检索结果-南通市图书馆

Grain growth behavior and properties of high-entropy pseudobrookite(Mg,Co,Ni,Zn)Ti_(2)O_(5) ceramics

在线全文

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2024年第6期13卷 757-768页

作者： Xiaohui Ma Jinyu Wu Lingyi Meng Jinfeng Zhang Heng Chen Liwen Yan Anran Guo Jiachen Liu Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education School of Materials Science and EngineeringTianjin UniversityTianjin 300072China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China

It is well known that the grain size of high-entropy ceramics is quite small owing to the sluggish diffusion effect. However, abnormal grain growth often occurs in high-entropy pseudobrookite ceramics, ultimately resulting in the formation of many abnormally grown grains with a grain size as large as 50 μm. To study this phenomenon, the grain growth behavior of high-entropy pseudobrookite ceramics was systematically investigated in this paper. The results demonstrate that the starting material powders first react with each other to form a high-entropy intermediate phase and calcined TiO_(2) powders (TiO_(2)-1100 ℃), and then as the sintering temperature increases, the formed high-entropy intermediate phase further reacts with TiO_(2)-1100 ℃ to form high-entropy pseudobrookite ceramics. Thus, in this system, in addition to the sluggish diffusion effect, the grain sizes of the high-entropy intermediate phase and TiO_(2)-1100 ℃ also affect the morphology of high-entropy pseudobrookite. Compared to nanosized TiO_(2), micron-sized TiO_(2) has a lower sintering activity. Therefore, the high-entropy intermediate phases (Mg,Co,Ni,Zn)TiO_(3) and TiO_(2)-1100 ℃ prepared with micron-sized starting materials exhibit lower grain sizes, finally resulting in the formation of high-entropy (Mg,Co,Ni,Zn)Ti_(2)O_(5) with small grain sizes. Moreover, nano-indentation and thermal conductivity tests were carried out on high-entropy (Mg,Co,Ni,Zn)Ti_(2)O_(5) with different morphologies. The results show that the hardness of high-entropy (Mg,Co,Ni,Zn)Ti_(2)O_(5) increases from 6.05 to 9.95 GPa as the grain size increases, whereas the thermal conductivity decreases from 2.091±0.006 to 1.583±0.006 W·m^(−1)·K^(−1). All these results indicate that high-entropy (Mg,Co,Ni,Zn)Ti_(2)O_(5) with a small grain size is a potential material for thermal protection.

关键词： grain size sluggish diffusion effect two-step solid phase process high-entropy intermediate phase high-entropy pseudobrookite ceramic

A neural m^(6)A pathway regulates behavioral aggregation in migratory locusts

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life sciences) 2024年第6期67卷 1242-1254页

作者： Xianliang Huang Qing Li Yanan Xu Ang Li Shanzheng Wang Yusheng Chen Chunrui Zhang Xia Zhang Hailin Wang Cong Lv Baofa Sun Shaoqin Li Le Kang Bing Chen School of Life Science Institutes of Life Science and Green DevelopmentHebei UniversityBaoding 071002China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Health sciences Anhui UniversityHefei 230601China Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100101China

RNA N6-methyladenosine(m^(6)A),as the most abundant modification of messenger RNA,can modulate insect behaviors,but its specific roles in aggregation behaviors remain ***,we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta *** results demonstrated that METTL3,METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or *** individual knockdown of methyltransferases(i.e.,METTL3 and METTL14)promoted locust movement and conspecific attraction,whereas ALKBH5 knockdown induced a behavioral shift toward the solitary ***,global transcriptome profiles revealed that m^(6)A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of *** summary,our in vivo characterization of the m^(6)A functions in migratory locusts clearly demonstrated the crucial roles of the m^(6)A pathway in effectively modulating aggregation behaviors.

关键词： RNA methylation N^(6)-methyladenosine transcriptional orchestration aggregation behavior Locusta migratoria

Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第5期14卷 2006-2025页

作者： Bingwen Ding Zhu Zhu Cong Guo Jiaxin Li Yong Gan Miaorong Yu State Key Laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of sciences Beijing 100049China School of Pharmacy Henan UniversityKaifeng 475004China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China

Diabetes,characterized by hyperglycemia,is a major cause of death and disability ***,such as insulin and glucagon-like peptide-1(GLP-1)analogs,have shown promise as treatments for diabetes due to their ability to mimic or enhance insulin's actions in the *** to subcutaneous injection,oral administration of anti-diabetic peptides is a preferred ***,biological barriers significantly reduce the efficacy of oral peptide *** advancements in drug delivery systems and formulation techniques have greatly improved the oral delivery of peptide therapeutics and their efficacy in treating *** review will highlight(1)the benefits of oral anti-diabetic peptide therapeutics;(2)the biological barriers for oral peptide delivery,including pH and enzyme degradation,intestinal mucosa barrier,and biodistribution barrier;(3)the delivery platforms to overcome these biological ***,the review will discuss the prospects in this *** information provided in this review will serve as a valuable guide for future developments in oral anti-diabetic peptide therapeutics.

