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Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus

World Journal of Clinical Cases 2024年第3期12卷 525-537页

作者： Dharmsheel Shrivastav Desh Deepak Singh Amity institute of Biotechnology Amity University RajasthanJaipur 303002India

BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose *** high sugar levels lead to advanced glycation end products(AGEs),which affects several metabolic pathways by its receptor of advanced glycation end products(RAGE)and causes diabetic *** are small RNA molecules which regulate genes linked to diabetes and affect AGEs pathogenesis,and target tissues,influencing health and disease *** To explore miRNA roles in T2DM's metabolic pathways for potential therapeutic and diagnostic advancements in diabetes *** We systematically searched the electronic database PubMed using *** included free,full-length research articles that evaluate the role of miRNAs in T2DM and its complications,focusing on genetic and molecular disease *** assessing the full-length papers of the shortlisted articles,we included 12 research *** Several types of miRNAs are linked in metabolic pathways which are affected by AGE/RAGE axis in T2DM and its ***-96-5p,miR-7-5p,miR-132,has_circ_0071106,miR-143,miR-21,miR-145-5p,and more are associated with various aspects of T2DM,including disease risk,diagnostic markers,complications,and gene *** Targeting the AGE/RAGE axis,with a focus on miRNA regulation,holds promise for managing T2DM and its *** have therapeutic potential as they can influence the metabolic pathways affected by AGEs and RAGE,potentially reducing inflammation,oxidative stress,and vascular ***,miRNAs may serve as early diagnostic biomarkers for *** research in this area may lead to innovative therapeutic strategies for diabetes and its associated complications.

关键词： Type 2 diabetes mellitus MicroRNAs Advanced glycation end products Receptor for advanced glycation end products

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Influence of Sanitization Process on Maintaining Sweet Potato Quality for Export

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Journal of Agricultural Science and Technology(A) 2024年第1期14卷 31-37页

作者： Saneya M.El Neshawy Tharwa M.Elkholi Salah H.Hegazy Department of Post-harvest Diseases Plant Pathology Research InstituteAgricultural Research Center(ARC)Giza 12619Egypt Central Administration for Medical Services Ministry of AgricultureDokii 12611Egypt General Manager of AgroFood Company Limited Dokii 12611Egypt

The whole cold-chain for exporting sweet potato(native variety“Abees”),to foreign market included immediate curing operation directly after harvest helped in healing skin texture,however,in order to reduce postharvest soft rot(Rhizopus stolonifer)incidence following trimming,and washing,ultraviolet light(UV-C)treatment was used as a main sanitizer for eliminating the soft *** of the roots to UV-C(254 nm)was applied in a UV-C room on freshly harvested and cured sweet potato while rolling up on a movable line at 20 cm distance for 1,2,and 3 *** combining UV-C treatment with chlorine(200 ppm)on roots,marked and significant reduction of the total microbial load and Rhizopus potential was achieved on root surfaces respectively compared with chlorine *** also reduced soft rot percentage to almost 0%*** 3 months of cold-storage,quality assessment of sweet potato showed that root characteristics were markedly *** ability of UV-C light to induce phenylalanine ammonia lyase(PAL)enzyme activity in root tissue and maintain the activities of peroxidase and polyphenol oxidase,however with slight increase,was ***-C caused an increase of phenol content in sweet potato tissue that made an activation of defense reaction against the rot causal *** the exposure time to UV-C light increased,a higher content of phenols ***,UV-C application caused decrease in sugar content of root tissue that is flavored by soft rot-causal pathogen.

关键词： Sweet potato(Ipomoea batatas) soft rot Rhizopus stolonifer UV-C light cold storage microbial load

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Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus

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Animal Models and Experimental Medicine 2024年第4期7卷 433-443页

作者： Xin-Yue Liu Han-Wen Zheng Feng-Zhong Wang Tul-Wahab Atia Bei Fan Qiong Wang institute of Food Science and Technology Chinese Academy of Agricultural SciencesBeijingChina Sino-Portugal TCM International Cooperation Center the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhouChina Dr.Panjwani Center for Molecular Medicine and Drug research International Center for Chemical and Biological SciencesUniversity of KarachiKarachiPakistan

