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Enhanced conductivity and weakened magnetism in Pb-doped Sr2IrO4

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Chinese Physics B 2024年第1期33卷 696-701页

作者：岳智来甄伟立牛瑞焦珂珂朱文卡皮雳张昌锦 High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of Sciences science Island Branch of Graduate School University of Science and Technology of China collaborative innovation center of Advanced Microstructures Nanjing University

Group IV element Pb has been selected as the dopant to dope at the Sr site of Sr2IrO4. It is exciting to find that the single-phase crystal structure could be maintained with a high Pb doping level of up to x=0.3 in Sr2-xPbxIrO4. The mapping data obtained from energy-dispersive x-ray spectroscopy analyses give solid evidence that the Pb ions are uniformly distributed in the Sr2IrO4matrix. The incorporation of Pb leads to a moderate depression of the canted antiferromagnetic ordering state. The electrical conductivity could be greatly enhanced when the Pb doping content is higher than x=*** present results give a fresh material base to explore new physics in doped Sr2IrO4systems.

关键词： iridates doping conductivity magnetism

Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes

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National science Review 2024年第1期11卷 161-173页

作者： Feng Xue Fei Li Ke-ming Zhang Lufeng Ding Yang Wang Xingtao Zhao Fang Xu Danke Zhang Mingzhai Sun Pak-Ming Lau Qingyuan Zhu Pengcheng Zhou Guo-Qiang Bi Institute of Artiflcial Intelligence Hefei Comprehensive National Science Center Department of Precision Machinery and Precision Instruments University of Science and Technology of China Hefei National Laboratory for Physical sciences at the Microscale University of Science and Technology of China Interdisciplinary center for brain Information the Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Faculty of Life and Health sciences Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences School of Life sciences University of Science and Technology of China Institute of Semiconductors Chinese Academy of Sciences Department of Modern Life sciences and Biotecnology Xiongan Institute of Innovation Xiongan New Area Shenzhen-Hong Kong Institute of brain science-Shenzhen Fundamental Research Institutions Suzhou Institute for Advanced Research University of Science and Technology of China

To investigate the circuit-level neural mechanisms of behavior, simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired. Miniature head-mounted microscopes offer the capability of calcium imaging in freely behaving animals. However, implanting multiple microscopes on a mouse brain remains challenging due to space constraints and the cumbersome weight of the ***, we present TINIscope, a Tightly Integrated Neuronal Imaging microscope optimized for electronic and opto-mechanical design. With its compact and lightweight design of 0.43 g, TINIscope enables unprecedented simultaneous imaging of behavior-relevant activity in up to four brain regions in ***-of-concept experiments with TINIscope recorded over 1000 neurons in four hippocampal subregions and revealed concurrent activity patterns spanning across these regions. Moreover, we explored potential multi-modal experimental designs by integrating additional modules for optogenetics, electrical stimulation or local field potential recordings. Overall, TINIscope represents a timely and indispensable tool for studying the brain-wide interregional coordination that underlies unrestrained behaviors.

关键词： miniature microscope multiple sites calcium imaging multimodal integration hippocampus

Peripheral Mechanism of Cancer-Induced Bone Pain

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Neuroscience Bulletin 2024年第6期40卷 815-830页

作者： Yachen Yang Wei Yang Ruofan Zhang Yanqing Wang Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesShanghai Medical CollegeInstitute of Acupuncture ResearchInstitutes of Integrative MedicineFudan UniversityShanghai200032China Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function Shanghai Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceFudan UniversityShanghai200032China Zhongshan-Fudan Joint innovation center Zhongshan528437China

Cancer-induced bone pain(CIBP)is a type of ongoing or breakthrough pain caused by a primary bone tumor or bone *** constitutes a specific pain state with distinct characteristics;however,it shares similarities with inflammatory and neuropathic *** present,although various therapies have been developed for this condition,complete relief from CIBP in patients with cancer is yet to be ***,it is urgent to study the mechanism underlying CIBP to develop efficient analgesic ***,we focused on the peripheral mechanism associated with the initiation of CIBP,which involves tissue injury in the bone and changes in the tumor microenvironment(TME)and dorsal root *** nerve–cancer and cancer–immunocyte cross-talk in the TME creates circumstances that promote tumor growth and metastasis,ultimately leading to *** peripheral mechanism of CIBP and current treatments as well as potential therapeutic targets are discussed in this review.

