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Ultrasound-Modulated Optical Tomography in Reflective and Coaxial Configuration

Chinese Physics Letters 2003年第12期20卷 2165-2168页

作者：傅洪波邢达曾亚光王毅陈群 instituteoflaserlifescience SouthChinaNormalUniversityGuangzhou510631

Ultrasound-modulated optical tomography affords a very promising noninvasive imaging method for biomedical diagnosis. With this technique, an ultrasound beam is focused into a scattering medium to provide an accurate localization and, simultaneously, a modulation of laser light inside the medium. Based on the high-sensitivity detection technique, we have developed a unique reflective configuration, which was more convenient and practical than other existing configurations. Furthermore, the configuration also introduced a new scheme to improve the spatial resolution in the imaging. A phantom was imaged to validate the feasibility of the proposed configuration.

关键词： Ultrasound-Modulated Optical Tomography Reflective and Coaxial Configuration

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A Kind of Electrode Enhanced the Electrochemiluminescence

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Chinese Chemical Letters 2004年第1期15卷 101-104页

作者： GuiHongYAN DaXING ShiCiTAN instituteoflaserlifescience SouthChinaNormalUniversityGuangzhou510631

Three kinds of platinum electrodes with different geometry were designed. The relation of the electrochemiluminescence (ECL) intensity with the geometry of these electrodes has been investigated. The optical character of these electrodes was directly studied by observation of ECL image and measurement of the ECL intensity. The results showed that the ECL not only concentrated on the edge of the electrode but also concentrated on the edge of holes, which contain in the electrode. The ECL intensity from Ru(bpy)3Cl2·6H2O on round electrode was about half of that on four-hole round disk electrode for a same concentration of Ru(bpy)3Cl2·6H2O, so the detection limit was improved to 10-18 mol/L Ru(bpy)3Cl2·6H2O on four-hole round disk electrode, three times higher than that on round disk electrode.

关键词： Electrochemiluminescence electrode geometry.

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A High Sensitivity Detection Method of Singlet Oxygen and Superoxide Anion

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Chinese Chemical Letters 2004年第6期15卷 679-682页

作者： MinHAO DaXING QunCHEN JuanWANG instituteoflaserlifescience SouthChinaNormalUniversityGuangzhou510631

This paper, for the first time, reports a method that can be used as a highly sensitive probe for singlet oxygen (1O2) and superoxide anion (O2-) in vitro or in vivo. FCLA(3,7-dihydro-6-{4-[2-(N'-(5-fluoresceinyl)thioureido)ethoxy]phenyl}-2-methylimidazo{1,2-a}pyrazin-3-one sodium salt), a chemiluminescence (CL) analysis reagent, has been reported to sensitively react with 1O2 and O2- to emit photons with a spectral peak of 525nm. In this work, when human serum albumin (HSA) was added into FCLA solution to enhance the CL intensity, approximately 20 times, compared to that without HSA. The enhanced CL had the same 525 nm spectral peak, identical to that without HSA. By gradually reducing the molecular oxygen content in the solution, we find that the auto-oxidation of oxygen molecules dissolved in the solution plays an important role in the CL process. Based on these experimental evidences, we propose a novel and highly sensitive detection method of 1O2 and O2-, which may have a great potential in chemical and medical applications.

关键词： Singlet oxygen superoxide anion chemiluminescence.

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Determination of optical properties of normal and adenomatous human colon tissues in vitro using integrating sphere techniques

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World Journal of Gastroenterology 2005年第16期11卷 2413-2419页

作者： Hua-JiangWei DaXing Jian-JunLu Huai-MinGu Guo-YongWu YingJin instituteoflaserlifescience SouthChinaNormalUniversityGuangzhou510631GuangdongProvinceChina DepartmentofSurgery theFirstAffiliatedHospitalSunYat-SenMedicalUniversityGuangzhou510080GuangdongProvinceChina