关键词： Oral peptides Diabetes Delivery platforms Insulin Glucagon-like peptide-1 Biodistribution Biological barriers Targeted delivery

Basic Survey Scheduling for the Wide Field Survey Telescope(WFST)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第1期24卷 59-69页

作者： Yan-Peng Chen Ji-An Jiang Wen-Tao Luo Xian-Zhong Zheng Min Fang Chao Yang Yuan-Yu Hong Zong-Fei Lü Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Department of Astronomy University of Science and Technology of ChinaHefei 230026China National Astronomical Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Institute of Deep Space sciences Deep Space Exploration LaboratoryHefei 230026China

Aiming at improving the survey efficiency of the Wide Field Survey Telescope, we have developed a basic scheduling strategy that takes into account the telescope characteristics, observing conditions, and weather conditions at the Lenghu site. The sky area is divided into rectangular regions, referred to as “tiles,” with a size of2°. 577 × 2°. 634 slightly smaller than the focal area of the mosaic CCDs. These tiles are continuously filled in annulars parallel to the equator. The brightness of the sky background, which varies with the moon phase and distance from the moon, plays a significant role in determining the accessible survey fields. Approximately 50connected tiles are grouped into one block for observation. To optimize the survey schedule, we perform simulations by taking into account the length of exposures, data readout, telescope slewing, and all relevant observing conditions. We utilize the Greedy Algorithm for scheduling optimization. Additionally, we propose a dedicated dithering pattern to cover the gaps between CCDs and the four corners of the mosaic CCD array, which are located outside of the 3° field of view. This dithering pattern helps to achieve relatively uniform exposure maps for the final survey outputs.

关键词： telescopes surveys Moon

Seco-cyclic phorbol derivatives and their anti-HIV-1 activities

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第4期22卷 365-374页

作者： HUANG Xiaolei HUANG Xusheng LI Qirun MA Mengdi CUI Yadong YANG Liumeng WANG Haibo LUO Ronghua CHEN Jinglei YANG Jingxuan LIN Jinrong LI Duxin ZHENG Yongtang ZHANG Jian College of Pharmaceutical Science Soochow UniversitySuzhou 215123China Key Laboratory of Animal Models and Human disease Mechanisms of the Chinese Academy of sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204China College of Traditional Chinese Medicine Yunnan University of Chinese MedicineKunming 650500China

Phorbol esters are recognized for their dual role as anti-HIV-1 agents and as activators of protein kinase C(PKC).The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20,C3/C4,and C9 of ***,the lipids located at positions C12/C13 are essential for both the anti-HIV-1 activity and the formation of the PKC-ligand *** influence of the cyclopropane ring at positions C13 and C14 in phorbol derivatives on their anti-HIV-1 activity requires further *** research entailed the hydrolysis of phorbol,producing seco-cyclic phorbol *** anti-HIV-1 efficacy of these derivatives was assessed,and the affinity constant(Kd)for PKC-δprotein of selected seco-cyclic phorbol derivatives was determined through isothermal titration *** findings suggest that the chemical modification of cyclopropanols could affect both the anti-HIV-1 activity and the PKC binding ***,compound S11,with an EC_(50) of 0.27μmol·L^(−1) and a CC_(50) of 153.92μmol·L^(−1),demonstrated a potent inhibitory effect on the intermediate products of HIV-1 reverse transcription(ssDNA and 2LTR),likely acting at the viral entry stage,yet showed no affinity for the PKC-δ*** results position compound S11 as a potential candidate for further preclinical investigation and for studies aimed at elucidating the pharmacological mechanism underlying its anti-HIV-1 activity.

关键词： seco-Cyclic phorbol derivatives Hydrolysis reaction Cyclopropane ring Esterification Anti-HIV-1 agent

USH1C新杂合突变影响耳蜗毛细胞机械电转导功能并导致渐进性听力损伤（英文）

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2024年第2期 167-172页

作者：贾岩岩贾高干郭荦宋楠王雨萌蒋罗颖舒易来陈岩竺淑佳李华伟李文妍 ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan University institutes of Biomedical sciences Fudan University NHC Key Laboratory of Hearing Medicine (Fudan University) The institutes of brain Science and the Collaborative Innovation Center for brain Science Fudan University Shanghai Center for brain Science and brain-Inspired Intelligence Technology Institute of Neuroscience State Key Laboratory of Neuroscience CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Department of Cardiology and Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine

Hearing loss is one of the most common sensory disorders worldwide, affecting approximately 466 million people, including34 million children [1]. Genetic mutations accounts for approximately 60% of inherited hearing l...

关键词：

PARP1-DNA co-condensation:the driver of broken DNA repair

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2351-2353页

作者： Xiang Wei Fangfang Zhou Long Zhang Life sciences Institute The Second Affiliated Hospital of the Zhejiang University School of MedicineThe MOE Key Laboratory of Biosystems Homeostasis&Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell BiologyZhejiang UniversityHangzhouChina The First Affiliated Hospital the Institutes of Biology and Medical SciencesSuzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215123China

A recent study published by Simon Alberti1 in Cell has revealed that DNA double-strand break(DSB)sites that prevent the disjunction of broken DNA ends are formed through poly(ADPribose)(PAR)polymerase 1(PARP1)-DNA co-condensation.1(Fig.1).Here,a comprehensive and novel model was provided for the ordered assembly of PARP1-DNA condensates,which can rationally make clear broken DNA end synapses and how repair effectors are recruited to repair DSB.

关键词： PARP1 repair rational

Harnessing GABAergic Transmission for Slow Oscillations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2016年第5期32卷 501-502页

作者： Yang Zhan brain Cognition and brain disease Institute Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

Oscillatory neuronal activity is the fundamental signature of neural *** the EEG literature,the oscillations are described as belonging to different frequency bands that are commonly used in clinical monitoring.

关键词： signature neuronal bands excitatory hippocampal theta oscillation synaptic blocked hippocampus

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

在线全文

学校读者我要写书评

暂无评论

Science China(Life sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-Feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao Li Chang-Fa Fan Ke Song Yuan-Guo Li Run-Ze Ye Fang-Xu Li Dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi Ming-Zhu Zhang Liang-Jing Li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu Lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang Yan-Ling Hu Na Jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National institutes for Food and Drug Control Beijing 102629China Life sciences Institute Guangxi Medical UniversityNanning 530020China College of Life sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice