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Establishment of a blunt impact-induced brain injury model in rabbits

Chinese Journal of traumatology 2012年第2期

作者： LI Kui CAO Yun-xing YANG Yong-qiang YIN Zhi-yong~* ZHAO Hui and WANG Li-jun Chongqing Municipal Public Security Bureau Chongqing 400054 China Department of Neurosurgery First Affiliated Hospital of Liaoning Medical University Jinzhou 121001 China Chongqing Key Laboratory of Vehicle Crash/Bio-impact and Traffic Safety Department 4th Daping Hospital and institute of Surgery Research Third Military Medical University Chongqing 400042 China Chongqing Municipal Public Security Bureau Chongqing 400054 China Department of Neurosurgery First Affiliated Hospital of Liaoning Medical University Jinzhou 121001 China Chongqing Key Laboratory of Vehicle Crash Bio-impact and Traffic Safety Department 4th Daping Hospital and Institute of Surgery Research Third Military Medical University Chongqing 400042 China

Objective:To establish an animal model to replicate the blunt impact brain injury in forensic medicine. Methods:Twenty-four New Zealand white rabbits were randomly divided into control group(n=4),minor injury group(n=10) and severe injury group(n=10).Based on the BIM-ⅡHorizontal Bio-impact Machine,self-designed iron bar was used to produce blunt brain *** rabbits from each injury group were randomly selected to monitor the change of intracranial pressure(ICP) during the impacting process by pressure *** hours after injury, all the rabbits were dissected to observe the injury morphology and underwent routine pathological examination. Results:Varying degrees of nervous system positive signs were observed in all the injured *** 6 hours, the mortality rate was 1/10 in the minor injury group and 6/10 in the severe injury *** changes con- sisted of different levels of scalp hematoma,skull fracture, epidural hematoma,subdural hematoma,subarachnoid hemorrhage and brain *** the moment of hitting,the ICP was greater in severe injury group than in mild injury group; and within the same group,the impact side showed positive pressure while the opposite side showed negative pressure. Conclusions:Under the rigidly-controlled experimental condition,this animal model has a good reproducibility and stable ***,it is able to simulate the morphology of iron strike-induced injury,thus can be used to study the mechanism of blunt head injury in forensic medicine.

关键词： Brain injuries Forensic medicine Wounds,nonpenetrating Models,animal Rabbits

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Surgical management of transected injury to the pancreatic neck

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Chinese Journal of traumatology 2003年第4期6卷 205-208页

作者：母德清董庆华彭淑牖彭承宏吴育莲 Department of Surgery Second Hospital Affiliated to Medical College of Zhejiang UniversityHangzhou 310031China Cancer Research institute of Second Hospital Affiliated to Medical College of Zhejiang University Hangzhou 310031China Department of Surgery Second Hospital Affiliated to Medical College of Zhejiang UniversityHangzhou 310031Chinabjective: To present a batch of data of transected pancreatic neck injuries and to sum up the experience in surgical interventions for the injuries.Methods: We analysed 13 patients with a transected injury to the pancreatic neck from Jan. 1995 to Dec. 2000. External drainage was performed in all patients. Pancreatoduodenectomy was conducted in 2 patients with a transected injury to the pancreatic neck associated with duodenal ruptures and TPN was administered immediately after operation. Proximal closure of the transected margin and distal pancreaticojejunostomy was performed in 4 patients. Proximal closure of the transected margin and distal pancreaticojejunostomy plus splenectomy was performed in 7 patients associated with contusion of pancreatic body or tail plus spleen rupture.Results: 12 patients healed and one patient died of anesthetic accident during the course of restoration of the dislocation of his right hip joint. Complications occurred in 7 patients.Conclusions: The operation should be performed according to the degree of the injuries and associated duodenal injuries. Routine drainage and nutrient support should be recommended.

Objective: To present a batch of data of transected pancreatic neck injuries and to sum up the experience in surgical interventions for the ***: We analysed 13 patients with a transected injury to the pancreatic neck from Jan. 1995 to Dec. 2000. External drainage was performed in all patients. Pancreatoduodenectomy was conducted in 2 patients with a transected injury to the pancreatic neck associated with duodenal ruptures, and TPN was administered immediately after operation. Proximal closure of the transected margin and distal pancreaticojejunostomy was performed in 4 patients. Proximal closure of the transected margin and distal pancreaticojejunostomy plus splenectomy was performed in 7 patients associated with contusion of pancreatic body or tail plus spleen rupture. Results: 12 patients healed and one patient died of anesthetic accident during the course of restoration of the dislocation of his right hip joint. Complications occurred in 7 ***: The operation should be performed according to the degree of the injuries and associated duodenal injuries. Routine drainage and nutrient support should be recommended.

