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ANALYSIS OF DIFFERENT RISK FACTORS IN PRIMARY OPEN ANGLE GLAUCOMA

国际眼科杂志 2003年第1期3卷 39-39页

作者： F.De Gregorio G.Stecchi E.D'Ubaldo institute of oph-thalmology ' La Sapienza' UniversityL. Sacco Hospital University of Milan ItalyInstitute of Oph-thalmology ' La Sapienza' University

Purpose: To investigate the clinical relevance of different risk factors in glaucoma progressioa Methods: A retrospective study was performed on 133 glaucomatous patients. All the patients were under pharmacological treatment and their mean IOP was mantained below 22mmHg. The mean follow up was 5 years (range 3-15 years). 12 risk factors (ocular hypertension,

关键词：原发性开角型青光眼风险因子病理 IPO 眼压

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伴近视和红色盲的X连锁视锥细胞功能障碍综合征

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世界核心医学期刊文摘(眼科学分册) 2006年第2期 61-61页

作者： Michaelides M Johnson S Bradshaw K. D.M. Hunt 白芳 institute of oph thalmology University College London 11- 43 Bath Street London EC1V 9EL Un ited Kingdom Dr.

Purpose: To perform a detailed clinical, psychophysical, and molecular assessment of members of 4 families with an unusual X-linked cone dysfunction syndrome associated with myopia. Participants: Affected and unaffected members of 4 British nonconsanguineous families. Methods: Subjects underwent both detailed clinical examination and psychophysical testing. After informed consent was obtained, blood samples were taken for DNA extraction, and molecular genetic analysis was performed. The strategy for molecular analysis was to amplify the coding regions of the long and middle wavelength-sensitive cone opsin genes and the upstream locus control region by polymerase chain reaction and to examine these fragments for mutations by sequencing of DNA. Results: The phenotype was almost identical in all 4 families, consisting of moderate to high myopia, astigmatism, moderately reduced acuity, and normal fundi. Electroretinography showed abnormal cone but normal rod responses. Psychophysical testing showed a selective impairment of long cones in combination with well-preserved middle cone and short cone function. There was no evidence to suggest that the phenotype was progressive. Molecular analysis of the X-linked opsin gene array in the 4 families indicated that affected males have inherited the same X-chromosome from their mother. In 2 families, a long/middle hybrid gene was detected. In a third family, the commonly described deleterious Cys203Arg amino acid substitution was identified in both the long and middle opsin genes. In the fourth family, the only abnormality was absence of a middle opsin exon 2; the cause of the protanopia in this family is uncertain. Conclusions: The Xlinked cone dysfunction syndrome associated with myopia and dichromacy described here has many similarities to Bornholm eye disease, a condition previously mapped to Xq28. Except for the Cys203Arg substitution in one family, no alterations in the opsin gene array were identified that could underlie t

关键词：视锥细胞红色盲近视屈光不正功能障碍综合征综合病症

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Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022)

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Chinese Medical Sciences Journal 2023年第2期38卷 77-93页

作者： You-Xin Chen Yu-Qing Zhang Chang-Zheng Chen Hong Dai Su-Yan Xiang Ma Xiao-Dong Sun Shi-Bo Tang Yu-Sheng Wang Wen-Bin Wei Feng Wen Ge-Zhi Xu Wei-Hong Yu Mei-Xia Zhang Ming-Wei Zhao Yang Zhang Fang Qi Xun Xu Xiao-Xin Li Department of ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing China Key Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical College Department of Health Research Methods Evidenceand ImpactMc Master University Ningbo Nottingham GRADE center University of Nottingham institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences CEBIM(Center for Evidence Based Integrative Medicine)-Clarity Collaboration Guang'anmen HospitalChina Academy of Chinese Medical Sciences Department of ophthalmology Renmin Hospital of Wuhan University Department of ophthalmology Beijing Hospital Department of ophthalmology Xuzhou Municipal Hospital Affiliated to Xuzhou medical University Department of ophthalmology the First Affiliated Hospital of Dalian Medical University Department of oph thalmology Shanghai General HospitalShanghai Jiao Tong University School of Medicine Aire Eye Hospital Department of ophthalmology Xijing HospitalFouth Military Medical University Department of ophthalmology Beijing Tongren Hospital State Key Laboratory of ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University ophthalmology the Affiliated Eye and ENT HospitalShanghai Medical SchoolFudan University Department of ophthalmology West China School of MedicineWest China HospitalSichuan University Department of ophthalmology Peking University People’s Hospital Systematic Review Solutions Ltd Department of ophthalmology Shanghai General Hospital Eye Center of Xiamen University People Eye Center of People’s Hospital Peking University