关键词： Cancer-induced bone pain Peripheral mechanism Tumor microenvironment Sensory nerve Immunocytes

Improving the electrical performances of InSe transistors by interface engineering

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Chinese Physics B 2024年第4期33卷 153-158页

作者：曹天俊郝松吴晨晨潘晨戴玉頔程斌梁世军缪峰 Institute of brain-Inspired Intelligence National Laboratory of Solid State MicrostructuresSchool of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Institute of Interdisciplinary Physical sciences School of PhysicsNanjing University of Science and TechnologyNanjing 210014China

InSe has emerged as a promising candidate for next-generation electronics due to its predicted ultrahigh electrical ***,the efficacy of the InSe transistor in meeting application requirements is hindered due to its sensitivity to *** this study,we have achieved notable enhancement in the electrical performance of InSe transistors through interface *** engineered an InSe/h-BN heterostructure,effectively suppressing dielectric layer-induced ***,we successfully established excellent metal-semiconductor contacts using graphene ribbons as a buffer *** a methodical approach to interface engineering,our graphene/InSe/h-BN transistor demonstrates impressive on-state current,field-effect mobility,and on/off ratio at room temperature,reaching values as high as 1.1 mA/μm,904 cm^(2)·V^(-1)·s^(-1),and>10~6,*** computations corroborate that the graphene/InSe heterostructure shows significant interlayer charge transfer and weak interlayer interaction,contributing to the enhanced performance of InSe *** research offers a comprehensive strategy to elevate the electrical performance of InSe transistors,paving the way for their utilization in future electronic applications.

关键词： two-dimensional materials InSe van der Waals heterostructure electrical performances charge density difference

Anisotropic metal–insulator transition in strained VO_(2)(B) single crystal

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Chinese Physics B 2024年第6期33卷 56-61页

作者：马泽成闫胜楠刘增霖徐涛陈繁强陈思成曹天俊孙立涛程斌梁世军缪峰 Institute of brain-Inspired Intelligence National Laboratory of Solid State MicrostructuresSchool of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China SEU-FEI Nano-Pico center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 210096China Institute of Interdisciplinary of Physical sciences School of ScienceNanjing University of Science and TechnologyNanjing 210094China

Mechanical strain can induce noteworthy structural and electronic changes in vanadium dioxide, imparting substantial scientific importance to both the exploration of phase transitions and the development of potential technological applications. Unlike the traditional rutile(R) phase, bronze-phase vanadium dioxide [VO_(2)(B)] exhibits an in-plane anisotropic structure. When subjected to stretching along distinct crystallographic axes, VO_(2)(B) may further manifest the axial dependence in lattice–electron interactions, which is beneficial for gaining insights into the anisotropy of electronic ***, we report an anisotropic room-temperature metal–insulator transition in single-crystal VO_(2)(B) by applying in-situ uniaxial tensile strain. This material exhibits significantly different electromechanical responses along two anisotropic *** reveal that such an anisotropic electromechanical response mainly arises from the preferential arrangement of a straininduced unidirectional stripe state in the conductive channel. This insulating stripe state could be attributed to the in-plane dimerization within the distorted zigzag chains of vanadium atoms, evidenced by strain-modulated Raman spectra. Our work may open up a promising avenue for exploiting the anisotropy of metal–insulator transition in vanadium dioxide for potential technological applications.

关键词： vanadium dioxide strain anisotropy electrical transport

Pressure-induced magnetic phase and structural transition in SmSb2

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Chinese Physics B 2024年第6期33卷 484-489页

作者：李涛王舒阳陈绪亮陈春华房勇杨昭荣 science Island Branch of Graduate School University of Science and Technology of China Anhui Key Laboratory of Low-Energy Quantum Materials and Devices High Magnetic Field LaboratoryHFIPS Chinese Academy of Sciences Jiangsu Laboratory of Advanced Functional Materials Department of Physics Changshu Institute of Technology institutes of Physical science and Information Technology Anhui University collaborative innovation center of Advanced Microstructures

Motivated by the recent discovery of unconventional superconductivity around a magnetic quantum critical point in pressurized CeSb2,here we present a high-pressure study of an isostructural antiferromagnetic（AFM） SmSb2through electrical transport and synchrotron x-ray diffraction *** PC～2.5 GPa,we found a pressure-induced magnetic phase transition accompanied by a Cmca→P4/nmm structural phase *** the pristine AFM phase below PC,the AFM transition temperature of SmSb2is insensitive to pressure;in the emergent magnetic phase above PC,however,the magnetic critical temperature increases rapidly with increasing *** addition,at ambient pressure,the magnetoresistivity（MR） of SmSb2increases suddenly upon cooling below the AFM transition temperature and presents linear nonsaturating behavior under high field at 2 *** increasing pressure above PC,the MR behavior remains similar to that observed at ambient pressure,both in terms of temperature-and field-dependent *** leads us to argue an AFM-like state for SmSb2above *** the investigated pressure of up to 45.3 GPa and the temperature of down to 1.8 K,we found no signature of superconductivity in SmSb2.

