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MiR-106a targets ATG7 to inhibit autophagy and angiogenesis after myocardial infarction

Animal Models and Experimental Medicine 2024年第4期7卷 408-418页

作者： Guofeng Bai Jinghao Yang Weili Liao Xiaofeng Zhou Yingting He Nian Li Liuhong Zhang Yifei Wang Xiaoli Dong Hao Zhang Jinchun Pan Liangxue Lai Xiaolong Yuan Xilong Wang Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring InstituteGuangzhouChina Guangdong Laboratory of Lingnan Modern Agriculture National Engineering Research Center for Breeding Swine IndustryState Key Laboratory of Swine and Poultry Breeding IndustryGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular BreedingCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouGuangdongChina Huidong County Animal quarantine and inspection institute HuizhouGuangdongChina Department of Cardiology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHainan Clinical Medicine Research InstitutionHaikouPeople's Republic of China Key Laboratory of Regenerative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouGuangdongChina

Background:Myocardial infarction(MI)is an acute condition in which the heart mus-cle dies due to the lack of blood *** research has suggested that au-tophagy and angiogenesis play vital roles in the prevention of heart failure after MI,and miR-106a is considered to be an important regulatory factor in *** the specific mechanism remains *** this study,using cultured venous endothelial cells and a rat model of MI,we aimed to identify the potential target genes of miR-106a and discover the mechanisms of inhibiting autophagy and ***:We first explored the biological functions of miR-106a on autophagy and angiogenesis on endothelial *** we identified ATG7,which was the down-stream target gene of *** expression of miR-106a and ATG7 was investi-gated in the rat model of ***:We found that miR-106a inhibits the proliferation,cell cycle,autophagy and angiogenesis,but promoted the apoptosis of vein endothelial ***,ATG7 was identified as the target of miR-106a,and ATG7 rescued the inhibition of autophagy and angiogenesis by *** expression of miR-106a in the rat model of MI was decreased but the expression of ATG7 was increased in the infarction ***:Our results indicate that miR-106a may inhibit autophagy and angiogenesis by targeting *** mechanism may be a potential therapeutic treatment for MI.

关键词： angiogenesis ATG7 autophagy miR-106a miRNAs myocardial infarction

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Self-Aggregation Enhanced Third-Order Optical Nonlinearities of Aryloxy Substituted Zinc Phthalocyanines

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Chinese Physics Letters 2013年第12期30卷 42-45页

作者： LI Zhong-Yu WU Chun-Hui HUANG Xin XU Song Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology Department of Petrochemical EngineeringChangzhou UniversityChangzhou 213164 institute of Animal and plant quarantine of Chinese Academy of inspection and quarantine Beijing 100029

Third-order optical nonlinearities of three aryloxy substituted phthalocyanines are measured by femtosecond forward degenerate four-wave mixing technique at 800 *** optical responses are observed and the magnitude of the second-order hyperpolarizabilitiesγof the phthalocyanines is measured to be as large as 10?31 *** to the enhancement of J-aggregates,theγvalue of an aryloxy substituted zinc phthalocyanine in chloroform is approximately 2.2 times larger than that of the dye in ***,the morphologies of aryloxy substituted zinc phthalocyanine in chloroform exhibit that the nanowires with a diameter of 50–100 nm are connected to each other to form an indefinite network structure,while no aggregates are detected when the samples are prepared from a solution in the methanol.

关键词： phthalocyanine substituted methanol

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Determine the position of nanoparticles in cells by using surfaceenhanced Raman three-dimensional imaging

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Nano Research 2021年第10期14卷 3402-3406页

作者： Wei Liu Wentao Li Yahui Li Junfang Li Hua Bai Mingqiang Zou Guangcheng Xi institute of Industrial and Consumer Product Safety Chinese Academy of Inspection and QuarantineBeijing 100176China

The development of efficient three-dimensional cell imaging technology is a necessary means to study cell composition and structure,especially to track and monitor the phagocytosis process of nanoparticles by ***,we prepared a MoO_(2)hollow nanosphere with a strong surface plasmon resonance effect in the visible light region,which exhibited an excellent surface enhanced Raman scattering *** the 4-mercaptobenzoic acid(4-MBA)molecules are modified,it can be efficiently used as Raman probe molecules to perform clear three-dimensional cell *** matter when the nanoparticles are located inside the cell,outside the cell or partly inside the cell,they all can be clearly presented by this enhanced Raman probe *** results provide a rapid and accurate method for three-dimensional imaging of cells,especially for tracking the phagocytosis of nanoparticles.

