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Autologous peripheral blood-derived orthobiologics:Different types and their effectiveness in managing knee osteoarthritis

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World Journal of Orthopedics 2024年第5期15卷 400-403页

作者： Ashim Gupta Vijay Kumar Jain Department of orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of orthopaedics South Texas Orthopaedic Research Institute(STORI Inc.)LaredoTX 78045United States Department of Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States Department of orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301India Department of orthopaedics Atal Bihari Vajpayee Institute of Medical SciencesDr.Ram Manohar Lohia HospitalDelhi 110001New DelhiIndia

Knees are the most commonly impacted weight-bearing joints in osteoarthritis(OA),affecting millions of people *** increasing life spans and obesity rates,the incidence of knee OA will further increase,leading to a significant increase in the economic *** treatment modalities utilized to manage knee OA have *** the last decade,the role of various autologous peripheral blood-derived orthobiologics(APBOs)for the treatment of knee OA has been extensively *** editorial provided an overview and focused on defining and shedding light on the current state of evidence based on the most recent published clinical studies concerning the use of APBO for the management of knee *** numerous studies have demonstrated promising results for these preparations,a notable gap exists in the comparative analysis of these diverse *** absence of head-to-head studies poses a considerable challenge for physicians/surgeons in determining the optimal preparation for managing knee OA and achieving sustained longterm ***,more adequately powered,multicenter,prospective,doubleblind,randomized controlled trials with longer follow-ups are needed to establish the long-term efficacy and to aid physicians/surgeons in determining the optimal APBO for the management of knee OA.

关键词： Knee osteoarthritis Platelet-rich plasma Platelet lysate Autologous conditioned serum Gold-induced cytokine Plasma rich in growth factors Growth factor concentrate Autologous protein solution Platelet-rich fibrin Hyperacute serum

Effect of weight-adjusted antimicrobial antibiotic prophylaxis on postoperative dosage and surgical site infection incidence in total joint arthroplasty

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World Journal of Orthopedics 2024年第4期15卷 318-320页

Surgical site infections(SSI)following total joint arthroplasty pose a significant concern for both providers and patients across the ***,administration of antimicrobial antibiotic prophylaxis is used throughout the world to reduce the incidence of ***,the correct dosage and frequency of administration remains *** this editorial,we emphasized the determination of the effect of administration of weight-adjusted antimicrobial antibiotic prophylaxis regime on the incidence of SSI and postoperative dosage reduction compared to the conventionally used regime during total joint *** results demonstrated similar efficacy between both regimes with respect to the incidence of *** addition,weight-adjustment led to reduced postoperative dosage and has the potential to reduce chances of achieving lower therapeutic concentration,drug resistance,drug toxicity,and costs.

关键词： Antibiotics Antimicrobial prophylaxis Weight-adjusted Surgical site infections Total joint arthroplasty Knee arthroplasty Hip arthroplasty

Genetic Engineered Ultrasound-Triggered Injectable Hydrogels for Promoting Bone Reconstruction

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Research 2024年第2期2023卷 431-447页

作者： Zhenyu Zhao Huitong Ruan Aopan Chen Wei Xiong Mingzhu Zhang Ming Cai Wenguo Cui Department of orthopaedics Shanghai Tenth People's HospitalSchool of MedicineTongji University No.301 Middle Yanchang RoadShanghai 200072China Department of orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University Schoolof Medicine197 Rujin 2nd RoadShanghai 200025China Department of Foot and Ankle Surgery Beijing Tongren HospitalCapital Medical University1 Dongjiao MinxiangBeijing 100730China

Genetic engineering technology can achieve specific gene therapy for a variety of diseases, but the current strategy still has some flaws, such as a complex system, single treatment, and large implantation trauma. Herein, the genetic engineering injectable hydrogels were constructed by ultrasonic technology for the first time to realize in vivo ultrasound-triggered in situ cross-linking and cell gene transfection, and finally complete in situ gene therapy to promote bone reconstruction. First, ultrasound-triggered calcium release was used to activate transglutaminase and catalyze the transamidation between fibrinogen. Simultaneously, liposome loaded with Zinc-finger E-box-binding homeobox 1 (ZEB1) gene plasmid (Lip-ZEB1) was combined to construct an ultrasound-triggered in situ cross-linked hydrogels that can deliver Lip-ZEB1. Second, ultrasound-triggered injectable hydrogel introduced ZEB1 gene plasmid into endothelial cell genome through Lip-ZEB1 sustained release, and then acted on the ZEB1/Notch signal pathway of cells, promoting angiogenesis and local bone reconstruction of osteoporosis through genetic engineering. Overall, this strategy provides an advanced gene delivery system through genetic engineered ultrasound-triggered injectable hydrogels.

