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Effects of inorganic ions,organic particles,blood cells,and cyclic loading on in vitro corrosion of Mg–Al alloys

镁合金学报(英文) 2023年第7期11卷 2429-2441页

作者： Guanqi Liu Jianmin Han Ying Li Yuzhu Guo Xiaodong Yu Shenpo Yuan Zhihua Nie Chengwen Tan Chuanbin Guo School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China department of Dental Materials National Center of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsPeking University School and Hospital of StomatologyBeijing 100081China department of Oral and Maxillofacial Surgery National Center of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsPeking University School and Hospital of StomatologyBeijing 100081China

Recently,magnesium(Mg)alloys have attracted extensive attention as biodegradable implant ***,cyclic loading and the corrosive environment of the body are significant challenges for the practical use of alloys,and there are few studies on this *** this study,we conducted a four-point bending fatigue test for 86,400 cycles(12 h)in simulated body fluid(SBF),plasma,and whole blood with an AZ series alloy Mg-9Al-0.5Zn-0.27Mn-0.12Ag,to examine the effects of inorganic ions,organic particles,blood cells,and cyclic loading on Mg alloy *** Mg^(2+)concentration and solution pH were measured before and after experimentation,and the sample surfaces were characterized by 3D digital microscopy,scanning electron microscopy(SEM),energy-dispersive X-ray spectroscopy(EDS),Fourier-transform infrared(FTIR)spectroscopy,Raman spectroscopy,and X-ray photoelectron spectroscopy(XPS).Our results showed that in the non-loading condition,a porous and weak inorganic product layer(mainly Mg/Ca phosphate and carbonate)formed on the surface of the Mg alloy sample immersed in SBF,which hardly had a protective effect on Mg alloy *** the samples immersed in plasma,the organic particles promoted the formation of an organic and more compact product layer,which protected the Mg alloy from severe *** the sample immersed in whole blood,the blood cells affected organic particle deposition on the product layer and thus interfered with the formation of an organic compact product layer,which slightly accelerated the corrosion ***,cyclic loading damaged the layer integrity and significantly increased the corrosion rates of all the studied materials compared to the samples not subjected to cyclic ***,under cyclic loading,blood cells adsorbed on the Mg alloy surfaces,and formed films,which protected the Mg alloy substrate and delayed Mg alloy corrosion.

关键词： Magnesium alloy Cyclic loading Corrosive environment In vitro Corrosion behavior

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Knockdown of PGC1α suppresses dysplastic oral keratinocytes proliferation through reprogramming energy metabolism

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International Journal of Oral Science 2023年第3期15卷 502-512页

作者： Yunkun Liu Nengwen Huang Xianghe Qiao Zhiyu Gu Yongzhi Wu Jinjin Li Chengzhou Wu Bo Li Longjiang Li State Key Laboratory of Oral Diseases&National Center for stomatology&National Clinical Research Center for Oral Diseases&department of Head and Neck Oncology West China Hospital of StomatologySichuan UniversityChengduChina department of Preventive and Pediatric Dentistry Hospital of StomatologyZunyi Medical UniversityZunyiChina State Key Laboratory of Oral Diseases&National Center for stomatology&National Clinical Research Center for Oral Diseases&department of orthodontics West China Hospital of StomatologySichuan UniversityChengduChina

Oral potentially malignant disorders(OPMDs)are precursors of oral squamous cell carcinoma(OSCC).Deregulated cellular energy metabolism is a critical hallmark of cancer *** proliferator-activated receptor-gamma coactivator-1 alpha(PGC1α)plays vital role in mitochondrial energy ***,the molecular mechanism of PGC1αon OPMDs progression is less ***,we investigated the effects of knockdown PGC1αon human dysplastic oral keratinocytes(DOKs)comprehensively,including cell proliferation,cell cycle,apoptosis,xenograft tumor,mitochondrial DNA(mtDNA),mitochondrial electron transport chain complexes(ETC),reactive oxygen species(ROS),oxygen consumption rate(OCR),extracellular acidification rate(ECAR),and glucose *** found that knockdown PGC1αsignificantly inhibited the proliferation of DOKs in vitro and tumor growth in vivo,induced S-phase arrest,and suppressed PI3K/Akt signaling pathway without affecting cell ***,downregulated of PGC1αdecreased mtDNA,ETC,and OCR,while enhancing ROS,glucose uptake,ECAR,and glycolysis by regulating lactate dehydrogenase A(LDHA).Moreover,SR18292(an inhibitor of PGC1α)induced oxidative phosphorylation dysfunction of DOKs and declined DOK xenograft tumor ***,our work suggests that PGC1αplays a crucial role in cell proliferation by reprograming energy metabolism and interfering with energy metabolism,acting as a potential therapeutic target for OPMDs.