关键词： cell imaging surface enhanced Raman spectroscopy(SERS) MoO_(2) three-dimensional imaging hollow nanospheres

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Dynamic behavior of stormwater quality parameters in South Texas

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Frontiers of Environmental Science & Engineering 2012年第6期6卷 825-830页

作者： Xubin PAN Jingyi ZHANG Wei-Ta FANG Kim D.JONES institute of plant quarantine Chinese Academy of Inspection and QuarantineBeijing 100029China Department of Environmental Engineering Texas A&M University-KingsvilleKingsvilleTX 78363USA Graduate institute of Environmental Education Taiwan Normal UniversityTaipei 116China

To control water impairment in urban storm- water, it is important to evaluate changing patterns of water quality parameters in stormwater runoff. Thus, the authors performed a series of experiments to investigate the dynamics of common water parameters during storm events in semi-arid areas, with multiple samples collected and analyzed in field stormwater applications. At this field monitoring site within McAuliffe Park, McAllen, Texas, in the United States, a storm event increased the concentra- tions of Escherichia coli （E. coli）, but this event represented a decreasing trend over the entire event period. Besides, peak intensity of different pollutants in the stormwater runoff occurred at different times other than at any peak flows, representing a complexity of the temporal and spatial measurements. Multi-sample per- event approaches recommended based on the complexity of the hydrograph and different peak intensity times of pollutants. In addition, high bacteria and total suspended solids （TSS） concentrations in the initial stage of the storm event should be considered when designing Best Manage- ment Practices （BMPs） and Low Impact Developments （LIDs）. New strategies and solutions for addressing ecohydrological challenges should be proposed to avoid collateral damages to their both common wealth in ecosystems and human well-beings.

关键词： event mean concentration first flush multi-sample per event ecohydrology

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Evaluation of genetically modified rice detection methods 2011/884/EU and 2008/289/EC proposed by the European Union

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Journal of Integrative Agriculture 2016年第12期15卷 2899-2910页

作者： XIAO Qi-sheng XU Wen-tao YANG Jie-lin PAN Liang-wen Technical Center for Animal Plant and Food Inspection and QuarantineShanghai Entry and Exit Inspection and Quarantine Bureau College of Food Science & Technology Shanghai Ocean University Beijing Laboratory for Food Quality and Safety/College of Food Science and Nutritional Engineering China Agricultural University

Increases in the number of cases of identified genetically modified （GM） rice contamination can be traced back to the first Rapid Alert System for Food and Feed （RASFF） in 2006. In response to the lack of reliable detection methods, Decision 2011/884/EU proposed that new screening methods replace Decision 2008/289/EC, to identify all possible GM rice products originating in China. However, the synergy brands （SYBR） Green real-time PCR assay proposed by Decision 2011/884/EU has been shown to lack conformity with other TaqMan methods currently in use. To evaluate the specificity and repeatability of the methods recommended in Decision 2011/884/EU and Decision 2008/289/EC, we collected 74 rice products originating from six countries or districts. The 74 rice samples were tested using the Decision 2011/884/EU and Decision 2008/289/ EC methods. The parallel use of different instruments and reagents were used for testing in parallel, and the results were analyzed statistically. To avoid the limitations of specific laboratories, eight GM organism detection laboratories in China participated in a collaborative trial. In our tests, 24.3% （18/74） of the samples tested were positive with the SYBR Green real-time PCR assay using the Decision 2011/884/EU method, but were negative with the TaqMan real-time PCR assay using the Decision 2011/884/EU and Decision 2008/289/EC methods. Sequencing the PCR-amplified CrylA（b/c） genes in three samples （6, 30 and 43） showed that the products consisted of primer dimers rather than the targeted sequence. The combined experimental results showed that testing for the nopaline synthase gene （NOS） of Agrobacterium tumefasciens terminator and CrylA（b/c） produced false-positive results when the Decision 2011/884/EU method was used. Because of the high rate of false-positive results, the Decision 2011/884/EU SYBR Green method to detect GM rice requires improvement.

