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Science China chemistry 2025年第1期68卷 257-263页

作者： Jiapian Huang Chenxin Wang Xu Wang Xiaoyu Zhou Wei Xiao Jie Wu School of pharmaceutical and Chemical Engineering&institute for Advanced Studies Taizhou UniversityTaizhou 318000China State Key Laboratory of Organometallic chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

The generation of variousβ-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is *** method features a broad substrate scope and excellent *** studies reveal that the dispersion interaction between sulfinyl group and CH_(2)SO_(2)Ph group plays a crucial role in the stereoselectivity control.

关键词： β-chiral sulfones chiral cyclic sulfinamides sulfur dioxide insertion asymmetric radical cyclization stereoselectivity

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Context-dependent role of sirtuin 2 in inflammation

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Neural Regeneration Research 2025年第3期20卷 682-694页

作者： NoemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado Elena Puerta Department of pharmaceutical Sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain Navarra institute for Health Research(IdiSNA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation NLRP3 nuclear factorκB sirtuin 2

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Recent advances in semi-heterogenous photocatalysis in organic synthesis

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Chinese Chemical Letters 2025年第2期36卷 94-117页

作者： Jia-Cheng Hou Wei Cai Hong-Tao Ji Li-Juan Ou Wei-Min He School of chemistry and Chemical Engineering University of South China School of pharmaceutical Sciences Hunan University of Medicine School of Materials Science and Engineering Hunan Institute of Technology

Semi-heterogeneous photocatalysis has emerged as a powerful and productive platform in organic chemistry, which provides mild and eco-friendly conditions for a diverse range of bond-forming *** synergy of homogeneous catalysts and heterogeneous catalysts inherits their main advantages, such as higher activities, easy separation and superior recyclability. In this review, we summarize the recent advances in recyclable semi-heterogenous protocols for the light promoted bond-forming reactions and identify directions for future research according to the different photocatalysts/metal/redox catalysts involved. Notably, this review is not a comprehensive description of reported literature but aim to highlight and illustrate key concepts, strategies, reaction model, reaction conditions and mechanisms.

关键词： Bond-forming Organic synthesis Photocatalysis Recyclable Semi-heterogeneous

Targeting novel sites represents an effective strategy for combating drug resistance

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Chinese Chemical Letters 2025年第1期36卷 3-5页

作者： Shaoqing Du Xinyong Liu Xueping Hu Peng Zhan Department of Medicinal chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJi’nan 250012China institute of Frontier chemistry School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237China

Drug resistance poses an escalating global challenge in the battle against *** effectiveness of conventional antibiotics and other anti-infective drugs is waning as microbes develop heightened resistance to existing *** resistance poses a formidable challenge to global health and development,ranking among the top 10 public health threats to humanity as declared by the World Health *** indicate that if left unaddressed,antimicrobial resistance could inflict an annual economic burden on the global GDP ranging from$1trillion to$3.4 trillion by ***,the management of common infections becomes increasingly arduous,while the likelihood of disease transmission,severe illness,and mortality escalates.

关键词： resistance drugs humanity

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Selective activation of dioxygen to singlet oxygen over La-Si co-doped TiO_(2)microspheres for photocatalytic degradation of formaldehyde

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Journal of Environmental Sciences 2025年第5期151卷 594-607页

作者： Shuaitao Li Haodi Liu Xun Hu Yanfen Fang Xiaofeng Cao Qifeng Chen School of Materials Science&Engineering University of JinanJinan 250022China College of Biological and pharmaceutical Sciences China Three Gorges UniversityYichang 443002China Technical institute of Physics and chemistry Chinese Academy of SciencesBeijing 100190China

Volatile Organic Compounds(VOCs)are highly harmful to human beings and other organisms,and thus the elimination of VOCs is extremely ***,La-Si co-doped TiO_(2)microsphere photocatalysts,which were prepared by a hydrothermal method,exhibited high photocatalytic activity in the decomposition of formaldehyde compared with TiO_(2).The improved activity can be attributed to the promoted separation efficiency and density of the charge carriers,as verified by the electrochemical results in combination with density functional theory *** addition,the Si dopant changed the microstructure and surface acidity,while the addition of La promoted the separation efficiency of charge *** interestingly,it was found that singlet oxygen was the key species in the activation of molecular dioxygen,and it played a pivotal role in the photocatalytic decomposition of *** work provides a novel strategy for the selective activation of dioxygen for use in the decomposition of formaldehyde.

