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Journal of Rare Earths 2021年第8期39卷 1003-1009页

作者： Y.Slimani M.A.Almessiere A.Demir Korkmaz A.Baykal I.Ercan Department of Biophysics Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityP.0.Box 198231441 DammamSaudi Arabia Department of Chemistry Istanbul Medeniyet University34700 UskudarIstanbulTurkey Department of nanomedicine Research Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityP.O.Box 198231441 DammamSaudi Arabia

In this comparative study,Tb and Tm substituted Sr-hexafe rrites(HFs) with the chemical compositions of SrTb_(x)Fe_(12-x)O_(19) and SrTm_(x)Fe_(12-x)O_(19)(x=0.00,0.02 and 0.04) were fabricated via citrate sol-gel *** AC susceptibility and FC-ZFC magnetization were *** product structure and morphologies were also investigated via XRD,TEM and SEM along with *** of temperature dependence of magnetization M-T and AC magnetic susceptibility versus temperature were carried *** various synthesized HFs displayed ferrimagnetic behavior within 10-325 *** lower temperatures,super-spin glass-like behavior was ***-Arrhenius and Vogel-Fulcher models were employed to explore the experimental data of AC susceptibility.

关键词： M-type hexaferrites Magnetic properties AC susceptibility FC/ZFC Rare earths

Translation of the long-term fundamental studies on viral DNA packaging motors into nanotechnology and nanomedicine

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Science China(Life Sciences) 2020年第8期63卷 1103-1129页

作者： Chenxi Liang Tao Weitao Lixia Zhou Peixuan Guo Center for RNA Nanobiotechnology and nanomedicine College of PharmacyCollege of MedicineDorothy M.Davis Heart and Lung Research Instituteand Comprehensive Cancer Center.The Ohio State UniversityColumbusOhio 43210USA Biology Department College of Science and MathematicsSouthwest Baptist UniversityBolivarMissouri 65613USA

Many years of fundamental studies on viral genome packaging motors have led to fruitful *** double-stranded DNA(dsDNA)viruses package their genomes into preformed protein shells via nanomotors including several elegant and meticulous coaxial *** motor is geared by the hexameric RNA *** open washer displayed as hexametric string of phi29 motor ATPase has been *** open washer linked into a filament as a queue with left-handed chirality along the dsDNA *** was found that a free 5′-and 3′-dsDNA end is not required for one gp16 dimer and four monomers to assemble into the hexametric washer on *** above studies have inspired several applications in nanotechnology and *** applications include:(i)studies on the precision motor channels have led to their application in the single pore sensing;(ii)investigations into the hand-in-hand integration of the hexametric pRNA ring have resulted in the emergence of the new field of RNA nanotechnology;and(iii)the studies on the motor stoichiometry of homologous multi-subunits that subsequently have inspired the discovery of new methods in highly potent drug *** review focuses on the structure and function of the viral DNA packaging motors and describes how fundamental studies inspired various *** these advantages,more nanotechnological and biomedical applications using bacteriophage motor components are expected.

关键词： nanopores packaging motor phi29 pRNA single pore sensing chemical detection peptide differentiation and sensing nanotechnology nanobiotechnology

Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery

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Acta Pharmaceutica Sinica B 2021年第2期11卷 560-571页

作者： Shaojun Peng Boshu Ouyang Yongjie Xin Wei Zhao Shun Shen Meixiao Zhan Ligong Lu Zhuhai Precision Medical Center Zhuhai Interventional Medical CenterZhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000China The institute for Translational nanomedicine Shanghai East HospitalTongji University School of MedicineShanghai 200120China Zhejiang Cancer Hospital Institute of Cancer ResearchHangzhou 310012China Central Laboratory First Affiliated HospitalInstitute(College)of Integrative MedicineDalian Medical UniversityDalian 116021China

Tumor microenvironment has been widely utilized for advanced drug delivery in recent years,among which hypoxia-responsive drug delivery systems have become the research *** hypoxia-responsive micelles or polymersomes have been successfully developed,a type of hypoxia-degradable nanogel has rarely been reported and the advantages of hypoxia-degradable nanogel over other kinds of degradable nanogels in tumor drug delivery remain ***,we reported the synthesis of a novel hypoxia-responsive crosslinker and the fabrication of a hypoxia-degradable zwitterionic poly(phosphorylcholine)-based(HPMPC)nanogel for tumor drug *** obtained HPMPC nanogel showed ultra-long blood circulation and desirable immune compatibility,which leads to high and long-lasting accumulation in tumor ***,HPMPC nanogel could rapidly degrade into oligomers of low molecule weight owing to the degradation of azo bond in hypoxic environment,which leads to the effective release of the loaded ***,HPMPC nanogel showed superior tumor inhibition effect both in vitro and in vivo compared to the reduction-responsive phosphorylcholine-based nanogel,owing to the more complete drug ***,the drug-loaded HPMPC nanogel exhibits a pronounced tumor inhibition effect in a humanized subcutaneous liver cancer model with negligible side effects,which showed great potential as nanocarrier for advanced tumor drug delivery.

