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In vivo femtosecond laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi

Microsystems & Nanoengineering 2024年第2期10卷 251-267页

作者： Tanja Pajić Katarina Stevanović Nataša V.Todorović Aleksandar J.Krmpot Miroslav Živić Svetlana Savić-Šević Steva M.Lević Marina Stanić Dejan Pantelić Brana Jelenković Mihailo D.Rabasović institute of Physiology and Biochemistry“Ivan Djaja” Faculty of BiologyUniversity of BelgradeStudentski trg 1611158BelgradeSerbia institute for Biological Research“Siniša Stanković” University of BelgradeNational Institute of the Republic of SerbiaBulevar Despota Stefana 14211000BelgradeSerbia institute of Physics Belgrade University of BelgradeNational Institute of the Republic of SerbiaPregrevica 11811080BelgradeSerbia University of Belgrade Faculty of AgricultureNemanjina Street 611080BelgradeSerbia institute for Multidisciplinary Research University of BelgradeKneza Višeslava 111030BelgradeSerbia

Studying the membrane physiology of filamentous fungi is key to understanding their interactions with the environment and crucial for developing new therapeutic strategies for disease-causing ***,their plasma membrane has been inaccessible for a micron-sized patch-clamp pipette for pA current recordings due to the rigid chitinous cell ***,we report the first femtosecond IR laser nanosurgery of the cell wall of the filamentous fungi,which enabled patch-clamp measurements on protoplasts released from hyphae.A reproducible and highly precise(diffraction-limited,submicron resolution)method for obtaining viable released protoplasts was *** release from the nanosurgery-generated incisions in the cell wall was achieved from different regions of the *** plasma membrane of the obtained protoplasts formed tight and high-resistance(GΩ)contacts with the recording *** entire nanosurgical procedure followed by the patch-clamp technique could be completed in less than 1 *** to previous studies using heterologously expressed channels,this technique provides the opportunity to identify new ionic currents and to study the properties of the ion channels in the protoplasts of filamentous fungi in their native environment.

关键词： patch recording laser

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Selenium,Type-2 Diabetes,and the Possible Protective Role of Vitamin D

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Biomedical and Environmental Sciences 2024年第6期37卷 661-665页

作者： Runxue Ma Ce Liu Ling Zhang Jingzhe Guo Erkai Zhou Ling Zheng Li He Xiaobing Shan Yunhui Yu Bin Luo institute of Occupational health and Environmental health School of Public HealthLanzhou UniversityLanzhou 730000GansuChina

Diabetes is a pervasive and serious global health *** to the International Diabetes Federation report,463 million adults worldwide were living with diabetes in 2019,and this number is projected to reach 700 million in... 详细信息

关键词： Diabetes Selenium Vitamin

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Physiological strategies in wild rodents:immune defenses of commensal rats

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Integrative Zoology 2024年第3期19卷 350-370页

作者： Ivana MIRKOV Dina TUCOVIC Jelena KULAS Anastasija MALESEVIC Dragan KATARANOVSKI Milena KATARANOVSKI Aleksandra POPOV ALEKSANDROV Immunotoxicology Group Department of EcologyInstitute for Biological Research“Sinisa Stankovic”—National Institute of Republic of SerbiaUniversity of BelgradeBelgradeSerbia

The importance of issues associated with urban/commensal rats and mice(property damage,management costs,and health risks)press upon research on these *** the demography of commensal rodents is mostly studied,the need for understanding factors influencing their natural morbidity/mortality is also *** this respect,more attention is expected to be paid to immunity,the physiological mechanism of defense against host survival threats(pathogens,parasites,diseases).Commensal rats and mice carry numerous pathogens that evoke diverse immune *** state of immunity in commensal house mice is studied in great detail,owing to the use of laboratory strains in biomedical *** commensal rats are,compared to mice,carriers of more zoonotic agents,rats’immunity is studied mainly in that *** of these zoonotic agents cause chronic,asymptomatic infections,which justified studies of immunological mechanisms of pathogen tolerance versus clearance regulation in *** of some infections in specific tissues/organs pressed upon analysis of local/regional immune responses and/or immunopathology.A survey of immunological activity/responses in commensal rats is given in this review,with mention of existing data in commensal *** should throw some light on the factors relevant to their morbidity and lifespan,supplementing the knowledge of commensal rodent ecology.

