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Effects of higher femoral tunnels on clinical outcomes,MRI,and second-look findings in double-bundle anterior cruciate ligament reconstruction with a minimal 5-year follow-up

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Chinese Medical Journal 2024年第4期137卷 465-472页

作者： Lin Lin Haijun Wang Jian Wang Yongjian Wang Yourong Chen Jiakuo Yu Sports medicine Department Beijing Key Laboratory of Sports InjuriesPeking University Third HospitalBeijing 100191China Peking University institute of Sports medicine Beijing 100191China

Background:To perform anatomical anterior cruciate ligament reconstruction(ACLR),tunnels should be placed relatively higher in the femoral anterior cruciate ligament(ACL)footprint based on the findings of direct and indirect femoral *** the clinical results of higher femoral tunnels(HFT)in double-bundle ACLR(DB-ACLR)remain *** purpose was to investigate the clinical results of HFT and lower femoral tunnels(LFT)in ***:From September 2014 to February 2016,83 patients who underwent DB-ACLR and met the inclusion and exclusion criteria were divided into HFT-ACLR(group 1,n=37)and LFT-ACLR(group 2,n=46)according to the position of femoral *** and at the final follow-up,clinical scores were evaluated with International Knee Documentation Committee(IKDC),Tegner activity,and Lysholm *** stability of the knee was evaluated with KT-2000,Lachman test,and pivot-shift *** degeneration grades of the International Cartilage Repair Society(ICRS)were evaluated on magnetic resonance imaging(MRI).Graft tension,continuity,and synovialization were evaluated by second-look ***-to-sports was assessed at the final ***:Significantly better improvement were found for KT-2000,Lachman test,and pivot-shift test postoperatively in group 1(P>0.05).Posterolateral bundles(PL)showed significantly better results in second-look arthroscopy regarding graft tension,continuity,and synovialization(P0.05).No statistically significant differences were found in IKDC subjective score,Tegner activity,and Lysholm score between the two *** return-to-sports rate was found in group 1 with 86.8%(32/37)vs.65.2%(30/46)in group 2(P=0.027).Conclusion:The HFT-ACLR group showed better stability results,better PL,and higher return-to-spo

关键词： Anterior cruciate ligament reconstruction Direct insertion Double bundle Second-look arthroscopy Femoral tunnel Anterior cruciate ligament rupture

Biomarkers in aortic dissection:Diagnostic and prognostic value from clinical research

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Chinese Medical Journal 2024年第3期137卷 257-269页

作者： Yufei Zhao Weiguo Fu Lixin Wang Department of vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China vascular Surgery institute Zhongshan HospitalFudan UniversityShanghai 200032China National Clinical Research Center for Interventional medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of vascular Surgery Xiamen BranchZhongshan HospitalFudan UniversityXiamenFujian 361015China

Aortic dissection is a life-threatening condition for which diagnosis mainly relies on imaging examinations,while reliable biomarkers to detect or monitor are still under *** advances in technologies provide an unprecedented opportunity to yield the identification of clinically valuable biomarkers,including proteins,ribonucleic acids(RNAs),and deoxyribonucleic acids(DNAs),for early detection of pathological changes in susceptible patients,rapid diagnosis at the bedside after onset,and a superior therapeutic regimen primarily within the concept of personalized and tailored endovascular therapy for aortic dissection.

关键词： Aortic dissection Biomarker Protein Cell-free DNA miRNA Inflammation Lipid-metabolism

miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma

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BIOCELL 2024年第4期48卷 581-590页

作者： LIJUAN ZHANG QINGYIN MENG LI ZHUANG QUAN GONG XIANDA HUANG XUEQIN LI SHIJUAN LI GUOQIN WANG XICAI WANG Department of Rehabilitation and Palliative medicine The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Department of Pathology The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Emergency Department(Outpatient Chemotherapy Center) The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Department of Cancer BioTreatment Center The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Department of Cancer institute The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina

Background:Lung adenocarcinoma is a very pervasive histological form of lung cancers,and inhibiting metastasis is crucial for effective *** this investigation,we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain(PHTF2)in dictating the aggressiveness and metastasis of lung ***:We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal *** experiments including cell count kit(CCK)-8 growth assay,apoptosis analysis,migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma ***,we examined tumorigenesis and metastasis in a nude mouse ***:MiR-30a-5p exhibited downregulation pattern in lung adenocarcinoma *** of miR-30a-5p mimic in lung adenocarcinoma cells resulted in the suppression of malignant ***,the administration of miR-30a-5p mimic also curbed tumorigenesis and metastasis of lung adenocarcinoma cells in animal ***,PHTF2 was found to be a molecular target of *** PHTF2 counteracted the tumor-suppressive effect of the miR-30a-5p ***:miR-30a-5p functions as a tumor-suppressive molecule while PHTF2 acts as an oncogenic factor in the development and metastasis of lung ***,targeting miR-30a-5p and PHTF2 could be developed into a promising therapeutic approach for inhibiting metastasis in lung adenocarcinoma.

关键词： Lung cancer Malignant phenotype Tumor formation Tumor suppressor Oncogene

LLMs in medicine:The need for advanced evaluation systems for disruptive technologies

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The Innovation 2024年第3期5卷 1-2页

作者： Yi-Da Tang Er-Dan Dong Wen Gao Department of Cardiology and institute of vascular medicine Peking University Third HospitalBeijing 100191China State Key Laboratory of vascular Homeostasis and Remodeling Peking UniversityBeijing 100191China University of Health and Rehabilitation Sciences Qingdao 266000China Peking University Beijing 100871China

In an era of rapid advancements in artificial intelligence(AI),the potential role of large language models(LLMs)in the medical field is receiving increasing *** progression of this technology not only highlights upcoming revolutionary changes in medical services but also offers unprecedented opportunities for the health care sector.1 LLMs’formidable capability to process natural language opens vast prospects for application in the medical field,including in the contexts of emergency triage,geriatric care,and digital medical workflows.

关键词： dis highlights services

Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm

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Chinese Medical Journal 2024年第9期137卷 1105-1114页

作者： Xinsheng Xie Ye Yuan Yulong Huang Xiang Hong Shichai Hong Gang Chen Yihui Chen Yue Lin Weifeng Lu Weiguo Fu Lixin Wang Department of vascular Surgery Zhongshan Hospital(Xiamen)Fudan UniversityXiamenFujian 361015China Department of vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China vascular Surgery institute of Fudan University Fudan UniversityShanghai 200032China

Background:Thoracic aortic aneurysm(TAA)is a fatal cardiovascular disease,the pathogenesis of which has not yet been *** study aimed to identify and validate the diagnostic markers of TAA to provide a strong theoretical basis for developing new methods to prevent and treat this ***:Gene expression profiles of the GSE9106,GSE26155,and GSE155468 datasets were acquired from the Gene Expression Omnibus(GEO)*** expressed genes(DEGs)were identified using the"limma"package in *** absolute shrinkage and selection operator(LASSO),support vector machine-recursive feature elimination(SVM-RFE),random forest,and binary logistic regression analyses were used to screen the diagnostic marker ***-sample gene set enrichment analysis(ssGSEA)was used to estimate immune cell infiltration in ***:A total of 16 DEGs were *** enrichment and functional correlation analyses showed that DEGs were mainly associated with inflammatory response pathways and collagen-related *** type I alpha 1 chain(COL1A1)and synaptotagmin like 2(SYTL2)were identified as diagnostic marker genes with a high diagnostic value for *** expression of COL1A1 and SYTL2 was considerably higher in TAA vascular wall tissues than in the corresponding normal tissues,and there were significant differences in the infiltration of immune cells between TAA and normal vascular wall ***,COL1A1 and SYTL2 expression were associated with the infiltration of immune cells in the vascular wall ***-cell analysis showed that COL1A1 in TAA was mainly derived from fibroblasts and SYTL2 mainly from cluster of differentiation(CD)8+T *** addition,single-cell analysis indicated that fibroblasts and CD8+T cells in TAA were significantly higher than those in normal arterial wall ***:COL1A1 and SYTL2 may serve as diagnostic marker genes for *** upregulation of SYTL2 and COL1A1 may be involved in the inflammat

