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The synergistic effect of 3D-printed microscale roughness surface and nanoscale feature on enhancing osteogenic differentiation and rapid osseointegration

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Journal of Materials Science & Technology 2021年第4期63卷 18-26页

作者： Hui Wang Jiaqiang Liu Chengtao Wang Steve Guofang Shen Xudong Wang Kaili Lin Department of Oral and Cranio-maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011China School&Hospital of stomatology Tongji UniversityShanghai Engineering Research Center of Tooth Restoration and RegenerationShanghai200072China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China Shanghai University of Medicine&Health Sciences Shanghai201318China

Personalized precision therapy and rapid osseointegration are the main development directions of dental implants.3 D printing is a vital advanced manufacturing technology for personalized precision ***,the osteogenesis of the 3 D printed Ti6 Al4 V implants is *** the bionic perspective,the hierarchical micro/nano-topography can mimic the microenvironment of the multilevel structure of natural bone tissue and may endow the implant surface with superior *** the present study,the hierarchical micro/nano-topography was successfully fabricated by construction the nanoscale feature on 3 D printed microscale roughness surface of 3 D-printed Ti6 Al4 V implants by alkali-heat treatment and hydrothermal *** the cell biological responses in vitro and osseointegration performance in vivo were systematically *** hierarchical micro/nano-topography evidently increased the roughness,improved the hydrophilicity and accelerated the hydroxyapatite deposition and mineralization,which significantly enhanced the adhesion,differentiation and extracellular matrix mineralization of bone marrow derived mesenchymal stromal cells(BMSCs).Most importantly,the hierarchical micro/nano-topography on 3 D-printed implants facilitated the new bone formation and rapid osseointegration in *** study suggested that 3 D-printed implant with micro/nano-topography may be a promising candidate to be applied in orthopedic field to meet the need of customized therapy and rapid osseointegration.

关键词： rapid roughness topography

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Preservation of alveolar ridge height through mechanical memory: A novel dental implant design

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Bioactive Materials 2021年第1期6卷 75-83页

作者： Shi Yin Wenjie Zhang Yanmei Tang Guangzheng Yang Xiaolin Wu Sihan Lin Xuanyong Liu Huiliang Cao Xinquan Jiang Department of Prosthodontics Shanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyNational Clinical Research Center for Oral DiseasesShanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China center of Materials Science and Optoelectronics Engineering University of Chinese Academy of ScienceBeijing100049China

Irreversible marginal bone loss can hinder recovery around dental *** alveolar osteogenesis and stress concentration during chewing contribute to marginal bone resorption and can result in implant failure.A biomaterial with a micropore-channel structure was developed using 3D printing *** design facilitated bony ingrowth and provided similar mechanical stimulation at the implant neck during mastication to a natural *** micropore channels provided a guiding structure for bone mesenchymal stem cell proliferation and differentiation without the need for growth ***,this was achieved through mechanical transduction by F-actin remodeling and the activation of Yes-associated protein(YAP).The implants were verified in a canine dental implant surgery model,which demonstrated the promising use of biomaterialbased dental implants in future clinical applications.

关键词： 3D-printing Alveolar bone Pore-channel YAP Mechanical transduction

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Biomimetic mineralized hybrid scaffolds with antimicrobial peptides

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Bioactive Materials 2021年第8期6卷 2250-2260页

作者： Zhou Ye Xiao Zhu Isha Mutreja Sunil Kumar Bod Nicholas G.Fischer Anqi Zhang Christine Lui Yipin Qi Conrado Aparicio The State Key Laboratory Breeding Base of Basic Science of stomatology&Key Laboratory of Oral Biomedicine Ministry of Education School of StomatologyWuhan UniversityWuhan430079China Minnesota dental research center for Biomaterials and Biomechanics Department of Restorative SciencesSchool of DentistryUniversity of MinnesotaMN55455USA Department of Operative Dentistry and Endodontics Guanghua School of StomatologyHospital of StomatologyGuangdong Key Laboratory of StomatologySun Yat-sen UniversityGuangzhou510000China

Infection in hard tissue regeneration is a clinically-relevant *** of scaffolds with dual function for promoting bone/dental tissue growth and preventing bacterial infections is a critical need in the *** we fabricated hybrid scaffolds by intrafibrillar-mineralization of collagen using a biomimetic process and subsequently coating the scaffold with an antimicrobial designer peptide with cationic and amphipathic *** highly hydrophilic mineralized collagen scaffolds provided an ideal substrate to form a dense and stable coating of the antimicrobial *** amount of hydroxyapatite in the mineralized fibers modulated the rheological behavior of the scaffolds with no influence on the amount of recruited peptides and the resulting increase in *** developed scaffolds were potent by contact killing of Gram-negative Escherichia coli and Gram-positive Streptococcus gordonii as well as cytocompatible to human bone marrow-derived mesenchymal stromal *** process of scaffold fabrication is versatile and can be used to control mineral load and/or intrafibrillar-mineralized scaffolds made of other biopolymers.

