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Chinese Journal of Electronics 2025年第1期34卷 114-124页

作者： Xiaozhu Lu Lingnan Song Hui Xu Donglin Su School of Electronics and Information Engineering Beihang University research institute for frontier Science Beihang University

This paper systematically studies the impact of imbalances between adjacent lines and effects on crosstalk. A novel perspective of displacement current is introduced to analyze and explain the simulated observations. The imbalances caused by coupling between single-single, single-differential, and differential-differential lines are studied and analyzed by considering the near-field coupling through the generated displacement currents. Measurements are conducted for various cases of coupled adjacent lines. An equivalent model considering the variation of displacement current with geometrical parameters is also proposed, and the corresponding coupling coefficients are extracted based on simulations to characterize the impact of imbalances. The methods and results presented in this paper provide useful guidelines for designing high-speed circuit layouts with closely spaced transmission lines.

关键词： Couplings Voltage measurement Power transmission lines Systematics Current measurement Layout Crosstalk Transmission line measurements Topology Integrated circuit modeling

Bulk photovoltaic effect in two-dimensional ferroelectric α-In2Se3

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Science China(Information Sciences) 2025年第2期68卷 285-292页

作者： Huiting WANG Shuaiqin WU Yan CHEN Qianru ZHAO Jinhua ZENG Ruotong YIN Yuqing ZHENG Chang LIU Shukui ZHANG Tie LIN Hong SHEN Xiangjian MENG Jun GE Xudong WANG Junhao CHU Jianlu WANG State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences Shanghai frontiers Science research Base of Intelligent Optoelectronics and Perception Institute of OptoelectronicsFudan University Hangzhou institute for Advanced Study University of Chinese Academy of Sciences frontier institute of Chip and System Fudan University

Non-centrosymmetric material systems can generate spontaneous photocurrent without a p-n junction under uniform illumination, which is known as the bulk photovoltaic effect（BPVE）. It has garnered significant attention for its application potential in the fields of energy harvesting and photoelectric detection. In this study, we report the BPVE observed in twodimensional ferroelectric α-In2Se3multilayer flakes. The reversal in spontaneous photocurrent polarity is observed and associated with the out-of-plane ferroelectric polarization direction. The spontaneous photocurrent originating from the shift current is also polarization-sensitive. The amplitude of spontaneous photocurrent is further increased by one order of magnitude through vacuum annealing. Our results provide a further application potential for new-generation photodetectors based on BPVE with low power consumption and multi-dimensional optoelectronic detection.

关键词： bulk photovoltaic effect 2D ferroelectrics 3R $\alpha$-In$_2$Se$_3$ shift current self-powered photodetection

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Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha J.Holdsworth Alistair J.Gunn Laura Bennet Hamid Abbasi Mātai Medical research institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain research The University of AucklandAucklandNew Zealand Auckland Bioengineering institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

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Decoupling the roles of grain boundary strength and grain size hidden in grain-level electro-chemo-mechanical failure of solid-state electrolyte

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Journal of Energy Chemistry 2025年第2期101卷 685-691页

作者： Ming Xu Xuyang Wang Zhengqian Jin Xingxing Jiao Ya Gao Zhongxiao Song Xieyu Xu Kai Xi Yangyang Liu School of Chemistry Engineering Research Center of Energy Storage Materials and Devices Ministry of Education Xi'an Jiaotong University State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University research institute of frontier Science Southwest Jiaotong University School of Instrument Science and Technology Xi'an Jiaotong University

Garnet lithium lanthanum zirconium oxide(Li7La3Zr2O12,LLZO) is a benchmark solid-state electrolyte（SSE） material receiving considerable attention owing to its high conductivity and chemical stability against Li *** its electro-chemo-mechanical failure mechanisms have been much investigated,the equivocal roles of grain boundary strength and grain size of LLZO remain under-explored,hindering further performance *** we decoupled the effects of grain size and grain boundary strength of polycrystalline LLZO via the combination of electrochemical kinetics and the cohesive zone *** discovered that the disintegration of LLZO is initiated by the accumulation of local displacements,which strongly relates to the changes in both grain size and grain boundary ***,variations in grain boundary strength affect the diffusion and propagation pathways of damage,while the failure of LLZO is determined by the grain *** LLZO grains facilitate transgranular damage under low grain boundary strength,which can alter local chemo-mechanics within the bulk of LLZO,leading to more extensive damage *** results showcase the structure optimization pathways by preferentially controlling the growth of lithium dendrites at grain boundaries and their penetration in garnet-type SSE.

