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A Triode-like Enzyme-free Catalytic Circuit with Junction Fuel

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Chemical Research in Chinese Universities 2020年第2期36卷 261-267页

作者： LUO Tao WANG Xiaojing FAN Sisi LIU Yan CHENG Jin TANG Linlin SONG Jie Institute of Nano Biomedicine and Engineering Department of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240P R.China

Target detection circuits have been previously designed,which are propelled by conventional PCR,isothermal amplification and strand-displacement reaction.These detection circuits obtain the target signal via the replication of the target strand,the aggregation of the signal particles or the branch migration.Here we constructed a tri-ode-like enzyme-free catalyst strand-displacement circuit for target DNA detection.The target strand triggered die reaction and released the fluorescence signal strand circularly through branch migration.However,the main challenge of strand-displacement reaction is the signal leakage.Therefore,we designed a double strand structure"junction fuel",which was used to increase the binding energy across the displacement process.Ultimately,the leakage of the system obtained stable inhabitation due to the junction fuel strand.The limit of detection of the system was as low as 0.11 nmol/L and the gain of the system was as high as 28-fold(the concentration of target was 50 nmol/L).Furthermore,the process of the system was visualized vividly in the reaction curve through the kinetic simulation implemented,which suggests that the combination of the kinetic simulation and the experiment exhibits a promising prospect towards the use of strand-displacement circuit in analytical,diagnostic application and synthetic biology.

关键词： Catalysis Strand-displacement Junction fuel Triode-like Kinetic simulation

Efficient photocatalysis triggered by thin carbon layers coating on photocatalysts:recent progress and future perspectives

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Science China Chemistry 2020年第10期63卷 1416-1427页

作者： Yu-Long Men Peng Liu Xingcui Peng Yun-Xiang Pan Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Solar-energy-driven photocatalysis,such as photocatalytic reduction of CO2,is promising simultaneously for the energy and environmental issues.Coating thin carbon layers with the thickness less than 10 nm on photocatalysts has been developed as an efficient strategy for enhancing the photocatalytic efficiency in recent years.In the present review,we summarize the crucial progress on carbon-coated photocatalysts.Origins for the improved light absorption,charge separation,reactant adsorption and photocatalytic stability on carbon-coated photocatalysts as well as the applications of carbon-coated photocatalysts are discussed.Future opportunities and challenges associated with carbon-coated photocatalysts are shown at the end of the review.We hope that the present review can trigger more deep insights on carbon-coated photocatalysts and provide new opportunities for developing low-cost but efficient photocatalysts.

关键词： carbon-coated photocatalysts light absorption charge separation reactant adsorption photocatalytic stability

Noble-metal-free cobalt hydroxide nanosheets for efficient electrocatalytic oxidation

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Frontiers of Chemical Science and engineering 2020年第6期14卷 948-955页

作者： Jie Lan Daizong Qi Jie Song Peng Liu Yi Liu Yun-Xiang Pan Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Cobalt hydroxide has been emerging as a promising catalyst for the electrocatalytic oxidation reactions,including the oxygen evolution reaction(OER)and glucose oxidation reaction(GOR).Herein,we prepared cobalt hydroxide nanoparticles(CoHP)and cobalt hydroxide nanosheets(CoHS)on nickel foam.In the electrocatalytic OER,CoHS shows an overpotential of 306 mV at a current density of 10 mA·cm^-2.This is enhanced as compared with that of CoHP(367 mV at 10 mA·cm^-2).In addition,CoHS also exhibits an improved performance in the electrocatalytic GOR.The improved electrocatalytic performance of CoHS could be due to the higher ability of the two-dimensional nanosheets on CoHS in electron transfer.These results are useful for fabricating efficient catalysts for electrocatalytic oxidation reactions.

关键词： electrocatalytic oxidation cobalt hydroxide nanosheet water glucose

Advances in isolation and detection of circulating tumor cells based on microfluidics

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Cancer Biology & Medicine 2018年第4期15卷 335-353页

作者： Dan Zou Daxiang Cui Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Center for Intelligent Instrument for Diagnosis and Therapy Department of Instrument Science & Engineering School of Electronic Information and Electrical Engineering National Center for Translational Medicine Collaborative Innovational Center for System Biology Shanghai Jiao Tong University

Circulating tumor cells(CTCs) are the cancer cells that circulate in the peripheral blood after escaping from the original or metastatic tumors. CTCs could be used as non-invasive source of clinical information in early diagnosis of cancer and evaluation of cancer development. In recent years, CTC research has become a hotspot field wherein many novel CTC detection technologies based on microfluidics have been developed. Great advances have been made that exhibit obvious technical advantages, but cannot yet satisfy the current clinical requirements. In this study, we review the main advances in isolation and detection methods of CTC based on microfluidics research over several years, propose five technical indicators for evaluating these methods, and explore the application prospects. We also discuss the concepts, issues, approaches, advantages, limitations, and challenges with an aim of stimulating a broader interest in developing microfluidics-based CTC detection technology.