关键词： Biomimetic mineralization Antimicrobial Cationic and amphipathic peptides Hard tissue cytocompatibility

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Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair

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Bioactive Materials 2023年第1期19卷 626-641页

作者： Lan Ma Chider Chen Dawei Liu Zhiqing Huang Jiaqi Li Haixiang Liu Ryan Tsz Kin Kwok Benzhong Tang Bingdong Sui Xiao Zhang Jianxia Tang Xueli Mao Weiying Huang Songtao Shi Xiaoxing Kou Hospital of stomatology Guanghua School of StomatologySun Yat-sen UniversitySouth China Center of Craniofacial Stem Cell ResearchGuangdong Provincial Key Laboratory of Stomatology510055GuangzhouChina Department of Anatomy and Cell Biology University of PennsylvaniaSchool of Dental MedicinePhiladelphiaPA19104USA Department of Orthodontics Peking University School&Hospital of Stomatology#22 Zhongguancun South AvenueBeijing100081China Department of Chemical and Biological Engineering Department of ChemistryThe Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Shenzhen institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen2001 Longxiang BoulevardLonggang DistrictShenzhen CityGuangdong518172China Key Laboratory of Stem Cells and Tissue Engineering(Sun Yat-Sen University) Ministry of EducationGuangzhouGuangdong510055China

Over 300 billion of cells die every day in the human body,producing a large number of endogenous apoptotic extracellular vesicles(apoEVs).Also,allogenic stem cell transplantation,a commonly used therapeutic approach in current clinical practice,generates exogenous *** is well known that phagocytic cells engulf and digest apoEVs to maintain the body’s *** this study,we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair ***,apoEVs activate the Wnt/β-catenin pathway to facilitate their metabolism in a wave-like *** migration of apoEVs is enhanced by treadmill exercise and inhibited by tail suspension,which is associated with the mechanical force-regulated expression of DKK1 in ***,we show that exogenous apoEVs promote wound healing and hair growth via activation of Wnt/β-catenin pathway in skin and hair follicle mesenchymal stem *** study reveals a previously unrecognized metabolic pathway of apoEVs and opens a new avenue for exploring apoEV-based therapy for skin and hair disorders.

关键词： Apoptosis Extracellular vesicle Metabolized regulator Integumentary system Mesenchymal stem cells

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Sensory innervation around immediately vs. delayed loaded implants: a pilot study

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International Journal of Oral Science 2015年第1期7卷 49-55页

作者： Yan Huang Jeroen van Dessel Wendy Martens Ivo Lambrichts Wei-Jian Zhong Guo-Wu Ma Dan Lin Xin Liang Reinhilde Jacobs Department of Imaging & Pathology Faculty of Medicine University of Leuven and Oral & Maxillo-facial Surgery University Hospitals Leuven State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Biomedical research institute Hasselt University School of stomatology Dalian Medical University center for Statistics Hasselt University