关键词： metabolism energy OCR

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The effect of low fluoride concentrations on microdamage accumulation in mouse tibias under impact loading

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Acta Mechanica Sinica 2015年第6期31卷 944-951页

作者： Qing Luo Nan Chen Yan-Heng Zhou Qi-Guo Rong department of orthodontics Peking University School and Hospital of Stomatology College of Engineering Peking University

Microdamage accumulation in bone is one of the mechanisms for energy dissipation during the fracture process. Changes in the ultrastructure and composition of bone constituents due to aging or diseases could affect microdamage accumulation. Low concentration （1 mM） of sodium fluoride （NaF） has been used in this study to investigate the effect of ultrastructural changes on microdamage accumu- lation in mouse tibias following free-fall impact loadings. Twenty-two tibias were divided randomly into control and NaF-treated groups. Free-fall impact loading was conducted twice on each tibia to produce microdamage. The elas- tic modulus of NaF-treated tibias decreased significantly after the impact loadings, while there was no significant difference in the modulus of untreated samples between pre- and post-damage loadings. Microdamage morphology analysis showed that less and shorter microcracks existed in NaF-treated tibias compared with control bones. Meanwhile, more and longer microcracks were observed in tensile regions in untreated samples compared with that in compressive regions, whereas no significant difference was observed between tensile and compressive regions in NaF-treated bones. The results of this study indicate that more energy is required to generate microcracks in NaF-treated bone than in normal bone. A low concentration of fluoride treatment may increase the toughness of bone under impact loading.

关键词： Microdamage accumulation · Fluoridetreatment · Ultrastructural changes · Free-fall impact

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Micromechanical interlocking structure at the filler/resin interface for dental composites: a review

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International Journal of Oral Science 2023年第2期15卷 204-216页

作者： Shuning Zhang Xiao Wang Jiawei Yang Hongyan Chen Xinquan Jiang department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of Medicine College of stomatology Shanghai Jiao Tong University Shanghai Engineering Research Center of Advanced Dental Technology and Materials National Center for stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of stomatology Shanghai Research institute of stomatology ShanghaiChina

Dental resin composites(DRCs)are popular materials for repairing caries or dental defect,requiring excellent properties to cope with the complex oral ***/resin interface interaction has a significant impact on the phy... 详细信息

关键词： composites resin interface

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Electrochemical flow aziridination of unactivated alkenes

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National Science Review 2023年第10期10卷 86-95页

作者：王盛淳王鹏杰李树劲陈宜鸿孙志军雷爱文 institute for Advanced Studies (IAS) College of Chemistry and Molecular SciencesWuhan University State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School & Hospital of Stomatology Wuhan University department of Oral Maxillofacial-Head Neck Oncology School and Hospital of Stomatology Wuhan University

Aziridines derived from bioactive molecules may have unique pharmacological activities,making them useful in pharmacology(*** C).Furthermore,the substitution of the epoxide moiety in epothilone B with aziridine,an analog of epoxides,yielded a pronounced enhancement in its anticancer ***,there is interest in developing novel synthetic technologies to produce aziridines from bioactive ***,known methods usually require metal catalysts,stoichiometric oxidants and/or pre-functionalized amination reagents,causing difficulty in application.A practical approach without a metal catalyst and extra-oxidant for the aziridination of bioactive molecules is in demand,yet ***,we report an ele ctro-oxidative flow protocol that accomplishes an oxidant-free aziridination of natural *** process is achieved by an oxidative sulfonamide/alkene cross-coupling,in which sulfonamide and alkene undergo simultaneous oxidation or alkene is oxidized *** anticancer treatments in cell lines have demonstrated the pharmacological activities of these aziridines,supporting the potential of this method for drug discovery.

