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Investigation of Dilaton-Gluon Coupling Potential in Charmonium Family

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Chinese Physics Letters 2006年第1期23卷 48-51页

作者：平荣刚陈洪平荣祥 institute of high Energy Physics Chinese Academy of Sciences PO Box 918 Beijing 100049 School of Physics Southwest China Normal University Chongqing 400715 Earthquake Administration of Fuyuan County of Yunnan Province Fuyuan 655500

The behaviour of dilaton-gluon coupling （DGC） potential is investigated by studying charmonium spectra, annihilation rates and E1 transition rates systematically. We find that in the non-relativistic quantum chromod... 详细信息

关键词： D-WAVE QUARKONIUM RELATIVISTIC CORRECTIONS BOUND-STATES GAUGE-THEORY ANTIQUARK MODEL CONFINEMENT SPECTRA DECAYS

Research on magnetic centermeasurement of quadrupole and sextupole using vibrating wire alignment technique in HEPS-TF

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Radiation Detection Technology and Methods 2018年第2期2卷 140-147页

作者： Lei Wu Xiao-long Wang Chun-hua Li Hua-min Qu Zi-hao Wang Min-xian Li Ling-ling Gong institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan institute of Neutron Sciences Dongguan 523808China University of Chinese Academy of Sciences Beijing 100049China

Purpose In order to meet the extremely low emittance requirement,the magnets in the storage ring of high-energy photon source(HEPS)need to have a stable support and precise *** HEPS-TF,the key and difficult technologies of HEPS should be researched and *** wire alignment technique is one important project of *** can be used to pre-align the quadrupoles and sextupoles on one girder with high precision.A vibrating wire measurement system was set up and tested to verify the magnetic center measurement precision and the magnet adjustment *** There are one sextupole and one quadrupole installed on a multipole *** wire is stretched through mechanical center of the magnet apertures and supported by the test benches on the two sides.A single conducting wire is stretched through themagnet aperture and electrified by alternating *** wire will vibrate for a period of Lorentz *** matching the current frequency to one mode of natural frequency of the wire,the vibrating amplitude will be *** by measuring the vibrating amplitude,the magnetic field at the wire position can be *** the wire across the magnet aperture in the transversal or vertical direction,the distribution of magnetic field and magnetic center position can be *** to the magnetic center position error to adjust the *** the magnetic center of all magnets installed on the multipole girder one by one,and adjust their magnetic center to a *** The magnetic center measurement precision is better than±3μm,and the magnet adjustment error is less than 6μ*** The vibrating wire system design and a series of magnetic center measurement experiments have gained good *** has been proved the vibrating wire system is designed reasonable and using the vibrating wire to align the magnets installed on a multipole girder is feasible and can reach a high precision.

关键词： Vibrating wire Magnetic center Measurement precision Magnet adjustment

Anticancer drug discovery by targeting cullin neddylation

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Acta Pharmaceutica Sinica B 2020年第5期10卷 746-765页

作者： Qing Yu Yihan Jiang Yi Sun Cancer institute of the 2nd Affiliated Hospital Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Division of Radiation and Cancer biology Department of Radiation OncologyUniversity of MichiganAnn ArborMI 48109.USA

Protein neddylation is a post-translational modification which transfers the ubiquitin-like protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic *** bestknown substrates of neddylation are cullin family proteins,which are the core component of Cullin-RING E3 ubiquitin ligases(CRLs).Given that cullin neddylation is required for CRL activity,and CRLs control the turn-over of a variety of key signal proteins and are often abnormally activated in cancers,targeting neddylation becomes a promising approach for discovery of novel anti-cancer *** the past decade,we have witnessed significant progress in the field of protein neddylation from preclinical target validation,to drug screening,then to the clinical trials of neddylation *** this review,we first briefly introduced the nature of protein neddylation and the regulation of neddylation cascade,followed by a summary of all reported chemical inhibitors of neddylation *** then discussed the structure-based targeting of protein-protein interaction in neddylation cascade,and finally the available approaches for the discovery of new neddylation *** review will provide a focused,up-to-date and yet comprehensive overview on the discovery effort of neddylation inhibitors.

