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Novel PIO Algorithm with Multiple Selection Strategies for Many-Objective Optimization Problems

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Complex System Modeling and Simulation 2021年第4期1卷 291-307页

作者： Zhihua Cui Lihong Zhao Youqian Zeng Yeqing Ren Wensheng Zhang Xiao-Zhi Gao School of Computer Science and Technology Taiyuan University of Science and TechnologyTaiyuan 030024China School of Cyberspace Security Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Laboratory of Intelligent Control and Management of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China Computing University of Eastern FinlandKuopioFI-70211Finland

With the increase of problem dimensions,most solutions of existing many-objective optimization algorithms are ***,the selection of individuals and the retention of elite individuals are *** algorithms cannot provide sufficient solution precision and guarantee the diversity and convergence of solution sets when solving practical many-objective industrial ***,this work proposes an improved many-objective pigeon-inspired optimization(ImMAPIO)algorithm with multiple selection strategies to solve many-objective optimization *** selection strategies integrating hypervolume,knee point,and vector angles are utilized to increase selection pressure to the true Pareto ***,the accuracy,convergence,and diversity of solutions are *** is applied to the DTLZ and WFG test functions with four to fifteen objectives and compared against NSGA-III,GrEA,MOEA/D,RVEA,and many-objective Pigeon-inspired optimization *** results indicate the superiority of ImMAPIO on these test functions.

关键词： pigeon-inspired optimization algorithm many-objective optimization problem multiple selection strategy elite individual retention

Sex-dependent increase of movement activity in the freshwater isopod Asellus aquaticus following adaptation to a predator-free cave habitat

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Current Zoology 2023年第4期69卷 418-425页

作者： ELTE Eötvös Loránd University Hajriz Berisha Gergely Horváth Žiga Fišer Gergely Balázs Cene Fišer Gábor Herczeg Author Notes Behavioural Ecology Group Department of Systematic Zoology and EcologyBiological InstituteELTE Eötvös Loránd UniversityPázmány Péter sétány 1/CBudapestHungary H-1117 ELKH-ELTE-MTM Integrative Ecology Research Group Pázmány Péter sétány 1/CBudapestHungary H-1117 Department of Biology Biotechnical FacultyUniversity of LjubljanaJamnikarjeva 1011000 LjubljanaSlovenia

Populations experiencing negligible predation pressure are expected to evolve higher behavioral ***,when sexes have different expected benefits from high activity,the adaptive shift is expected to be ***,we compared movement activity of one cave(lack of predation)and three adjacent surface(high and diverse predation)populations of Asellus aquaticus,a freshwater isopod known for its independent colonization of several caves across *** predicted 1)higher activity in cave than in surface populations,with 2)the difference being more pronounced in males as they are known for active mate searching behavior,while females are *** was assessed both in the presence and absence of *** results supported both predictions:movement activity was higher in the cave than in the surface populations,particularly in *** predation pressure in the cave-adapted population is most likely the main selective factor behind increased behavioral activity,but we also showed that the extent of increase is sex-specific.

关键词： adaptation cave colonization movement activity predator-free environment

New advances in gated materials of mesoporous silica for drug controlled release

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Chinese Chemical Letters 2021年第12期32卷 3696-3704页

作者： Ping Huang Daizheng Lian Hualin Ma Nansha Gao Limin Zhao Ping Luan Xiaowei Zeng institute of Pharmaceutics School of Pharmaceutical Sciences(Shenzhen)Sun Yat-sen UniversityShenzhen 518107China Shenzhen Key Laboratory of Kidney Diseases Department of Nephrology.Department of Radiation OncologyShenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510000China Health Science Center Shenzhen UniversityShenzhen 518060China

Drug delivery systems(DDS) are used to deliver therapeutic drugs to improve selectivity and reduce side effects. With the development of nanotechnology, many nanocarriers have been developed and applied to drug delivery, including mesoporous silica. Mesoporous silica nanoparticles(MSNs) have attracted a lot of attention for simple synthesis, biocompatibility, high surface area and pore volume. Based on the pore system and surface modification, gated mesoporous silica nanoparticles can be designed to realize on-command drug release, which provides a new approach for selective delivery of antitumor ***, this review mainly focuses on the “gate keepers” of mesoporous silica for drug controlled release in nearly few years(2017–2020). We summarize the mechanism of drug controlled release in gated MSNs and different gated materials: inorganic gated materials, organic gated materials, self-gated drug molecules, and biological membranes. The facing challenges and future prospects of gated MSNs are discussed rationally in the end.

关键词： Mesoporous silica Gated materials Surface modification Drug delivery Controlled release

Boosting the Energy Migration Upconversion through Inter-Shell Energy Transfer in Tb^(3+)-Doped Sandwich Structured Nanocrystals

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CCS Chemistry 2022年第6期4卷 2031-2042页

作者： Dan Xu Jin Xu Xiaoying Shang Shaohua Yu Wei Zheng Datao Tu Renfu Li Xueyuan Chen CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Key Laboratory of Nanomaterialsand State Key Laboratory of Structural ChemistryFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002 University of Chinese Academy of Sciences Beijing 100049 Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China FuzhouFujian 350108

It remained challenging to fabricate Tb^(3+)-doped lanthanide nanocrystals(NCs)to simultaneously acquire strong energy migration upconversion(EMU)emissions of Tb^(3+)while suppressing the Tm3+UV upconversion emissions that cause background biofluorescence issues in bioapplications based on Tb^(3+)-doped EMU ***,we report a novel sandwich structured core@shell@shell scheme for the design of EMU NCs,for example,NaLuF4∶Yb/Gd@NaGdF4∶Tm@NaLuF4∶Tb NCs,wherein Yb^(3+),Tm^(3+),and Tb^(3+)are incorporated separately into the inner core,middle shell,and outer shell,*** found that in the sandwich structured NCs,the effective inter-shell energy transfer from Gd^(3+)in the middle shell to Tb^(3+)in the outer shell accelerated the Yb^(3+)-Tm^(3+)five-photon upconversion and the subsequent Tm^(3+)to Gd^(3+)energy transfer processes,which could eventually lead to almost complete inhibition of Tm^(3+)UV upconversion emissions,concurrent with the strong EMU emissions of Tb^(3+).Our findings might stimulate new concepts for manipulating upconversion emissions of lanthanide NCs.

关键词： lanthanide nanocrystals energy migration upconversion sandwich structured inter-shell energy transfer energy management

The Digital Belt and Road program in support of regional sustainability

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international Journal of Digital Earth 2018年第7期11卷 657-669页

作者： Huadong Guo Jie Liu Yubao Qiu Massimo Menenti Fang Chen Paul F.Uhlir Li Zhang John van Genderen Dong Liang Ishwaran Natarajan Lanwei Zhu Jiuliang Liu institute of Remote Sensing and Digital Earth Chinese Academy of SciencesBeijingPeople’s Republic of China Department of Geoscience and Remote Sensing Delft University of TechnologyDelftNetherlands Department of Earth Observation Science University of TwenteEnschedeNetherlands College of Resources and Environment University of Chinese Academy of SciencesBeijingPeople’s Republic of China College of Geospatial Information Science and Technology Capital Normal UniversityBeijingPeople’s Republic of China Information Policy and Management CallicoonNYUSA

The Belt and Road initiative has a significant focus on infrastructure,trade,and economic development across a vast region,and it also provides significant opportunities for sustainable *** combined pressure of climate variability,intensified use of resources,and the fragility of ecosystems make it very challenging,however,to achieve future *** develop the path in a sustainable way,it is important to have a comprehensive understanding of these issues across nations and evaluate them in a scientific and well-informed *** this context,the Digital Belt and Road(DBAR)program was initiated as an international venture to share expertise,knowledge,technologies,and data to demonstrate the role of Earth observation science and technology and big Earth data applications to support large-scale *** this paper,we identify pressing challenges,present the research priorities and foci of the DBAR program,and propose solutions where big Earth data can make significant *** paper calls for further joint actions and collaboration to build a digital silk road in support of sustainable development at national,regional and global levels.