关键词： Bioinformatics Thoracic aortic aneurysm Immune response Single cell analysis Machine learning

Reliability of Echocardiographic Pulmonary vascular Resistance to Screen for the New Definition of Precapillary Pulmonary Hypertension in Uncorrected Secundum Atrial Septal Defect

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Congenital Heart Disease 2024年第3期19卷 315-324页

作者： Risalina Myrtha Hasanah Mumpuni Real Kusumanjaya Marsam Dyah Wulan Anggrahini Anggoro Budi Hartopo Lucia Kris Dinarti Department of Cardiology and vascular medicine Faculty of MedicineUniversitas Sebelas MaretSurakarta57126Indonesia Department of Cardiology and vascular medicine Universitas Sebelas Maret HospitalSukoharjo57161Indonesia Department of Cardiology and vascular medicine Faculty of MedicinePublic Healthand NursingUniversitas Gadjah MadaYogyakarta55281Indonesia Department of Cardiology and vascular medicine Dr.Sardjito HospitalYogyakarta55284Indonesia

Background and Objective:The most feared complication of uncorrected secundum Atrial Septal Defect(ASD)is pulmonary arterial hypertension(PAH).Pulmonary vascular resistance(PVR)is crucial in detecting precapil-lary pulmonary hypertension(PH)to guide the need for PAH-specific *** is a change in the cut-off value of PVR according to the recently updated PH *** echocardiographic PVR(PVRecho)correlates to PVR by right heart catheterization(RHC)(PVRcath)according to the new guidelines has not been *** aim of this study is to determine the reliability of PVRecho in detecting PAH in Uncorrected Ostium Secundum ASD based on the current updated guideline and to help screen the high PVR ***:429 ostium secun-dum ASD in the COngenital HeARt Disease in Adult and Pulmonary Hypertension(COHARD-PH)registry was divided into three groups according to the *** was calculated using Abbas’Formula and compared the its gold standard,the *** correlation between the two methods was *** Bland-Altman plot was used to analyze the agreement between the two *** operating characteristics(ROC)analysis was used to determine the PVRecho cut-off value for high ***:The majority of the population(63.5%)had high *** gender dominated the study population(84%).PVR_(echo) was significantly correlated with PVRcath(r=0.6225,pthird groups,PVR_(echo) underestimated PVRcath 0.52 and 10.77 WU,***:PVRecho is reliable in predicting high PVR in uncorrected secun-dum ***,there is a wide range of ***_(echo) cut-off value of>1.62 WU showed good dis-criminatory power in determining high PVR.

关键词： Pulmonary vascular resistance atrial septal defect echocardiography

Revolutionizing tumor immunotherapy:unleashing the power of progenitor exhausted T cells

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Cancer Biology & medicine 2024年第6期21卷 499-512页

作者： Zhang Fang Xinyi Ding Hao Huang Hongwei Jiang Jingting Jiang Xiao Zheng Department of Tumor Biological Treatment The Third Affiliated Hospital of Soochow UniversityChangzhou 213003China Jiangsu Engineering Research Center for Tumor Immunotherapy The Third Affiliated Hospital of Soochow UniversityChangzhou 213003China institute for Cell Therapy of Soochow University The Third Affiliated Hospital of Soochow UniversityChangzhou 213003China

In exploring persistent infections and malignancies, a distinctive subgroup of CD8^(+) T cells, progenitor exhausted CD8^(+) T(Tpex) cells, has been identified. These Tpex cells are notable for their remarkable self-renewal and rapid proliferation abilities. Recent strides in immunotherapy have demonstrated that Tpex cells expand and differentiate into responsive exhausted CD8^(+) T cells, thus underscoring their critical role in the immunotherapeutic retort. Clinical examinations have further clarified a robust positive correlation between the proportional abundance of Tpex cells and enhanced clinical prognosis. Tpex cells have found noteworthy applications in the formulation of inventive immunotherapeutic approaches against tumors. This review describes the functions of Tpex cells in the tumor milieu, particularly their potential utility in tumor immunotherapy. Precisely directing Tpex cells may be essential to achieving successful outcomes in immunotherapy against tumors.

