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Evolution and Continuity of Linguistic Systems

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Language and Semiotic Studies 2022年第1期8卷 24-36页

作者： Isabel Victoria Galleguillos Jungk Pontifical Catholic University of sao paulo University of sao paulo Brazil

In the inspiring extract highlighted in this paper,Saussure observes how the relation between the elements of the sign change and evolve over *** his Cours,he also details the elements of the linguistic sign and the principles governing them,defining language as a system of *** the natural resistance to changes in language in order to enable it to continually fulfill its function,that is,despite the necessary immutability of linguistic signs,they change over time,by being in constant contact with the communities of speakers,to whom language actually *** may seem paradoxical because language is composed of arbitrary relations between signified and signifier that seek to represent *** refers to a principle of change in language linked to a principle of *** present study focuses on the semiotic and communicational aspects of the development of linguistic systems in time,understood from a systemic *** is sought to evince how signs perpetuate themselves and evolve through their constant interaction with real communities of language *** approach can offer new insights about the continuity of linguistic systems as systems of signs that present immutable and mutable characters,and whose evolution can be understood based on open systems parameters,such as permanence,autonomy and sensitivity to flows of information,as studied by current theories and authors,showing that,to preserve its semiological life (CGL,1959,p.76),a living language must continuously reflect the purposes of its users.

关键词： linguistic systems linguistic mutability evolution continuity systems parameters

Status of bariatric endoscopy–what does the surgeon need to know? A review

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World Journal of Gastrointestinal Surgery 2022年第2期14卷 185-199页

作者： Diogo Turiani Hourneaux de Moura Anna Carolina Batista Dantas Igor Braga Ribeiro Thomas R McCarty Flávio Roberto Takeda Marco Aurelio Santo Sergio Carlos Nahas Eduardo Guimarães Hourneaux de Moura departamento de Gastroenterologia Faculdade de MedicinaUniversidade de Sao PauloServiço de Endoscopia Gastrointestinal do Hospital das Clínicas HCFMUSPSao Paulo 05403-010Brazil departamento de Gastroenterologia Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloUnidade de Cirurgia Bariátrica e MetabólicaDisciplina de Cirurgia do Aparelho Digestivo e ColoproctologiaSao Paulo 05403-010Brazil Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s HospitalBostonMA 021115United States

BACKGROUND Obesity is a chronic and multifactorial disease with a variety of potential treatment options ***,there are several multidisciplinary therapeutic options for its management,including conservative,endoscopic,and surgical *** To clarify indications,technical aspects,and outcomes of bariatric *** Narrative review of current literature based on electronic databases including MEDLINE(PubMed),Cochrane Library,and *** Bariatric endoscopy is in constant development and comprises primary and revisional treatment options as well as management of surgical *** devices act upon different mechanisms of action,which may be individualized to each *** favorable results for the endoscopic treatment of obesity,prospective randomized studies with long-term follow-up are required to fully validate primary and revisional endoscopic *** the management of bariatric surgery complications,endoscopic therapy may be considered the procedure of choice in a variety of ***,as there is no standardized algorithm,local experience should be considered in *** The treatment of patients with obesity is complex,and a multidisciplinary approach is *** endoscopy has shown impressive results both in the treatment of obesity and its surgical complications,and therefore,must be part of the armamentarium in the fight against this disease.

关键词： Endoscopy Gastrointestinal Surgery Obesity Bariatric Weight regain

A Cost-Benefit Evaluation of the Air Quality and Health Impacts in sao paulo,Brazil

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Journal of Environmental Protection 2012年第9期3卷 1161-1166页

作者： Diego Velloso Veronez Luiz Alexandre Kulay paulo Hilario Nascimento Saldiva Simone Georges El Khouri Miraglia Purchasing department Lear Corporation CacapavaBrazil Escola Politecnica Universidade de Sao PauloSao PauloBrazil Faculdade de Medicina da Universidade de sao paulo Sao PauloBrazil Earth and Exact Sciences departament Universidade Federal de Sao Paulo—UNIFESPDiademaBrazil

The objective was to assess the impact on health due to the exposure to air pollution derived from the renewal of the urban bus fleet in S?o paulo. The study analyzed the substitution of the bus fleet through the variation of the concentration of atmospheric pollutants such as PM10 in the municipality of S?o paulo and its associated health’s benefits values compared to the investments performed in the bus fleet renewal. PM10 average annual reduction due to the bus improvement system resulted on 22.3%. A cost-benefit evaluation considered the renewal investments’ costs compared to the obtained valued health benefits and it resulted in 4.31. Although the result may suggest a not viable investment, it must be observed that air pollution reduction favors health impacts and that this relation could be improved if additional investments on sustainable transportation increase.