Background In China's Mainland,patients with neovascular age-related macular degeneration(nAMD)have approximately an 40%prevalence of polypoidal choroidal vasculopathy(PCV).This disease leads to recurrent retinal pigment epithelium detachment(PED),extensive subretinal or vitreous hemorrhages,and severe vision *** has introduced various treatment modalities in the past years and gained comprehensive experience in treating *** A total of 14 retinal specialists nationwide with expertise in PCV were empaneled to prioritize six questions and address their corresponding outcomes,regarding opinions on inactive PCV,choices of anti-vascular endothelial growth factor(anti-VEGF)monotherapy,photodynamic therapy(PDT)monotherapy or combined therapy,patients with persistent subretinal fluid(SRF)or intraretinal fluid(IRF)after loading dose anti-VEGF,and patients with massive subretinal *** evidence synthesis team conducted systematic reviews,which informed the recommendations that address these *** guideline used the GRADE(Grading of Recommendations,Assessment,Development,and Evaluation)approach to assess the certainty of evidence and grade the strengths of *** The panel proposed the following six conditional recommendations regarding treatment choices.(1)For patients with inactive PCV,we suggest observation over treatment.(2)For treatment-na?ve PCV patients,we suggest either anti-VEGF monotherapy or combined anti-VEGF and PDT rather than PDT monotherapy.(3)For patients with PCV who plan to initiate combined anti-VEGF and PDT treatment,we suggest later/rescue PDT over initiate PDT.(4)For PCV patients who plan to initiate anti-VEGF monotherapy,we suggest the treat and extend(TE)regimen rather than the pro re nata(PRN)regimen following three monthly loading doses.(5)For patients with persistent SRF or IRF on optical coherence tomography(OCT)after three monthly anti-VEGF treatments,we suggest proceeding with anti-VEGF treatment r

关键词： polypoidal choroidal vasculopathy anti-vascular endothelial growth factor photodynamic therapy surgery

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Accuracy of crescent sign on ocular ultrasound in diagnosing papilledema

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World Journal of Methodology 2017年第3期7卷 108-111页

作者： Ananth Bhosale Virna M Shah Parag K Shah Department of Retina and Vitreous Aravind Eye Hospital and Postgraduate Institute of Ophthalmology Department of Neuro ophthalmology Aravind Eye Hospital and Postgraduate Institute of Ophthalmology

AIM To study the usefulness of orbital ultrasonography in the diagnosis of *** Fifty patients who were referred to the neurophthalmology clinic and clinically suspected to have papilledema were selected. Thorough, clinical examination with slitlamp biomicroscopy and visual acuity assessment was done. These patients underwent ultrasonography to demonstrate the crescent sign. The patients were further evaluated with the neurologist and magnetic resonance imaging(MRI) thus confirming the diagnosis of papilledema. The results of our ultrasonographic evaluation were correlated with final diagnosis after thorough clinical evaluation, imaging and the neurologist's *** Out of 50 patients diagnosed having papilledema on MRI, 46(92%) showed crescent sign on B scan ultrasonography. Headache was most common presenting complaint in 47(94%) and idiopathic intracranial hypertension was most common underlying cause of papilledema in 30(60%) ***"Crescent sign" seen on ultrasonography is a sensitive tool for diagnosis of papilledema. It is cost effective, less cumbersome and effective tool to differentiatebetween papilledema and pseudo papilledema before subjecting the patients to costly investigations like MRI. A positive crescent sign should always be followed by MRI to find out the cause of papilledema.

关键词： Papilledema Orbital ultrasound Doughnut sign Crescent sign B scan

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