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Establishing the vector-meson-exchange dominance for the short range interactions of light quarks

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 190-191页

作者： Bing-Song Zou Department of Physics Tsinghua UniversityBeijing100084China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing100190China School of Physics University of Chinese Academy of SciencesBeijing100049China southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou516000China

Understanding the interactions between constituent quarks is one of the fundamental and challenging problems in hadron *** present,the constituent quark models have achieved great success in describing the properties of hadrons,whereas some long-standing disputes remain,especially for the short range interactions between constituent *** exploring the dynamic mechanism between u/d quarks,it is found that the one gluon exchange and/or vector meson exchange induced interactions may dominate the short range interactions[1].

关键词： quark exchange meson

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Can Emax and platelet count truly differentiate between benign and malignant liver lesions?

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World Journal of Gastroenterology 2025年第3期31卷 120-122页

作者： Manjeet Kumar Goyal Omesh Goyal Department of Gastroenterology and Human Nutrition Unit All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Dayanand Medical College and HospitalLudhiana 141001PunjabIndia

This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet *** notable findings,significant methodological and interpretative limitations are *** study lacks detailed assay conditions for Emax measurement,employs inadequate statistical methods without robust multivariate analysis,and does not provide clinically relevant threshold *** nomogram's reliance on Emax as a major diagnostic contributor is questionable due to attenuation in hepatocellular carcinoma patients with ***,the study's limitations,such as selection bias and confounding factors,are not adequately *** research should adopt more rigorous methodologies,including prospective studies with larger cohorts and standardized protocols for biomarker measurement,to enhance validity and clinical applicability.

关键词： Emax Platelet count Benign liver lesions Malignant liver lesions Hepatocellular carcinoma Cirrhosis Diagnostic biomarkers Shear wave elastography Methodological limitations Clinical utility

The electromagnetic form factors and spin polarization of Λc+ in the process ■

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Chinese Physics C 2025年第02期 23-30页

作者：陈诚闫冰谢聚军 institute of Modern Physics Chinese Academy of Sciences School of Nuclear Sciences and Technology University of Chinese Academy of Sciences southern Center for Nuclear-Science Theory (SCNT) Institute of Modern PhysicsChinese Academy of Sciences

The total cross sections of the process ■ close to the threshold are calculated within the vector meson dominance *** is found that the theoretical results can describe the current experimental *** nontrivial near-threshold energy dependence of the total cross sections of the process ■ can be well reproduced by considering the contributions from charmonium-like states and the Coulomb *** particular,the results for the angular distribution parameters about the differential cross section are consistent with the experiments from the BESⅢ *** addition,the relative phase ΔΦ of the electromagnetic form factors is given,and the spin polarization of Λc+is predicted at center-mass energy 4.7 *** is hopeful that this work will provide a new perspective on the characteristics of the charmed baryon Λc+.

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG LUJI HUANG FU CHENG XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

Estimating Optimal Location of STATCOM and Minimization of Congestion Cost by Locational Marginal Price Using Flower Pollination and Particle Swarm Optimization Techniques

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Journal of Harbin institute of Technology(New Series) 2025年第1期32卷 67-75页

作者： Gagandeep Kaur Akhil Gupta Electrical Engineering Department M.R.Singh Punjab Technical UniversityBathinda 151001PunjabIndia Electrical Engineering Department I.K.Gujral Punjab Technical University Main CampusKapurthala 144603PunjabIndia

Restructuring of power market not only introduces competition but also brings complexity which increases overloading of Transmission Lines(TL).To obviate this complexity,this paper aims to mitigate the overloading and estimate the optimal location of Static Synchronous Compensator(STATCOM) by reducing congestion for a deregulated power *** proposed method is based on the use of Locational Marginal Price(LMP) difference technique and congestion *** are obtained as a by-product of Optimal Power Flow(OPF),whereas Congestion Cost(CC) is a function of difference in LMP and power *** effiectiveness of this approach is demonstrated by reducing the CC and solution space which can identify the TLs more suitable for placement of ***,total real power loss,reactive power loss and total CC are the three main objective functions in this optimization *** process is implemented by developing an IEEE-69 bus test system which verifies and validates the effectiveness of proposed optimization ***,a comparative analysis is enumerated by implementing two optimization techniques:Flower Pollination Algorithm(FPA) and Particle Swarm Optimization(PSO).The comparative analysis is sufficient to demonstrate the superiority of FPA technique over PSO technique in estimating an optimal placement of a *** results from the load-flow analysis illustrate the reduction in CC,total real and reactive power loss using FPA technique compared to PSO ***,satisfactory results are obtained without using complex calculations which verify the effectiveness of optimization techniques.