关键词： Air Quality Cost-Benefit Health Impacts Transportation sao paulo Brazil

Spatial-temporal pattern of cutaneous leishmaniasis in Brazil

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Infectious Diseases of Poverty 2021年第3期10卷 47-57页

作者： Tatiana P.Portella Roberto A.Kraenkel departsmento de Ecologia Instituto de BiocienciasUniversidade de Sao PauloSao PauloBrazil lnstituto de Fisica Teorica Universidade Estadual PaulistaSao PauloBrazil.

Background:Cutaneous leishmaniasis(CL)is a vector-borne disease classified by the World Health Organization as one ofthe most neglected tropical *** has the highest incidence of CL in America and is one of the ten countries in the world with the highest number of *** the spatiotemporal dynamics of CL is essential to provide guidelines for public health policies in *** the present study we used a spatial and temporal statistical approach to evaluate the dynamics ofCL in ***:We used data of cutaneous leishmaniasis cases provided by the Ministry of Health of Brazil from 2001 to *** calculated incidence rates and used the Mann-Kendall trend test to evaluate the temporal trend of CL in each *** addition,we used Kuldorff scan method to identify spatiotemporal clusters and emerging hotspots test to evaluate hotspot areas and their temporal ***:We found a general decrease in the number of CL cases in Brazil(from 15.3 to 8.4 cases per 100000 habitants),although 3.2%of municipalities still have an increasing tendency of CL incidence and 72.5%showed no tendency at *** scan analysis identified a primary cluster in northern and central regions and 21 secondary clusters located mainly in south and southeast *** emerging hotspots analysis detected a high spatial and temporal variability of hotspots inside the main cluster area,diminishing hotspots in eastern Amazon and permanent,emerging,and new hotspots in the states of Amapa and parts of Para,Roraima,Acre and Mato *** central coast the state of Bahia is one of the most critical areas due to the detection of a cluster of the highest rank in a secondary cluster,and because it is the only area identified as an intensifying ***:Using a combination of statistical methods we were able to detect areas of higher incidence of CL and understand how it changed over *** suggest that these areas,especially those identified as perman

关键词： Cutaneous leishmaniasis Spatiotemporal cluster Emerging hotspot Temporal trend Brazil

Comparing shoulder maneuvers to magnetic resonance imaging and arthroscopic findings in patients with supraspinatus tears

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World Journal of Orthopedics 2022年第1期13卷 102-111页

作者： Fabio Anauate Nicolao Joao Alberto Yazigi Junior Fabio Teruo Matsunaga Nicola Archetti Netto Joao Carlos Belloti Marcel Jun Sugawara Tamaoki Orthopedics and Traumatology department Escola Paulista de Medicina–Universidade Federal de São Paulo–UNIFESPSao Paulo 04038-001Brazil Orthopedics and Traumatology Discipline Universidade de Santo Amaro–UNISASao Paulo 04829-300Brazil

BACKGROUND Shoulder maneuvers and magnetic resonance imaging(MRI)are performed to diagnose supraspinatus tendon tears regardless of arthroscopy *** there are many studies on this subject,there is a lack of studies comparing the sensitivity(Se)and specificity(Sp)of shoulder maneuvers and MRI to arthroscopic findings(intact,partial,or full thickness supraspinatus tendon tear).AIM To compare the diagnostic values of shoulder maneuvers with MRI for supraspinatus tendon tears in patients undergoing shoulder *** A total of 199 consecutive patients from four orthopedic centers met the eligibility criteria of shoulder pain persisting for at least four *** were prospectively enrolled in this study from April 2017 to April *** clinical tests(full can,empty can,drop arm,Hawkins’,painful arc,Neer’s sign and resisted external rotation)and MRI were performed,and all were compared with surgical *** can,empty can and resisted external rotation tests were interpreted as positive in the case of pain and/or *** assessed the Se,Sp,accuracy,positive predictive value(PPV)and negative predictive value(NPV),positive and negative likelihood ratio and diagnostic odds ratio for overall,partial and fullthickness supraspinatus *** MRI had the highest Se for overall(0.97),partial(0.91)and full-thickness(0.99)tears;moreover,MRI had the highest NPV:0.90,0.88 and 0.98 for overall,partial and full-thickness tears,*** overall supraspinatus tears,the Se and PPV were:Painful arc(Se=0.85/PPV=0.91),empty can(pain)(Se=0.80/PPV=0.89),full can(pain)(Se=0.78/PPV=0.90),resisted external rotation(pain)(Se=0.48/PPV=0.87),drop arm(Se=0.19/PPV=0.97),Neer’s sign(Se=0.78/PPV=0.93)and Hawkins’(Se=0.80/PPV=0.88).MRI had the highest PPV(0.99).The Hawkin’s test had the highest false positive rate in patients with intact tendons(0.36).The Sp of the empty can and full can(both tests positive for pain and weakness),drop arm and MRI were:0.93,