关键词： commensal rats and mice immunopathology infection inflammation tolerance

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Splenic hamartomas in children

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World Journal of Clinical Cases 2024年第11期12卷 1909-1917页

作者： Maja Milickovic Petar Rasic Sofija Cvejic Dejana Bozic Djordje Savic Tanja Mijovic Sava Cvetinovic Slavisa M Djuricic Department of Abdominal Surgery Mother and Child Health Care Institute of Serbia"Dr.Vukan Cupic"Belgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia Department of Radiology The Children’s University HospitalBelgrade 11000Serbia Department of Clinical Pathology Mother and Child Health Care Institute of Serbia"Dr.Vukan Cupic"Belgrade 11000Serbia Faculty of Medicine University of Banja LukaBanja Luka 78000Bosnia and Herzegovina

Splenic hamartomas(SHs)are uncommon,benign vascular lesions of unclear etiology and are mostly found incidentally on abdominal images,at surgery,or at *** the first case description,in 1861,less than 50 pediatric SH cases have been reported in the *** this article,we have performed an analysis of all SH cases in children published in the literature to date and presented our case of an 8-year-old male with *** lesions in children were shown to cause symptoms more often than in the adult *** observed SH sizes in children ranged from a few millimeters to 18 cm,and the symptomatic lesions were mostly larger or *** most common clinical finding was *** of hypersplenism were present in children with a single SH larger than 4.5 cm(diameter range:4.5-18.0 cm)and in those with multiple hamartomas,ranging from a few millimeters to 5 *** percent of patients with available laboratory findings had hematological abnormalities such as anemia,thrombocytopenia,or *** symptoms and signs included abdominal pain,recurrent infections,fever,night sweats,lethargy,growth retardation,and weight *** use of multiple imaging modalities may suggest the preoperative diagnosis of a splenic mass in children and determine the therapeutic ***,the final diagnosis of SH relies on histopathological ***,including total or partial splenectomy(PS),is the mainstay of SH *** M et *** in children WJCC https://*** 1910 April 16,2024 Volume 12 Issue 11 Although total splenectomy carries a greater risk of overwhelming post-splenectomy infection than PS it has remained the most performed surgical procedure in children with *** the majority of pediatric patients with symptomatic SH,resolution of symptoms and resolution or improvement of cytopenias occurred after surgical treatment.

关键词： Splenic hamartoma Pediatric Splenoma Clinical features Radiological features Histopathology Treatment

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A Prospective Cohort Study of Antimony Exposure and Cognitive Impairment in Older Adults—China,2017–2021

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China CDC weekly 2024年第23期6卷 537-541,I0001-I0007页

作者： Yidan Qiu Saisai Ji Chen Chen Jinhui Zhou Jun Wang Bing Wu Yuan Wei Fangyu Li Xulin Zheng Lanjing Xu Zheng Zhang Feng Zhao Guangdi Chen John SJi Yuebin Lyu Shilu Tong Xiaoming Shi Department of Big Data in health Science School of Public HealthZhejiang UniversityHangzhou CityZhejiang ProvinceChina China CDC Key Laboratory of Environment and Population health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Center for Global health School of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Epidemiology and Biostatistics School of Public HealthJilin UniversityChangchun CityJilin ProvinceChina School of public health China Medical UniversityShenyang CityLiaoning ProvinceChina institute of Environmental health School of Public Healthand Bioelectromagnetics LaboratorySchool of MedicineZhejiang UniversityHangzhou CityZhejiang ProvinceChina Environmental Research Center Duke Kunshan UniversityKunshan CityJiangsu ProvinceChina Nicholas School of the Environment Duke UniversityDurhamNCUSA School of public health Institute of Environment and Population HealthAnhui Medical UniversityHefei CityAnhui ProvinceChina School of public health and Social Work Queensland University of TechnologyBrisbaneAustralia

What is already known about this topic?Antimony(Sb)has been identified as a new neurotoxicant that impacts neurological functions in animal ***,its effects on the human population remain *** is added by this report?The study reveals that there is an association between exposure to Sb and a higher incidence of cognitive impairment in older *** dose-response curve demonstrates that the risk of cognitive impairment consistently increased with higher levels of Sb exposure without a discernible *** are the implications for public health practice?Reducing exposure to Sb may have a beneficial effect in delaying or preventing the onset of cognitive *** intervention has the potential to significantly decrease the disease burden associated with cognitive impairment,ultimately contributing to social development.