In traditional Chinese medicine(TCM),based on various pathogenic symptoms and the‘golden chamber’medical text,Huangdi Neijing,diabetes mellitus falls under the category‘collateral disease’.TCM,with its wealth of experience,has been treating diabetes for over two *** antidiabetic Chinese herbal medicines re-duce blood sugar,with their effective ingredients exerting unique *** well as a glucose lowering effect,TCM also regulates bodily functions to prevent diabetes associated complications,with reduced side effects compared to western synthetic *** herbal medicine is usually composed of polysaccharides,saponins,al-kaloids,flavonoids,and *** active ingredients reduce blood sugar via various mechanism of actions that include boosting endogenous insulin secretion,enhancing insulin sensitivity and adjusting key enzyme activity and scavenging free *** actions regulate glycolipid metabolism in the body,eventually achiev-ing the goal of normalizing blood *** different animal models,a number of molecular markers are available for the detection of diabetes induction and the molecular pathology of the disease is becoming ***,there is a dearth of scientific data about the pharmacology,dose-effect relationship,and structure-activity relationship of TCM and its *** research into the efficacy,toxicity and mode of action of TCM,using different metabolic and molecular markers,is key to developing novel TCM antidiabetic formulations.

关键词： animal model Chinese herbal medicine diabetes mellitus evaluation index mechanism of action

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Role of the Alleviating Aβ Toxicity in the Anti-AD Effect of Brown Wolfberry

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Food Science and Human Wellness 2024年

作者： Miaosi Zhang Rui Liu Ran Yang Jilite Wang Xiaozhi Liu Baorui Li Ye Zhang Hao Wang State Key Laboratory of Food Nutrition and Safety， Tianjin University of Science and Technology (TUST) Department of Agriculture， Hetao College Tianjin Key Laboratory of Epigenetic for Organ Development of Preterm Infants， Tianjin Fifth Central Hospital High Altitude Characteristic Medical research institute， Huangnan Tibetan Autonomous Prefecture People's Hospital institute of Food & Nutrition Science and Technology， Shandong Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Key Laboratory of Novel Food Resources Processing， Ministry of Agriculture and Rural Affairs/Shandong Engineering research Center of Food for Special Medical Purpose

Wolfberry (Lycium barbarum L.) is a medicinal herb with anti-aging and neuroprotective effects. The purpose of this study was to explore the enhanced neuroprotective effects of wolfberry water extract (RW)， and brown wolfberry water extract (BBW). The reduced percentage of reducing sugar in BBW was shown to be 62.8%， 64.3%， 39.8%， and 11.6% for glucose， fructose， maltose， and lactose compared to those of RW， as well as free amino acids. And the contents of total phenols and total flavonoids were increased by 62.0% and 33.1%. Melanoidins (1% ± 0.05%) were first isolated from BBW. RW and BBW increased anti-stress abilities (oxidative stress: 24.2% vs 35.7%， and heat stress: 10.9% vs 19.1%) while decreasing the ROS levels in vivo. RW and BBW reduced the rate of paralysis and odor cognitive deficits. At the same time， RW and BBW reduced the number of fluorescent spots of Aβ::GFP. The RW and BBW activated autophagy by upregulating the gene levels (bec-1， lgg-1， lgg-2， unc-51， vps-34， atg-5， atg-18， and sqst-1). Additionally， BBW promoted the nuclear-cytoplasmic ratio of DAF-16::GFP and fluorescence intensity of SOD-3::GFP by 39.4 fold and 1.16 fold. This study laid a new insight for exploring the Maillard reaction in improving the anti-AD activity of wolfberry.

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C60intercalating Ti_(3)C_(2)T_(x) MXenes assisted by γ-cyclodextrin for electromagnetic interference shielding films with high stability

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Journal of Materials Science & Technology 2022年第32期127卷 71-77页

作者： Kunpeng Qian Shuang Li Jianhui Fang Yuhuan Yang Shaomei Cao Miao Miao Xin Feng School of Materials Sciences and Engineering Shanghai UniversityShanghai 200444China research Center of Nano Science and Technology Shanghai UniversityShanghai 200444China Dehong Autonomous Prefecture institute of sugar Industry Yunnan 678400China

Ti_(3)C_(2)T_(x)MXenes with excellent metallic conductivity and flexibility have shown a promising prospect as electromagnetic interference(EMI) shielding materials. Ultrathin, hierarchical hybrid films were fabricated by using C60intercalating Ti_(3)C_(2)T_(x)MXenes with the assistance of water-soluble γ-cyclodextrin(CD). The C_(60)/CD complex was obtained by high-speed vibration milling using hydrophilic CD as dispersing agent. After thermal annealing treatment, the obtained hybrid film exhibited excellent EMI shielding(53.52±0.43 dB), hydrophobicity(water contact angle: 93.7°) and mechanical stability(over 0.9 million bending times). Taking advantage of the antioxidant of C_(60), the chemical durability of Ti_(3)C_(2)T_(x) MXenes based hybrid films was also improved as expected. These results indicate that the well-designed hierarchical hybrid films with the intercalation of C_(60) have promising potential for high-performance EMI shielding applications.