关键词： Dioxygen molecular activation La-Si co-doped TiO_(2)microspheres Formaldehyde degradation Photocatalysis

Enantioselective copper-catalyzed dearomative borylative cyclization of indoles and mechanistic insights

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Science China chemistry 2025年第2期68卷 670-678页

作者： Yanfei Li Xuetao Li Zheng Zhang Yiliang Zhang Xiuping Yuan Jianjun Yin Simin Wang Wei Guan Qian Zhang Tao Xiong Jilin Province Key Laboratory of Organic Functional Molecular Design&Synthesis Department of ChemistryNortheast Normal UniversityChangchun 130024China institute of Functional Material chemistry Department of ChemistryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Organometallic chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of chemistry and Chemical Engineering Harbin Normal UniversityHarbin 150025China

Alicyclic nitrogen heterocycles,such as enantioenriched polycyclic fused[1,2-a]indoline derivatives,are widespread in natural products,agrochemicals and pharmaceutical *** methods predominantly rely on the recent emerging Heck-type catalytic asymmetric dearomatization(CADA)protocol,wherein noble palladium catalysts commonly necessitate the form arylPd species-triggered these *** contrast,a more sustainable base metal catalysis paradigm through alkyl metal species disrupting the aromaticity,that is,the utilization of challenging asymmetric Csp3–Csp3 bond formation entry to such important chiral densely functionalized polycyclic molecular scaffolds,remains an elusive ***,we report the first copper-catalyzed dearomative borylative cyclization of indoles under mild reaction conditions,affording an array of valuable Bpin-containing pyrrolo-fused[1,2-a]indolines bearing four consecutive stereogenic centers with excellent enantioand *** synthetic potential was documented via an array of useful *** functional theory(DFT)calculation studies elucidated the origin of the chemo-,regio-,enantio-and diastereoselectivities of this conversion.

关键词： copper catalysis dearomatization borylative cyclization indoles DFT calculations

Modular miniaturized synthesis and in situ biological evaluation facilitate rapid discovery of potent Mra Y inhibitors as antibacterial agents

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Chinese Chemical Letters 2025年第2期36卷 29-31页

作者： Mianling Yang Meehyein Kim Peng Zhan Department of Medicinal chemistry Key Laboratory of Chemical Biology Ministry of Education School of Pharmaceutical SciencesShandong University Infectious Diseases Therapeutic Research Center Korea Research Institute of Chemical Technology (KRICT)

Despite the availability of effective antibacterial drugs, the increasing prevalence of antibiotic-resistant bacteria is primarily attributed to their excessive and inappropriate utilization. Antimicrobial resistance (AMR) represents one of the most concerning global health and development threats [1]. Thereby, the continuous escalation in AMR necessitates urgent advancements in novel antibacterial strategies. The MraY enzyme, which plays a pivotal role in synthesizing bacterial cell wall-composing polysaccharides, holds significant potential as a target for antibacterial agents [2]. However, its conformational dynamics have presented substantial challenges in developing MraY-targeting inhibitors.

