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Genes & Diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-de Egea Alex Dominguez-Vargas Jorg e l.Velez Gustavo Aroca Luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny del Toro-Camargo Leticia Martinez-Ariza Tatiana Gonzalez-Vargas Susana Garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

GTP-bound Rab3A exhibits consecutive positive and negative roles during human sperm dense-core granule exocytosis

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Journal of Molecular Cell Biology 2014年第4期8卷 286-298页

作者： Matias A. Bustos Carlos M. Roggero Paola X. de la Iglesia Luis S. Mayorga Claudia N. Tomes instituto de Histologia y Embriologia IHEM-CONICET Facultad de Ciencias Medicas Universidad Nacional de Cuyo Mendoza Argentina department of Biophysics UT Southwestern Medical Center Dallas TX USA Servicio de Patologla Hospital Italiano de Buenos Aires Buenos Aires Argentina

哺乳动物的精子的 Exocytosis 稠密核心的能分泌的小粒作为所有另外的能分泌的房间依靠一样的熔化分子；一个如此的分子是小 GTPase Rab3A。这里，我们由细看 streptolysin O-permeabilized 人的精子的 exocytotic 反应到很多包含 Rab3A... 详细信息

哺乳动物的精子的 Exocytosis 稠密核心的能分泌的小粒作为所有另外的能分泌的房间依靠一样的熔化分子；一个如此的分子是小 GTPase Rab3A。这里，我们由细看 streptolysin O-permeabilized 人的精子的 exocytotic 反应到很多包含 Rab3A 构造的尖锐 applicationof 并且相关报导 Rab3Ain 分泌物的角色的深入的生物化学的描述有那些的调查结果与内长的蛋白质聚在一起。Fulllength， geranylgeranylated，和活跃 Rab3A 得到了人的精子 exocytosis 本身。与 Rab3A/Rab22A 妄想的蛋白质，我们证明 Rab3A 分子的 carboxy 终端领域是足够的 necessaryand 支持 exocytosis，而它的氨基终点的阻止的被触发钙的分泌物。有趣地，当在停靠 acrosome 到血浆膜以后增加了时， fulllength Rab3A 停止了分泌物。这效果看情况到水解 GTP 的 Rab3A 的在无能。我们联合了在单个房间同时染色协议到 detectmembrane 熔化和内长的 Rab3 的激活地位的修改 immunofluorescence 和 acrosomal，并且发现那 GTP hydrolysison 内长的 Rab3 是强制的让熔化毛孔开。我们的调查结果贡献证实 Rab3 调制不同地在学习下面取决于核苷酸界限和 exocytosis 阶段的 regulatedexocytosis。

关键词： Rab3a G-蛋白胞吐过程分泌颗粒致密核精子负面作用人类

Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2007年第31期13卷 4242-4248页

作者： Silvia Sookoian Gustavo Castao Carolina Gemma Tomas Fernández Gianotti Carlos Jose Pirola instituto de investigaciones medicas A. Lanari. Universidad de Buenos Aires CONICET Combatiente de Malvinas 3150 1427-Ciudad Autonoma de Buenos Aires Argentina Consejo de Investigación GCBA Buenos Aires Argentina Consejo de Investigación GCBA Buenos Aires Argentina instituto de investigaciones medicas A. Lanari. Universidad de Buenos Aires CONICET Combatiente de Malvinas 3150 1427-Ciudad Autonoma de Buenos Aires Argentina

AIM: To investigate the role of gene variants and derived haplotypes of the CLOCK transcription factor in nonalcoholic fatty liver disease (NAFLD) and their relation with the disease severity. METHODS: A total of 136 patients with NAFLD and 64 healthy individuals were studied. Liver biopsy was performed in 91 patients. Six tag SNPs showing a minor allele frequency > 10% (rs1554483 C/G; rs11932595 A/G; rs4580704 C/G; rs6843722 A/C; rs6850524 C/G and rs4864548 A/G) encompassing 117 kb of chromosome 4 and representing 115 polymorphic sites (r2 > 0.8) were genotyped. RESULTS: rs11932595 and rs6843722 showed signifi cant associations with NAFLD (empiric P = 0.0449 and 0.023, respectively). A significant association was also observed between clinical or histologic spectrum of NAFLD and rs1554483 (empiric P = 0.0399), rs6843722 (empiric P = 0.0229) and rs6850524 (empiric P = 0.00899) and between fibrosis score and rs1554483 (empiric P = 0.02697), rs6843722 (empiric P = 0.01898) and rs4864548 (empiric P = 0.02697). Test of haplotypic association showed that CLOCK gene variant haplotypes frequencies in NAFLD individuals significantly differed from those in controls (empiric P = 0.0097). CONCLUSION: Our study suggests a potential role of the CLOCK polymorphisms and their haplotypes insusceptibility to NAFLD and disease severity.

