgoMéxico Centro de Investigación y Estudios Avanzados en salud Animal Facultad de Medicina Veterinaria y ZootecniaUniversidad Autónoma del Estado de MéxicoKm 15.5 Carretera Panamericana Toluca-AtlacomulcoC.P.50200 TolucaEstado de MéxicoMéxico Centro Universitario del Sur/División de ciencias de la salud/departamento de ciencias Clínicas/Hospital Veterinario CUSUR universidad de Guadalajara Av.Enrique Arreola Silva No.883colonia centro C.P.49000Ciudad GuzmánJaliscoMéxico

Objective:To isolate and identify the exact species of the genus Mycobacterium from Didelphis(D.)virginiana,and the direct implications of this bacterium to public health and veterinary medicine.Methods:Thirty-one D.virginiana were captured and necropsied in hidalgo,Mexico.Tissue samples were collected to culture mycobacteria present and examine individual specimens’histopathology.Mycobacterium identification was obtained through the application of amplification and sequencing of 16S rDNA techniques.Results:Three strains were isolated and identified as Mycobacterium(M.)avium subsp.hominissuis by utilizing M.avium complexspecific primers.Granulomatous lesions were observed in the subpleural zone(granuloma gradeⅡ)and bronchial(granuloma gradeⅠ)of the lungs of D.virginiana with positive isolation.Conclusions:Three strains of M.avium subsp.hominissuis,from lung tissue samples of D.virginiana were identified.This subspecies of M.avium has important implications in public health and veterinary medicine.

关键词： Didelphis virginiana Mycobacterium avium complex Mycobacterium avium subsp.hominissuis Public health

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Protective effect of some vitamins against the toxic action of ethanol on liver regeneration induced by partial hepatectomy in rats

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World Journal of Gastroenterology 2008年第6期14卷 899-907页

作者： Carlett Ramírez-Farías Eduardo Madrigal-Santillán José Gutiérrez-Salinas Nidia Rodríguez-Sánchez Maricela Martínez-Cruz Ilse Valle-Jones Ingrid Gramlich-Martínez Alejandra Hernández-Ceruelos José A Morales-González Unidad de Genética de la Nutrición Instituto Nacional de Pediatría México instituto de ciencias de la salud Universidad Autónoma del Estado de Hidalgo México laboratorio de Bioquímica y Medicina Experimental Unidad de Investigación Biomédica División de Investigación Centro Médico Nacional "20 de Noviembre" ISSSTE México Gatorade Sports Science Institute Mexico City México Escuela de Dietética y Nutrición ISSSTE México University of Ryerson Toronto

AIM: To investigate the effects of vitamins (A, C and E) on liver injury induced by ethanol administration during liver regeneration in rats. METHODS: Male Wistar rats subjected to 70% partial hepatectomy were divided into five groups (groups 1-5). During the experiment, animals of Group 1 drank only water. The other four groups (2-5) drank 30 mL of ethanol/L of water. Group 3 additionally received vitamin A, those of group 4 vitamin C and those of group 5 received vitamin E. Subsequently serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin and bilirubin were measured colorimetrically. Lipid peroxidation (thiobarbituric-acid reactive substances, TBARS) both in plasma and liver was measured, as well as liver mass gain assessment and total DNA. RESULTS: Compared with sham group, serum AST and ALT increased significantly under ethanol treatment (43% and 93%, respectively, with P decreased serum albumin concentration compared to sham group (3.1 ± 0.4 g/dL vs 4.5 ± 0.2 g/dL; P lasma lipid peroxidation. Vitamins (C and E) treatment attenuated hepatic and plasma lipid peroxidation. CONCLUSION: Vitamins C and E protect against liver injury and dysfunction, attenuate lipid peroxidation, and thus appear to be significantly more effective than vitamin A against ethanol-mediated toxic effects during liver regeneration.

关键词：过氧化反应抗氧化剂维生素肝损伤肝移植

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Side Effects of Vincristine and L-Asparaginase in Patients with Acute Lymphoblastic Leukemia in a Mexican Pediatric Hospital

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Pharmacology & Pharmacy 2013年第3期4卷 347-354页

作者： Mario I.Ortiz Sandra Rivera-Roldan Marco A.Escamilla-Acosta Georgina Romo-Hernandez Hector A.Ponce-Monter Rita Escarcega-Angeles Area Academica de Medicina Instituto de Ciencias de la SaludUniversidad Autonoma del Estado de HidalgoPachucaMexico Graduate Coordination Universidad del Futbol y Ciencias del DeporteSan Agustin TlaxiacaMexico Hospital del Nino DIF hidalgo PachucaMexico Area Academica de Farmacia Instituto de Ciencias de la SaludUniversidad Autonoma del Estado de HidalgoPachucaMexico