关键词： Neddylation Anticancer Drug discovery Ubiquitin-proteasome system Small molecule inhibitors Virtual screen high-throughput screening

Ubi1 intron-mediated enhancement of the expression of Bt cry1Ah gene in transgenic maize (Zea mays L.)

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Chinese Science Bulletin 2008年第20期53卷 3185-3190页

作者： WANG YueBing LANG Zhihong ZHANG Jie HE KangLai SONG FuPing HUANG DaFang Biotechnology Research institute Chinese Academy of Agricultural Sciences Beijing 100081 China State Key Laboratory for biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100193 China

The cry1Ah gene was one of novel insecticidal genes cloned from Bacillus thuringiensis isolate BT8. Two plant expression vectors containing cry1Ah gene were constructed. The first intron of maize ubiqutin1 gene was inserted between the maize Ubiquitin promoter and cry1Ah gene in one of the plant expressing vectors (pUUOAH). The two vectors were introduced into maize immature embryonic calli by microprojectile bombardment, and the reproductively plants were acquired. PCR and Southern blot analysis showed that foreign genes had been integrated into maize genome and inherited to the next generation stably. The ELISA assay to T1 and T2 generation plants showed that the expression of Cry1Ah protein in the construct containing the ubi1 intron (pUUOAH) was 20% higher than that of the intronless construct (pUOAH). Bioassay results showed that the transgenic maize harboring cry1Ah gene had high resistance to the Asian corn borers and the insecticidal activity of the transgenic maize containing the ubi1 intron was higher than that of the intronless construct. These results indicated that the maize ubi1 intron can enhance the expression of the Bt cry1Ah gene in transgenic maize

关键词：苏云金芽孢杆菌 cry1Ah基因转基因玉米 Ubi1基因区基因表达

Effects of minerals in ferric bauxite on sodium carbonate decomposition and volatilization

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Journal of Central South University 2015年第7期22卷 2503-2507页

作者：胡文韬王化军刘欣伟孙传尧 Key Laboratory of high-Efficient Mining and Safety of Metal Mines (USTB) of Ministry of Education(University of Science and Technology Beijing) State Key Laboratory of Mineral Processing Science and Technology(Beijing General Research institute of Mining and Metallurgy)

Direct reduction is an emerging technology for ferric bauxite utilization. However, because of sodium volatilization, its sodium carbonate consumption is considerably higher than that in ordinary bauxite processing technology. TG-DSC and XRD were applied to detecting phase transformation and mass loss in direct reduction to reveal the mechanism on sodium volatilization. The results show that the most significant influence factor of ferric bauxite on sodium volatilization in direct reduction system is its iron content. Sodium volatilization is probably ascribed to the instability of amorphous substances structure. Amorphous substances are the intermediate-products of the reaction, and the volatilization rate of sodium increases with its generating rate. These amorphous substances are volatile, thus, more sodium is volatilized with its generation. A small amount of amorphous substances are generated in the reaction between Na2CO3 and Al2O3; thus, only 3.15% of sodium is volatilized. Similarly, the volatilization rate is 1.87% in the reaction between Na2CO3 and SiO2. However, the volatilization rate reaches 7.64% in the reaction between Na2CO3 and Fe2O3 because of the generation of a large amount of amorphous substances.

关键词： Na2CO3 decomposition Na2CO3 volatilization ferric bauxite direct reduction

Interactions Between TLR7 and TLR9 Agonists and Receptors Regulate Innate Immune Responses by Astrocytes and Microglia

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神经损伤与功能重建 2010年第2期5卷 122-134页

作者： NIRANJAN B. BUTCHI MIN DU KARIN E. PETERSON Laboratory of Persistent Viral Diseases Rocky Mountain LaboratoriesNational Institute of Allergy and Infectious Diseases