关键词： Digital Belt and Road program(DBAR) big Earth data Earth observation research data international cooperation sustainable development goals(SDGs)

Control of Distributed Generation Using Non-Sinusoidal Pulse Width Modulation

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Computers, Materials & Continua 2023年第2期74卷 4149-4164页

作者： Mehrdad Ahmadi Kamarposhti Phatiphat Thounthong Ilhami Colak Kei Eguchi Department of Electrical Engineering Jouybar BranchIslamic Azad UniversityJouybar***Iran Renewable Energy Research Centre(RERC) Department of Teacher Training in Electrical EngineeringFaculty of Technical EducationKing Mongkut’s University of Technology North Bangkok1518Pracharat 1 RoadBangsueBangkok10800Thailand Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitecturesNisantasi UniversityIstanbul34398Turkey Department of Information Electronics Fukuoka Institute of TechnologyFukuoka811-0295Japan

The islanded mode is one of the connection modes of the grid distributed generation *** this study,a distributed generation resource is connected to linear and nonlinear loads via a three-phase inverter where a control method needing no current sensors or compensator elements is applied to the distribute generation system in the islanded *** control method has two main loops in each *** first loop controls the voltage control loops that adjust the three-phase point of common coupling,the amplitude of the non-sinusoidal reference waveform and the near-state pulse width modulation(NSPWM)*** next loop compensates the harmonic compensator loop that calculates the voltage harmonics of the point of common coupling in each phase,and injects them to compensate the non-sinusoidal reference waveforms of each *** simulation results in MATLAB/SIMULINK show that this method can generate balanced threephase sinusoidal voltage with an acceptable total harmonic distortion(THD)at the joint connection point.

关键词： Islanded mode distributed generation resource the point of common coupling voltage total harmonic distortion

Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis

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药物分析学报:英文版 2023年第7期13卷 817-829页

作者： Jiayun Chen Xueling He Yunmeng Bai Jing Liu Yin Kwan Wong Lulin Xie Qian Zhang Piao Luo Peng Gao Liwei Gu Qiuyan Guo Guangqing Cheng Chen Wang Jigang Wang State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing100700China Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhenGuangdong518020China Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhenGuangdong518020China

Sepsis is characterized by a severe and life-threatening host immune response to polymicrobial infection accompanied by organ *** on the therapeutic effect and mechanism of immunomodulatory drugs on the sepsis-induced hyperinflammatory or immunosuppression states of various immune cells remain *** study aimed to investigate the protective effects and underlying mechanism of artesunate(ART)on the splenic microenvironment of cecal ligation and puncture-induced sepsis model mice using single-cell RNA sequencing(scRNA-seq)and experimental *** scRNA-seq analysis revealed that ART inhibited the activation of pro-inflammatory macrophages recruited during *** could restore neutrophils’chemotaxis and immune function in the septic *** inhibited the activation of T regulatory cells but promoted the cytotoxic function of natural killer cells during *** also promoted the differentiation and activity of splenic B cells in mice with *** results indicated that ART could alleviate the inflammatory and/or immunosuppressive states of various immune cells involved in sepsis to balance the immune homeostasis within the ***,this study provided a comprehensive investigation of the regulatory effect of ART on the splenic microenvironment in sepsis,thus contributing to the application of ART as adjunctive therapy for the clinical treatment of sepsis.

关键词： Artesunate Sepsis Single-cell RNA sequencing Immunomodulatory activity

Epstein-Barr virus DNA loads in the peripheral blood cells predict the survival of locoregionally-advanced nasopharyngeal carcinoma patients

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Cancer Biology & Medicine 2021年第3期18卷 888-899页

作者： Yongqiao He Dawei Yang Ting Zhou Wenqiong Xue Jiangbo Zhang Fangfang Li Fang Wang Tongmin Wang Ziyi Wu Ying Liao Meiqi Zheng Changmi Deng Danhua Li Yijing Jia Leilei Yuan Wenli Zhang Weihua Jia Department of Radiation Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou 510030China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou 510030China School of Public Health Sun Yat-sen UniversityGuangzhou 510030China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510030China