关键词： Hypoxia-degradable Zwitterionic nanogel Long blood circulation Drug release Drug delivery

Interface Effect of Ru-MoS_(2) Nanoflowers on Lignin Substrate for Enhanced Hydrogen Evolution Activity

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Energy & Environmental Materials 2021年第1期4卷 117-125页

作者： Yeqing Xu Xingxing Jiang Gonglei Shao Haiyan Xiang Sisi Si Xing Li Travis Shihao Hu Guo Hong Shengyi Dong Huimin Li Yexin Feng Song Liu institute of Chemical Biology and nanomedicine (ICBN) State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan UniversityChangsha Hunan 410082China Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices School of Physics and Electronics Hunan UniversityChangsha Hunan 410082 China institute of Chemical Biology and nanomedicine State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical Engineering Hunan UniversityChangsha Hunan 410082 China College of Chemistry and Chemical Engineering Hunan UniversityChangsha Hunan 410082 China Department of Mechanical Engineering California State UniversityLos Angeles CA 90032 USA institute of Applied Physics and Materials Engineering Department of Physics and Chemistry Faculty of Science and Technology University of MacaoAvenida da UniversidadeTaipa Macao SAR 999078 China School of Physics Peking UniversityBeijing 100871 China

The catalytic performance of Molybdenum disulfide(MoS_(2)) has been still far from that of Pt-based catalysts for inadequate active sites and sluggish electron transfer kinetics. Through engineering the interface between MoS_(2)-based materials and supported substrates, hybrid Ru-doped MoS_(2) on carbonized lignin(CL) is designed and prepared as efficient catalyst for hydrogen evolution reaction(HER). The CL substrate not only facilitates the growth of MoS_(2) nanoflowers, but also promotes the electron transfer. Ru doping increases active sites greatly for HER. The hybrid catalyst achieves a low onset overpotential of 25 mV and a low Tafel slope of 46 m V dec^(-1). The favorable HER activity ascribes to the interfacial interaction between MoS_(2) and CL. Density functional theory calculations further confirm the improved HER performance with doped Ru atoms. This study presents a prototype application to design electrocatalysts with enhanced carrier mobility and high-density active sites based on interface effect.

关键词： carbonized lignin hydrogen evolution reaction interface effect molybdenum disulfide

Organic Nanocrystals Based on a Solid-emission-tunable AIEgen for Cell Imaging

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Chemical Research in Chinese Universities 2021年第1期37卷 129-136页

作者： YANG Liming GUO Lixin YU Hao WANG Guan SUN Jiangman ZHANG Pengfei GU Xinggui TANG Ben Zhong Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Materials Science and EngineeringState Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijing100029P.R.China Guangdong Key Laboratory of nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS Key Laboratory of Health InformaticsInstitute of Biomedicine and BiotechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055P.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyThe Hong Kong University of Science and TechnologyHong KongP.R.China

The development of fluorescent nanocrystals based on organic small molecules is of great importance in bioimaging due to the merits of easy modification,high brightness and excellent photostability,however suffering from the emission-detrimental aggregation-caused quenching(ACQ)***,we successfully designed and synthesized an AIE-active di(N,N-dimethylaniline)-dibenzofulvene(named as NFTPE),which exhibits the crystallization-induced emission enhancement(CIEE)***,two types of yellow-and orange-emissive crystals for NFTPE were obtained,exhibiting aggregation microenvironment-dependent emission tuning in the solid ***-crystal analysis and density functional theory(DFT)calculations reveal that different aggregation microenvironments result in the distinct molecular conformation for various ***,the crystallization of NFTPE in an aqueous solution under the assistance of amphiphilic PEG polymer matrices could be monitored in situ by the fluorescence changes,facilitating the preparation of NFTPE nanocrystals(NFTPE-NCs)by adjusting the aggregation *** obtained NFTPE-NCs exhibit the superior performance in cell imaging in respect to high brightness,photostability,and biocompatibility,thus demonstrating the potential in bioimaging applications.

关键词： Aggregation-induced emission(AIE) Crystallization-induced emission enhancement(CIEE) Aggregation microenvironment Nanocrystal Cell imaging

Surface Modified Persistent Luminescence Probes for Biosensing and Bioimaging:A Review

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Chinese Journal of Chemistry 2021年第4期39卷 1009-1021页

作者： Qiang Luo Wenjie Wang Jie Tan Quan Yuan institute of Chemical Biology and nanomedicine(ICBN) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan410082 China Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry College of Chemistry and Molecular SciencesWuhan UniversityWuhanHubei430072 China

Persistent luminescence materials(PLMs)are a class of unique luminescent materials that can remain luminescent for a few milliseconds to days without constant *** virtue of the super long decay time,PLMs have been extensively explored in biosensing and bioimaging applications to elimin ate autofluorescence interference and improve signal-to-noise ratio in complex samples and ***,nude PLMs often suffer from the poor stability,selectivity,and biocompatibility in biological system and in vivo,which greatly impedes their applications in biomedicine and ***,surface modification is a viable solution that endows PLMs with span-new features and can make PLMs suitable for organisms by altering PLMs’interaction with biological *** this review,commonly used strategies for surface modification of PLMs are briefly introduced,and the applications of surface modified PLMs in biosensing and bioimaging as well as their challenges are summarized.