关键词： genetically modified organism Decision 2011/884/EU SYBIR Green real-time PCR false positive

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Suppressor of RNA silencing encoded by Rice gall dwarf virus genome segment 11

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Chinese Science Bulletin 2008年第3期53卷 362-369页

作者： LIU FuXiu ZHAO Qin RUAN XiaoLei HE YunWei LI HuaPing Laboratory of plant Virology South China Agricultural University Guangzhou 510642 China Post-Entry quarantine Station for Tropical plant Hainan Entry-Exit Inspection and Quarantine Bureau Haikou 570206 China

Rice gall dwarf virus(RGDV)is an important rice pathogen in China and Southeast ***,little is known about the molecular mechanisms of RGDV interactions with plant ***,we have identi-fied an RGDV protein,Pns11,which acts as a suppressor of RNA silencing in coinfiltration assays with the reporter,green fluorescent protein(GFP)in transgenic Nicotiana benthamiana line 16c carrying ***11 suppressed local and systemic silencing induced by sense *** spread of mobile RNA si-lencing signals was blocked or inactivated by *** of Pns11 also enhanced Potato virus X pathogenicity in *** suppressor could reduce,but not eliminate,siRNA in the local and systemic RNA silencing suppression assays,suggesting that Pns11 functions by interfering with initial stages of RNA silencing.

关键词：水稻矮化病毒 RNA噪声抑制抑制物基因片段

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Environmental deterioration of farmlands caused by the irrational use of agricultural technologies

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Frontiers of Environmental Science & Engineering 2016年第4期10卷 3-5页

作者： Xubin Pan Zhongkui Luo Yongbo Liu institute of plant quarantine Chinese Academy of Inspection and Quarantine Beijing 100029 China CSIRO Agriculture Black Mountain ACT 2913 Australia State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing 100012 China

Without considering the ecosystem-depen- dence of agricultural production, irrational use of agricultural technologies could bring only short-term economic benefits but leave long-term environmental deterioration. If some agricultural lands have to be abandoned because of these technologies such as chemical films or groundwater depletion, it will aggravate the burden of remaining lands for maintaining or enhancing production. Thus, agricultural production should be a part of public services, requiring the consideration of interests of different stakeholders and sustainability.

关键词： agricultural film groundwater exploitation food security environmental cost

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Identification and Functional Analysis of Differentially Expressed Genes of Ascaris suum Goeze,1782 from Ascaris lumbricoides Linnaeus, 1758

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Agricultural Sciences in China 2010年第6期9卷 903-910页

作者： WU Shao-qiang LIN Xiang-mei ZHU Xing-quan institute of Animal and plant quarantine Chinese Academy of Inspection and Quarantine Beijing 100029 P.R.China State Key Laboratory of Veterinary Etiological Biology Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou 730046 P.R. China

In order to provide further evidence to prove that Ascaris suum Goeze,1782 and Ascaris lumbricoides Linnaeus,1758 are really different species in taxonomy,and to identity *** larval migrans-related genes for diagnosis and prevention use,*** genes that were differentialy expressed from the same gender of *** were enriched by subtracting the same expressed genes using suppression subtractive hybridization （SSH） *** of the selectively enriched cDNA was verified by Southern blot *** female *** specific cDNA library was then constructed and *** local alignment search tool （BLAST） analysis of female *** specific cDNA identified 6 specific ESTs with tentative functions related to larva *** study provided further evidence for differentiating *** from *** for the detailed information and application of the 6 ESTs are worth being done in the future studies.