关键词： sustained release linking

Does topical vancomycin prevent fracture-related infections in closed fractures undergoing open reduction and internal fixation?A randomised controlled trial

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Chinese Journal of Traumatology 2024年第2期27卷 71-76页

作者： Mohit Gandhi Gopisankar Balaji Jagdish Menon Ruben Raj Thomas Department of orthopaedics Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia Department of Preventive and Social Medicine Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia

Purpose:The role of topical vancomycin in fracture-related infection(FRI)is *** few studies have reported their efficacy in open and high-risk extremity *** study aimed to assess topical vancomycin's role in reducing FRI in closed fractures undergoing open surgical intervention with an ***:This prospective randomized cohort study was carried out between February 2021 to January *** with isolated closed fractures,who were planned for open reduction and internal fixation within 2 weeks from the time of injury were included for this *** data collected included age,gender,socioeconomic status,mechanism of injury,diagnosis,Tscherne classification,and time interval to take up for *** were randomized into the intervention and control groups using the block randomization *** control group received only systemic antibiotic prophylaxis,whereas the intervention group received topical application of vancomycin powder in the surgical wound alongside systemic antibiotic *** primary outcome measure was the incidence of FRI among these *** and radiological findings and culture reports(in cases with infection)were recorded during the post-operative period and at 6 weeks of *** relevant statistical calculations were done using STATA statistical/data analysis-parallel edition version 16.0(StataCorp LLC).The quantitative variables like age and duration of the surgery were assessed for normalcy by Shapiro-Wilk W *** independent samples t-test with equal variances was applied to the age ***'s exact test was used for the analysis of the primary outcome measure(presence of FRI following surgery),and"Risk of FRI"and"Risk difference"between the 2 groups was *** strength of the association between qualitative variables was assessed using the Fisher's exact and Chi-square tests,***:There were 88 patients included in this *** statistical si

关键词： Infections Antibiotics Vancomycin Fractures

Clinical outcomes of triceps reflecting anconeus pedicle and olecranon osteotomy approach for distal humerus intercondylar fractures

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World Journal of Orthopedics 2024年第6期15卷 570-577页

作者： Rohit Ailani Sanjeev Kumar Bhuyan Brejesh Kumar Prasad Amit Kumar Namrata Dawani Department of orthopaedics Lovee Shubh HospitalLucknowUttar Pradesh 226002India Department of orthopaedics Gauhati Medical CollegeGuahati 781032India Department of orthopaedics ESIC Medical College and HospitalFaridabadHaryana 121001India Department of orthopaedics All India Institute of Medical SciencesKalyaniWest Bengal 741245India Department of Obstetric and Gynecology Kannauj Medical CollegeKannaujUttar Pradesh 209732India

BACKGROUND The preferred treatment for distal humeral intercondylar fractures is open reduction and internal *** there is consensus about the posterior approach,several posterior approaches have been *** is debatable as to which approach is *** To compare triceps reflecting anconeus pedicle(TRAP)and olecranon osteotomy approaches for internal fixation of distal humeral intercondylar *** In total,40 cases of Arbeitsgemeinschaft für Osteosynthesefragen/Association of the Study of Internal Fixation type C,closed,and Gustilo type I intercondylar humeral fractures were *** ranged in age from 18 years to 70 *** patients were randomized into two groups:TRAP group and olecranon osteotomy group,with 20 cases in *** were followed up at 6 wk,3 months,6 months,and 12 *** outcomes were measured in terms of flexion-extension arc,Disabilities of Arm,Shoulder and Hand score,and Mayo Elbow Performance *** The mean age was 43.2 years in the TRAP group and 37.5 years in the olecranon osteotomy *** mean operative time and mean duration of hospital stay in the TRAP group were significantly higher than in the olecranon osteotomy group(119.5 vs 111.5 min and 9.85 vs 5.45 d,respectively).The mean arc of flexion-extension,Disabilities of Arm,Shoulder and Hand score,and Mayo Elbow Performance Score were comparable without any significant difference in the groups at the 12-month follow-up(107.0 vs 106.2,18.3 vs 15.7,and 84.2 vs 86.2,respectively).Ulnar paresthesia and superficial infections were comparable in both groups(2 cases vs 3 cases and 3 cases vs 2 cases,respectively).Hardware prominence was significantly higher in the olecranon osteotomy group,mostly due to tension band *** Both approaches were equivalent,but there is a need for further study including higher numbers of subjects and longer study duration to prove the benefits of one approach over the other.

关键词： Elbow joint Humeral fracture Osteotomy Internal Fracture fixation

Enhanced antibacterial activity,corrosion resistance and endothelialization potential of Ti-5Cu alloy by oxygen and nitrogen plasma-based surface modification

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Journal of Materials Science & Technology 2024年第1期168卷 250-264页

作者： Xiaotong Zhao Jiali Hu Jingjun Nie Dafu Chen Gaowu Qin Erlin Zhang Key Lab.for Anisotropy and Texture of Materials Education Ministry of ChinaSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsNational Center for OrthopaedicsBeijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing 100035China