关键词：生理节奏蛋白质基因变异肝疾病

Immune response-related genes associated to blocking midgut dengue virus infection in Aedes aegypti strains that differ in susceptibility

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Insect Science 2019年第4期26卷 635-648页

作者： Paola A. Caicedo Idalba Mildred Serrato Shuzhen Sim George Dimopoulos Heather Coatsworth Carl Lowenberger Clara B. Ocampo Centro Internacional de Entrenamiento e investigaciones medicas (CIdeIM) Cali Colombia 2W. Harry Feinstone department of Molecular Microbiology and Immunology Bloomberg School of Public Health Johns Hopkins University Baltimore Maryland USA department of Biological Sciences Simon Fraser University Burnaby Canada

Aedes (Stegomyia) aegypti, the principal global vector of dengue viruses, has difTerences in its susceptibility to dengue virus infection. We compared the global expres? sion of genes in the midguts of Colombian Ae. aegypti dengue-susceptible (Cali-S) and dengue-refractory (Cali-MIB) field derived strains after ingesting either a sugarmeal, a bloodmeal, or a bloodmeal containing dengue virus serotype 2 (deNV-2). Microarraybased transcriptome analysis among treatments indicated a total of 4725 transcripts with differential expression between the two strains. Eleven genes were selected from different functional groups based on their significant up or down expression levels as well as reports in the literature suggesting they are associated with dengue virus elimination. We measured mRNA abundance of these 11 genes at 0, 8, 24, and 36 h postinfection using quantitative real time PCR (qPCR) to confirm the microarray results and assess any temporal patterns. Four genes were selected (Gram-negative binding protein—GNBP [AAEL009176], Niemann Pick Type-C2一NPC2 [AAEL015136], Keratinocyte lectin [AAEL009842], and Cathepsin-b [AAEL007585]) for knockdown experiments using RNA interference (RNAi) methodology to determine the phenotype (deNV-2 susceptible or refractory). Silencing GNBP、Cathepsin-b and Keratinocyte lectin reduced the percentage of mosquitoes with disseminated virus in the Cali-S strain to 8%, 20%, and 12% respectively compared with 96% in the controls. Sile ncing of NPC2 increased the percentage of mosquitos with disseminated virus infections in Cali-MIB to 66% compared with 35% in the controls. This study provides in sight into genes that may contribute to the Cali-S susceptible and Cali-MIB refractory phenotypes in 昇匕 aegypti.

关键词： Aedes aegypti dengue virus innate immune response knockdown microarray vector competence

Documentary research on social innovation in health in Latin America

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Infectious Diseases of Poverty 2020年第2期9卷 92-92页

作者： Diana Maria Castro-Arroyave Luisa Fernanda Duque-Paz Centro Internacional de Entrenamiento e investigaciones medicas(CIdeIM) CaliColombia Icesi University CaliColombia

Background:Identifying social innovation in health initiatives,promoting quality of life through them,and transforming current health conditions demand the knowledge,comprehension and appropriation of the theoretical and methodological developments of this concept Academic developments in social innovation have mainly occurred in and been documented for English-speaking countries,although relevant experiences have been implemented in Latin *** this article,we describe and analyze how social innovation in health is being approached and understood in this *** text:To identify the theoretical and methodological developments of social innovation in health between 2013 and 2018,a scoping review with a mixed approach was carried *** texts in English,Spanish and Portuguese were selected for a process of reflexive analysis of intra and intertextual *** approaches identified in the studied initiatives were *** most applied approaches were innovation in health,technological innovation in health and social innovation,each with twelve publications,and social innovation in health and ecohealth with ten and seven publications *** approaches showed a general interest in reaching the goals of the Sustainable development Goals(SDGs),the Alma Ata declaration and the Ottawa ***:The social innovation in health approach in Latin America adopts educational strategies,identifies risk factors,optimizes resources,promotes interculturality,participation,community empowerment,and enhances intersectorality and *** an approach,process,program or solution,social innovation in health is a conceptual category under *** research provides a baseline for other systematic reviews on the subject.

关键词： Community-based health Documental research Public health Social innovation in health Social change

Integrated vector control of Chagas disease in Guatemala: a case of social innovation in health

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Infectious Diseases of Poverty 2020年第2期9卷 105-105页

作者： Diana Castro-Arroyave Maria Carlota Monroy Maria Isabel Irurita Centro Internacional de Entrenamiento e investigaciones medicas CIDEIMCaliColombia Universidad Icesi CaliColombia 不详

Background:Improved access to health care and quality of services require integrated efforts and innovations,including community empowerment and participation in transformation *** disease is a neglected tropical disease that is generally controlled by insecticide *** achieve community empowerment in a health program,actions for social innovations may include:community-based research,interdisciplinary and intersectoral participation,community perception of direct benefits and participation in health or environmental *** aim of this study was to describe and analyze the processes by which an interdisciplinary team,in collaboration with communities of Comapa,Guatemala,developed an effective solution to address the risk for Chagas ***:A qualitative study involving interviews semi-structured and direct observation was conducted using a case study approach to describe and understand the community-based research and intervention process developed by researchers from the Laboratory of Applied Entomology and Parasitology of the Universidad de San Carlos of Guatemala(Laboratorio de Entomologia y Parasitologia Aplicada).Nine interviews were conducted with the investigators,innovators,members of the community in which the intervention had been *** software(version 12)was used for the emergent coding and analysis of the ***:Processes of social transformation were evident within households,and the communities that transcended the mere improvement of walls and *** social dynamics that favored the household economy and conditions of hygiene and home care that positively impacted the health of the *** describe how the integration of criteria of social innovation into a home improvement strategy for Chagas disease control,can generate processes of transformation in health by considering sociocultural conditions,encouraging dialogue between public health approaches and traditional ***

关键词： Chagas disease Community empowerment Interdisciplinarity Intersectorality Social innovation in health

Intermediate-advanced hepatocellular carcinoma in Argentina:Treatment and survival analysis

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World Journal of Gastroenterology 2019年第27期25卷 3607-3618页

作者： Federico Pinero Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Gustavo Romero Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva Hospital Universitario Austral Facultad de Ciencias BiomédicasUniversidad AustralBuenos Aires B1629HJArgentina Latin American Liver Research Educational and Awareness Network(LALREAN) Buenos Aires B1629HJArgentina Hospital Italiano de Buenos Cuidad Autónoma de Buenos AiresBuenos Aires C1424BYEArgentina Hospital Británico Cuidad Autonoma de Buenos AiresBuenos Aires C1280AEBArgentina Hospital G Rawson San Juan 5400Argentina Hospital Aleman Cuidad Autonoma de Buenos AiresBuenos Aires C1280AEBArgentina Sanatorio Allende from Córdoba Córdoba 5016Argentina Centro de Educación Médica e investigaciones Clínicas“Norberto Quirno”(CEMIC) Ciudad de Buenos Aires 1431Argentina Hospital Udaondo Cuidad Autonoma de Buenos Aires C1264AAAArgentina Hospital Ramos Mejía Ciudad de Buenos Aires C1221ADCArgentina Centro Especialidades medicas Ambulatorias(CEMA) Mar del PlataBuenos Aires 7600Argentina Clínica de Nefrología Santa Fe 3000Argentina Hospital del Centenario RosarioSanta Fe S2002KDTArgentina

BACKGROUND Hepatocellular carcinoma(HCC) represents the sixteenth most frequent cancer in Argentina. The rise of new therapeutic modalities in intermediate-advanced HCC opens up a new paradigm for the treatment of *** To describe real-life treatments performed in patients with intermediateadvanced HCC before the approval of new systemic *** This longitudinal observational cohort study was conducted between 2009 and2016 in 14 different regional hospitals from Argentina. Included subjects had intermediate-advanced Barcelona Clinic Liver Cancer(BCLC) HCC stages(BCLC B to D). Primary end point analyzed was survival, which was assessed for each BCLC stage from the date of treatment until last patient follow-up or *** Meier survival curves and Cox regression analysis were performed, with hazard ratios(HR) calculations and 95% confidence intervals(95%CI).RESULTS From 327 HCC patients, 41% were BCLC stage B, 20% stage C and 39% stage *** median survival were 15 mo(IQR 5-26 mo), 5 mo(IQR 2-13 mo)and 3 mo(IQR 1-13 mo)(P < 0.0001), respectively. Among BCLC-B patients(n =135), 57% received TACE with a median number of 2 sessions(IQR 1-3 sessions).Survival was significantly better in BCLC-B patients treated with TACE HR =0.29(CI: 0.21-0.40) than those without TACE. After tumor reassessment by RECIST 1.1 criteria following the first TACE, patients with complete response achieved longer survival (HR = 0.15(CI: 0.04-0.56, P = 0.005))Eighty-two patients were treated with sorafenib, mostly BCLC-B and C(87.8%). However,12.2% were BCLC-D. Median survival with sorafenib was 4.5 mo(IQR 2.3-11.7 mo);which was lower among BCLC-D patients 3.2 mo(IQR 2.0-14.1 mo). A total of 36 BCLC-B patients presented tumor progression after TACE. In these patients,treatment with sorafenib presented better survival when compared to those patients who received sorafenib without prior TACE [HR = 0.26(CI: 0.09-0.71);P= 0.013].CONCLUSION In this real setting, our results we

关键词： Hepatocellular carcinoma Therapeutics Survival Real-life

Universities as catalysts of social innovation in health systems in low-and middle-income countries: a multi-country case study

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Infectious Diseases of Poverty 2020年第4期9卷 151-151页

作者： Lindi van Niekerk Don Pascal Mathanga Noel Juban Diana Maria Castro-Arroyave Dina Balabanova The Bertha Centre for Social Innovation and Entrepreneurship University of Cape Town Graduate School of BusinessCape TownSouth Africa London School of Hygiene and Tropical Medicine LondonUK The Special Programme for Research and Training in Tropical Medicine(TDR) GenevaSwitzerland University of Malawi College of MedicineBlantyreMalawi University of the Philippines School of MedicineManilathe Philippines Centro Internacional de Entrenamiento e investigaciones medicas(CIdeIM) CaliColombia ICESI University CaliColombia

Background Social innovation(SI)in health holds potential to contribute to health systems strengthening and universal health coverage(UHC).The role of universities in SI has been well described in the context of high-income *** evidence gap exits on SI in healthcare delivery in the context of low-and middle-income countries(LMICs)as well as on the engagement of universities from these *** is thus a need to build capacity for research and engagement in SI in healthcare delivery within these *** aim of this study was to examine the adoption and implementation of network of university hubs focused on SI in healthcare delivery within five countries across Africa,Asia and Latin *** objectives were to describe the model,components and implementation process of the hubs;identify the enablers and barriers experienced and draw implications that could be relevant to other LMIC universities interested in *** A case study design was adopted to study the implementation process of a network of university *** from documentation,team discussions and post-implementation surveys were collected from 2013 to 2018 and analysed with aid of a modified policy analysis ***/discussion SI university-based hubs serve as cross-disciplinary and cross-sectoral platforms,established to catalyse SI within the local health system through four core activities:research,community-building,storytelling and institutional embedding,and adhering to values of inclusion,assets,co-creation and *** were implemented as informal structures,managed by a small core team,in existing *** of hub implementation and functioning were the availability of strong in-country social networks,legitimacy attained from being part of a global network on SI in health and receiving a capacity building package in the initial *** encountered were internal institutional resistance,administrative challenges associated with university

关键词： Social innovation University Healthcare delivery Health system Low-and middle-income countries

Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina

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World Journal of Hepatology 2018年第1期10卷 41-50页

作者： Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva Hepatology and Liver Transplantation Unit Hospital Universitario AustralBuenos Aires 1629Argentina Hepatology Section Liver Transplant ProgramDepartment of Academic ResearchHospital Italiano from Buenos AiresBuenos Aires 1424Argentina Sanatorio Trinidad San Isidro Buenos Aires 1642Argentina Clínica Privada San Fernando Buenos Aires 2013Argentina Hepatology and Gastroenterology Hospital BritánicoBuenos Aires 1280Argentina Hepatobiliary Surgery Hospital G RawsonSan Juan 5400Argentina department of Hepatology and Liver Transplant Program Hospital AlemanBuenos Aires 1118Argentina department of Hepatology and Liver Transplantation Sanatorio AllendeCórdoba 5016Argentina Hepatology Section Department of MedicineCentro de Educación Médica e Investigaciones Clínicas Norberto department of Hepatology Hospital Ramos MejíaBuenos Aires 1221Argentina department of Hepatology Centro Especialidades Medicas Ambulatorias(CEMA)Mar del Plata 7600Argentina department of Hepatology and Liver Transplantation Clínica de Nefrología de Santa FeSanta Fe 3000Argentina department of Hepatology and Gastroenterology Hospital C Bonorino UdaondoBuenos Aires 1264Argentina department of Hepatology and Gastroenterology Hospital CentenarioSanta Fe 2002Argentina

AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical *** A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P dence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications.

关键词： Hepatocellular carcinoma Etiology Fatty liver South America