关键词： Ti_(3)C_(2)T_(x)MXenes C_(60) High conductivity Stability EMI shielding

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Comparative Analysis of Statistical Thickness Models for the Determination of the External Specific Surface and the Surface of the Micropores of Materials: The Case of a Clay Concrete Stabilized Using sugar Cane Molasses

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Geomaterials 2024年第2期14卷 13-28页

作者： Nice Mfoutou Ngouallat Narcisse Malanda Christ Ariel Ceti Malanda Kris Berjovie Maniongui Erman Eloge Nzaba Madila Paul Louzolo-Kimbembe Mechanics Energy and Engineering Laboratory Higher National Polytechnic School Marien Ngouabi University Brazzaville Republic of the Congo National institute for research in Engineering Sciences Innovation and Technology (INRSIIT) Brazzaville Republic of the Congo Higher institute of Architecture Building Planning and Public Works Denis SASSOU N&#8217GUESSO University Kint&#233l&#233 Republic of the Congo Hydrogen research institute University of Quebec in Trois Rivieres Quebec Canada Superior Normal School (ENS) Marien Ngouabi University Brazzaville Republic of the Congo

In this work, four empirical models of statistical thickness, namely the models of Harkins and Jura, Hasley, Carbon Black and Jaroniec, were compared in order to determine the textural properties (external surface and surface of micropores) of a clay concrete without molasses and clay concretes stabilized with 8%, 12% and 16% molasses. The results obtained show that Hasley’s model can be used to obtain the external surfaces. However, it does not allow the surface of the micropores to be obtained, and is not suitable for the case of simple clay concrete (without molasses) and for clay concretes stabilized with molasses. The Carbon Black, Jaroniec and Harkins and Jura models can be used for clay concrete and stabilized clay concrete. However, the Carbon Black model is the most relevant for clay concrete and the Harkins and Jura model is for molasses-stabilized clay concrete. These last two models augur well for future research.

关键词： Statistical Thickness Model External Specific Surface Microporous Surface Clay Concrete Molasses

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Effectiveness of dietary xylo-oligosaccharides for broilers fed a conventional corn-soybean meal diet

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Journal of Integrative Agriculture 2015年第10期14卷 2050-2057页

作者： SUO Hai-qing LU Lin XU Guo-hui XIAO Lin CHEN Xiao-gang XIA Rui-rui ZHANG Li-yang LUO Xu-gang Mineral Nutrition research Division Institute of Animal Sciences Chinese Academy of Agricultural Sciences High-Technology Development Zone Functional Sugar Engineering Research Center of Shandong Province High-Technology Development Zone Shandong Key Laboratory of Straw and Stover Biorefinement Technologies

An experiment was conducted to investigate the effect of dietary supplementation of xylo-oligosaccharides（XOS） on growth performance, meat quality, immune functions, duodenal morphology and intestinal microbial populations of broilers fed a conventional corn-soybean meal basal diet. A total of 450 1-day-old commercial Arbor Acres male broiler chicks were randomly allocated by bodyweight to 1 of 5 treatments with 6 replicate cages（15 broilers per cage） for each of 5 treatments in a completely randomized design. Chicks were fed the basal corn-soybean meal diets supplemented with 0, 25, 50, 75, or 100 mg of XOS kg–1 of diet, respectively, for an experimental duration of 42 days. The results showed that supplementation of XOS affected feed conversion rate（feed/gain, F/G） during days 22–42 and 1–42（P〈0.03）, drip loss in thigh muscle（P=0.02）, and duodenal crypt depth（P=0.005） on day 42, but had no effect（P〉0.05） on all other measured indices. The chicks fed the diet supplemented with 100 mg of XOS kg–1 had the lowest（P〈0.05） F/G and drip loss in thigh muscle. The drip loss in thigh muscle decreased linearly（P=0.003） as the supplemented XOS increased. Duodenal crypt depth decreased（P〈0.05） at the supplemental level of 75 mg of XOS kg–1. The results indicate that dietary supplementations of 75 and 100 mg of XOS kg–1 are beneficial to broilers fed a conventional corn-soybean meal diet.