关键词： Ascaris suum Ascaris lumbricoides nematode suppression subtractive hybridization EST larva migrans

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First Report of Clinacanthus nutans Leaf Spot Caused by Corynespora cassiicola in China

First Report of Clinacanthus nutans Leaf Spot Caused by Cory...

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中国植物病理学会2024年学术年会

作者： ZHANG Jinan HAO Zhigang LUO Laixin JIA Ruizong LI Jianqiang Department of plant Pathology College of Plant ProtectionChina Agricultural UniversityBeijing Key Laboratory of Seed Disease Testing and ControlChina Agricultural University Key Laboratory of Surveillance and Management for plant quarantine Pests Ministry of Agriculture and Rural AffairsChina Agricultural University Sanya institute of China Agricultural University Sanya Research Institution Hainan Key Laboratory for Biosafety Monitoring and Molecular Breeding in Off-Season Reproduction RegionsChinese Academy of Tropical Agricultural Sciences

Clinacanthus nutans is a traditional herb,mainly distributed in South China and Southeast Asia,possesses a broad range of biological properties,such as anti-inflammatory,antiviral,antioxidant,and anti-diabetic activities,in its *** 2023,we discovered a leaf spot disease of Clinacanthus nutans widely distributed in Hainan *** the disease first appears,the leaf spot is circular and dark *** later expands to irregular *** disease causes the leaves to fall off,leading to significant economic *** isolate the pathogen,the leaf tissues were surface-sterilized,and rinsed with sterile water three times before being placed on potato dextrose agar and cultured at 28℃ in the dark for 5 *** isolated fungi were recorded and their pathogenicity was tested on healthy leaves of Clinacanthus *** conidial suspension was collected from the 7-day-old colonies on PDA,and sprayed onto the surface of *** a result,leaves inoculated with the isolate CnLF101 appeared the leaf spot symptoms similar to those in the diseased *** identify the pathogenic isolate,the fungal morphological characteristics were *** colony of CnLF101 on PDA was greyish-green and the mycelium was white *** conidia were brown,clavate,(25.0-131.8) μm×(9.2-11.6) μm,0 to 11 *** on the morphological characteristics,the isolate CnLF101 was similar to the genus of *** mycelium of 7-days-old colony of CnLF101 was collected and used for DNA *** genes were amplified using the primers of ITS1/ITS4,EF-728 F/EF-986 R,Bt2 a/Bt2 b and ACT-512 F/ACT-783 R respectively,and sent for *** to the comparison results in BLAST programme of NCBI,the sequences of ITS,TEF1-α,β-tublin,actin showed 100%,99.64%,100%,and 97.90% identity to Corynespora cassiicola,respectively and the phylogenetic tree was *** on the morphological and molecular analysis,the isolate CnLF101 was identified as Corynespora cassiicol

关键词： Corynespora Cassiicola Clinacanthus nutans pathogen leaf spot

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Adsorption of 2,4-Dichlorophenol from Aqueous Solution onto Microwave Modified Activated Carbon: Kinetics and Equilibrium

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Transactions of Tianjin University 2009年第6期15卷 408-414页

作者：邹学权万先凯史惠祥汪大翚 institute of Environmental Science and Technology Zhejiang University Zhejiang Academy of Science and Technology for inspection and quarantine

Batch experiments were conducted to investigate the adsorption of 2,4-dichlorophenol （2,4-DCP） onto microwave modified activated carbon （AC） at three different temperatures （303 K, 313 K and 323 K）. Adsorption isotherms, kinetics, and thermodynamics of the adsorption process were explored. Equilibrium data were fitted into Langmuir and Freundlich equations, and the result reveals that the Freundlich isotherm model fits better than the Langmuir model. Three simplified kinetic models： pseudo-first-order, pseudo-second-order, and intrapartiele diffusion equations were adopted to examine the mechanism of the adsorption process, and the pseudo-second-order kinetic model proved to be the best in describing the adsorption data. The thermodynamic parameters of the adsorption process were estimated, showing that the adsorption of 2,4-DCP was exothermic and spontaneous, and the adsorption studied in this paper can be assigned to a physisorption mechanism.

关键词： activated carbon adsorption microwave kinetics 2,4-DCP

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