关键词： alkene aziridination electro-oxidative cross-coupling flow chemistry N -centered radical alkene radical cation

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Loss of cathepsin C enhances keratinocyte proliferation and inhibits apoptosis

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Science Bulletin 2016年第14期61卷 1107-1114页

作者： Xin Li Ling-Fei Jia Yunfei Zheng Yiping Huang Man Qin Yuan Yang department of Pediatric Dentistry Peking University School and Hospital of Stomatology department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Central Laboratory Peking University School and Hospital of Stomatology department of orthodontics Peking University School and Hospital of Stomatology

Papillon–Lefe`vre Syndrome is a rare autosomal recessive disorder characterized by rapidly progressive periodontitis and confined palmoplantar hyperkeratosis resulting from genetic mutations in cathepsin C(CTSC).The present study investigated the effect of CTSC on keratinocyte proliferation and apoptosis. Ha Ca T keratinocytes were transfected with wild-type CTSC and CTSC-targeted si RNAs to investigate the effects of CTSC expression on cell keratosis. Real-time PCR and Western blot analyses showed that the levels of loricrin and keratin(KRT)-1, but not KRT9, was correlated with CTSC expression. Loricrin was increased in the CTSC-overexpression group and downregulated in the CTSC-silenced group. A positive association between loricrin expression and cell apoptosis was detected in Ha Ca T ***1 was decreased in the CTSC-overexpression group and increased in the CTSC-silenced group. Prominent,punctuate KRT1 aggregates were present in CTSC-knockdown Ha Ca T cells. This study suggested that loss of CTSC contributes to keratinocyte hyperkeratosis via downregulation of loricrin and enhanced cell proliferation.

关键词：角质形成细胞细胞凋亡细胞增殖损失实时荧光定量PCR 组织蛋白酶 HaCaT细胞 blot分析

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New horizons for therapeutic applications of nanozymes in oral infection

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Particuology 2023年第9期80卷 61-73页

作者： Yanting Cai Yue Li Jin Zhang Nan Tang Xingfu Bao Zhen Liu department of orthodontics Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilinUniversityChangchun130021China Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and TechnologyBeijing University of ChemicalTechnologyBeijing100029China

As a category of nanomaterials with excellent catalytic efficiency,great substrate specificity,and highrecovery efficiency,nanozymes have attracted increasing attention in various biomedical ***,numbers of nanozyme-assisted strategies have been well developed for the theranostics ofvarious diseases by taking advantages of their multienzyme-like characteristics,low cost,and *** the most prevalent oral diseases,oral infection poses a global hazard to human health,andcurrent therapeutic options are insufficient to resolve all the clinical *** on their admirableactivity,nanozymes can be frequently employed in the identification and treatment of various oral infectious ***,we provide a brief review focused on the classification of nanozymes,analysesof nanozyme-based antibacterial mechanism,research progress in oral bacterial control,and representative studies of nanozyme-assisted oral inflammatory ***,major challenges andpotential opportunities regarding the use of nanozymes in oral infectious diseases are also highlightedand *** review not only summarizes the recent studies of nanozymes in oral infection butalso promotes the further development of enzyme-mimetic strategies towards various oral diseases.

关键词： Nanozymes Oral infection Antibacterial therapy Anti-inflammatory therapy

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Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair

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Signal Transduction and Targeted Therapy 2022年第6期7卷 2053-2065页

作者： Yi Fan Chen Cui Clifford JRosen Tadatoshi Sato Ruoshi Xu Peiran Li Xi Wei Ruiye Bi Quan Yuan Chenchen Zhou State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Cariology and EndodonticsWest China Hospital of StomatologySichuan University610041 ChengduSichuanChina Hospital of stomatology Guanghua School of StomatologySun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Stomatology510055 GuangzhouGuangdongChina Maine Medical Center Research institute ScarboroughME 04074USA Endocrine Unit Massachusetts General HospitalHarvard Medical SchoolBostonMA 02215USA State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Orthognathic and TMJ SurgeryWest China Hospital of StomatologySichuan University610041 ChengduSichuanChina State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral ImplantologyWest China Hospital of StomatologySichuan University610041 ChengduSichuanChina State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan University610041 ChengduSichuanChina

Maxillofacial bone defects are commonly seen in clinical practice.A clearer understanding of the regulatory network directing maxillofacial bone formation will promote the development of novel therapeutic approaches for bone *** fibroblast growth factor(FGF)signalling pathway is critical for the development of maxillofacial ***,a type I transmembrane protein,is an important components of FGF receptor *** studies have reported the presence of Klotho expression in ***,the role of Klotho in cranioskeletal development and repair remains ***,we use a genetic strategy to report that deletion of Klotho in Osx-positive mesenchymal progenitors leads to a significant reduction in osteogenesis under physiological and pathological ***-deficient mensenchymal progenitors also suppress osteoclastogenesis in vitro and in *** conditions of inflammation and trauma-induced bone loss,we find that Klotho exerts an inhibitory function on inflammation-induced TNFR signaling by attenuating Rankl *** importantly,we show for the first time that Klotho is present in human alveolar bone,with a distinct expression pattern under both normal and pathological *** summary,our results identify the mechanism whereby Klotho expressed in Osx+-mensenchymal progenitors controls osteoblast differentiation and osteoclastogenesis during mandibular alveolar bone formation and ***-mediated signaling is an important component of alveolar bone remodeling and *** may also be a target for future therapeutics.

关键词： Klotho progenitor alveolar

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Decellularized extracellular matrix:A promising strategy for skin repair and regeneration

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Engineered Regeneration 2023年第4期4卷 357-374页

作者： Shengjie Jiang Yu Zhuang Ming Cai Xudong Wang Kaili Lin department of Oral and Cranio-maxillofacial Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of Medicine/College of StomatologyShanghai Jiao Tong University/National Center for Stomatology/National Clinical Research Center for Oral Diseases/Shanghai Key Laboratory of Stomatology/Shanghai Research Institute of StomatologyShanghai 200011China

The skin is an important organ of the human body that resists external threats but lacks sufficient self-regeneration ability when severe damage ***,most of the available skin substitutes cannot achieve ideal restoration of complex structures and multiple functions of native skin ***,the advent of decellularized extracellular matrix(dECM)offers a promising approach to overcome these *** dECM,derived from the natural extracellular matrix(ECM),possesses a similar structure and composition,which constructs an environment favorable for cell performance in ***,dECM retains good bioactivity,low immunogenicity,and high availability,making it a suitable biomaterial for skin repair and *** this review,various decellularization methods and subsequent evaluations of dECM are introduced first,and the main sources of dECM are then ***,the recent progress of dECM-based biomaterials applied in skin regeneration and future perspectives are summarized.

关键词： Decellularization Extracellular matrix Skin regeneration Biomaterial Bioink

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Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration

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Bone Research 2022年第1期10卷 46-64页

作者： Hongpu Wei Jinjie Cui Kaili Lin Jing Xie Xudong Wang department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai 200011China State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China

Bone defects combined with tumors, infections, or other bone diseases are challenging in clinical practice. Autologous and allogeneic grafts are two main traditional remedies, but they can cause a series of complications. To address this problem,researchers have constructed various implantable biomaterials. However, the original pathological microenvironment of bone defects, such as residual tumors, severe infection, or other bone diseases, could further affect bone regeneration. Thus, the rational design of versatile biomaterials with integrated bone therapy and regeneration functions is in great demand. Many strategies have been applied to fabricate smart stimuli-responsive materials for bone therapy and regeneration, with stimuli related to external physical triggers or endogenous disease microenvironments or involving multiple integrated strategies. Typical external physical triggers include light irradiation, electric and magnetic fields, ultrasound, and mechanical stimuli. These stimuli can transform the internal atomic packing arrangements of materials and affect cell fate, thus enhancing bone tissue therapy and regeneration. In addition to the external stimuli-responsive strategy, some specific pathological microenvironments, such as excess reactive oxygen species and mild acidity in tumors, specific p H reduction and enzymes secreted by bacteria in severe infection, and electronegative potential in bone defect sites, could be used as biochemical triggers to activate bone disease therapy and bone ***, we summarize and discuss the rational construction of versatile biomaterials with bone therapeutic and regenerative functions. The specific mechanisms, clinical applications, and existing limitations of the newly designed biomaterials are also clarified.

关键词： biomaterials smart rational

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