关键词： xylo-oligosaccharide effectiveness F/G drip loss broiler chick

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Production of chitosan-based composite film reinforced with lignin-rich lignocellulose nanofibers from rice husk

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Journal of Bioresources and Bioproducts 2024年第2期9卷 174-184页

作者： Hye Jee Kang Yeon Ju Lee Jin Kyoung Lee Irnia Nurika Sri Suhartini Deokyeong Choe Dong Hyun Kim Hoon Choi Natasha P.Murphy Ho Yong Kim Young Hoon Jung School of Food Science and Biotechnology Kyungpook National UniversityDaegu 41566Republic of Korea CPR S&T Co. Ltd.Gunpo 15880Republic of Korea Department of Agroindustrial Technology Faculty of Agricultural TechnologyUniversitas BrawijayaMalang 65145Indonesia Renewable Resources and Enabling Sciences Center National Renewable Energy LaboratoryGoldenCO 80401United States Center for Bio-based Chemistry Korea Research Institute of Chemical TechnologyUlsan 44429Republic of Korea

Lignocellulosic nanofibers(LCNFs),implying lignin-containing cellulose fibers,maintain the prop-erties of both lignin and cellulose,which are hydrophobic and hydrophilic,*** pres-ence of hydrophobic lignin in LCNFs is expected to be an economical and attractive option that can improve the thermal and mechanical properties of ***,this study was conducted to produce lignin-rich LCNFs from sugar-rich waste obtained from rice husks after acidic *** LCNFs were produced from the lignin-rich solid fractions obtained after pretreatment and enzymatic hydrolysis,which were then incorporated as an additive into a chitosan-based *** variations in lignin content in the range of approximately 50.6%-66.8%in differently obtained LCNFs gave significantly different optical strengths and mechanical *** controllable processes may allow for customized film ***,the glucose-rich liquid fractions obtained after pretreatment and enzymatic hydrolysis were used as a substrate for ethanol fermentation to achieve total utilization of rice husk biomass *** conclusion,the lignin-rich biomass fraction holds promise as a suitable material for chitosan-LCNF film and has the potential to increase the economic feasibility of the biomaterial industry.

关键词： Rice husk Lignocellulose nanofiber Lignin-based material Chitosan film Upcycling

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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural Regeneration research 2025年第8期20卷 2218-2230页

作者： Rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana R.N.Lemos Jeenu Mittal Khemraj Hirani Diabetes research institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

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Characterization of meiotic chromosome behavior in the autopolyploid Saccharum spontaneum reveals preferential chromosome pairing without distinct DNA sequence variation

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作物学报:英文版 2023年第5期11卷 1550-1558页

作者： Xin Zhang Zhuang Meng Jinlei Han Haris Khurshid Ayman Esh Robert Hasterok Kai Wang School of Life Sciences Nantong UniversityNantong 226019JiangsuChina Plant Cytogenetics and Molecular Biology Group Institute of BiologyBiotechnology and Environmental ProtectionFaculty of Natural SciencesUniversity of Silesia in KatowiceKatowice 40-032Poland College of Agriculture Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina sugar Crops research institute Agriculture Research CenterGiza 12111Egypt Oilseeds research Program National Agricultural Research CentreIslamabad 44000Pakistan

Autopolyploidy and allopolyploidy may represent an evolutionary advantage and are more common in plants than assumed. However, less attention has been paid to autopolyploidy than to allopolyploidy,and its evolutionary consequences are largely unclear, especially for plants with high ploidy levels. In this study, we developed oligonucleotide(oligo)-based chromosome painting probes to identify individual chromosomes in S. spontaneum. Using fluorescence in situ hybridization(FISH), we investigated chromosome behavior during pachytene, metaphase, anaphase, and telophase of meiosis I(MI) in autotetraploid,autooctoploid, and autodecaploid S. spontaneum clones. All autopolyploid clones showed stable diploidized chromosome behavior;so that homologous chromosomes formed almost exclusively bivalents during MI. Two copies of homologous chromosome 8 with similar sizes in the autotetraploid clone showed preferential pairing with each other with respect to the other copies. However, sequence variation analysis showed no apparent differences among homologs of chromosome 8 and all other chromosomes. We suggest that either the stable diploidized pairing or the preferential pairing between homologous copies of chromosome 8 in the studied autopolyploid sugarcane are accounted for by unknown mechanisms other than DNA sequence similarity. Our results reveal evolutionary consequences of stable meiotic behavior in autopolyploid plants.

关键词： Autopolyploidy Saccharum spontaneum Meiosis I Chromosome behavior Chromosome pairing

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