关键词： Antimony development. exposure

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Construction of Prediction Model of Foodborne Disease Outbreaks and Its Trend Prediction—Guizhou Province,China,2023-2025

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China CDC weekly 2024年第18期6卷 408-408,I0009,409-412,I0010-I0015页

作者： Li Zhang Sufang Xiong Shu Zhu Jigui Tian Qingyuan Chen Xiaobo Luo Hua Guo institute of public health Surveillance and Evaluation Guizhou Center for Disease Control and PreventionGuiyang CityGuizhou ProvinceChina School of public health Guizhou Medical University.Guiyang CityGuizhou ProvinceChina

Objective:Foodborne diseases pose a significant public health concern *** study aims to analyze the correlation between disease prevalence and climatic conditions,forecast the pattern of foodborne disease outbreaks,and offer insights for effective prevention and control strategies and optimizing health resource allocation policies in Guizhou ***:This study utilized theχ^(2) test and four comprehensive prediction models to analyze foodborne disease outbreaks recorded in the Guizhou Foodborne Disease Outbreak system between 2012 and *** best-performing model was chosen to forecast the trend of foodborne disease outbreaks in Guizhou Province,***:Significant variations were observed in the incidence of foodborne disease outbreaks in Guizhou Province concerning various meteorological factors(all P≤0.05).Among all models,the SARIMA-ARIMAX combined model demonstrated the most accurate predictive performance(RMSE:Prophet model=67.645,SARIMA model=3.953,ARIMAX model=26.544,SARIMA-ARIMAX model=26.196;MAPE:Prophet model=42.357%,SARIMA model=37.740%,ARIMAX model=15.289%,SARIMA-ARIMAX model=13.961%).Conclusion:The analysis indicates that foodborne disease outbreaks in Guizhou Province demonstrate distinct seasonal *** is recommended to concentrate prevention efforts during peak *** SARIMA-ARIMAX hybrid model enhances the precision of monthly forecasts for foodborne disease outbreaks,offering valuable insights for future prevention and control strategies.

关键词： Guizhou prevention offering

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Higher intakes of lysine,threonine and valine are inversely associated with non-alcoholic fatty liver disease risk:a community-based case-control study in the Chinese elderly

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Food Science and Human Wellness 2024年第1期13卷 191-197页

作者： Xueqi Li Wenjun Ma Ting Yang Chong Wang Wei Zhang Hui Li Ting Zhao Xiaofei Guo institute of Nutrition&health School of Public HealthQingdao UniversityQingdao 260071China Affiliated Hospital of Qingdao University Qingdao 260071China

The associations of individual amino acid with non-alcoholic fatty liver disease(NAFLD)risk remained *** present study aimed to investigate the associations between the two in the Chinese ***:A community-based health check-up program was conducted in Qingdao,*** was diagnosed by ultrasonography accompanied by epidemiological *** dietary intakes of amino acids were investigated with 3-day,24-h dietary records and calculated by Nutrition Calculator *** cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD ***:400 NAFLD subjects were identified,and 400 participants were randomly selected as controls and matched by gender and age(±3 years)Dose-response analysis showed that 1000 mg increment of aromatic amino acids(AAAs)was associated with reduced 16%risk of *** increments of 750 mg/d threonine,950 mg/d valine,or 1700 mg/d lysine were associated with a 20%reduction in the NAFLD risk(all P for linearity<0.05).Conclusion:The present study demonstrated that the dietary increases in milk,eggs and deep-sea fish,which are rich in the amino acids,might contribute to protecting against NAFLD in the elderly.

关键词： Amino acid Non-alcoholic fatty liver disease Senior citizen Dose-response analysis

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Impact of Microstructural and Surface Modifications on the Ti-45Nb Alloy’s Response to Bio-Environment

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1215-1230页

作者： Ivana Cvijović-Alagić Slađana Laketić MilošMomčilović Jovan Ciganović Jelena Bajat Vesna Kojić Vinča institute of Nuclear Sciences-National institute of the Republic of serbia University of BelgradeMike Petrovića Alasa 12-1411000BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411000BelgradeSerbia Oncology institute of Vojvodina Faculty of MedicineUniversity of Novi SadPut Doktora Goldmana 4Sremska Kamenica21204Sremska KamenicaSerbia

