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Localization of Active Caspase-3 and Caspase-8 in Nasal Polyps and Nasal Hyperplasia in Consideration of Mast Cell Function: A Semiquantitatively Analysis

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International Journal of Otolaryngology and Head & Neck Surgery 2012年第3期1卷 63-70页

作者： Nadine Franzke Sibylle Koehler Peter Middel Claudia Fuoco Francesco Cecconi Fabio Quondamatteo Rainer Laskawi Saskia Rohrbach Anatomy National University of Ireland Galway Ireland Department of Audiology and Phoniatrics Charite Medical University of Berlin Berlin Germany Department of Dermatology University Hamburg-Eppendorf Hamburg Germany Department of Histology University of Goettingen Goettingen Germany Department of Otorhinolaryngology University of Goettingen Goettingen Germany Dulbecco Telethon institute Department of Biology University of Rome Tor Vergata Rome Italy institute of pathology Klinikum Kassel Kassel Germany

Introduction: The pathogenesis of nasal polyposis and nasal hyperplasia is still unknown. The localization of caspases in nasal polyps and nasal hyperplasia of patients with and without allergic rhinitis was studied. Methods: Sections of human nasal polyps (n = 5) and hyperplastic nasal turbinates (5 with, 5 without allergy) were stained for active caspase-3 and caspase-8. Double immunofluorescence was used to evaluate colocalization of the caspases with Ki-M1P and tryptase. TUNEL was performed. Results: Active caspase-3 and caspase-8 were seen in nearly all nasal polyps and hyperplastic nasal turbinates. Active caspase-3 was predominantly localized in stromal cells, identified as mast cells. Caspase-8 was localized in mast cells with the pattern similar to active caspase-3 and additionally found in epithelial cells at the nasal and polyp surface and in epithelial cells of glands. Conclusion: Our results suggest that mast cell apoptosis may be involved in the pathological mechanisms which characterize and sustain chronic inflammatory disorders of the nasal mucosa with and without allergy.

关键词： Nasal Polyposis Caspase-3 Caspase-8 Allergic Rhinitis Non-Allergic Rhinitis Mast Cells Nasal pathology Chronic Rhinosinusitis Apoptosis Nasal Hyperplasia

心理治疗效果评定量表(简式)在中、德应用的心理测量学研究(英文)

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心理学报 2007年第5期39卷 880-891页

作者： Gerhard Zarbock 王希林 Marko Drews Bernhard Dahme Wolfgang Lutz Department of Psychology University of Hamburg 北京大学精神卫生研究所 institute of Psychology University of Bern

419名中国和德国被试参加了本研究,并回答了若干简式心理健康量表。所选的这套量表能对心理治疗不同阶段的效果(Howard’s阶段模型:重新认识期-转变期-康复期)进行测查。本研究目的在于考察这些简式量表能否用于认知-行为治疗跨文化培... 详细信息

419名中国和德国被试参加了本研究,并回答了若干简式心理健康量表。所选的这套量表能对心理治疗不同阶段的效果(Howard’s阶段模型:重新认识期-转变期-康复期)进行测查。本研究目的在于考察这些简式量表能否用于认知-行为治疗跨文化培训项目中的质量管理。结果显示,这些量表在中德两种文化背景下都有很高的信度和效度(聚合效度和敏感性)。尽管项目间的高相关似乎提示心理健康模型只有一个维度,但探索性因素和理论分析则更支持心理健康是一个分为8个亚维度的模型,其中每个亚维度或者与基础情绪、或者与社会性情感相连关联。本文最后就研究结果及其对心理治疗质量控制的意义进行了详细讨论。

关键词：质量控制心理治疗阶段模型过程评估跨文化研究简式量表

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194例肾性骨病的病理分析

中华病理学杂志 1991年第4期20卷 280-283,I057页

作者：俞育飞朱萍 200025，上海第二医科大学病理学教研室上海第二医科大学瑞金医院 hamburg university Institute of PathologyDepartment of Osteopathology

肾性骨病是慢性肾功能衰竭引起的一种骨代谢性疾病。我们收集了194例慢性肾功能衰竭患者的髂骨活检标本,其中10例作了磷、钙、甲状旁腺激素及1,25(OH)D的测定。肾性骨病的特征是:纤维性骨炎、骨吸收增强、破骨细胞活跃及数量增多、骨样... 详细信息

肾性骨病是慢性肾功能衰竭引起的一种骨代谢性疾病。我们收集了194例慢性肾功能衰竭患者的髂骨活检标本,其中10例作了磷、钙、甲状旁腺激素及1,25(OH)D的测定。肾性骨病的特征是:纤维性骨炎、骨吸收增强、破骨细胞活跃及数量增多、骨样组织增多包括骨母细胞性骨样组织和无细胞性骨样组织、骨改建活跃、铝沉积于骨组织。按组织学变化,肾性骨病分为下列三种亚型:继发性甲状旁腺机能亢进性肾性骨病(又名高转化性肾性骨病)、骨软化(又名低转化性肾性骨病)、混合性肾性骨病。我们结合10例生化测定结果,初步探讨了肾性骨病的发病机理,提出了铝中毒在肾性骨病发病中的意义。

关键词：铅中毒肾功能衰竭骨疾病

Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2022年第6期117卷 1-272页

作者： Ruvishika S.Jayawardena Kevin D.Hyde Song Wang Ya‑Ru Sun Nakarin Suwannarach Phongeun Sysouphanthong Mohamed A.Abdel‑Wahab Faten A.Abdel‑Aziz Pranami D.Abeywickrama Vanessa P.Abreu Alireza Armand AndréAptroot Dan‑Feng Bao Dominik Begerow Jean‑Michel Bellanger Jadson D.P.Bezerra Digvijayini Bundhun Mark S.Calabon Ting Cao Taimy Cantillo João LVRCarvalho Napalai Chaiwan Che‑Chih Chen Régis Courtecuisse Bao‑Kai Cui Ulrike Damm Cvetomir M.Denchev Teodor T.Denchev Chun Y.Deng Bandarupalli Devadatha Nimali Ide Silva Lidiane Ados Santos Nawal K.Dubey Sylvain Dumez Himashi SFerdinandez André L.Firmino Yusufon Gaforov Achala J.Gajanayake Deecksha Gomdola Sugantha Gunaseelan Shucheng‑He Zin H.Htet Malarvizhi Kaliyaperumal Martin Kemler Kezhocuyi Kezo Nuwan DKularathnage Marco Leonardi Ji‑Peng Li Chunfang Liao Shun Liu Michael Loizides Thatsanee Luangharn Jian Ma Hugo Madrid S.Mahadevakumar Sajeewa S.N.Maharachchikumbura Dimuthu S.Manamgoda María P.Martín Niranjan Mekala Pierre‑Arthur Moreau Yan‑Hong Mu Pasouvang Pahoua Dhandevi Pem Olinto L.Pereira Wiphawanee Phonrob Chayanard Phukhamsakda Mubashar Raza Guang‑Cong Ren Andrea C.Rinaldi Walter Rossi Binu C.Samarakoon Milan CSamarakoon Vemuri V.Sarma Indunil C.Senanayake Archana Singh Maria F.Souza Cristina M.Souza‑Motta Adriano A.Spielmann Wenxin Su Xia Tang XingGuo Tian Kasun M.Thambugala Naritsada Thongklang Danushka S.Tennakoon Nopparat Wannathes DingPeng Wei Stéphane Welti Subodini N.Wijesinghe Hongde Yang Yunhui Yang Hai‑Sheng Yuan Huang Zhang Jingyi Zhang Abhaya Balasuriya Chitrabhanu SBhunjun Timur S.Bulgakov Lei Cai Erio Camporesi Putarak Chomnunti Y.S.Deepika Mingkwan Doilom Wei‑Jun Duan Shi‑Ling Han Naruemon Huanraluek EBGareth Jones NLakshmidevi Yu Li Saisamorn Lumyong Zong‑Long Luo Surapong Khuna Jaturong Kumla Ishara S.Manawasinghe Ausana Mapook Wilawan Punyaboon Saowaluck Tibpromma Yong‑Zhong Lu JiYe Yan Yong Wang Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Innovative institute for Plant Health Zhongkai University of Agriculture and EngineeringGuangzhou 510225P.R.China Department of Plant pathology College of AgricultureGuizhou UniversityGuiyang 550025GuizhouChina Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Biotechnology and Ecology institute Ministry of Agriculture and ForestryP.O.Box:811Vientiane CapitalLao PDR Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Beijing Key Laboratory of Environment-Friendly Management on Fruit Diseases and Pests in North China Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Departamento de Fitopatologia Universidade Federal de ViçosaViçosaMinas GeraisBrazil Laboratório de Botânica/Liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva S/NBairro UniversitárioCampo GrandeMato Grosso do Sul CEP 79070-900Brazil College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanChina Department of Entomology and Plant pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand institute of Plant Science and Microbiology Universität HamburgOrganismic Botany and MycologyOhnhorststr.1822609 HamburgGermany CEFE CNRSUniv.MontpellierEPHEIRDINSERM1919Route de Mende34293 Montpellier Cedex 5France Setor de Micologia Departamento de Biociências e TecnologiaInstituto de Patologia Tropical e Saúde PúblicaUniversidade Federal de GoiásRua 235S/NSetor UniversitárioGoiâniaGO CEP:74605-050Brazil Division of Biological Sciences College of Arts and SciencesUniversity of the Philippines Visayas5023 MiagaoIloiloPhilippines CA

This article is the 14th in the Fungal Diversity Notes series,wherein we report 98 taxa distributed in two phyla,seven classes,26 orders and 50 families which are described and *** in this study were collected from Australia,Brazil,Burkina Faso,Chile,China,Cyprus,Egypt,France,French Guiana,India,Indonesia,Italy,Laos,Mexico,Russia,Sri Lanka,Thailand,and *** are 59 new taxa,39 new hosts and new geographical distributions with one new *** 59 new species comprise Angustimassarina kunmingense,Asterina lopi,Asterina brigadeirensis,Bartalinia bidenticola,Bartalinia caryotae,Buellia pruinocalcarea,Coltricia insularis,Colletotrichum fexuosum,Colletotrichum thasutense,Coniochaeta caraganae,Coniothyrium yuccicola,Dematipyriforma aquatic,Dematipyriforma globispora,Dematipyriforma nilotica,Distoseptispora bambusicola,Fulvifomes jawadhuvensis,Fulvifomes malaiyanurensis,Fulvifomes thiruvannamalaiensis,Fusarium purpurea,Gerronema atrovirens,Gerronema favum,Gerronema keralense,Gerronema kuruvense,Grammothele taiwanensis,Hongkongmyces changchunensis,Hypoxylon inaequale,Kirschsteiniothelia acutisporum,Kirschsteiniothelia crustaceum,Kirschsteiniothelia extensum,Kirschsteiniothelia septemseptatum,Kirschsteiniothelia spatiosum,Lecanora immersocalcarea,Lepiota subthailandica,Lindgomyces guizhouensis,Marthe asmius pallidoaurantiacus,Marasmius tangerinus,Neovaginatispora mangiferae,Pararamichloridium aquisubtropicum,Pestalotiopsis piraubensis,Phacidium chinaum,Phaeoisaria goiasensis,Phaeoseptum thailandicum,Pleurothecium aquisubtropicum,Pseudocercospora vernoniae,Pyrenophora verruculosa,Rhachomyces cruralis,Rhachomyces hyperommae,Rhachomyces magrinii,Rhachomyces platyprosophi,Rhizomarasmius cunninghamietorum,Skeletocutis cangshanensis,Skeletocutis subchrysella,Sporisorium anadelphiae-leptocomae,Tetraploa dashaoensis,Tomentella exiguelata,Tomentella fuscoaraneosa,Tricholomopsis lechatii,Vaginatispora favispora and Wetmoreana *** new combin

关键词： 59 New taxa 39 New records Ascomycota Basidiomycota Dothideomycetes Lecanoromycetes Leotiomycetes Sordariomycetes Ustilaginomycotina

Wart-aSsociated Rather Than Beta/Gamma HPV Cause Cutaneous Warts Independently Of The Immune Status

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Wart-aSsociated Rather Than Beta/Gamma HPV Cause Cutaneous W...

