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Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling

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food Science and Human Wellness 2024年

作者： Yongyong Liu Kai Huang Xiao Guan Sen Li Hongdong Song Ying Zhang Yu Zhang Zhu Sun Zhiquan Yu School of Health Science and Engineering University of Shanghai for Science and Technology National Grain industry (Urban Grain and Oil Security) Technology Innovation Center Inner Mongolia Yangufang Whole Grain industry development Co. Ltd.

Oat avenanthramides (AVNs) have been found to exhibit novel lipid-lowering effects. However， the mechanism remains unclear. In this study， the effect of avenanthramide B (AVN B)， as one of the major AVNs， on high-fat diet (HFD)-induced mice was investigated. Results showed that AVN B significantly inhibited weight gain and improved hepatic and serum lipid biochemical indices. Hepatic RNA-Sequencing analysis suggested that AVN B significantly modulates fatty acid (FA) metabolism. Hepatic real-time qualitative polymerase chain reaction (RT-qPCR) and Western blot results indicated that AVN B could alleviate FA synthesis by activating the AMPK- SREBP1c-FAS， and increase FA oxidation by activating the AMPK/CPT1A and PPARα. Additionally， AVN B had a regulating effect on ileum lipid metabolism by inhibiting intestinal cell differentiation and down-regulating the expression levels of FA absorption-related protein and gene. Moreover， AVN B promoted the growth of beneficial bacteria and fungi such as Coriobacteriaceae＿UCG-002， Parvibacter， Enterococcus， and Aspergillus， while decreasing the abundance of Roseburia， unclassified＿f＿Lachnospiraceae Cladosporium， Eurotium， unclassified＿f＿Aspergillaceae and unclassified＿f＿Ceratocystidaceae. All these results provided new points of the lipid-lowing mechanism of AVNs and oats via the gut-liver axis.

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Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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food Science and Human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi Chun-Hsu Pan Hui-Yu Huang Chieh-Hsi Wu Program in Clinical Drug development from Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in Drug Discovery and development industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pharmacy Taipei Medical UniversityTaipei 11031China Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT Restenosis Macrophage Vascular smooth muscle cells Gut microbiota

维普期刊数据库

Polygonatum Sibiricum Saponin-Lactic acid bacteria combination attenuate hyperglycemia in T2DM mice by modulating amino acid metabolism

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food Science and Human Wellness 2024年

作者： Jiayuan Luo Mingjie Jia Shuang Liang Yangyang Chai Yihong Bao Shilong Jiang Key Laboratory of Forest food Resources Utilization of Heilongjiang Province Colleage of Life Science Northeast Forestry University Heilongjiang Feihe Dairy industry

Some researches have shown that the combination of plant extracts and probiotics may be a better way to treat type 2 diabetes mellitus (T2DM) than a single intervention. However， there are still relatively few relevant reports in this aspect. Therefore， this study aims to investigate whether the treatment of polygonatum sibiricum saponin (PSS) and lactic acid bacteria (LAB) combination can better manage T2DM. And the anti-diabetes mechanism of the combination was studied from the perspectives of glucose metabolism， microbiome and metabolome. The results showed that PSS+LAB could better improve FBG level， insulin sensitivity， lipid metabolism disorder， and liver function. Protein analysis showed that PSS+LAB treatment significantly increased the expression of p-PI3K/PI3K， p-AKT/AKT， GLUT2， IRS2， and GSK-3β in the liver of T2DM mice， while inhibiting the expression of FOXO1. This combination positively regulated the composition and abundance of the gut microbiota. Metabolomic analysis showed that the combination treatment exhibited more changes in gut microbiota metabolites compared to PSS treatment alone. The alteration of gut microbiota by LAB+PSS led to significant changes in alanine， aspartate and glucose metabolism pathways. This study may provide a theoretical basis for the combined application of plant extracts and probiotics for the management of T2DM.

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Expression and characterization of a novel GH128 laminarinase OUC-BsLam26 harboring both hydrolyzing and transferring activities

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food Science and Human Wellness 2024年

作者： Yueyang Dong Yongyi Quan Hong Jiang Hamed I.Hamouda Zewei Lu Yimiao Chen Chengqiang Li Xiangzhao Mao State Key Laboratory of Marine food Processing and Safety Control College of food Science and Engineering Ocean University of China Qingdao Key Laboratory of food Biotechnology Sanya Ocean Research Institute Ocean University of China Processes Design and development Department Egyptian Petroleum Research Institute Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Key Laboratory of Biological Processing of Aquatic Products China National Light industry