关键词： antiferromagnet high pressure magnetoresistivity structural transition

MAL2 DNA methylation serves as a biomarker for the diagnosis and prognosis of glioma

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Genes & Diseases 2024年第5期11卷 36-39页

作者： Hao Luo Xing Xiao Weiliang Hou Jing Cai Ming Chen Qisheng Tang Yusheng Tong Zengxin Qi Kaicheng Li Liang Chen Department of Neurosurgery Huashan HospitalShanghai Medical CollegeState Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain Science and Institutes of Brain ScienceFudan UniversityShanghai 200040China National center for Neurological Disorders Shanghai 200040China Shanghai Key Laboratory of brain Function and Restoration and Neural Regeneration Shanghai 200040China Tianqiao and Chrissy Chen Institute Clinical Translational Research center Shanghai 200040China Shanghai QuietD Biotechnology Co. Ltd.Shanghai 201210China

Glioma is a common and malignant brain tumor,and molecular diagnostics for glioma have received increasing attention.1,2 Previous studies have suggested that the MAL2 gene may be involved in the transcytosis of various cancers.3 This study aimed to investigate the potential of MAL2 as a biomarker for *** candidate MAL2 CpG sites were validated by pyrosequencing and used to construct a diagnostic model for *** analysis was also conducted to determine the relationship between highly methylated MAL2-specific CpG sites and the prognosis of *** findings also showed that MAL2 was more highly methylated in glioma than in other *** constructed diagnostic model can distinguish glioma from other cancers with high sensitivity(93.3%)and specificity(86.5%).Additionally,a risk score model was built based on MAL2 methylation to assess the prognosis of glioma。

关键词： glioma diagnosis MAL

Exploring reservoir computing:Implementation via double stochastic nanowire networks

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Chinese Physics B 2024年第3期33卷 572-582页

作者：唐健峰夏磊李广隶付军段书凯王丽丹 College of Artificial Intelligence Southwest UniversityChongqing 400715China brain-inspired Computing & Intelligent Control of Chongqing Key Laboratory Chongqing 400715China National & Local Joint Engineering Laboratory of Intelligent Transmission and Control Technology Chongqing 400715China Chongqing brain science collaborative innovation center Chongqing 400715China Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of EducationSouthwest UniversityChongqing 400715China State Key Laboratory of Intelligent Vehicle Safety Technology Chongqing 400715China

Neuromorphic computing,inspired by the human brain,uses memristor devices for complex *** studies show that self-organizing random nanowires can implement neuromorphic information processing,enabling data *** paper presents a model based on these nanowire networks,with an improved conductance variation *** suggest using these networks for temporal information processing via a reservoir computing scheme and propose an efficient data encoding method using voltage *** nanowire network layer generates dynamic behaviors for pulse voltages,allowing time series prediction *** experiment uses a double stochastic nanowire network architecture for processing multiple input signals,outperforming traditional reservoir computing in terms of fewer nodes,enriched dynamics and improved prediction *** results confirm the high accuracy of this architecture on multiple real-time series datasets,making neuromorphic nanowire networks promising for physical implementation of reservoir computing.

关键词： double-layer stochastic(DS)nanowire network architecture neuromorphic computation nanowire network reservoir computing time series prediction

Individual dynamics and local heterogeneity provide a microscopic view of the epidemic spreading

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Chinese Physics B 2024年第5期33卷 656-663页

作者：朱友源沈瑞哲董昊王炜 Kuang Yaming Honors School Nanjing UniversityNanjing 210023China collaborative innovation center of Advanced Microstructures National Laboratory of Solid State MicrostructureSchool of PhysicsNanjing UniversityNanjing 210093China Institute for brain sciences Nanjing UniversityNanjing 210023China State Key Laboratory of Analytical Chemistry for Life science Nanjing UniversityNanjing 210023China

The COVID-19 pandemic has caused severe global disasters,highlighting the importance of understanding the details and trends of epidemic transmission in order to introduce efficient intervention *** the widely used deterministic compartmental models have qualitatively presented continuous “analytical” insight and captured some transmission features,their treatment usually lacks spatiotemporal ***,we propose a stochastic individual dynamical(SID)model to mimic the random and heterogeneous nature of epidemic *** SID model provides a unifying framework for representing the spatiotemporal variations of epidemic development by tracking the movements of each *** this model,we reproduce the infection curves for COVID-19 cases in different areas globally and find the local dynamics and heterogeneity at the individual level that affect the disease *** macroscopic trend of virus spreading is clearly illustrated from the microscopic perspective,enabling a quantitative assessment of different ***,this model is also applicable to studying stochastic processes at the “meter scale”,e.g.,human society’s collective dynamics.

关键词： Brownian motion epidemic spreading heterogeneity