24th International Papillomavirus Conference and Clinical Workshop

作者： A Kohler S Buchholtz T Meyer K.M Michael T Waterboer M Pawlita E Stockfleth I Nindll Department of Dermatology Venerology and AllergologyChariteSkin Cancer Center ChariteUniversity Hospital of BerlinBerlinGermany Department of Dermatology Venerology and AllergologyChariteSkin Cancer Center ChariteUniversity Hospital of BerlinBerlinGermany institute of pathology and Molecular Biology （IPM） HamburgGermany Research Program Infection and Cancer German Cancer Research Center （DKFZ）HeidelbergGermany Research Program Infection and Cancer German Cancer Research Center （DKFZ）HeidelbergGermany Research Program Infection and Cancer German Cancer Research Center （DKFZ）HeidelbergGermany Department of Dermatology Venerology and AllergologyChariteSkin Cancer Center ChariteUniversity Hospital of BerlinBerlinGermany Department of Dermatology Venerology and AllergologyChariteSkin Cancer Center ChariteUniversity Hospital of BerlinBerlinGermany

＜正＞Introduction Wart-associated alpha but also beta and gamma HPV have been frequently detected in cutaneous warts from immunocompetent patients（IC）and with even greater diversity in warts from immunosuppressed organ transplant recipients （OTR）.We attempted to identify the causal HPV type and to assess differences between HPV positive and negative warts. Patients/Method Ninety-four warts from 29 IC and 33 OTR were analysed by several PCR for presence of mucosal alpha,

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肺癌循环肿瘤源性生物标志物

国际病理科学与临床杂志 2013年第6期33卷 476-477页

作者： Aline Taenzer Catherine Alix-Panabières Harriet Wikman Klaus Pantel 王欢欢袁光金 Department of Tumour Biology Centre of Experimental Medicine University Cancer Center Hamburg University Medical Centre Hamburg-Eppendorf university Medical Centre University Montpellier 1 Saint-Eloi Hospital Institute of Research in BiotherapyLaboratory of Rare Human Circulating Cells university Medical Centre Laboratory of Cell and Hormonal BiologyArnaud de Villeneuve Hospital university institute of Clinical Research UM1 - EA2415 - Epidemiology Biostatistics & Public Health 天津医科大学附属肿瘤医院放射治疗科天津300060 重庆市黔江区黔江民族医院肿瘤科重庆409000

美国国立卫生研究院生物标志物定义工作组将生物标志物定义为“一种具有能客观测量同时可用于评价一般生物过程、发病过程或医疗干预相关药物反应的指示物”[1]。大量正在进行的肺癌相关研究致力于探讨用于早期诊断和高风险预测的气道... 详细信息

美国国立卫生研究院生物标志物定义工作组将生物标志物定义为“一种具有能客观测量同时可用于评价一般生物过程、发病过程或医疗干预相关药物反应的指示物”[1]。大量正在进行的肺癌相关研究致力于探讨用于早期诊断和高风险预测的气道上皮细胞、痰液、呼气、尿液和血液中的生物标志物。在此，着重评述肺癌的循环生物标志物，尤其是循环肿瘤细胞（circulating tumor cells，CTCs）与循环核酸（circulating nucleic acids，CNAs）。

关键词：循环肿瘤细胞生物标志物肺癌美国国立卫生研究院源性气道上皮细胞 cells 药物反应

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循环肿瘤细胞的检测方法

国际病理科学与临床杂志 2013年第6期33卷 473-475页

作者： Klaus Pantel Catherine Alix-Panabières 李金銮王继纲 Department of Tumour Biology Centre of Experimental Medicine University Cancer Center Hamburg University Medical Centre Hamburg-Eppendorf university Medical Centre University Montpellier 1 Saint-Eloi Hospital Institute of Research in BiotherapyLaboratory of Rare Human Circulating Cells university Medical Centre Laboratory of Cell and Hormonal BiologyArnaud de Villeneuve Hospital university institute of Clinical Research UM1-EA2415-Epidemiology Biostatistics & Public Health 福建省肿瘤医院放疗科福州350014 青岛大学医学院附属医院病理科山东青岛266003 复旦大学上海医学院病理学系上海200032