Laminarin oligosaccharides (LOSs) with a specific degree of polymerization prepared through the laminarin degradation via laminarinase present more significant nutritional functions and application values. Human intestinal bacteria are promising potential producers of novel carbohydrate-active enzymes with unique properties. Here， a novel glycoside hydrolase family 128 (GH128) laminarinase OUC-BsLam26 from the intestinal bacterium Bacteroides sp. CBA7301 was heterologously expressed and characterized. The recombinant OUC-BsLam26 with a molecular mass of 49.86 kDa exhibits highest activity (6.60 U/mg) at 45 ℃ and pH 6.0， which shows noticeable temperature and pH stability. The purified OUC-BsLam26 could degrade laminarin via an endo-type mode with the generation of laminaripentaose， laminaritetraose， laminaritriose， and laminaribiose， among them， laminaritetraose is the principal product， which accounts for 45.25% of the total products， which is significantly different from the reported GH128 laminarinases. The minimum recognition substrate of OUC-BsLam26 is laminarihexaose. Furthermore， OUC-BsLam26 also could catalyze the transglycosylation process with the production of some novel glycosides. Altogether， the intestinal bacterium Bacteroides sp. CBA7301 contains laminarinase with unique product composition and OUC-BsLam26 is a hopeful bio-catalyst with the potential to produce laminaritetraose and some novel glycosides.

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Role of bitter contributors and bitter taste receptors:a comprehensive review of their sources,functions and future development

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food Science and Human Wellness 2024年第4期13卷 1806-1824页

作者： Xinyue Zhou Han Wang Ming Huang Jin Chen Jianle Chen Huan Cheng Xingqian Ye Wenjun Wang Donghong Liu College of Biosystems Engineering and food Science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingZhejiang Engineering Laboratory of Food Technology and EquipmentFuli Institute of Food ScienceZhejiang UniversityHangzhou 310058China Innovation Center of Yangtze River Delta Zhejiang UniversityJiashan 314100China Ningbo Research Institute Zhejiang UniversityNingbo 315100China Changshan Aijia Huyou food Research and development Center Changshan 324200China The Collaborative Innovation Center for Intelligent Production Equipment of Characteristic Forest Fruits in Hilly and Mountainous Areas of Zhejiang Province Hangzhou 311300China

Bitterness,one of the 5“basic tastes”,is usually undesired by ***,abundant literature reported that bitter fruits and vegetables have beneficial health effects due to their bitter *** review provided an updated overview of the main bitter contributors of typical bitter fruits and vegetables and their health *** main bitter contributors,including phenolics,terpenoids,alkaloids,amino acids,nucleosides and purines,were *** bioactivities and wide range of beneficial effects of them on anti-cancers,anti-inflammations,anti-microbes,neuroprotection,inhibiting chronic and acute injury in organs,as well as regulating behavior performance and metabolism were ***,not only did the bitter taste receptors(taste receptor type 2 family,T2Rs)show taste effects,but extra-oral T2Rs could also be activated by binding with bitter components,regulating physiological activities via modulating hormone secretion,immunity,metabolism,and cell *** review provided a new perspective on exploring and explaining the nutrition of bitter foods,revealing the relationship between the functions of bitter contributors from food and *** trends may focus on revealing the possibility of T2Rs being targets for the treatment of diseases,exploring the mechanism of T2Rs mediating the bioactivities,and making bitter foods more acceptable without getting rid of bitter contributors.

关键词： Bitter contributors Bitter taste receptor Health benefits Fruits Vegetables

维普期刊数据库

Pomegranate juice combined with inulin promote their mutual metabolic transformation by gut microbiota and prevent HFD-induced metabolic disorder in rats

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food Science and Human Wellness 2024年

作者： Xiaoyu Song Zhuoting Luo Mengting Li Jianke Li Chen Hou College of food Engineering and Nutritional Science Shaanxi Normal University University Key Laboratory of food Processing Byproducts for Advanced development and High Value Utilization Shaanxi Normal University

High-fat diet (HFD) promotes the imbalance of gut microbiota， contributing to the development of metabolic disorders. Pomegranate juice (PJ) and inulin， as dietary polyphenol and dietary fiber respectively， have been reported to ameliorate diet-induced gut microbiota dysbiosis and metabolic disorders. However， the combined effect of PJ and inulin on HFD-induced metabolic disorders has not been elucidated. In current study， we found that the combination of PJ and inulin prevent HFD-induced obesity， dyslipidemia， and gut microbiota dysbiosis. Moreover， the fecal levels of short-chain fatty acids (SCFAs) produced by inulin were increased after inulin combined with PJ. The levels of pomegranate polyphenol metabolites produced by PJ were also increased after PJ combined with inulin， especially pharmacokinetic analysis showed that the presence of inulin enhance the absorption level of urolithin A. Fecal metabolomic analysis found that PJ combined with inulin alter the metabolic status compared with PJ. It was also showed that the levels of SCFAs and pomegranate polyphenol metabolites among groups were correlated with gut microbiota and metabolic disorders indicators. Our results suggested that PJ combined with inulin prevent HFD-induced metabolic disorders， which may be attributed to the promotion of mutual metabolic transformation and absorption of PJ and inulin by gut microbiota.

