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Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha J.Holdsworth Alistair J.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

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In vivo transfection of enhanced green fluorescent protein in rat retinal ganglion cells mediated by ultrasound-induced microbubbles

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Neural Regeneration Research 2009年第6期4卷 413-417页

作者： Hong Su Su Liu Zhigang Wang Wenyue Xie Bing Jiang Haibo Xiong Department of Ophthalmology Second Hospital of Chongqing Medical University Chongqing 400010 China institute of ultrasonic imaging Chongqing Medical University Chongqing 400010 China

BACKGROUND： Studies have demonstrated that ultrasound-mediated microbubble destruction significantly improves transfection efficiency of enhanced green fluorescent protein （EGFP） in in vitro cultured retinal ganglial cells （RGCs）. OBJECTIVE： To investigate the feasibility of ultrasound-mediated microbubble destruction for EGFP transfection in rat RGCs, and to compare efficiency and cell damage with traditional transfection methods. DESIGN, TIME AND SETTING： In vivo, gene engineering experiment. The study was performed at the Central Laboratory, institute of ultrasonic imaging, Chongqing Medical University from March to July 2008. MATERIALS： Eukaryotic expression vector plasmid EGFP and microbubbles were prepared by the institute of ultrasonic imaging, Chongqing Medical University. The microbubbles were produced at a concentration of 8.7 × 10^11/L, with a 2-4 μm diameter, and 10-hour half-life in vitro. METHODS： A total of 50 Sprague Dawley rats were randomly assigned to four groups. Normal controls （n = 5） were infused with 5 μL normal saline to the vitreous cavity; the naked plasmid group （n = 15） was infused with 5 pL EGFP plasmid to the vitreous cavity; in the plasmid with ultrasound group （n = 15）, the eyes were irradiated with low-energy ultrasound wave （0.5 W/cm^2） for a total of 60 seconds （irradiated for 5 seconds, at 10-second intervals） immediately following infusion of EGFP plasmids to the vitreous cavities. In the microbubble-ultrasound group （n = 15）, the eyes were irradiated with the same power of ultrasonic wave immediately following infusion of microbubbles containing EGFP plasmids to the vitreous cavities. MAIN OUTCOME MEASURES： After 7 days, retinal preparations and EGFP expression in RGCs were observed by fluorescence microscopy. RGC quantification in the retinal ganglion cell layer was performed. In addition, EGFP mRNA expression was semi-quantitatively determined by RT-PCR. RESULTS： The transfection efficiency of EGFP to RGCs by microbubbles wit

关键词： ultrasound contrast agent microbubble retinal ganglion cells in vivo gene therapy enhanced green fluorescent protein

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Sex differences in aging and injured brain

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Neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan N.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA Northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Compressed sensing application in interferometric synthetic aperture radar

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Science China(Information Sciences) 2017年第10期60卷 187-203页

作者： Liechen LI Daojing LI Zhouhao PAN Science and Technology on Microwave imaging Laboratory institute of Electronics Chinese Academy of Sciences

A novel interferometric synthetic aperture radar(In SAR) signal processing method based on compressed sensing(CS) theory is investigated in this paper. In SAR image formation provides the scene reflectivity estimation along azimuth and range coordinates with the height information. While surveying the height information of the illuminated scene, the data volume enlarges. CS theory allows sparse sampling during the data acquisition, which can reduce the data volume and release the pressure on the record devices. In SAR system which configures two antennas to cancel the common backscatter random phase in each resolution element implies the sparse nature of the complex-valued In SAR image. The complex-valued image after conjugate multiplication that only a phase term proportional to the differential path delay is left becomes sparse in the transform domain. Sparse sampling such as M-sequence can be implemented during the data acquisition. CS theory can be introduced to the processing due to the sparsity and a link between raw data and interferometric complex-valued image can be built. By solving the CS inverse problem, the magnitude image and interferometric phase are generated at the same time. Results on both the simulated data and real data are presented. In comparison with the conventional SAR interferometry processing results, CS-based method shows the ability to keep the imaging quality with less data acquisition.

关键词： synthetic aperture radar(SAR) interferometric synthetic aperture radar(In SAR) compressed sensing(CS) sparse sampling sparsity in the transform domain

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Three-dimensional trees for virtual globes

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International Journal of Digital Earth 2014年第10期7卷 789-810页

作者： Cristina Rebollo Inmaculada Remolar Jesus Gumbau Miguel Chover institute of New imaging Technologies Universitat Jaume ICastellonSpain

One of the problems in virtual globes technologies is the real-time representation of vegetal *** forest or garden representations,the low detailed plants produce a lack of *** techniques are required to achieve accurate interactive visualisation due to the great number of polygons the vegetal species *** article presents a multi-resolution model based on a geometric representation of vegetal species that allows the application to perform the progressive transmission of the model,that is,the transmission of a simple representation followed by successive refinements of *** has a hardware-oriented design in order to obtain interactive frame *** geometric data of the objects are stored in the graphics processing unit and,moreover,the change from one approximation to another is obtained by performing mathematical calcula-tions in this graphics *** multi-resolution model presented here enables instancing:as many vegetal species as desired can be rendered with different levels of detail,while all of them are accessing the same geometric *** model has been used to build a real-time representation of a not imaginary scenario.