关键词： Electro-chemo-mechanics Grain boundary Growth of lithium metal Solid-state electrolyte

Polymer Fibers Based on Dynamic Covalent Chemistry

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Chinese Journal of Polymer Science 2025年第2期43卷 245-260页

作者： Luzhi Zhang Xiaozhuang Zhou Xinhong Xiong Jiaxi Cui Yangtze Delta Region institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China institute of Fundamental and frontier Sciences University of Electronic Science and Technology of ChinaChengdu611731China

Polymer fibers are an important class of materials throughout human history,evolving from natural fibers such as cotton and silk to modern synthetic fibers such as nylon and *** the advancement of materials science,the development of new fibers is also *** fibers based on dynamic covalent chemistry have attracted widespread attention due to their unique reversibility and *** covalent chemistry has shown great potential in improving the spinnability of materials,achieving green preparation of fibers,and introducing self-healing,recyclability,and intelligent response properties into *** this review,we divide these fiber materials based on dynamic covalent chemistry into monocomponent fibers,composite fibers,and fiber *** preparation methods,structural characteristics,functional properties,and application performance of these fibers are *** application potential and challenges of fibers based on dynamic covalent chemistry are discussed,and their future development trends are prospected.

关键词： Dynamic covalent chemistry Monocomponent fibers Composite fibers Fiber membranes

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China(Life Sciences) 2025年第1期68卷 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming Guo Shan Bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level,limiting their applications in biological ***,we introduce ImSpiRE,an image feature-aided spatial resolution enhancement method for in situ capturing spatial *** the information stored in histological images,ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution,together with extending the gene expression profiles into unmeasured *** to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains,signaling communication patterns,and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

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Sodium channel mutation SCN1A T875M,D188V and associated dysfunction with drug resistant epilepsy

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World Journal of Psychiatry 2025年第2期15卷 41-47页

作者： Pradeep Kumar Dabla Swapan Gupta Swati Singh Aroop Viswas Manisha Yadav Subash Chandra Sonkar Bidhan Chandra Koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education&ResearchNew Delhi 110002DelhiIndia Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education&ResearchNew Delhi 110002DelhiIndia Multi-disciplinary research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACKGROUND The NaV1.1 sodium channel alpha subunit,encoded by SCN1A,is crucial for initiating and propagating action potentials in ***1A gene has long been an established target in the etiology and therapy of ***,very few studies have investigated the relevance of genetic variations in epilepsy and anti-epileptic drug *** To investigate associations between polymorphisms,rs121917953 T/A and rs121918623 C/T,and drug resistance in epilepsy patients in the north Indian *** A total of 100 age-and sex-matched epilepsy patients(50 drug responsive and 50 drug resistant subjects)were recruited and SCN1A rs121918623 C/T*and rs121917953 T/A*polymorphisms were analyzed by the allele specific-PCR technique.χ^(2)and Fisher’s exact test were used to estimate differences between the distribution of SCN1A rs121918623 and rs121917953 gene polymorphisms among various *** association between distinct rs121917953 genotypes and drug resistance was analyzed using logistic regression *** For the SCN1A rs121917953 T/A*(D188V)polymorphism,a significantly higher proportion of individuals with AT genotype were observed in the drug-resistant group as compared to the drug-responsive ***,a higher risk association was exhibited by AT genotype for drug resistance with an odds ratio of 3.51 and P value=*** the SCN1A rs121918623 C/T*(T875M)polymorphism,no significant difference in genotype distribution was observed between the drug-resistant and drug-sensitive *** Our findings indicate that the SCN1A polymorphism D188V is associated with a higher risk of drug resistance for the AT variant as compared to the homozygous TT *** research is needed at the functional level and in larger cohorts to determine the potential of these genes as a therapeutic target in epilepsy subjects.

关键词： Epilepsy Single nucleotide polymorphisms Drug-resistant epilepsy SCN1A receptor SCN1A rs121918623 and SCN1A rs121917953 gene polymorphism

Lattice-mismatch-induced formation of defect-rich Pd-Cu alloy nanocages for enhanced formic acid oxidation activity

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Science China Chemistry 2025年第2期68卷 481-491页

作者： Zhaojun Liu Zhengyan Wang Zhaoyu Wang Hao Yuan Yuke Bai Xiaoxiao Wang Zerui Mu Chunxia Wu Kai Liu Zhun Hu Chuanbo Gao Sate Key Laboratory of Multiphase Flow in Power Engineering Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China institute of Industrial Catalysis School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China

Crystallographic defects in noble metal nanocrystals are recognized as highly active catalytic sites,significantly enhancing activities in many important *** their importance,synthesizing noble metal nanocrystals with a high density of defects poses a considerable synthetic ***,we present a novel lattice mismatch-induced formation mechanism to create high-density defects in noble metal *** approach takes advantage of lattice mismatch to enable nonepitaxial nucleation and growth of a noble metal on a foreign metal substrate,forming abundant noble metal crystallites with random lattice orientations not dictated by the substrate *** these crystallites grow extensively,they merge,forming numerous grain boundaries and yielding defect-rich noble metal ***-rich alloy nanocrystals can also be synthesized through a subsequent vacancy-diffusion alloying *** take defective PdCu alloy nanocages as an example and demonstrate the effectiveness of crystallographic defects in enhancing catalytic performance of noble metal *** nanocages exhibit superior activity in the electrocatalytic formic acid oxidation reaction,which is 1.6 times greater than their defect-free *** strategy offers a new avenue for creating defect-rich noble metal nanocrystals as highly efficient catalysts for a wide array of catalytic applications.

关键词： noble metal nanocrystals defects non-epitaxial growth electrocatalysis formic acid oxidation reaction

A dopant-assisted iodide-adduct chemical ionization time-of-flight mass spectrometer based on VUV lamp photoionization for atmospheric low-molecular-weight organic acids analysis

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Journal of Environmental Sciences 2025年第3期149卷 500-511页

作者： Yonglei Zhang Ruidong Liu Mei Li Yingzhe Guo Jichuang Kong Keyong Hou Environment research institute Shandong UniversityQingdao 266237China

Formic and acetic acids are the most abundant gaseous organic acids and play the key role in the atmospheric *** iodine-adduct chemical ionizationmass spectrometry(CIMS),the low utilization efficiency of methyl iodide and humidity interference are two major issues of the vacuum ultraviolet(VUV)lamp initiated CIMS for on-line gaseous formic and acetic acids *** this work,we present a new CIMS based on VUV lamp,and the ion-molecular reactor is separated into photoionization and chemical ionization zones by a reducer *** was added to the photoionization zone,and the VUV photoionization acetone provided low-energy electrons for methyl iodide to generate I−,and the addition of acetone reduced the amount of methyl iodide by 2/*** the chemical ionization zone,a headspace vial containing ultrapure water was added for humidity calibration,and the vial changes the sensitivity as a function of humidity from ambiguity to well linear correlation(R2>0.95).With humidity calibration,the CIMS can quantitatively measure formic and acetic acids in the humidity range of 0%-88%*** this mode,limits of detection of 10 and 50 pptv are obtained for formic and acetic acids,*** the relative standard deviation(RSD)of quantitation stability for 6 days were less than 10.5%.This CIMS was successfully used to determine the formic and acetic acids in the underground parking and ambient environment of the Shandong University campus(Qingdao,China).In addition,we developed a simple model based formic acid concentration to assess vehicular emissions.

关键词： Formic acid Acetic acid Vacuum ultraviolet(VUV)lamp photoionization(PI) Chemical ionization(CI) Time-of-flight mass spectrometry (TOFMS) Trace gases measurement

Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration research 2025年第1期20卷 21-28页

作者： Tomomi Tanaka Hyung-Lok Chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

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