Toll样受体7(TLR7)和Toll样受体9(TLR9)是固有免疫反应中的重要介质。它们均定位于内涵体间隔,识别核酸和经过髓样分化因子88(MyD88)传导来的信号。本文分析TLR7和TLR9导致的在中枢神经系统固有免疫反应中起作用的星形胶质细胞和小胶质... 详细信息

Toll样受体7(TLR7)和Toll样受体9(TLR9)是固有免疫反应中的重要介质。它们均定位于内涵体间隔,识别核酸和经过髓样分化因子88(MyD88)传导来的信号。本文分析TLR7和TLR9导致的在中枢神经系统固有免疫反应中起作用的星形胶质细胞和小胶质细胞的活化。TLR7和TLR9激动剂引起星形胶质细胞和小胶质细胞相似的细胞因子反应,但二者仍有区别,小胶质细胞产生抗炎因子IL-10、抗凋亡因子G-CSF及IL-9,但星形胶质细胞不产生。对2种细胞的共刺激研究均显示,TLR7激动剂——咪喹莫特,能浓度依赖性地抑制TLR9激动剂引起的固有免疫反应。令人惊讶的是,这种抑制并非由TLR7介导,因为在TLR7的缺乏的情况下,TLR9激动剂导致的固有免疫反应仍然被抑制。固有免疫反应的抑制也并非由于抑制TLR9激动剂摄取所致。这提示咪喹莫特的抑制效应可能是直接作用,也许是通过阻滞CpG-ODN结合和/或TLR9介导的信号转导所致,从而限制细胞活化。这种拮抗关系也存在于小胶质细胞中的这2类受体之间,TLR7的缺乏导致CpG-ODN刺激的细胞因子反应增强。因此,在胶质细胞中,TLR7及其激动剂对TLR9介导的细胞因子反应有抑制作用。

关键词：大脑细胞因子共刺激咪喹莫特 CpG-ODN

In vivo fluorescence observation of parasporal inclusion formation in Bacillus thuringiensis

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Science China(Life Sciences) 2010年第9期53卷 1106-1111页

作者： YANG Hui RONG Rong SONG FuPing SUN ChangPo WEI Juan ZHANG Jie HUANG DaFang State Key Laboratory for biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Biotechnology Research institute Chinese Academy of Agricultural SciencesBeijing 100081China

A recombinant gene expressing a Cry1Ac-GFP fusion protein with a molecular mass of approximately 160 kD was constructed to investigate the expression of cry1Ac,the localization of its gene product Cry1Ac,and its role in crystal development in Bacillus *** cry1Ac-gfp fusion gene under the control of the cry1Ac promoter was cloned into the plasmid pHT304,and this construct was designated ***1Ac-gfp was transformed into the crystal-negative strain,HD-73 cry-,and the resulting strain was named HD-73-(pHTcry1Ac-gfp).The gfp gene was then inserted into the large HD-73 endogenous plasmid pHT73 and fused with the 3' terminal of the cry1Ac gene by homologous recombination,yielding HD-73Φ(cry1Ac-gfp)*** confocal microscopy and Western blot analyses showed for the first time that the Cry1Ac-GFP fusion proteins in both HD-73-(pHTcry1Ac-gfp) and HD-73Φ(cry1Ac-gfp)3534 were produced during asymmetric septum ***,the Cry1Ac-GFP fusion protein showed polarity and was located near the septa in both *** was no significant difference between Cry1Ac-GFP and Cry1Ac in their toxicity to Plutella xylostella larvae.

