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Benzimidazole derivatives: search for GI-friendly anti-inflammatory analgesic agents

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Acta Pharmaceutica Sinica B 2015年第4期5卷 337-342页

作者： Monika Gaba Punam Gaba Deepika Uppal Neelima Dhingra Malkeet Singh Bahia Om Silakari Chander Mohan Department of Pharmaceutical Sciences ASBASJSM College of Pharmacy Research Scholar Punjab Technical University University institute of Pharmaceutical Sciences Panjab University Department of Pharmaceutical Sciences and Drug Research Punjabi University Rayat-Bahra institute of Pharmacy Hoshiarpur Affiliated to Punjab Technical University

Non-steroidal anti-inflammatory drugs(NSAIDs) have been successfully used for the alleviation of pain and inflammation in the past and continue to be used daily by millions of patients worldwide. However, gastrointestinal(GI) toxicity associated with NSAIDs is an important medical and socioeconomic problem. Local generation of various reactive oxygen species plays a significant role in the formation of gastric ulceration associated with NSAIDs therapy. Co-medication of antioxidants along with NSAIDs has been found to be beneficial in the prevention of GI injury. This paper describes the synthesis and biological evaluation of N-1-(phenylsulfonyl)-2-methylamino-substituted-1H-benzimidazole derivatives as anti-inflammatory analgesic agents with lower GI toxicity. Studies in vitro and in vivo demonstrated that the antioxidant activity of the test compounds decreased GI toxicity.

关键词： Benzimidazole Analgesic Gastrointestinal toxicity Antioxidant activity

Efficient Energy and Delay Reduction Model for Wireless Sensor Networks

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Computer Systems Science & Engineering 2023年第7期46卷 1153-1168页

作者： Arslan Iftikhar M.A.Elmagzoub Ansar Munir Hamad Abosaq Al Salem Mahmood ul Hassan Jarallah Alqahtani Asadullah Shaikh institute of southern punjab Multan60000Pakistan College of Computer Science and Information Systems Najran UniversityNajran61441Saudi Arabia Department of Computer Skills Deanship of Preparatory YearNajran UniversityNajran61441Saudi Arabia

In every network,delay and energy are crucial for communication and network *** wireless sensor networks,many tiny nodes create networks with high energy consumption and compute routes for better *** Sensor Networks(WSN)is a very complex scenario to compute minimal delay with data aggregation and energy *** this research,we compute minimal delay and energy efficiency for improving the quality of service of any *** proposed work is based on energy and distance parameters as taken dependent variables with data *** aggregation performs on different models,namely Hybrid-Low Energy Adaptive Clustering Hierarchy(H-LEACH),Low Energy Adaptive Clustering Hierarchy(LEACH),and Multi-Aggregator-based Multi-Cast(MAMC).The main contribution of this research is to a reduction in delay and optimized energy solution,a novel hybrid model design in this research that ensures the quality of service in *** model includes a whale optimization technique that involves heterogeneous functions and performs optimization to reach optimized *** cluster head selection,Stable Election Protocol(SEP)protocol is used and Power-Efficient Gathering in Sensor Information Systems(PEGASIS)is used for driven-path in *** results evaluate that H-LEACH provides minimal delay and energy consumption by sensor *** the comparison of existing theories and our proposed method,HLEACH is providing energy and delay reduction and improvement in quality of *** 2019 is used for simulation work.

关键词： Data aggregation wireless sensor network energy efficiency quality of services delay reduction

Information hiding with adaptive steganography based on novel fuzzy edge identification

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Defence Technology（防务技术） 2019年第2期15卷 162-169页

作者： Sanjeev Kumar Amarpal Singh Manoj Kumar I.K.G punjab Technical University Department of ECE Beant College of Engineering & Technology DAV institute of Engineering & Technology

The evolution in communication techniques has created wide threats for crucial information transfer through a communication channel. Covert communication with steganography is a skill of concealing secret information within cover object and hence shields the data theft over rapidly growing ***, diverse steganography techniques using edge identification have been proposed in *** methods however utilize certain pixels in the cover image for inserting edge information,resulting in significant deformation. The conventional edge detection method limits the deployment of edge detection in steganography as concealing the information would introduce some variations to the cover image. Hence inserting data in pixel areas recognized by existing conventional edge detection techniques like canny cannot ensure the recognition of the exact edge locations for the cover and stego images. In this paper, an Adaptive steganography method based on novel fuzzy edge identification is proposed. The method proposed is proficient of estimating the precise edge areas of a cover image and also ensures the exact edge location after embedding the secret message. Experimental results reveal that the technique has attained good imperceptibility compared to the Hayat AI-Dmour and Ahmed AIAni Edge XOR method in spatial domain.

关键词： Information security Adaptive steganography Fuzzy edge detection Pattern recognition

Cu/chiral phosphoric acid-catalyzed radical-initiated asymmetric aminosilylation of alkene with hydrosilane

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Science China Chemistry 2019年第11期62卷 1529-1536页

作者： Yang Zeng Xiao-Dong Liu Xian-Qi Guo Qiang-Shuai Gu Zhong-Liang Li Xiao-Yong Chang Xin-Yuan Liu Shenzhen Grubbs institute Southern University of Science and TechnologyShenzhen 518055China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055Chin

The catalytic radical-initiated asymmetric 1,2-aminosilylation of alkene with a hydrosilane under Cu(I)/CPA cooperative catalysis has been *** method features the use of hydrosilane as the reductive radical precursor,enabling efficient access to skeletally diverse silicon-containing azaheterocycles including pyrrolidine,indoline and isoindoline bearing anα-tertiary stereocenter with high *** key to the success includes the use of Cu(I)/CPA cooperative catalyst system and theβ-silicon effect of the silyl group to stabilize the in situ generated carbocation intermediate.

关键词： asymmetric radical chemistry aminosilylation alkenes Cu/chiral phosphoric acid silyl radical

A Longitudinal Survey for Genome-based Identification of SARS-CoV-2 in Sewage Water in Selected Lockdown Areas of Lahore City, Pakistan: A Potential Approach for Future Smart Lockdown Strategy

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Biomedical and Environmental Sciences 2021年第9期34卷 729-733页

作者： Tahir Yaqub Muhammad Nawaz Muhammad Z.Shabbir Muhammad A.Ali Imran Altaf Sohail Raza Muhammad A.B.Shabbir Muhammad A.Ashraf Syed Z.Aziz Sohai l Q.Cheema Muhammad B.Shah Saira Rafique Sohail Hassan Nageen Sardar Adnan Mehmood Muhammad W.Aziz Sehar Fazal Nadir Hussain Muhammad T.Khan Muhammad M.Atique Ali Asif Muhammad Anwar Nabeel A.Awan Muhammad U.Younis Muhammad A.Bhattee Zarfishan Tahir Nadia Mukhtar Huda Sarwar Maaz S.Rana Omair Farooq institute of Microbiology University of Veterinary and Animal SciencesLahorePakistan Water and Sanitation Agency LahorePunjabPakistan Specialized Healthcare&Medical Education Department PunjabPakistan Primary and Secondary Healthcare Department PunjabPakistan institute of Public Health LahorePakistan Farooq Hospital LahorePakistan

In 2019,the newly emerged SARS-CoV-2 virus caused pneumonia-like *** disease rapidly spread globally,leading to a worldwide outbreak referred to as the COVID-19 pandemic.

关键词： globally Strategy Smart

ηmesons in hot magnetized nuclear matter

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Chinese Physics C 2022年第2期46卷 160-177页

作者： Rajesh Kumar Arvind Kumar Department of Physics Dr.B R Ambedkar National Institute of Technology JalandharJalandhar-144011PunjabIndia

ηN interactions are investigated in hot magnetized asymmetric nuclear matter using the chiral SU(3)model and chiral perturbation theory(ChPT).In the chiral modcl,thc in-medium properties of η-mesons are calcu-lated using medium modified scalar densities under the influence of an extermal magnetic ***,in a com-bined chiral model and ChPT approach,off-shell contributions of the ηN interactions are evaluated from the ChPTeffective ηN Lagrangian,and the in-medium effect of scalar densities are incorporated from the chiral SU(3)*** find that the magnetic field has a significant effect on the in-medium mass and optical potential of η mesons,andwe observe a deeper mass-shift in the combined chiral model and ChPT approach than in the solo chiral SU(3)*** both approaches,no additional mass-shift is observed due to the uncharged nature of η mesons in the presenceof a magnetic field.

关键词： hadron physics ηinteractions in-medium mesons

D2 analysis for estimating genetic divergence in different clones of Dalbergia sissoo

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Journal of Forestry Research 2016年第5期27卷 1085-1097页

作者： Ashok Kumar S. Ravichandran Shivani Dobhal Vijay Kumar Forest Research institute (Indian Council of Forestry Research and Education) Dehradun India Directorate of Rice Research Rajendra Nagar HyderabadAndhra Pradesh India Research Circle Punjab Forest Department HoshiarpurPunjab India

Genetic divergence was studied in selected 36 genotypes of Dalbergia sissoo Roxb. on the basis of seven morphological parameters. The divergence among genotypes was estimated by Mahalanobis method and genotypes were grouped into clusters by Tocher＇s method. All the genotypes were classified into seven distinct clusters on the basis of seven morphological traits. Cluster 1 was the largest with 25 genotypes followed by Cluster 2 （four genotypes）. Cluster 3, 5, 6 and 7 were the divergent clusters. The D2 analysis revealed that D2 value （39.42） between clone 5040 and clone 201 was recorded maximum. The intra-cluster distance ranged from 0.00 （Cluster 3, 5, 6 and 7） to 3.89 （Cluster 1）, the Cluster 3 （clone 33） was the most divergent cluster with maximum inter cluster distance （13.97） with the Cluster 7. By the divergence analysis, the parents for hybridization from diverse clusters could be selected for heterotic hybrids.

关键词： Dalbergia sissoo Roxb. Genetic divergence Hybridization D2 analysis Heterotic

Impact of Salinity on Respiration and Organic Matter Dynamics in Soils is More Closely Related to Osmotic Potential than to Electrical Conductivity

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Pedosphere 2017年第5期27卷 949-956页

作者： Manpreet S.MAVI Petra MARSCHNER School of Agriculture Food and Wine The Waite Research Institute The University of Adelaide Department of Soil Science Punjab Agricultural University

Osmotic potential （OP） of soil solution may be a more appropriate parameter than electrical conductivity （EC） to evaluate the effect of salts on plant growth and soil biomass. However, this has not been examined in detail with respect to microbial activity and dissolved organic matter in soils with different texture. This study evaluated the effect of salinity and sodicity on respiration and dissolved organic matter dynamics in salt-affected soils with different texture. Four non-saline and non-sodic soils differing in texture （S-4, S-13, S-24 and S-40 with 4%, 13%, 24~ and 40~~ clay, respectively） were leached using combinations of 1 mol L-1 NaC1 and 1 mol L-1 CaC12 stock solutions, resulting in EC （1：5 soil：water ratio） between 0.4 and 5.0 dS m-1 with two levels of sodicity （sodium absorption ratio （SAR）〈 3 （non-sodic） and 20 （sodic）, 1：5 soil：water ratio）. Adjusting the water content to levels optimal for microbial activity~ which differed among the soils, resulted in four ranges of OP in all the soils： from -0.06 to -0.24 （controls, without salt added）, -0.55 to -0.92, -1.25 to -1.62 and -2.77 to -3.00 Mpa. Finely ground mature wheat straw （20 g kg-1） was added to stimulate microbial activity. At a given EC, cumulative soil respiration was lower in the lighter-textured soils （S-4 and S-13） than in the heavier-textured soils （S-24 and S-40）. Cumulative soil respiration decreased with decreasing OP to a similar extent in all the soils, with a greater decrease on Day 40 than on Day 10. Cumulative soil respiration was greater at SAR ---- 20 than at SAR 〈 3 only at the OP levels between -0.62 and -1.62 MPa on Day 40. In all the soils and at both sampling times, concentrations of dissolved organic C and N were higher at the lowest OP levels （from -2.74 to -3.0 MPa） than in the controls （from -0.06 to -0.24 MPa）. Thus, OP is a better parameter than EC to evaluate the effect of salinity on dissolved organic matter and microbial activity in different textured soils.

关键词： dissolved organic C dissolved organic N salt-affected soils sodium absorption ratio soil microbial activity soil texture

Investigation of performance and emission characteristics using ethanol-blended gasoline fuel as a flex-fuel in two-wheeler vehicle mounted on a chassis dynamometer

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Clean Energy 2024年第3期8卷 174-193页

作者： Sourabh Gupta Sumit Kanchan Rupinder Kaur Sarbjot Singh Sandhu School of Mechanical Engineering Lovely Professional UniversityPunjabIndia Division of Innovation and Entrepreneurship Lovely Professional UniversityPunjabIndia Department of Mechanical Engineering Dr BR Ambedkar National Institute of TechnologyJalandharIndia

This study investigated the performance and emissions of flex fuels in a 110-cc BS6-compliant fuel-injected two-wheeler without ethanol adaptation *** tests were carried out under controlled conditions on a chassis dynamometer at 1000,2000 and 3000 *** ethanol blends from 10%ethanol(E10)to 85%ethanol(E85).Parameters examined included brake power(BP)output,brake-specific fuel consumption(BSFC),peak in-cylinder pressure and exhaust ***,including carbon monoxide(CO),hydrocarbons(HC),nitrogen oxide(NOx)and unregulated emissions,were also *** the percentages of the ethanol blend increased from E10 to E85,there was a noticeable improvement in power *** 1000 r.p.m.,the BP ranged from 2.4 to 4.6 kW for different *** BSFC and the peak in-cylinder pressure followed a similar pattern,indicating enhanced performance and fuel efficiency with higher ethanol ***,using E85 at 1000 *** in a significant 41.08%reduction in exhaust temperature compared with E10,although this difference decreased with higher blend ***,replacing E10 with E85 at 1000 *** CO and HC emissions by 9.17%and 38.34%,*** contrast,NOx emissions increased at all *** with higher-ethanol blends,peaking at a 415 parts per million increase at 3000 ***,unregulated emissions decreased significantly with increased *** ethanol *** summary,the use of flex-fuel blends in a two-wheeler resulted in a modest increase in BP output,improved fuel efficiency and lower CO and HC *** findings are vital for optimizing ethanol blend utilization in two-wheeler engines under low-load conditions,considering both performance and environmental aspects.

关键词： flex fuel ethanol regulated emissions unregulated emissions chassis dynamometer performance characteristics