关键词： Progenitor exhausted CD8^(+)T cells TCF-1 immunotherapy tumor microenvironment cellular crosstalk

Apatinib and gamabufotalin co-loaded lipid/Prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 707-721页

作者： Binlong Chen Yanzhong Zhao Zichang Lin Jiahao Liang Jialong Fan Yanyan Huang Leye He Bin Liu Health Management Center The Third Xiangya HospitalCentral South UniversityChangsha410013China Department of Urology The Third Xiangya HospitalCentral South UniversityChangsha410013China Department of Laboratory medicine The Third Xiangya HospitalCentral South UniversityChangsha410013China College of Biology Hunan UniversityChangsha410082China

Due to the non-targeted release and low solubility of anti-gastric cancer agent,apatinib(Apa),a first-line drug with long-term usage in a high dosage often induces multi-drug resistance and causes serious side *** order to avoid these drawbacks,lipid-film-coated Prussian blue nanoparticles(PB NPs)with hyaluronan(HA)modification was used for Apa loading to improve its solubility and targeting ***,anti-tumor compound of gamabufotalin(CS-6)was selected as a partner of Apawith reducing dosage for combinational gastric ***,HA-Apa-Lip@PB-CS-6 NPs were constructed to synchronously transport the two drugs into tumor *** vitro assay indicated that HA-Apa-Lip@PB-CS-6 NPs can synergistically inhibit proliferation and invasion/metastasis of BGC-823 cells via downregulating vascular endothelial growth factor receptor(VEGFR)and matrix metalloproteinase-9(MMP-9).In vivo assay demonstrated strongest anti-tumor growth and liver metastasis of HA-Apa-Lip@PB-CS-6 NPs administration in BGC-823 cells-bearing mice compared with other groups due to the excellent penetration in tumor tissues and outstanding synergistic *** summary,we have successfully developed a new nanocomplexes for synchronous Apa/CS-6 delivery and synergistic gastric cancer(GC)therapy.

关键词： Apatinib Gamabufotalin Lipid/Prussian blue nanoparticles Gastric cancer

Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease

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Science China Life Sciences 2024年

作者： Wen-Tao Sun Jian-Yong Du Jia Wang Yi-Long Wang Er-Dan Dong Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital)School of Health and Life SciencesUniversity of Health and Rehabilitation Sciences Department of Cardiology and institute of vascular medicine Peking University Third HospitalThe Institute of Cardiovascular SciencesPeking UniversityState Key Laboratory of Vascular Homeostasis and RemodelingPeking University

Cardiac rehabilitation, a comprehensive exercise-based lifestyle and medical management, is effective in decreasing morbidity and improving life quality in patients with coronary heart disease. Endothelial function, an irreplaceable indicator in coronary heart disease progression, is measured by various methods in traditional cardiac rehabilitation pathways, including medicinal treatment, aerobic training, and smoking cessation. Nevertheless, studies on the effect of some emerging cardiac rehabilitation programs on endothelial function are limited. This article briefly reviewed the endothelium-beneficial effects of different cardiac rehabilitation pathways, including exercise training, lifestyle modification and psychological intervention in patients with coronary heart disease, and related experimental models, and summarized both uncovered and potential cellular and molecular mechanisms of the beneficial roles of various cardiac rehabilitation pathways on endothelial function. In exercise training and some lifestyle interventions, the enhanced bioavailability of nitric oxide, increased circulating endothelial progenitor cells(EPCs), and decreased oxidative stress are major contributors to preventing endothelial dysfunction in coronary heart disease. Moreover, the preservation of endothelial-dependent hyperpolarizing factors and inflammatory suppression play roles. On the one hand, to develop more endothelium-protective rehabilitation methods in coronary heart disease, adequately designed and sized randomized multicenter clinical trials should be advanced using standardized cardiac rehabilitation programs and existing assessment methods. On the other hand, additional studies using suitable experimental models are warranted to elucidate the relationship between some new interventions and endothelial protection in both macro-and microvasculature.

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