关键词： congestion management congestion cost optimal power particle swarm flower pollination optimization

New perspectives and prospects for the next generation of combination therapy in inflammatory bowel disease

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World Journal of Gastroenterology 2025年第5期31卷 124-128页

作者： Wen-Ting Xie Hui Yang Lan Bai Feng-Fei Wu Guangdong Provincial Key Laboratory of Gastroenterology Institute of Gastroenterology of Guangdong ProvinceDepartment of GastroenterologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

This article comments on the letter by Lowell et al,which addresses the next generation of combination therapy for inflammatory bowel disease(IBD).As the understanding of the pathogenesis of IBD continues to improve,treatment strategies are evolving *** letter examines the current status and future directions of combination therapy for IBD,focusing on approaches that combine biologics with immunomodulators and the emerging dual-biologic therapy(DBT).The traditional combination of biologics and immunomodulators has demonstra-ted preliminary efficacy by enhancing the effects of biologics through ***,concerns regarding long-term safety warrant careful *** trials,including DUET-Crohn's disease and DUET-ulcerative colitis,have shown promising potential for the broader adoption of ***,comprehensive data on efficacy and safety,as well as the effective integration of supportive treatments,remain essential to establish new paradigms for the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Dual-biologic therapy Supportive treatment The next generation of combination therapy

miR-2940-1 is involved in the circadian regulation of oviposition in Aedes albopictus

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Insect Science 2025年第1期32卷 69-79页

作者： Xiaolin Xiao Ling Kong Zhensheng Xie Hongkai Liu Lijun Cai Siyu Zhao Jiayong Zhou Shuang Liu Jing Wu Yiming Wu Peilin Wu Anthony A.James Xiao-Guang Chen Department of Pathogen Biology Institute of Tropical MedicineSchool of Public HealthSouthern Medical UniversityGuangzhouChina Department of Microbiology&Molecular Genetics University of CaliforniaIrvineCAUSA Department of Molecular Biology&Biochemistry University of CaliforniaIrvineCAUSA

The vast majority of all global species have circadian rhythm cycles that allow them to adapt to natural *** regular rhythms are regulated by core clock genes and recent studies have also implicated roles for microRNAs in this *** is an important circadian behavior in the reproductive cycle of insect vectors of diseases,and little is known about the rhythm or its regulation in *** albopictus is a diurnal mosquito that transmits arboviruses and is the major cause of outbreaks of dengue fever in *** analyzed the oviposition rhythm patterns of *** under different light/dark conditions and show that the mosquitoes have an oviposition peak between zeitgeber time 9(ZT 9)and ZT ***,the antagomir-mediated knockdown of expression of the microRNA miR-2940-1 affected the oviposition rhythm of *** data support the conclusion that miR-2940-1 is involved in the regulation of oviposition rhythm in *** and provide a foundation for using oviposition rhythms as a new target for vector mosquito control.

关键词： Aedes albopictus miR-2940-l oviposition rhythm regulation

New insights into the phylogeny and infrageneric taxonomy of Saussurea based on hybrid capture phylogenomics(Hyb-Seq)

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Plant Diversity 2025年第1期47卷 21-33页

作者： Liansheng Xu Zhuqiu Song Tian Li Zichao Jin Buyun Zhang Siyi Du Shuyuan Liao Xingjie Zhong Yousheng Chen Plant Science Research Center South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in southern China Guangzhou 510650China University of the Chinese Academy of Sciences Beijing 100049China Central-southern Safety and Environment Technology institute Co. LTDWuhan 430064China

Saussurea is one of the largest and most rapidly evolving genera within the Asteraceae,comprising approximately 520 species from the Northern Hemisphere.A comprehensive infrageneric classification,supported by robust phylogenetic trees and corroborated by morphological and other data,has not yet been *** the first time,we recovered a well-resolved nuclear phylogeny of Saussurea consisting of four main clades,which was also supported by morphological *** analyses show that ancient hybridization is the most likely source of deep cytoplasmic-nuclear conflict in Saussurea,and a phylogeny based on nuclear data is more suitable than one based on chloroplast data for exploring the infrageneric classification of *** on the nuclear phylogeny obtained and morphological characters,we proposed a revised infrageneric taxonomy of Saussurea,which includes four subgenera and 13 ***,1)***,***,***,and *** were moved from *** to ***,2)*** was moved from *** to ***,and 3)*** was moved from *** to ***.

关键词： Asteraceae Morphology Next-generation sequencing Phylogenomics Subgenus

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke