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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang Guo Di Lan Zirui Jia Zhenguo Gao Xuetao Shi Mukun He Hua Guo Guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

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“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： Yan Zhao Qiang Yuan Liting Yang Guisheng Liang Yifeng Cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

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Dynamic Adsorption of Toluene on Hierarchical Porous Carbons with Varying Pore Structure

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Journal of Wuhan University of Technology(Materials Science) 2021年第2期36卷 189-195页

作者： YAN Xi SINOPEC Research institute of safety engineering Qingdao 266071China

Hierarchical porous carbon material(MMC)was successfully fabricated via hard template synthesis method by carbonization of furfury alcohol within the template(MCM-41).The prepared MMC was studied with characterization methods including scanning electron microscopy(SEM),transmission electron microscopy(TEM),nitrogen adsorption-desorption analyses,and infrared spectral analysis(FTIR).To investigate kinetics of toluene adsorption of hierarchical porous carbon materials,the adsorption performances of these carbon samples with varying pore structure(MC-1,MMC,MMHPC)were analyzed via dynamic *** the Langmuir model and Freundlich equation were employed to correspond with adsorption isotherms to study the adsorption *** experimental results demonstrate that the Langmuir model is more appropriate to describe the adsorption *** capacities of toluene adsorption follow the order of MMCengineering application.

关键词： hierarchical porous carbon toluene adsorption pore structure

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Identification of abnormal conditions in high-dimensional chemical process based on feature selection and deep learning

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Chinese Journal of Chemical engineering 2020年第7期28卷 1875-1883页

作者： Wende Tian Zijian Liu Lening Li Shifa Zhang Chuankun Li College of Chemical engineering Qingdao University of Science&TechnologyQingdao 266042China qingdao NOVAN Electromechanical Technology Qingdao 266100China State Key Laboratory of safety and Control for Chemicals SINOPEC Qingdao Research Institute of Safety EngineeringQingdao 266071China

Identification of abnormal conditions is essential in the chemical *** the rapid development of artificial intelligence technology,deep learning has attracted a lot of attention as a promising fault identification method in chemical process *** the high-dimensional data identification using deep neural networks,problems such as insufficient data and missing data,measurement noise,redundant variables,and high coupling of data are often *** tackle these problems,a feature based deep belief networks(DBN)method is proposed in this ***,a generative adversarial network(GAN)is used to reconstruct the random and non-random missing data of chemical ***,the feature variables are selected by Spearman’s rank correlation coefficient(SRCC)from high-dimensional data to eliminate the noise and redundant variables and,as a consequence,compress data dimension of chemical ***,the feature filtered data is deeply abstracted,learned and tuned by DBN for multi-case fault *** application in the Tennessee Eastman(TE)process demonstrates the fast convergence and high accuracy of this proposal in identifying abnormal conditions for chemical process,compared with the traditional fault identification algorithms.

关键词： Chemical process Deep Belief Networks Fault identification Generative Adversarial Networks Spearman Rank Correlation

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Effect of ring baffle configuration in a self-priming venturi scrubber using CFD simulations

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Particuology 2019年第6期17卷 63-69页

作者： Shuai Yang Xiangdi Zhao Wanfu Sun Jiwu Yuan Zheng Wang State Key Laboratory of safety and Control for Chemicals SINOPEC Research Institute of Safety EngineeringQingdao 266071China

This study uses computational fluid dynamics to survey the gas‒liquid flow hydrodynamics of a self-priming venturi scrubber with and without ring *** on the simulation results,we explore how the structure and configuration parameters such as baffle height,opening-area ratio,and baffle thickness affect the injection flow rate and the homogeneity of the gas‒liquid *** addition,we report the best structure and configuration parameters for the ring *** best position for the ring baffle is at nearly 7/16 of the length of the diffuser above the *** the baffle too near the throat causes large pressure loss,decreasing the injection flow *** decrease in opening-area ratio leads to a lower injection flow rate and a more homogeneous gas‒liquid *** optimal value depends on the requirement of the injection flow *** the baffle thickness,5 mm is recommended;an overly thick baffle decreases the homogeneity of the gas‒liquid mixture near the *** structure parameters and configuration parameters must satisfy the requirement imposed by the injection flow rate and scrubbing efficiency.

关键词： Self-priming mode Venturi scrubber Computational fluid dynamics Injection flow rate Mixing degree Scrubbing efficiency

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Effect of thermodynamic parameters on prediction of phase behavior and process design of extractive distillation

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Chinese Journal of Chemical engineering 2018年第5期26卷 993-1002页

作者： HuiJia Huixin Wang Kang Ma Mengxiao Yu Zhaoyou Zhu Yinglong Wang College of Chemical engineering qingdao University of Science and Technology Qingdao 266042 China National Registration Center for Chemicals SINOPEC Research Institute of Safety Engineering Qingdao 266071 China

Extractive distillation was investigated for separation of the minimum azeotrope of n-propanol/water, via the Aspen Plus simulation platform. Experimental data of n-propanol/water, which could pass the thermodynamic consistency test, were regressed to get suitable binary interaction parameters(BIPs) by the UNIQUAC thermodynamic model. The azeotrope system was heterogeneous in the simulation with built-in BIPs, which was contrary to the experimental data. The study focused on the effect of thermodynamic parameters on the prediction of phase behavior, and process design of extractive distillation. N-methyl-2-pyrrolidone(NMP) and ethylene glycol were used as solvents to implement the separation. Processes with built-in and regressed BIPs were explored,based on the minimum total annual cost(TAC). There were significant differences in the phase behavior simulation using different thermodynamic parameters, which showed the importance of BIPs in the design and optimization of extractive distillation.