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Oscillatory flow reactor facilitates fast photochemical Wolff rearrangement toward synthesis of α-substituted amides in flow

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Chinese Chemical Letters 2025年第2期36卷 389-393页

作者： Huashan Huang Jingze Chen Luyun Zhang Hong Yan Siqi Li Fen-Er Chen institute of pharmaceutical Science and Technology College of Chemistry Fuzhou University Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of Education Molecular Medicine Research Center College of Pharmacy Yanbian University Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of Chemistry Fudan University Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs

A visible light-promoted fast photochemical Wolff rearrangement was developed toward synthesis of α-substituted amides in continuous flow with the use of a photochemical oscillatory flow reactor(POFR).The control experiment indicates that a fast process of the Wolff rearrangement(<40 s) is involved. Notably, this protocol does not require excess use of any reactants, and the resulting α-substituted amides could be isolated by recrystallization in good to excellent yields.

关键词： Flow photochemistry Ketene Oscillatory flow reactor Wolff rearrangement α-Substituted amides

Phase-transfer-shuttle generated in situ enables novel SN1-type fluorination of sulfonium ylide with hydrofluoric acid

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Science China chemistry 2025年第2期68卷 641-648页

作者： Yisa Xiao Rui Wang Zhaoxuan Xu Qunchao Zhao Renyi Pang Tao Dong Long Lu Qilong Shen Key Laboratory of Fluorine and Nitrogen chemistry and Advanced Materials Shanghai Institute of Organic ChemistryUniversity of Chinese Academy SciencesChinese Academy of SciencesShanghai 200032China

The development of a nucleophilic fluorination protocol using hydrofluoric acid as the fluoride source represents a long-sought goal in the field of organofluorine *** report herein the realization of such a reaction that employed alkyl-substituted sulfonium ylides as the *** key to the success of the protocol was attributed to two factors:First,as a Brϕnsted base,the ylide was able to be protonated by HFaq,thus serving as a phase-transfer shuttle generated in situ to bring F−from aqueous phase to the organic phase promoting desolvation of fluoride ***,after protonation,a sulfonium salt,a good leaving group,was generated and subsequent attacked by the fluoride to afford the alkyl *** investigation indicates that the reaction occurs via an SN1 *** of the nature of the cationic intermediate in the reaction,two attractive rearrangement-fluorination approaches including 1,2-aryl migration fluorination and ring-expansion fluorination were disclosed.

关键词： SN1 fluorination hydrofluoric acid sulfonium ylide cation rearrangement

Construction of N-doped copper metal-organic frameworks for promoting photocatalytic carbon dioxide reduction to ethylene

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Science China chemistry 2025年第2期68卷 601-609页

作者： Fan Guo Zong-Zheng He Peng Wang Xiao-Yu Zhang Hongjian Yu Qin-Chao Wang Wei-Yin Sun School of chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Coordination chemistry institute State Key Laboratory of Coordination ChemistrySchool of Chemistry and Chemical EngineeringNanjing National Laboratory of MicrostructuresCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China

Engineering nonmetallic atom-doped metal-organic framework(MOF)catalyst to promote C−C coupling and realize conversion of CO_(2) into C_(2 )multi-carbon hydrocarbon products is still ***,with 2-methylimidazole as a dopant of N element,an N-doped NH_(2)-CuBDC catalyst was obtained via a facile and simple stirring *** illumination,compared with catalytic CO_(2) reduction to C1 product of CO by original MOF,N-doped NH_(2)-CuBDC can motivate generation of C_(2)H_(4),which is difficult to achieve in photocatalytic system by MOF-based *** transfer rates of photo-generated charges have been expedited due to the high electron density around Cu catalytic sites after *** importantly,C–C coupling intermediate CO–CHO*was identified by in situ Fourier transform infrared spectroscopy during the catalytic CO_(2) reduction reaction process,which further indicates the presence of Cu–N sites in the NH_(2)-CuBDC can facilitate the formation of C2H_(4) *** work uncovers a new paradigm to design photocatalysts for enhancing the reduction of CO_(2) to C_(2) products.

关键词： metal-organic frameworks C-C coupling doping photocatalytic CO_(2) reduction Cu-based catalysts