关键词： Bacillus thuringiensis Cry1Ac-GFP fusion protein laser confocal microscopy

Linkages among leaf nutrient concentration,resorption efficiency, litter decomposition and their stoichiometry to canopy nitrogen addition and understory removal in subtropical plantation

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Ecological Processes 2024年第2期13卷 90-102页

作者： Jawad Ali Shah Wenfei Liu Saif Ullah Honglang Duan Fangfang Shen Yingchun Liao Guomin Huang Jianping Wu Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology and Institute of Biodiversity School of Ecology and Environmental Science Yunnan University Laboratory of Soil Ecology and Health in Universities of Yunnan Province Yunnan University Jiangxi Key Laboratory for Restoration of Degraded Ecosystems & Watershed Ecohydrology Nanchang Institute of Technology Key Laboratory of Forest Cultivation in Plateau mountain of Guizhou Province Institute for Forest Resources and Environment of Guizhou College of ForestryGuizhou University

Background The prevalence of understory removal and anthropogenic nitrogen(N) deposition has significantly altered the ecological processes of forest ecosystems at both regional and global scales. However, it remains a pressing challenge to understand how N deposition and understory removal affect leaf nutrient dynamics, nutrient resorption, litter decomposition, and their linkages for better managing forest ecosystems under nutrient imbalances induced by N enrichment. To address this research gap, a field manipulation experiment was carried out in a subtropical Cunninghamia lanceolata plantation with four treatments including: control(CK), canopy N addition(CN), understory removal(UR), and canopy N addition plus understory removal(CN × UR). Green and senesced leaf N and phosphorus(P) concentrations, N and P resorption efficiencies, litter decomposition, and their correlations were *** The results revealed that the average N concentrations of green early and late leaves in UR were increased by 6.61 and 18.89% compared to CK. UR had the highest whereas CN had the lowest P concentrations in green leaves across the two sampling seasons. Following this, UR, leaf type, season, and their interactions significantly affected leaf N, P, and N:P(P highest leaf N resorption(32.68%) and P resorption efficiencies(63.96%) were recorded in UR. Litter decomposition was significantly retarded in UR(P < 0.01) relative to CN. The regression analysis demonstrated that leaf nutrient status was significantly interconnected with leaf nutrient resorption efficiencies. In addition, leaf nutrient dynamics were strongly correlated with litter nutrients, indicating that both were *** These findings can deepen our knowledge of biogeochemical cycling and reveal contrasting nutrientacquisition strategies on N and P limitation in response to UR and CN. Considering the P limitation, it is important to note that P was resorbed more efficiently, illustrating a

关键词： Nutrient resorption Nitrogen deposition Litter decomposition Stoichiometry Understory removal Subtropical plantation

Stable major QTL on chromosomes A07 and A08 increase shelling percentage in peanut(Arachis hypogaea L.)

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The Crop Journal 2022年第3期10卷 820-829页

作者： Weitao Li Nian Liu Li Huang Yuning Chen Jianbin Guo Bolun Yu Huaiyong Luo Xiaojing Zhou Dongxin Huai Weigang Chen Liying Yan Xin Wang Yong Lei Boshou Liao Huifang Jiang Key Laboratory of biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural AffairsOil Crops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062HubeiChina

Peanut is a major oilseed and food *** percentage(SP),closely associated with seed yield,is a trait whose improvement is a major goal of peanut *** this study,a mapping population(Xuhua 13×Zhonghua 6)was used to map quantitative trait loci(QTL)controlling SP in four *** stable major QTL for SP were mapped on both SSR-and SNP-based genetic maps.q SPA07.1 on chromosome A07 explained up to 31.7%of phenotypic variation,and q SPA08.2 on chromosome A08 explained up to 10.8%.Favorable alleles of q SPA07.1 and q SPA08.2 were derived from the female and male parents,*** recombinant inbred lines(RILs)carrying both favorable alleles showed superiority in SP over the two parents in all environmental trials.A combination of the two favorable alleles using the linked markers was verified to increase SP by~5%in the RIL population and by~3%SP in diverse peanut cultivars.q SPA07.1 and q SPA08.2 were delimited to respectively a 0.73-Mb interval harboring 96 genes and a 3.93-Mb interval harboring 238 *** five and eight genes with high expression in pods,including enzymes and transcription factors,were assigned as candidate genes for q SPA07.1 and q *** consistent major QTL provide an opportunity for fine mapping of genes controlling SP,and the linked markers may be useful for genetic improvement of SP in peanut.

关键词： Peanut Shelling percentage QTL mapping Genomic region Candidate genes InDel marker