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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Nonlinear vibration analysis of laminated composite Mindlin micro/nano-plates resting on orthotropic Pasternak medium using DQM

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Applied Mathematics and Mechanics(English Edition) 2015年第8期36卷 1033-1044页

作者： A.G.ARANI G.S.JAFARI Faculty of Mechanical Engineering University of Kashan institute of nanoscience & nanotechnology University of Kashan

The nonlocal nonlinear vibration analysis of embedded laminated micro- plates resting on an elastic matrix as an orthotropic Pasternak medium is investigated. The small size effects of micro/nano-plate are considered based on the Eringen nonlocal theory. Based on the orthotropic Mindlin plate theory along with the von Kármán geo- metric nonlinearity and Hamilton＇s principle, the governing equations are derived. The differential quadrature method （DQM） is applied for obtaining the nonlinear frequency of system. The effects of different parameters such as nonlocal parameters, elastic me- dia, aspect ratios, and boundary conditions are considered on the nonlinear vibration of the micro-plate. Results show that considering elastic medium increases the nonlinear frequency of system. F^lrthermore, the effect of boundary conditions becomes lower at higher nonlocal parameters.

关键词： nonlinear vibration laminated micro-plate orthotropic Pasternak medium,differential quadrature method

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Nonlocal buckling of embedded magnetoelectroelastic sandwich nanoplate using refined zigzag theory

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Applied Mathematics and Mechanics(English Edition) 2018年第4期39卷 529-546页

作者： A.GHORBANPOUR-ARANI F.KOLAHDOUZAN M.ABDOLLAHIAN Faculty of Mechanical Engineering University of Kashan institute of nanoscience & nanotechnology University of Kashan

This paper is concerned with a buckling analysis of an embedded nanoplate integrated with magnetoelectroelastic(MEE) layers based on a nonlocal magnetoelectroelasticity theory. A surrounding elastic medium is simulated by the Pasternak foundation that considers both shear and normal loads. The sandwich nanoplate(SNP) consists of a core that is made of metal and two MEE layers on the upper and lower surfaces of the core made of Ba Ti O3/Co Fe2 O4. The refined zigzag theory(RZT) is used to model the SNP subject to both external electric and magnetic potentials. Using an energy method and Hamilton’s principle, the governing motion equations are obtained, and then solved analytically. A detailed parametric study is conducted, concentrating on the combined effects of the small scale parameter, external electric and magnetic loads, thicknesses of MEE layers, mode numbers, and surrounding elastic medium. It is concluded that increasing the small scale parameter decreases the critical buckling loads.

关键词： sandwich nanoplate(SNP) refined zigzag theory(RZT) nonlocal magnetoelectroelasticity theory buckling magnetostrictive layer

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Electrochemically Assisted Photocatalytic Oxidation of Methanol on TiO_2 Nanotube Arrays

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Journal of Materials Science & Technology 2010年第6期26卷 535-541页

作者： R.Mohammadpour A.Iraji zad N.Taghavinia M.Rahman M.M.Ahadian institute for nanoscience and nanotechnology Sharif University of Technology Department of Physics Sharif University of Technology

The influence of an externally applied bias on photocatalytic performance of crystallized TiO2/Ti nanotubular electrode formed by anodization in fluoride-based electrolyte were investigated and compared to the behavior of multiporous TiO2 electrode. The photoelectrocatalytic oxidation behavior of methanol over the nanotubular electrode has been studied by measuring photocurrent response, potentiodynamic polarization spectroscopy and using electrochemical impedance spectroscopy （EIS）. It was found that the photoelectrocatalytic oxida- tion and the charge transfer rate constant of reaction on TiO2/Ti nanotubular electrode can significantly be increased by applying electrochemical bias. Moreover, TiO2 electrodes have considerably better performance alytic performance. based on the results, it was found that the nanotubular in comparison with porous samples in photoelectrocatalytic performance.