在原发上皮肿瘤形成和生长的早期，肿瘤细胞便可以通过血流播散到远处器官。这些循环肿瘤细胞（circulating tumor cells，CTCs）可以通过不同技术进行富集和检测，其分析被认为是对癌症患者的实时“液体活检”。这种活检能对CTCs特异... 详细信息

在原发上皮肿瘤形成和生长的早期，肿瘤细胞便可以通过血流播散到远处器官。这些循环肿瘤细胞（circulating tumor cells，CTCs）可以通过不同技术进行富集和检测，其分析被认为是对癌症患者的实时“液体活检”。这种活检能对CTCs特异性亚群进行表征，且有可能为癌症的检测和控制带来革命性的转变。本篇作者将着重讨论当前用于CTCs富集和检测的策略。

关键词：循环肿瘤细胞检测癌症患者 cells 肿瘤形成血流播散特异性控制带

Breast Cancer Risk Genes-Association Analysis in More than 113,000 Women

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四川生理科学杂志 2021年第1期43卷 7-7页

作者： Leila Dorling The authors' affiliations are as follows: the Centre for Cancer Genetic Epidemiology Departments of Public Health and Primary Care (L.D. S. Carvalho J.A. K.A.P. Q.W. M.K.B. J.D. B.D. N. Mavaddat K. Michailidou A.C.A. P.D.P.P. D.F.E.) and Oncology (C.L. P.A.H. C. Baynes D.M.C. L.F. V.R. M. Shah P.D.P.P. A.M.D. D.F.E.) University of Cambridge Cambridge the Centre for Genomic and Experimental Medicine MRC Institute of Genetics and Molecular Medicine (A. Campbell D.J.P.) and the Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology (D.J.P.) University of Edinburgh the Cancer Research UK Edinburgh Centre (D.A.C. J.F.) and the Usher Institute of Population Health Sciences and Informatics University of Edinburgh Medical School (A. Campbell J.F.) Edinburgh the Divisions of Informatics Imaging and Data Sciences (E.F.H.) Cancer Sciences (A. Howell) Population Health Health Services Research and Primary Care (A. Lophatananon K. Muir) and Evolution and Genomic Sciences School of Biological Sciences (W.G.N. E.M.V. D.G.E.) University of Manchester the NIHR Manchester Biomedical Research Unit (E.F.H.) and the Nightingale Breast Screening Centre Wythenshawe Hospital (E.F.H. H.I.) Academic Health Science Centre and North West Genomics Laboratory Hub and the Manchester Centre for Genomic Medicine St. Mary's Hospital Manchester University NHS Foundation Trust (W.G.N. E.M.V. D.G.E.) Manchester the School of Cancer and Pharmaceutical Sciences Comprehensive Cancer Centre Guy's Campus King's College London London (E.J.S.) the Institute of Cancer and Genomic Sciences University of Birmingham Birmingham (I.T.) and the Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre University of Oxford Oxford (I.T.) - all in the United Kingdom the Human Genotyping-CEGEN Unit Human Cancer Genetic Program (A.G.-N. M.R.A. N.Á. B.H. R.N.-T.) and the Human Genetics Group (V.F. A.O. J.B.) Spanish National Cancer Research

Background:Genetic testing for breast cancer susceptibility is widely used,but for many genes,evidence of an association with breast cancer is weak,underlying risk estimates are imprecise,and reliable subtype-specific risk estimates are ***:We used a panel of 34 putative susceptibility genes to perform sequencing on samples from 60,466 women with breast cancer and 53,461 *** separate analyses for protein-truncating variants and rare missense variants in these genes,we estimated odds ratios for breast cancer overall and tumor *** evaluated missense-variant associations according to domain and classification of pathogenicity.

关键词： cancer Breast Cancer