The Ti-45Nb (mass%) alloy’s corrosive and biocompatible response in simulated physiological conditions was investigated before and after its additional high-pressure torsion (HPT) and laser irradiation processing. The grain size reduction from 2.76 µm to ~ 200 nm and the appearance of laser-induced morphologically altered and highly oxidized surface led to the significant improvement of alloy corrosion resistance and cell–implant interaction. Moreover, an additional increase of the laser pulse energy from 5 to 15 mJ during the alloy irradiation in the air led to an increase in the surface oxygen content from 13.64 to 23.89% accompanied by an increase of excellent cell viability from 127.18 to 134.42%. As a result of the controlled alloy microstructural and surface modifications, the formation of protective bi-modal mixed Ti- and Nb-oxide external scale was enabled. The presence of this surface oxide scale enhanced the alloy’s resistance to corrosion deterioration and simultaneously boosted cell viability and proliferation.

关键词： Ti-45Nb alloy High-pressure torsion Laser surface scanning Corrosion resistance Biocompatible properties

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The effect of reactive plasticizer on viscoelastic and mechanical properties of solid rocket propellants based on different types of HTPB resin

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Defence Technology（防务技术） 2024年第3期33卷 66-77页

作者： Tihomir Kovacevic Slavko Mijatov Jelena Grzetic Suzana Cakic Bojana Fidanovski Sasa Brzic Military Technical institute Ministry of DefenceRatka Resanovica 1BelgradeSerbia Faculty of Technology University of NisBulevar osloboCenja 124LeskovacSerbia

Conventional plasticizers deteriorate mechanical and viscoelastic properties of the propellants due to their migration upon aging and long-term storage,which affects reliability and safety properties during *** address this issue,conventional plasticizer,dioctyl adipate(DOA),is replaced by reactive one,castor oil(CO).In addition,three different types of HTPB were used to obtain propellants with designed viscoelastic and mechanical *** CO increased propellants viscosity,without a significant impact on the propellant processability,regardless to the type of ***,mechanical properties were different depending on the type of resin,which were further analyzed by gel permeation chromatography(GPC).Addition of CO formed a denser polymer network and shifted T_(g) to higher values,compared to the compositions with *** tensile strength of CO-containing propellants was lower at +20℃ and +50℃ compared to the reference compositions,while the strain at maximum load and strain at break were significantly increased with pronounced plastic deformation,especially for samples at -30℃.The inclusion of CO in the propellants composition gives more room for adjusting a wide range of mechanical properties.

关键词： HTPB-based composite propellants Castor oil Reactive plasticizer Gel permeation chromatography Sol-gel analysis Mechanical and viscoelastic properties

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B7 homolog 3 in pancreatic cancer

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World Journal of Gastroenterology 2024年第31期30卷 3654-3667页

作者： Dijana Perovic Marija Dusanovic Pjevic Vladimir Perovic Milka Grk Milica Rasic Maja Milickovic Tanja Mijovic Petar Rasic institute of Human Genetics Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia institute of Microbiology and Immunology Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Department of Abdominal Surgery Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”Belgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia

Despite advances in cancer treatment,pancreatic cancer(PC)remains a disease with high mortality rates and poor survival *** B7 homolog 3(B7-H3)checkpoint molecule is overexpressed among many malignant tumors,including PC,with low or absent expression in healthy *** modulating various immunological and nonimmunological molecular mechanisms,B7-H3 may influence the progression of ***,the impact of B7-H3 on the survival of patients with PC remains a subject of ***,most available scientific data recognize this molecule as a suppressive factor to antitumor immunity in ***,it has been demonstrated that B7-H3 stimulates the migration,invasion,and metastasis of PC cells,and enhances resistance to *** preclinical models of PC,B7-H3-targeting monoclonal antibodies have exerted profound antitumor effects by increasing natural killer cell-mediated antibodydependent cellular cytotoxicity and delivering radioisotopes and cytotoxic drugs to the tumor ***,PC treatment with B7-H3-targeting antibody-drug conjugates and chimeric antigen receptor T cells is being tested in clinical *** review provides a comprehensive analysis of all PC-related studies in the context of B7-H3 and points to deficiencies in the current data that should be overcome by future research.

关键词： B7 homolog 3 Pancreatic cancer Prognosis Signaling pathways Immunotherapy

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