AIM: The purpose of the present study is to compare the optical properties of normal human colon mucosa/submucosa and muscle layer/chorion, and adenomatous human colon mucosa/submucosa and muscle layer/chorion in vitro at 476.5, 488, 496.5, 514.5 and 532 nm. We believe these differences in optical properties should help differential diagnosis of human colon tissues by using optical methods.METHODS: In vitro optical properties were investigated for four kinds of tissues: normal human colon mucosa/submucosa and muscle layer/chorion, and adenomatous human colon mucosa/submucosa and muscle layer/chorion. Tissue samples were taken from 13 human colons (13 adenomatous, 13 normal). From the normal human colons a total of 26 tissue samples, with a mean thickness of 0.40 mm, were used (13 from mucosa/submucosa and 13 from muscle layer/chorion), and from the adenomatous human bladders a total of 26 tissue samples, with a mean thickness of 0.40 mm, were used (13 from mucosa/submucosa and 13 from muscle layer/chorion). The measurements were performed using a double-integratingsphere setup and the optical properties were assessed from these measurements using the adding-doubling method that was considered reliable.RESULTS: The results of measurement showed that there were significant differences in the absorption coefficients and scattering coefficients between normal and adenomatous human colon mucosa/submucosa at the same wavelength,and there were also significant differences in the two optical parameters between both colon muscle layer/chorion at the same wavelength. And there were large differences in the anisotropy factors between both colon mucosa/submucosa at the same wavelength, there were also large differences in the anisotropy factors between both colon muscle layer/chorion at the same wavelength.There were large differences in the value ranges of the absorption coefficients, scattering coefficients and anisotropy factors between both colon mucosa/submucosa,and there were also large differences in these value range

关键词：光学道具肿瘤结肠组织黏膜球形结合技术光学治疗

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Optical properties of human normal small intestine tissue determined by Kubelka-Munk method in vitro

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World Journal of Gastroenterology 2003年第9期9卷 2068-2072页

作者： Hua-JiangWei DaXing Guo-YongWu YingJin Huai-MinGu instituteoflaserlifescience SouthChinaNormalUniversityGuangzhou510631GuangzhouProvinceChina DepartmentofSurgery theFirstAffiliatedHospitalSunYat-SenMedicalUniversityGuangzhou510080GuangdongProvinceChina

AIM: To study the optical properties of human normal small intestine tissue at 476.5 nm, 488 nm, 496.5 nm, 514.5 nm,532 nm, 808 nm wavelengths of laser irradiation.METHODS: A double-integrating-sphere system, the basic principle of measuring technology of light radiation, and an optical model of biological tissues were used in the study.RESULTS: The results of measurement showed that there were no significant differences in the absorption coefficients of human normal small intestine tissue at 476.5 nm, 488 nm,496.5 nm laser in the Kubelka-Munk two-flux model (P＞0.05).The absorption coefficients of the tissue at 514.5 nm, 532 nm,808 nm laser irradiation were obviously increased with the decrease of these wavelengths. The scattering coefficients of the tissue at 476.5 nm, 488 nm, 496.5 nm laser irradiation were increased with the decrease of these wavelengths.The scattering coefficients at 496.5 nm, 514.5 nm, 532 nm laser irradiation were obviously increased with the increase of these wavelengths. The scattering coefficient of the tissue at 532 nm laser irradiation was bigger than that at 808 nm.There were no significant differences in the total attenuation coefficient of the tissue at 476.5 nm and 488 nm laser irradiation (P＞0.05). The total attenuation coefficient of the tissue at 488 nm, 496.5 nm, 514.5 nm, 532 nm, 808 nm laser irradiation was obviously increased with the decrease of these wavelengths, and their effective attenuation coefficient revealed the same trend. There were no significant differences among the forward scattered photon fluxe,backward scattered photon fiuxe, and total scattered photon fiuxe of the tissue at 476.5 nm, 488 nm, 496.5 nm laser irradiation. They were all obviously increased with attenuation of tissue thickness. The attenuations of forward and backward scattered photon fluxes, and the total scattered photon fiuxe of the tissue at 514.5 nm laser irradiation were slower than those at 476.5 nm, 488 nm, 496.5 nm laser irradiation respectively. The attenuations of forward and backward

关键词：小肠组织学检查 Kubelka-Munk法光学参数波长

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