关键词： TiO2 nanotube Photoelectrocatalyst Electrochemical impedance spectroscopy Methanol

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Enhancing the powering ability of triboelectric nanogenerator through output signal’s management strategies

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Nano Research 2023年第9期16卷 11783-11800页

作者： Changxin Qi Zhenyue Yang Jinyan Zhi Ruichao Zhang Juan Wen Yong Qin institute of nanoscience and nanotechnology School of Materials and EnergyLanzhou UniversityLanzhou 730000China

As a new branch of efficient and low-cost mechanical energy conversion technology,triboelectric nanogenerator(TENG)is a potential solution to provide a long-term power supply for the Internet of Things(IoT)sensors and portable electronic ***,due to inherent working properties of TENG itself such as extremely high internal impedance,pulse,and alternating current(AC)output,TENG can not directly supply power to loads such as batteries *** on these,we describe TENG’s performance from a new perspective of powering *** consists of two aspects:the ability to transport charge effectively and the ability to output high power quality current *** order to push forward the developments and applications of TENG,it is necessary to improve its power supply capacity from different ***,in recent years,a variety of output signal’s management strategies aiming at effectively managing the generated electricity and significantly improving powering ability of TENG have obtained significantly ***,this paper discusses the working mechanisms and different load characteristics of TENG at first to clarify the electric performance of ***,on basis of theoretical analysis,the output signal’s management strategies are elaborated from four aspects:improving the cycle output electricity of TENG,increasing the surface charge density of TENG,improving the power quality of TENG-based energy harvesting system,promoting the application of TENG through integrated circuit(IC)technology and TENG network,and the relevant principles and applications are discussed ***,the advantages and disadvantages of the above output signal’s management strategies are summarized and discussed,and the future development of the output signal’s management strategies for TENG is prospected.

关键词： triboelectric nanogenerator(TENG) inherent working properties TENG-based energy harvesting system powering ability output signal’s management strategies.

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Dynamic surface wettability of three-dimensional graphene foam

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Chinese Physics B 2014年第4期23卷 472-475页

作者：黄文斌王广龙高凤岐乔中涛王刚陈闽江陶立邓娅孙连峰 institute of nanotechnology and Microsystems Mechanical Engineering College National Center for nanoscience and Technology

In this work, three-dimensional graphene foams （GFs） are synthesized and characterized by scanning electron micro- scope （SEM） and Raman spectroscopy. The SEM images indicate that after the growth of graphene, the graphene covers the surface of nickel （Ni） foam uniformly. Raman spectra show that the percentages of monolayer, bilayer, trilayer, and multilayer graphenes are - 58%, - 32%, - 8%, and ,.o 2%, respectively. The contact angle （CA）（-- 12°） of water droplet （3 p-L） on GF is found to be larger than that on Ni foam （,- 107°）, indicating that graphenes have changed the surface wettability of the Ni foam. Meanwhile, the dynamic characteristics of CA of water droplet on GF are different from those on Ni foam. The mechanisms for different behaviors are discussed, which are attributed to volatilization and seepage of water droplets.

关键词： graphene foam CVD surface wettability contact angle

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A Fully Self-Healing Piezoelectric Nanogenerator for Self-Powered Pressure Sensing Electronic Skin

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Research 2021年第1期2021卷 876-884页

作者： Maosen Yang Jinmei Liu Dong Liu Jingyi Jiao Nuanyang Cui Shuhai Liu Qi Xu Long Gu Yong Qin School of Advanced Materials and nanotechnology Xidian UniversityXi’an 710071China institute of nanoscience and nanotechnology Lanzhou UniversityGansu 730000China