关键词： Rotator cuff injuries Physical examination Magnetic resonance imaging Arthroscopy

Antipsychotics preserve telomere length in peripheral blood mononuclear cells after acute oxidative stress injury

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Neural Regeneration Research 2022年第5期17卷 1156-1160页

作者： Gabriel B.Polho Giancarlo M.Cardillo Daniel S.Kerr Thais Chile Wagner F.Gattaz Orestes V.Forlenza Helena P.Brentani Vanessa J.de-Paula Laboratório de Neurociências(LIM-27) Departamento e Instituto de PsiquiatriaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSPBrasil Laboratório de Psicobiologia(LIM-23) Departamento e Instituto de PsiquiatriaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSPBrasil

Antipsychotics may prolong or retain telomere length,affect mitochondrial function,and then affect the metabolism of nerve *** validate the hypothesis that antipsychotics can prolong telomere length after oxidative stress injury,leukocytes from healthy volunteers were extracted using Ficoll-Histopaque density *** mononuclear cells layer was resuspended in cell culture *** stress was induced with hydrogen peroxide in cultured *** days later,leukocytes were treated with aripiprazole,haloperidol or clozapine for 7 ***-time PCR revealed that treatments with aripiprazole and haloperidol increased the telomere length by 23%and 20%in peripheral blood mononuclear cells after acute oxidative stress *** results suggest that haloperidol and aripiprazole can reduce the damage to telomeres induced by oxidative *** experiment procedure was approved by the Ethics Committee of Faculty of Medicine of the University of sao paulo(FMUSP/CAAE approval No.52622616.8.0000.0065).

关键词： antipsychotic aripiprazole cell culture clozapine haloperidol oxidative stress peripheral blood mononuclear cell telomere length

Vitellogenin content in fat body and ovary homogenates of workers and queens of Melipona quadrifasciata anthidioides during vitellogenesis

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Insect Science 2012年第2期19卷 213-219页

作者： Vagner Tadeu Paes de Oliveira Bruno Berger Carminda da Cruz-Landim Zila Luz Paulino Simoes departamento de Biologia Instituto de Biociencias de Rio ClaroUNESP-Univ.Bela VistaRio ClaroSao Paulo departamento de Biologia FFFL de Ribeirao PretoUniversidade de Sao PauloUSPSao PauloBrazil

Vitellogenin （Vg） is an egg yolk protein that is produced primarily in the fat body of most female insects. In the advanced social structure of eusocial honeybees, the presence of the queen inhibits egg maturation in the workers＇ ovaries. However in the stingless bee Melipona quadrifasciata, the workers always develop ovaries and lay a certain amount of eggs while provisioning the brood cells with larval food during what is known as the worker nurse phase. The present work is a comparative study of the presence of Vg in homogenates of the fat bodies and ovaries of the nurse workers, and the virgin and physogastric queens of M. quadrifasciata. The presence of Vg was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis and irnmunoblotting using Apis mellifera anti-egg antibody. Vg was not detected in the fat bodies or ovaries of the workers, but it was found in the ovaries of virgin and physogastric queens and in the fat body ofphysogastric queens. The results are discussed, taking into account the reproductive state of the individuals and the other possible roles of Vg, such as a storage protein for metoabolism of other organs.

关键词： egg yolk electrophoresis immunoblotting nurse worker stingless bee virginand physogastric queen

Simple Classical Lie Algebras in Characteristic 2 and Their Gradations, II

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Algebra Colloquium 2014年第2期21卷 207-214页

作者： Alexandre N. Grishkov Marines Guerreiro instituto de Matematica e Estatfstica Universidade de sao paulo Sao Paulo-SP Brazil departamento de Matematica Universidade Federal de Vicosa Vicosa-MG Brazil

This paper is a continuation of [2]. We prove Conjecture 5.1 of [2] which gives a characterization of simple Lie algebras of finite dimension of type B2e, C2e, D2e＋1, E7 and Es in terms of some gradations of these al... 详细信息

关键词： Lie algebras characteristic 2 gradations

EFFECTIVE NETWORKS FOR REAL-TIME DISTRIBUTED PROCESSING

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Journal of Systems Science & Complexity 2011年第1期24卷 39-50页

作者： Gonzalo TRAVIESO Luciando da Fontoura COSTA instituto de Fisica de sao Carlos Universidade de Sao Paulo Av. do Trabalhador SSo-Carlensc 400 13566 - 590 Sao Carlos SP Brazil.

这份报纸把复杂网络的概念和方法用于模型的开发和由在许可的交货介绍上面的界限的分布式的即时系统与计算结果包预定的主人奴隶的模拟。二个代表性的互联模型被考虑：一致地。

关键词：分布式实时系统复杂网络分布式处理计算结果应用程序数据包随机和随机大