Although neurophysiological and psychophysical proof of osseoperception is accumulating, histomorphometric evidence for the neural mechanisms of functional compensation following immediate and delayed implant loading is still lacking. For this randomized split-mouth study, six mongrel dogs randomly received one of four treatment protocols at 36 implant-recipient sites over 16 weeks （third maxillary incisor, third and fourth mandibular premolar）： immediate implant placement and immediate loading （liP＋ IL）; delayed implant placement and delayed loading （DIP＋DL）; delayed implant placement and immediate loading （DIP＋IL）; and natural extraction socket healing （control）. Histomorphometry was performed in the peri-implant bone and soft tissues within 300 pm around the implants. Immunocytochemistry and transmission electron microscopy were used to confirm the presence of neural structures and to reveal their ultrastructural characteristics, respectively. Myelinated nerve fibres densely populated the peri-implant crestal gingival and apical regions, although they were also identified in the woven bone and in the osteons near the implant threads. Compared with the control group in the mandible, the group that received IIP＋IL showed a higher innervation （in ***^-2, 5.94±1.12 vs. 3.15±0.63, P〈0.001） and smaller fibre diameter （in pm, 1.37±0.05 vs. 1.64±0.13, P=0.016）, smaller axon diameter （in pm, 0.89±0.05 vs. 1.24±0,10, P=0.009） and g-ratio （0.64±0.04 vs. 0.76±0.05, P〈0.001） in the middle region around the implants. Compared with DIP＋IL in the mandible, IIP＋IL had a higher nerve density （in ***^-2, 13.23±2.54 vs. 9.64±1.86, P=0.027）, greater fibre diameter （in pm, 1.32±0.02 vs. 1.20±0.04, P=0.021）, greater axon diameter （in μm, 0.92±0.01 vs. 0.89±0.03, P=-0.035） and lower g-ratio （0.69±0.01 vs. 0.74±0.01, P=-0.033） in the apical region around the implants. It may be assumed that the treatment protocol with liP＋ IL is the preferred method to allow optimized peri-implant re-i

关键词： animal experiments dental implants histomorphometry immediate loading mechanoreceptor myelinated nerve fibres osseoperception

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Genetic Polymorphism and Relationship Analyses of Standard Poodle and Bichon Frise Groups Based on 19 Short Tandem Repeat Loci

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Journal of Forensic Science and Medicine 2023年第4期9卷 331-339,I0013-I0015页

作者： Shuyan Mei Jinlong Yang Jianping Li Xin Xiong Menglei Wang Zhichao Zhao Yuxin Guo Yajun Deng College of Basic Medicine and Forensic Medicine Henan University of Science and TechnologyHenanChina Guangzhou Key Laboratory of Forensic Multi‑Omics for Precision Identification School of Forensic MedicineSouthern Medical UniversityGuangzhouChina Beijing Zhongzheng DNA Evidence institute BeijingChina Key Laboratory of Shaanxi Province for craniofacial Precision Medicine research College of StomatologyXi’an Jiaotong UniversityXi’AnChina Clinical research center of Shaanxi Province for dental and Maxillofacial Diseases College of StomatologyXi’an Jiaotong UniversityXi’AnChina

Context:As the increasing number of pet canines,the identification of canine has attracted much attentions in the forensic field,however,the genetic diversities of pet canines still remained ***:To explore genetic polymorphisms of 19 short tandem repeat(STR)loci and genetic relationships between the two studied canine groups and reference *** and Methods:In the present study,genetic polymorphisms of 19 STR loci and a sex-linked zinc finger locus were analyzed in a total of 594 canines in Standard Poodle and Bichon Frise groups from ***:A total of 166,159 alleles were observed in the Standard Poodle,Bichon Frise groups with the corresponding allelic frequencies ranging from 0.0030-0.6108 to 0.0012-0.6148,*** combined discrimination power and probability of exclusion of 19 STR loci in Standard Poodle and Bichon Frise groups were 0.9999999999999497,0.999962884;and 0.99999999999999995,0.999965955,***,the genetic distances between the two canine groups and Labrador retriever group were calculated,and the results indicated that Standard Poodle and Bichon Frise groups showed a closer genetic relationship,while the two canine groups had distant genetic relationships with Labrador retriever *** result of population genetic structure revealed that genetic component distributions in the three canine groups were *** predicted accuracies of the constructed random forest prediction model for three validation sets(25%individuals randomly selected from three populations with 808 individuals)were higher than 0.9,especially for the individuals in validation set from the Bichon Frise group is ***:The 19 STR loci could be used for individual identification,canine breed identification and paternity testing in the two canine groups.

关键词： Short tandem repeat Standard Poodle Bichon Frise forensic parameter canine genetic polymorphism

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Recent advances in cell sheet technology for bone and cartilage regeneration: from preparation to application

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International Journal of Oral Science 2019年第2期11卷 90-102页

作者： Yuezhi Lu Wenjie Zhang Jie Wang Guangzheng Yang Shi Yin Tingting Tang Chunhua Yu Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of Stomatology & Shanghai Research Institute of StomatologyShanghaiChina Shanghai Key Laboratory of Orthopaedic implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Bone defects caused by trauma,tumour resection,infection and congenital deformities,together with articular cartilage defects and cartilage–subchondral bone complex defects caused by trauma and degenerative diseases,remain great challenges for *** strategies utilising cell sheet technology to enhance bone and cartilage regeneration are being *** cell sheet technology has shown great clinical potential in regenerative medicine due to its effective preservation of cell–cell connections and extracellular matrix and its scaffold-free *** review will first introduce several widely used cell sheet preparation systems,including traditional approaches and recent improvements,as well as their advantages and *** advances in utilising cell sheet technology to regenerate bone or cartilage defects and bone–cartilage complex defects will be *** key challenges and future research directions for the application of cell sheet technology in bone and cartilage regeneration will also be discussed.