Antibacterial Ti-5Cu alloy is a promising substitute material for Ti-made cardiovascular implants,so its surface engineering is crucial to expediting clinical *** the antibacterial and cardiovas-cular biological benefits of Cu^(2+)and titanium-nitride-oxide(TiN x O y)coatings,a Cu_(2)O/CuO-TiN x O y coating with upregulated Cu^(2+)release was successfully deposited on Ti-5Cu alloy for the first time using oxygen and nitrogen plasma-based surface *** superhydrophilic and nanostructured Cu_(2)O/CuO-TiN x O y coating had a dense structure and was well bonded to the substrate,resulting in enhanced cor-rosion resistance,while CuO/Cu_(2)O in the coating released Cu^(2+)faster than Ti_(2)Cu phase in the *** gratifying,the coating demonstrated perfect antibacterial properties(R>99.9%against ***),owing primarily to direct contact sterilization of Cu_(2)O/*** most encouraging phenomenon was that the coating dramatically accelerated HUVEC adhesion(1.4 times),proliferation(RGR:106%-116%),and particularly migration(RMR:158%-247%)compared with the control *** coating extract also signifi-cantly stimulated in vitro angiogenesis *** rapid endothelialization for Cu_(2)O/CuO-TiN x O y coating was attributed to the surface nanostructure and Cu^(2+)/NO_(2)−release,which upregulated the angiogenesis-related gene expression of HIF-1α,VEGF,and eNOS to increase VEGF secretion and NO *** of the findings indicated that the Cu_(2)O/CuO-TiN x O y coating could enhance the corrosion resistance,an-tibacterial properties,and endothelialization potential of Ti-Cu alloy,displaying great clinical potential in cardiovascular applications.

关键词： Titanium-copper alloy Titanium-nitride-oxide(TiNxOy) Cu^(2+)release Antibacterial property Cell compatibility

实现无缝合手术的未来之路:自粘性强韧水凝胶（英文）

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Science Bulletin 2024年第15期 2307-2310页

作者：项雷赵鼎李毅焓齐曼古丽·塞丁崔文国 Department of orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine

Surgical sutures serve as foundational elements in surgical procedures, facilitating wound closure, exudation minimization, infection prevention, structural support maintenance, and healing promotion. The classification of traditional surgical suturing methods is intricate, and contingent upon variables such as tissue type,wound morphology, and desired healing outcomes.

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Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

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World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： Madhan Jeyaraman Naveen Jeyaraman Tarun Jayakumar Swaminathan Ramasubramanian Rajni Ranjan Saurabh Kumar Jha Ashim Gupta Department of orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease *** regenerative medicine,current treatments have *** regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism *** To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee *** The study included 50 patients with Kellgren-Lawrence grades II and III *** were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)*** were followed up at 1,3,6,12,and 24 *** analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all *** safety of SVF in terms of adverse and severe adverse events was *** analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United *** Both groups had similar demographics and baseline clinical ***-up showed minor patient loss,resulting in 23 and 24 in groups A and B *** A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group *** difference in pain reduction in group A was statistically significant from the third month ***,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to *** improvement in Group A was statistically significant from 6 months and maintained through 24 *** Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in pa

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

Advancing orthopaedic trauma care through WhatsApp:An analysis of clinical and non-clinical applications,challenges,and future directions

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World Journal of Orthopedics 2024年第6期15卷 529-538页

作者： Ravi Saini Madhan Jeyaraman Naveen Jeyaraman Vijay Kumar Jain Swaminathan Ramasubramanian Karthikeyan P Iyengar Department of orthopaedics Atal Bihari Vajpayee Institute of Medical SciencesDr Ram Manohar Lohia HospitalNew Delhi 110001India Department of orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Trauma and orthopaedics Southport and Ormskirk HospitalsMersey and West Lancashire Teaching NHS TrustSouthport PR86PNUnited Kingdom

The integration of WhatsApp,a widely-used instant messaging application(IMA),into the realm of orthopaedics and trauma surgery has emerged as a significant development in recent *** paper explores the multifaceted role of WhatsApp in orthopaedics,focusing on its clinical and non-clinical applications,advantages,disadvantages,and future *** study synthesizes findings from various research papers,emphasizing the growing reliance on mobile technology in ***’s role in orthopaedics is notable for its ease of use,real-time communication,and ***,it facilitates triage,teleconsultation,diagnosis,treatment,patient advice,and post-operative ***-clinically,it supports telemedicine,teleradiology,virtual frac-ture clinics,research,and education in orthopaedic *** application has proven beneficial in enhancing communication among healthcare teams,providing quick responses,and motivating junior *** use in educational settings has been shown to improve learner’s understanding and patient ***,the use of WhatsApp in orthopaedics is not without *** include the potential spread of misleading information,privacy concerns,and issues with image quality affecting diagnosis and treatment *** paper acknowledges the importance of maintaining professional boundaries and the need for oversight measures to ensure content *** forward,the potential of WhatsApp and similar IMAs in orthopaedics lies in their ability to streamline data collection and retrieval,improve doctor-patient communication,and address challenges like bureaucratic red tape and limited *** paper suggests that future orthopaedic practice,particularly in emergency departments,will increasingly rely on such technologies for efficient patient *** shift,however,must be approached with an understanding of the ethical,legal,and practical implications of integrating social media and mobile

关键词： Social media WhatsApp orthopaedics Trauma Research