Objective:Circulating cell-free Epstein-Barr virus(EBV)DNA has been shown to be a valuable biomarker for population screening and prognostic surveillance for nasopharyngeal carcinoma(NPC).Despite important insights into the biology of persistence,few studies have addressed the clinical significance of cell-based EBV-DNA loads in peripheral blood cells(PBCs).Methods:A prospective observational cohort study was conducted involving 1,063 newly diagnosed,locoregionally-advanced NPC patients at Sun Yat-sen University Cancer Center from 2005 to *** regression analysis was conducted to identify the association of PBC EBV DNA loads to overall survival(OS)and other prognostic *** nomograms were developed based on PBC EBV DNA loads to predict survival outcomes for NPC ***:After a median follow-up of 108 months,patients with higher PBC EBV-DNA loads had significantly worse OS[hazard ratio(HR)of medium,medium-high,and high *** were 1.50,1.52,and 1.85 respectively;Ptrend<0.001].Similar results were found for progression-free survival and distant metastasis-free *** concordance index of the prognostic nomogram for predicting OS in the training set and validation set were 0.70 and 0.66,*** data showed that the PBC EBV DNA load was an independent and robust survival biomarker,which remained significant even after adjusting for plasma EBV DNA loads in a subset of 205 patients of the cohort(HR:1.88;P=0.025).Importantly,a combination of PBC EBV DNA load and plasma EBV DNA load improved the predicted ***:The EBV-DNA load in PBCs may be an independent prognosis marker for NPC patients.

关键词： Nasopharyngeal carcinoma Epstein-Barr virus DNA prognosis peripheral blood cells nomogram

Clinical observation on Wang Juyi＇s applied channel theory in treating stroke-sequel patients

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Journal of Traditional Chinese Medicine 2018年第4期38卷 593-600页

作者： Luo Lu Yu Zheng Yang Yuyang Liu Jing Zhou Wei Wang Juyi World Federation of Acupuncture-Moxibustion Societies China Academy of Chinese Medical Sciences Beijing 100700 China Pidu Distric Hospital of Traditional Chinese Medicine Sichuan 611730 China Acumox and Tuina College Beijing University of Chinese Medicine Beijing 100029 China Acupuncture-Moxibustion Department Huguosi Traditional Chinese Medicine Hospital Attached Hospital of Beijing University of Chinese Medicine Beijing 100035 China Acupuncture-Moxisbution Research institute China Academy of Chinese Medical Sciences Beijing 100700 China

OBJECTIVE:To explore the advantages of acupuncture treatment guided by channel palpation on stroke-sequel ***:This research was randomized,traditional acupuncture controlled trial using channel palpation acupuncture to treat stroke-sequel *** 148 patients who were randomly assigned to two experimental *** treatment group,i.e,the channel palpation group was treated with *** Juyi's Channel *** in control group received acupuncture according to New Century *** patient was needled at Renzhong(GV 26),Baihui(GV 20),Neiguan(PC 6),Jiquan(HT 1),Chize(LU 5),Weizhong(BL 40),Sanyinjiao(SP 6),Zusanli(ST 36),and each acupuncture treatment was modified according different syndrome differentiations including liver yang rising [Taichong(LR 3),Taixi(KI 3)],wind-phlegm blocking collaterals [Fenglong(ST 40),Hegu(LI 4)],phlegm-heat occupying in the Fu-organs [Quchi(LI11),Neiting(ST 44),Fenglong(ST 40)],Qi deficiency with blood stasis [Qihai(CV 6),Xuehai(SP 10)],Yin Deficiency with wind [Taixi(KI 3),Fengchi(GB 20)];for wry mouth,add Jiache(ST 6),Dicang(ST 4);for paralyzed arms,add Jianyu(LI 15),Quchi(LI 11),Shousanli(LI 10) and Hegu(LI 4),for paralyzed legs,add Huantiao(GB 30),Yinlingquan(SP 9) and Fengshi(GB 31).The duration of each treatment was 6 *** the Fugl-Meyer score,the Stroke Specific Quality of Life scale(SS-QOL),and the National institute of Health Stroke Scale(NIHSS) were assessed before treatments,after 6 and 12 weeks of treatments to evaluate the acupuncture effect in each *** data were collected and analyzed after the completion of treatment by SPSS 17 using paired sample ***:Totally 148 participants were recruited,and 136 eligible patients were included in this *** results showed that for FMA motor function and Fugl-Meyer balance function and NIHSS,there is no statistic difference between two groups at the baseline period,after 6-week treatment and after 12-week follow-up(P > 0

关键词： Acupuncture Channel Palpation Stroke-sequel Wang Juyi