Background: The treatment used to combat acute lymphoblastic leukemia (ALL) is multidrug;therefore it is important to use active pharmacovigilance to detect, assess and analyze the likely adverse reactions which may occur during the same period. Objective: To determine the frequency of adverse reactions to chemotherapeutic drugs in children with ALL. Material and Methods: Intensive pharmacovigilance was used to record the reports of adverse reactions to vincristine, L-asparaginase and the vincristine-L-asparaginase combination in children with ALL in a paediatric hospital. For each notification, the adverse reactions were analyzed in order to verify causality. Results: Forty patients were evaluated. Twenty children were female (50.0%) and 20 were male (50%). The children had a mean age, weight and height (±standard deviation: SD) of 8.1 (±3.4) years, 31.4 (±13.9) kg and 1.3 (±0.2) m, respectively. Vincristine was administered to 19 patients, vincristine plus L-asparaginase were given to 19 patients and only 2 patients used L-asparaginase. One-hundred-ninety adverse reactions were detected in the patients, with an average (±SD) of 4.8 (±2.6). Ondansetron was the drug administered for the treating of nausea and vomiting. One hundred eighty-one (95.3%) adverse reactions were identified as “definite”, 5 (2.6%) as “probable” and 4 (2.1%) as “doubtful”. Conclusions: There is a high incidence of adverse reactions by the administration of vincristine and L-asparaginase;the reactions of highest incidence were: nausea, vomiting, neutropenia, diarrhea, constipation, mucositis, headache, and abdominal pain. It is important to promote the detection, collection, reporting, assessment and treatment of ARD’s in children. It is necessary to promote the conduct further studies on pharmacovigilance with this type of treatments and to increase the duration of the studies.

关键词： Pharmacovigilance Acute Lymphoblastic Leukemia Vincristine L-Asparaginase Children

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Review of natural products with hepatoprotective effects

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World Journal of Gastroenterology 2014年第40期20卷 14787-14804页

作者： Eduardo Madrigal-Santillán Eduardo Madrigal-Bujaidar Isela álvarez-González María Teresa Sumaya-Martínez José Gutiérrez-Salinas Mirandeli Bautista ángel Morales-González Manuel García-Luna y González-Rubio J Leopoldo Aguilar-Faisal José A Morales-González laboratorio Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Casco de Santo Tomás Del. Miguel Hidalgo México DF 11340 México laboratorio de Genética Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Unidad profesional Adolfo López Mateos Col. Lindavista Delegación Gustavo A. Madero México DF 07738 México Secretaria de Investigación y Estudios de Posgrado Universidad Autónoma de Nayarit "Ciu-dad de la Cultura Amado Nervo" Nayarit 28000 México laboratorio de Bioquímica y Medicina Experimental División de Investigación Biomédica Centro Médico Nacional "20 de Noviembre" ISSSTE México DF 03100 México área Académica de Farmacia Instituto de Ciencias de la Salud UAEH Pachuca Hidalgo 42000 México Escuela Superior de Cómputo Instituto Politécnico Nacional Av. Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal Unidad Profesional Adolfo López Mateos México DF 07738 Mexico Facultad de Odontología UNAM México DF 04510 Mexico

The liver is one of the most important organs in the body,performing a fundamental role in the regulationof diverse processes,among which the metabolism,secretion,storage,and detoxification of endogenous and exogenous substances are prominent.Due to these functions,hepatic diseases continue to be among the main threats to public health,and they remain problems throughout the world.despite enormous advances in modern medicine,there are no completely effective drugs that stimulate hepatic function,that offer complete protection of the organ,or that help to regenerate hepatic cells.Thus,it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases,with the aim of these alternatives being more effective and less toxic.The use of some plants and the consumption of different fruits have played basic roles in human health care,and diverse scientific investigations have indicated that,in those plants and fruits so identified,their beneficial effects can be attributed to the presence of chemical compounds that are called phytochemicals.The present review had as its objective the collecting of data based on research conducted into some fruits(grapefruit,cranberries,and grapes)and plants[cactus pear(nopal)and cactus pear fruit,chamomile,silymarin,and spirulina],which are consumed frequently by humans and which have demonstrated hepatoprotective capacity,as well as an analysis of a resin(propolis)and some phytochemicals extracted from fruits,plants,yeasts,and algae,which have been evaluated in different models of hepatotoxicity.

关键词： Hepatoprotection Grapefruit Vaccinium spp Vitis vi

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