关键词： virtual globes real-time rendering vegetal species level of detail graphics hardware progressive transmission

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Current progress in sparse signal processing applied to radar imaging

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Science China(Technological Sciences) 2013年第12期56卷 3049-3054页

作者： ZHAO Yao FENG Jing ZHANG BingChen HONG Wen WU YiRong Science and Technology on Microwave imaging Laboratory institute of Electronics Chinese Academy of Sciences Beijing institute of Technology

Sparse signal processing is a signal processing technique that takes advantage of signal’s sparsity,allowing signal to be recovered with a reduced number of *** sensing,a new branch of the sparse signal processing,has become a rapidly growing research *** microwave imaging introduces the sparse signal processing theory to radar imaging to obtain new theories,new systems and new methodologies of microwave *** paper first summarizes the latest application of sparse microwave imaging,including Synthetic Aperture Radar(SAR),tomographic SAR and inverse *** sparse signal processing keeps evolving,an avalanche of results have been *** also highlight its recent theoretical advances,including structured sparsity,off-grid,Bayesian approaches,and point out new research directions in sparse microwave imaging.

关键词： sparse signal processing sparse microwave imaging compressive sensing radar imaging

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Influence of mantle convection to the crustal movement pattern in the northeastern margin of the Tibetan Plateau based on numerical simulation

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Science China Earth Sciences 2018年第11期61卷 1644-1658页

作者： Aiyu ZHU Dongning ZHANG Tao ZHU Yingxing GUO institute of Geophysics China Earthquake Administration Key Laboratory of Seismic Observation and Geophysical imaging Institute of GeophysicsChina Earthquake Administration

Based on the recent observations about the movement and rheological structure of the lithosphere and deformation pattern of the crust, we developed a three-dimensional finite element model for the northeastern margin of the Tibetan *** model considered the impacts of both external and internal conditions, including mantle convection, gravitational potential energy and block interactions. We compared the simulated surface movement rates to the observed GPS velocities, and the results revealed that crustal movement gradually decreased toward the edge of the plateau. The factors controlling this pattern are the interactions of adjacent blocks, gravitational potential energy of the plateau, and also mantle convection as well. Additionally,according to the observation that there was an apparent difference between the horizontal movement rate of the lithosphere and convective velocity of the underlying mantle, and also based on the results of seismic anisotropy studies that suggest different strengths and deformation regimes of the lithosphere in different tectonic blocks, we proposed that the impact of mantle convection on the lithosphere may have varied in space, and introduced a parameter named mantle convection intensity factor in numerical simulations. Our simulation results show consistent surface movement rates with GPS observations, which further supports the viewpoint of seismic anisotropy studies, i.e., the degree of coupling between the crust and mantle varies significantly among different blocks.

关键词： Northeastern margin of the Tibetan Plateau Crustal movement Mantle convection Numerical simulation

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Image guided percutaneous gastrostomy catheter placement: How we do it safely and efficiently

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World Journal of Gastroenterology 2020年第4期26卷 383-392页

作者： Sasan Partovi Xin Li Eunice Moon Dustin Thompson Section of Interventional Radiology Imaging Institute Cleveland Clinic Foundation

Gastrostomy tube is an effective and safe long-term feeding access that is welltolerated by *** typical placement routes include surgical,endoscopic and interventional radiologic *** particular,percutaneous interventional radiologic gastrostomy(PIRG)has increasingly become the preferred method of choice in many *** many PIRG techniques have been developed since the 1980s,there is still a paucity of evidence supporting the choice of a most-optimal PIRG ***,there is a large variation in institutional approach to *** are a large,quaternary academic institution with an extensive experience in ***,we aim to present the“push”PIRG technique utilized in our institution,to review the current literature,to discuss the optimal choice of PIRG technique and to generate further interests in comparison studies.

关键词： Percutaneous interventional radiologic gastrostomy Institutional approach Push technique

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Atmospheric temperature dependence of the aerosol backscattering coefficient

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Particuology 2016年第5期14卷 72-76页

作者： Binglong Chen Siying Chen Yinchao Zhang He Chen Pan Guo Hao Chen Key Laboratory of Photoelectronic imaging Technology Beijing Institute of Technology Beijing 100081 China

In extracting vertical profiles of aerosol backscattering coefficient from lidar signals, the effects of atmo- spheric temperature are usually ignored, In this study, these effects are analyzed using a rotational Raman-Mie lidar system, which is capable of simultaneously measuring atmospheric temperature and vertical profiles of aerosols, A method is presented to correct the aerosol backscattering coefficient using atmospheric temperature profiles, obtained from Raman scattering signals. The differences in the extracted aerosol backscattering coefficient with and without considering temperature effects are fur- ther discussed. The backscattering coefficients for scattering off clouds are shown to be more sensitive to temperature than that of aerosols and atmosphere molecules; the aerosol backscattering coefficient is more sensitive to temperature in summer due to higher atmospheric temperatures,

关键词： Lidar Atmospheric temperature Aerosol Raman scattering Backscattering coefficient

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