关键词： Luminescence Nanoparticles Surface chemistry Biosensors Bioimaging

Recent Progress in Exploiting Small Molecule Peptides as Supramolecular Hydrogelators

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Chinese Journal of Polymer Science 2017年第10期35卷 1194-1211页

作者： Hao Su Yuzhu Wang Caleb F.Anderson Jin Mo Koo Han Wang Honggang Cui Department of Chemical and Biomolecular Engineering The Johns Hopkins University Baltimore Maryland 21218 USA institute for NanoBio Technology The Johns Hopkins University Baltimore Maryland 21218 USA Department of Oncology and Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore MD 21205 USA Center for nanomedicine The Wilmer Eye Institute Johns Hopkins University School of Medicine 400 North Broadway Baltimore MD 21231 USA

Small molecule peptides and their derivatives are an emerging class of supramolecular hydrogelators that have attracted rapidly growing interest in the fields of drug delivery and regenerative medicine due to their inherent biodegradability and biocompatibility, as well as versatility in molecular design and ease of synthesis. Built upon the directional, intermolecular interactions such as hydrogen bonding and π-π stacking, peptide-based molecular units can associate in aqueous solution into filamentous assemblies of various sizes and shapes. Under appropriate conditions, these filamentous assemblies can percolate into a 3D network with materials properties tailorable for specific biomedical applications. In this review, we survey the literature published over the past three years in the development of peptide-based hydrogelators for biomedical applications. We highlight several representative examples and center our discussion on the fundamentals of molecular design, assembly, and gelation conditions.

关键词： PNIPAM spheres reversible assembled colloidal Highly ordered assembly leaving anhydride

Synthesis and Structure-Activity Relationships of Ring-Opened Bengamide Analogues against Methicillin-Resistant Staphylococcus aureus

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Chinese Journal of Chemistry 2021年第3期39卷 671-676页

作者： Chen-Xi Yu Bing-Yan Wei Xue-Qing Kong Cai-Guang Yang Fa-Jun Nan State Key Laboratory of Drug Research the National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhouZhejiang 310024China Yantai Key Laboratory of nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantaiShandong 264000China

Main observation and conclusion Methicillin-resistant Staphylococcus aureus(MRSA)has become a major threat on public health because of the increase of clinically isolated strains that exhibit resistance to many ***,development of new antibiotics for the treatment of MRSA in-fection is a sustained *** have previously identified a ring-opened bengamide analogue L472-2 that displays moderate ac-tivity against the growth of *** our previous work,we started from L472-2 and identified a class of analogues containing al-kynyl groups which have the potential to activate SaCIpP activity but moderate antibacterial ***,we focused on the anti-bacterial activity of L472-2,and a novel series of ring-opened bengamide analogues were synthesized and their activities were evalu-ated against *** conducting a compact analysis of the structure-activity relationships(SAR)of these analogues,we found that an adamantane ethanol ester bengamide 2j showed excellent antibacterial activity towards six *** strains,including MRSA,while it does not activate ***,these bengamide analogues represent a new class of candidates that suppress MRSA via-bility..

关键词： Bengamides Staphylococcus aureus Antibiotics Structure-activity relationships Pharmacokinetic

Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao Chen Xianzhe Tang Yueye Huang Chen Chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng Cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei Chen Zhitong Chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

Nanoparticle targeting cGAS-STING signaling in disease therapy

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Nano Research 2024年第8期17卷 7315-7336页

作者： Lan Zhou Yu Huang Yuzhang Wu Shupei Tang Frontier Medical Training Brigade Third Military Medical UniversityHutubi 831200China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China institute of Immunology Third Military Medical UniversityChongqing 400038China Shigatse Branch Xinqiao HospitalThird Military Medical UniversityShigatse 857000China

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon(IFN)genes(cGAS-STING)signaling pathway is crucial for sensing abnormal DNA accumulation in the *** binds to abnormal DNA,cGAS catalyzes the production of second messenger cyclic dinucleotides,followed by the activation of downstream *** activation induces the expression of type I interferon and other inflammatory cytokines,ultimately initiating an immune *** to the involvement of the cGAS-STING pathway in various diseases,including infection,tumor,autoimmune disease and kidney disease,ongoing research is focused on developing drugs and treatment methods to target and regulate this *** the development of nanotechnology,nanomedicines targeting cGAS-STING signaling are of great significance in clinical applications due to their targeted delivery,controlled drug release,improved solubility,multifunctionality,and enhanced *** comprehensive review focuses on the most recent progress of nanoplatforms targeting cGAS-STING in disease therapy,aiming to provide references and guidelines for further design and optimization of nanomedicines.

关键词： nanomedicine cGAS-STING pathway and related disease anti-tumor nanotherapy anti-viral nanotherapy