关键词： Extractive distillation Thermodynamic parameters Phase behavior UNIQUAC TAC

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Theoretical insights into the degradation mechanisms, kinetics and eco-toxicity of oxcarbazepine initiated by OH radicals in aqueous environments

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Journal of Environmental Sciences 2023年第7期129卷 189-201页

作者： Yanhui Sun Ming Li Mohammad Hassan Hadizadeh Lin Liu Fei Xu College of Environment and safety engineering Qingdao University of Science and TechnologyQingdao 266042China Environment Research institute Shandong UniversityQingdao 266237China

As an anticonvulsant,oxcarbazepine(OXC)has attracted considerable attention for its potential threat to aquatic *** functional theory has been used to study the mechanisms and kinetics of OXC degradation initiated by OH radicals in aqueous environment.A total of fourteen OH-addition pathways were investigated,and the addition to the C8 position of the right benzene ringwas themost vulnerable pathway,resulting in the intermediate *** H-abstraction reactions initiated by OH radicalswere also explored,where the extraction site of the methylene group(C14)on the seven-member carbon heterocyclic ring was found to be the optimal *** calculations show that the total rate constant of OXC with OH radicals is 9.47×10^(9)(mol/L)^(−1)sec^(−1),and the half-life time is 7.32 s at 298 K with the[·OH]of 10^(−11) mol/***,the branch ratio values revealed that OH-addition(89.58%)shows more advantageous than H-abstraction(10.42%).To further understand the potential eco-toxicity of OXC and its transformation products to aquatic organisms,acute toxicity and chronic toxicity were evaluated using ECOSAR *** toxicity assessment revealed that most degradation products such as OXC-2OH,OXC-4OH,OXC-1O-1OOH,and OXC-1OH’are innoxious to fish and ***,green algae are more sensitive to these *** study can provide an extensive investigation into the degradation of OXC by OH radicals and enrich the understanding of the aquatic oxidation processes of pharmaceuticals and personal care products(PPCPs).

关键词： Oxcarbazepine OH radicals Degradation mechanisms Kinetic calculation Eco-toxicity evaluation

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Advances of Metal-Organic Frameworks in Energy and Environmental Applications

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Chinese Journal of Chemistry 2017年第10期35卷 1501-1511页

作者： Ying Li Bing Zou Anshan Xiao Hongxing Zhang State Key Laboratory of safety and Control for Chemicals SINOPEC Safety Engineering Institute Qingdao Shandong 266071 China

Nowadays, energy shortage and environmental pollution issues are increasingly severe and urgent to be solved. The effective storage and use of environmentally friendly fuels and removal of harmful gases from the environment are great challenges and of great importance both for the environment protection and for human health. Porous met- al-organic frameworks （MOFs） are highly ordered crystalline materials formed by the self-assembly process of metal ions and organic ligands. Their good features such as ultrahigh porosity, large surface area, structural diversity and functionalities make them promising candidates for applications in energy and environmental fields. MOF thin films and MOF composites have also been investigated to further enhance the properties and introduce new func- tionalities. This review provides an overview of the synthesis methods of pristine MOFs, MOF thin films and MOF composites, and significant advances of MOFs in energy and environment applications such as energy storage （H2, CH4）, CO2 capture and separation, adsorption removal and sensing of harmful gases in the environment.

关键词： metal-organic frameworks energy storage C02 capture adsorption removal sensing

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Research on thermal risk and decomposition behavior of methyl nitrite

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Chinese Journal of Chemical engineering 2020年第8期28卷 2131-2136页

作者： Haoyu Zhai Shaomeng Wang Diankun Chen Xuanying Cheng Chuanxin Xie College of Environment and safety engineering Qingdao University of Science and TechnologyQingdao 266042China

The thermal hazards of methyl nitrite(MN)were investigated in the present *** determination and evaluation of MN decomposition were conducted using a C600 micro *** thermal runaway reaction characteristics of the compound under different initial pressures were obtained using a VSP2 *** kinetic parameters of MN were obtained by regression fitting and calculation of the microthermal experimental *** experimental and calculated results demonstrated that the potential explosion risk of MN is very *** addition,there was a high energy barrier in the early stage of the uncontrolled decomposition of MN;however,once the decomposition reaction was initiated,the subsequent decomposition was easily *** the conditions of adiabatic simulation,the possibility that the reaction was uncontrolled increases with the initial temperature and pressure of the system,and there is a great potential safety risk.

关键词： Methyl nitrite Process safety Thermal risk

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