关键词： cartilage regeneration preparation application

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Single-cell RNA-Seq reveals transcriptional regulatory networks directing the development of mouse maxillary prominence

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Journal of Genetics and Genomics 2023年第9期50卷 676-687页

作者： Jian Sun Yijun Lin Nayoung Ha Jianfei Zhang Weiqi Wang Xudong Wang Qian Bian Department of Oral and Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China National Clinical research center for Oral Diseases Shanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai 200011China Shanghai institute of Precision Medicine Shanghai 200125China Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghai 200025China

During vertebrate embryonic development,neural crest-derived ectomesenchyme within the maxillary prominences undergoes precisely coordinated proliferation and differentiation to give rise to diverse craniofacial structures,such as tooth and ***,the transcriptional regulatory networks underpinning such an intricate process have not been fully ***,we perform single-cell RNA-Seq to comprehensively characterize the transcriptional dynamics during mouse maxillary development from embryonic day(E)*** single-cell transcriptome atlas of~28,000 cells uncovers mesenchymal cell populations representing distinct differentiating states and reveals their developmental trajectory,suggesting that the segregation of dental from the palatal mesenchyme occurs at ***,we identify a series of key transcription factors(TFs)associated with mesenchymal fate transitions and deduce the gene regulatory networks directed by these ***,our study provides important resources and insights for achieving a systems-level understanding of craniofacial morphogenesis and abnormality.

关键词： craniofacial development Single-cell RNA-Seq Maxillary prominences Gene regulatory network Transcription factor

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Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

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International Journal of Oral Science 2017年第1期9卷 1-9页

作者： Yan Huang Michael M Bornstein Ivo Lambrichts Hai-Yang Yu Constantinus Politis Reinhilde Jacobs OMFS IMPATH research Group Department of Imaging and PathologyFaculty of MedicineKU Leuven and Oral and Maxillofacial SurgeryUniversity Hospitals Leuven State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan University Section of dental Radiology and stomatology Department of Oral Surgery and StomatologyUniversity of Bern Applied Oral Sciences Faculty of DentistryThe University of Hong KongPrince Philip Dental Hospital Group of Morphology Biomedical Research InstituteHasselt University

Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal rnechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma （PRP） therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and （pre-）clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of iniured peripheral nerves around dental implants is discussed.

关键词： neural regeneration osseoperception peripheral nerve degeneration peri-implant sensory feedback platelet-rich plasma

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Genetic distribution and forensic evaluation of multiplex autosomal short tandem repeats in the Chinese Xinjiang Mongolian group

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第3期20卷 287-293页

作者： Yuan-yuan WEI Xiao-ye JIN Qiong LAN Wei CUI Chong CHEN Ting-ting KONG Yu-xin GUO Jian-gang CHEN Bo-feng ZHU Key Laboratory of Shaanxi Province for craniofacial Precision Medicine research College of StomatologyXi’an Jiaotong UniversityXi’an 710004China Clinical research center of Shaanxi Province for dental and Maxillofacial Diseases College of StomatologyXi’an Jiaotong UniversityXi’an 710004China College of Medicine and Forensics Xi’an Jiaotong University Health Science CenterXi’an 710061China Department of Forensic Genetics School of Forensic MedicineSouthern Medical UniversityGuangzhou 510515China institute of Forensic Science Ministry of Public SecurityBeijing 100038China

To further enrich the genetic data of the Chinese Xinjiang Mongolian group,the genetic distribution and forensic parameters of 19 autosomal short tandem repeats(STRs)were ***,249 alleles were observed in these 19 *** mean values of the polymorphism information content(PIC),match probability(MP),discrimination power(DP),and probability of exclusion(PE)for these 19 STRs were 0.7775,0.0699,0.9301,and 0.6085,***,the cumulative DP and PE values obtained in the Mongolian group were 0.999 999 999 999 999 999 999 995 67 and 0.999 999 992 163,respectively.

关键词：新疆蒙古族短串联重复序列(STR) 法医学

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