As an important way of converting mechanical energy into electric energy,a piezoelectric nanogenerator(PENG)has been widely applied in energy harvesting as well as self-powered sensors in recent ***,its robustness and durability are still severely challenged by frequent and inevitable mechanical impacts in real application ***,a fully selfhealing PENG(FS-PENG)as a self-powered pressure sensing electronic skin is *** self-healing piezoelectric composite and self-healing Ag NW electrode fabricated through mixing piezoelectric PZT particles and conductive Ag NWs into self-healing polydimethylsiloxane(H-PDMS)are assembled into the sandwich structure *** FS-PENG could not only effectively convert external stimulation into electrical signals with a linear response to the pressure but also retain the excellent self-healing and stable sensing property after multiple cycles of cutting and self-healing ***,a self-healing pressure sensor array composed of 9 FS-PENGs was attached on the back of the human hand to mimic the human skin,and accurate monitoring of the spatial position distribution and magnitude of the pressure was successfully realized.

关键词： piezoelectric healing generator

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Design of multidimensional nanocomposite material to realize the application both in energy storage and electrocatalysis

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Science Bulletin 2018年第3期63卷 152-154页

作者： Qiancheng Zhu Desheng Cai Xiaoqin Lan Guodong Shi Kai Jin Jianqing Zhou Wenjuan Chen Ying Yu institute of nanoscience and nanotechnology College of Physical Science and Technology Central China Normal University

The development of clean,sustainable and renewable energy storage systems is in urgent need with the fast-growing energy demand in the areas of electric vehicles and mobile electronics ***-ion batteries(LIBs)have been deemed to be the most promising energy storage devices for their high power density,long cycle life and fast charge-discharge rates[1].Transition

关键词：存储系统精力材料设计应用程序多维锂离子电池存储设备电子学

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Challenges and opportunities in IR nanospectroscopy measurements of energy materials

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Nano Research 2019年第9期12卷 2200-2210页

作者： Elad Gross institute of Chemistry and Center far nanoscience and nanotechnology The Hebrew University of JerusalemJerusalem 91904Israel

The performance of functional materials and specifically energy-related functional materials,such as fuel cells,solar cells,batteries and catalysts depends on the their local,nanoscale ***,heterogeneities in the phase,structure and composition of these functional materials makes it difficult to directly monitor and identify the influence of local physicochemical parameters on their global *** this review we will discuss recent developments in the field of IR nanospectroscopy that enables the extraction of detailed chemical information at the nanoscale and the identification of nanoscale properties that influence the global performances of functional ***,we will discuss the ways by which infrared (IR) nanospectroscopy techniques,namely photo thermal induced resonance (PTIR) and scattering scanning near-field optical microscopy (s-SNOM),are utilized in order to identify nanoscale properties and their influence on the functionality of halide-perovskite solar cells and catalytic *** the last part of this review we will address the technical challenges and opportunities in expanding the scope of IR nanospectroscopy measurements into the field of electrochemistry-based functional materials.

关键词： infrared(IR)nanospectroscopy photo thermal in duced resonance(PTIR) scattering sea nning n ear-field optical microscopy(s-SNOM) heterogeneous catalysis perovskite solar cells

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Pauli Paramagnetic Susceptibility of an Ideal Anyon Gas within Haldane Fractional Exclusion Statistics

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Communications in Theoretical Physics 2012年第10期58卷 573-576页

作者：覃昉陈继胜 Physics Department and institute of nanoscience and nanotechnology Central China Normal University

The finite-temperature Pauli paramagnetic susceptibility of a three-dimensional ideal anyon gas obeying Haldane fractional exclusion statistics is studied *** from the result of an ideal Fermi gas,the susceptibility of an ideal anyon gas depends on a statistical factor g in Haldane statistics *** low-temperature and high-temperature behaviors of the susceptibility are investigated in *** Pauli paramagnetic susceptibility of the two-dimensional ideal anyons is also *** is found that the reciprocal of the susceptibility has the similar factorizable property which is exhibited in some thermodynamic quantities in two dimensions.

关键词： susceptibility pauli paramagnetism fractional exclusion statistics

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