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Beneficial effects of lacquer seed oil on bromocriptine-induced postpartum hypogalactia in rats

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food Science and Human Wellness 2024年

作者： Mengting Li Xiaoyu Song Lin Shi Jie Li Mayira·Ahat Yaojie Liu Chen Hou Jianke Li University Key Laboratory of food Processing Byproducts for Advanced development and High Value Utilization Shaanxi Normal University College of food Engineering and Nutritional Science Shaanxi Normal University

The high incidence of postpartum hypogalactia hinders the healthy development of postpartum women and the next generation. Lacquer seed oil (LSO)， the oil extracted from the seeds of the lacquer tree， has been traditionally used as a dietary supplement for promoting postpartum lactation and recovery in some districts of China. However， its physiological effects have not been verified， and the mechanism and active components of LSO have not been analyzed. Thus， we applied LSO to bromocriptine-induced postpartum hypogalactia rats. The results showed that LSO supplement effectively improves bromocriptine-induced postpartum hypogalactia. LSO also increased prolactin levels reduced by bromocriptine， promoted JAK2/STAT5 and PI3K/AKT pathways and several gene expression levels of milk synthesis in mammary gland. Moreover， metabolomic and network pharmacological analysis further revealed that JAK2/STAT5， PI3K/AKT， and estrogen signaling pathway are the potential main regulatory sites for the beneficial effects of LSO on postpartum hypogalactia， and that quercetin， kaempferol， arachidonic acid， epicatechin， and β-sitosterol are the top 5 main active ingredients of LSO. Our results suggested that LSO has great potential in the application of the improvement of postpartum hypogalactia.

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Pomegranate peel polyphenols improves diet-induced obesity and promotes adipose browning development through gut microbiota in mice

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food Science and Human Wellness 2024年

作者： Zhuoting Luo Xiaoyu Song Mengting Li Jianke Li Chen Hou University Key Laboratory of food Processing Byproducts for Advanced development and High Value Utilization Shaanxi Normal University College of food Engineering and Nutritional Science Shaanxi Normal University

Gut microbiota regulate the activation of adipose browning， which promote energy dissipation and combat diet-induced obesity. Pomegranate peel polyphenols (PPPs) have been shown to reduce obesity， regulate lipid metabolism in adipose tissue， and modulate the composition of gut microbiota in animal fed high-fat diet (HFD). However， the role of gut microbiota in the improvement of obesity by PPPs has not been elucidated. In current study， we applied antibiotics to inhibit gut microbiota in mice fed HFD and treated with PPPs. The results showed that the inhibition of gut microbiota impair the effect of PPPs on reducing obesity and promoting adipose browning， and change the fecal metabolomic profiles in respond to PPPs. Moreover， the inhibition of gut microbiota supressed the promotive effects of PPPs on the levels of Akkermansia and microbiota-related metabolites， such as urolithin A， short-chain fatty acids (SCFAs)， and bile acids (BAs)， which were associated with activating adipose browning. Therefore， our results suggested that the presence of gut microbiota is essential for PPPs to ameliorate HFD-induced obesity. The related bacteria or metabolites generated by the interaction between PPPs and microbiota promote adipose browning and facilitate the beneficial effects of PPPs.

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New food Sources and Production Systems: A Comparison of International Regulations and China’s Advancements in Novel foods with Synthetic Biology

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food Science and Human Wellness 2024年

作者： Xin Liu Di Wu Yi Shao Yongning Wu Key Laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education) College of food Science and Engineering Wuhan Polytechnic University Institute for Global food Security School of Biological Sciences Queen's University Belfast Department of Nutrition and food Safety Peking Union Medical College Research Unit of food Safety Chinese Academy of Medical Sciences NHC Key Laboratory of food Safety Risk Assessment China National Center for food Safety Risk Assessment

The global shift towards sustainable food systems has sparked innovations in food sources and production systems， including cell-based meat， plant-based food products， precision fermentation， and 3D food printing. These advancements pose regulatory challenges and opportunities， with China emerging as a critical player in adopting and regulating new food technologies. This review explores the international landscape of new food sources and production systems， focusing on China’s role and regulatory approaches compared to global practices. Through this comparative analysis， we aim to contribute to the ongoing dialogue on food safety regulation， offering insights and recommendations for policymakers， industry stakeholders， and researchers engaged in the global food system’s evolution. This comprehensive overview underscores the dynamic nature of regulatory frameworks governing NFPS， highlighting the international efforts to ensure food safety， consumer protection， and the sustainable evolution of the food industry.

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