关键词： Pancreas Wounds and injuries Treatment outcome

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Chinese Trauma Surgeon Association for management guidelines of vacuum sealing drainage application in abdominal surgeries-Update and systematic review

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Chinese Journal of traumatology 2019年第1期22卷 1-11页

作者： Yang Li Pei-Yuan Li Shi-Jing Sun Yuan-Zhang Yao Zhan-Fei Li Tao Liu Fan Yang Lian-Yang Zhang Xiang-Jun Bai Jing-Shan Huo Wu-Bing He Jun Ouyang Lei Peng Ping Hu Yan-An Zhu Ping Jin Qi-Feng Shao Yan-Feng Wang Rui-Wu Dai Pei-Yang Hu Hai-Ming Chen Ge-Fei Wang Yong-Gao Wang Hong-Xu Jin Chang-Ju Zhu Qi-Yong Zhang Biao Shao Xi-Guang Sang Chang-Lin Yin Trauma Center of PLA State Key Laboratory of Trauma Bums and Combined Injury Institute of Surgery Research Doping Hospital Third Military Medical University Chongqing China Ninth People's Hospital of Zhengzhou Zhengzhou China Zhongnan Hospital of Wuhan University Wuhan China Chengdu Military General Hospital ChengduChina Tiantai County People's Hospital Tiantai Zhejiang China The First Affiliated Hospital of Nanchang University Nanchang China Department of Surgery Jinling Hospital Medical School of Nanjing University Nanjing China Department of Surgery The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China Shenyang Military General Hospital Shenyang China The First Affiliated Hospital of Zhengzhou University Zhengzhou China The Affiliated Hospital of Guizhou Medical University Guiyang China Trauma Center/Department of Emergency and Trauma Surgery Tongji Hospital of Tongji Medical College Huazhong University of Science & Technology Wuhan China The First People's Hospital of Kunming Kunming China Qilu Hospital of Shandong University Jinan China The First Affiliated Hospital of Third Military Medical University Chongqing China Foshan Hospital of Traditional Chinese Medicine Foshan Guangzhou Province China Fujian Provincial Hospital Fuzhou China Emergency Surgery of the First Affiliated Hospital Shihezi University School of Medicine Shihezi Xinjiang Autonomous Region China The First Affiliated Hospital of Hainan Medical University Haikou China Chongqing Emergency Medical Center Chongqing China Taizhou Hospital of Zhejiang Province Taizhou Zhejiang Province China Yuyao People's Hospital of Zhejiang Province Yuyao Zhejiang Province China

Vacuum sealing drainage (VSD) is frequently used in abdominal surgeries. However, relevant guidelines are rare. Chin ese Trauma Surge on Associati on orga nized a committee composed of 28 experts across China in July 2017, aiming to provide an evidence-based recommendation for the application of VSD in abdominal *** questions regarding the use of VSD in abdominal surgeries were addressed:(1) which type of materials should be respectively chosen for the intraperitoneal cavity, retroperitoneal cavity and superficial incisions?(2) Can VSD be preventively used for a high-risk abdominal incision w让h primary suture?(3) Can VSD be used in severely contaminated/infected abdominal surgical sites?(4) Can VSD be used for temporary abdominal cavity closure under some special conditions such as severe abdominal trauma, infection, liver transplantation and intra-abdominal volume increment in abdominal compartment syndrome?(5) Can VSD be used in abdominal organ inflammation, injury, or postoperative drainage?(6) Can VSD be used in the treatment of intestinal fistula and pancreatic fistula?(7) Can VSD be used in the treatment of intra-abdominal and extra-peritoneal abscess?(8) Can VSD be used in the treatment of abdominal wall wounds, wound cavity, and defects?(9) Does VSD in crease the risk of bleeding?(10) Does VSD increase the risk of intestinal wail injury?(11) Does VSD increase the risk of peritoneal adhesion? Focusing on these questions, evidence-based recommendations were given accordingly. VSD was strongly recommended regarding the questions 2-4. Weak recommendations were made regarding questions 1 and 5-11. Proper use of VSD in abdominal surgeries can lower the risk of infection in abdominal incisions with primary suture, treat severely contaminated/infected surgical sites and facilitate temporary abdominal cavity closure.

关键词： Guideline Vacuum sealing drainage Abdominal surgery

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