关键词： Circulating tumor cells isolation and detection microfluidics

Potassium sodium tartrate-assisted hydrothermal synthesis of BaLuFs ：Yb3＋/Er3＋ nanocrystals

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Particuology 2016年第1期14卷 164-169页

作者： Rongjin Sun Peiyu Qiu Ting Yin Guo Gao Hualin Fu Kan Wang Chunlei Zhang Daxiang Cui Institute of Nano Biomedicine and Engineering Department of Instrument Science and Technology Key Laboratory for Thin Film and MicrofabricationTechnology of Ministry of Education School of Electronic Information and Electrical Engineering School of Materials Science and Engineering Shanghai JiaoTong University Shanghai 200240 China

Highly-dispersed BaLuFs：yb3＋/Er3＋ nanocrystals were prepared by a facile potassium sodium tartrate- assisted hydrothermal method. The average particle size was approximately 20-25 nm. The formation mechanism is discussed. Potassium sodium tartrate led to form a complex with an approximately three- dimensional network structure, which insured largely concurrent nucleation. As a result, we acquired uniform nanoparticles. The hydrothermal temperature, holding time, and pH value were important fac- tors affecting the formation of the BaLuF5 ：yb3＋/Er3＋ nanocrystals. We investigated their influence on the formation and realized the optimal reaction parameters. Remarkably, potassium sodium tartrate also con- tributed to the biocompatibility and potential biomedical applications of BaLuFs ：Yb3＋/Er3＋ nanocrystals by decomposing into small organic groups attached to the nanoparticles.

关键词： Upconversion BaLuFs PST Hydrothermal synthesis

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表征不同DNA高阶结构的单分子方法

工程(英文) 2023年第5期24卷 276-291,I0008页

作者： Yonglin Liu Tianyuan Bian Yan Liu Zhimin Li Yufeng Pei Jie Song School of Molecular Medicine Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China The Cancer Hospital of the University of Chinese Academy of Sciences Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Academy of Medical engineering and Translational Medicine(AMT) Tianjin UniversityTianjin 300072China Institute of Nano Biomedicine and Engineering Department of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

DNA不仅是生命遗传信息的载体,而且是一种高度可编程和自组装的纳米材料。不同的DNA结构与其生物和化学功能有关。因此,了解各种DNA结构的物理和化学性质在生物学和纳米化学中具有重要意义。然而,批量分析忽略了溶液中DNA结构的异质性... 详细信息

DNA不仅是生命遗传信息的载体,而且是一种高度可编程和自组装的纳米材料。不同的DNA结构与其生物和化学功能有关。因此,了解各种DNA结构的物理和化学性质在生物学和纳米化学中具有重要意义。然而,批量分析忽略了溶液中DNA结构的异质性。单分子方法是观察单个分子行为和探测自由能态高度非均质性的有力工具。在本文中,介绍了单分子方法,包括单分子检测和操作方法,并讨论了这些方法如何有助于测量单链/双链DNA(ss/dsDNA)、DNA高阶结构和DNA纳米结构的分子性质。本文为DNA纳米技术与单分子方法的结合提供了一个新的视角,以了解DNA和其他生物物质和软物质的生物物理特性。

关键词： DNA结构单分子生物物质分子性质软物质遗传信息操作方法批量分析

Two birds with one stone:Amine-functionalized MSNs@Eu(OH)CO_(3) nanoprobe for efficient dissolution-enhanced afterglow bioassay

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nano Research 2022年第9期15卷 8360-8366页

作者： Fuying Zhang Donghao Hu Xianlong Su Zhengdao Hong Wei Feng Ming Xu Fuyou Li Department of Chemistry&State Key Laboratory of Molecular engineering of Polymers&institute of biomedicine Science Fudan UniversityShanghai 200433China

ABSTRACT The efficient detection of tumor markers is crucial to early cancer diagnosis and monitoring.Here,we propose a unique“two birds with one stone”dissolution-enhanced afterglow bioassay based on amino-functionalized mesoporous SiO2 nanoparticles(MSNs-NH2)encapsulated Eu(OH)CO_(3)nanoprobes.These nanoprobes(i)stably conjugate to the antibody and(ii)are highly soluble in the acidic enhancer solution,and provide a high Eu3+concentration.The released Eu3+ions further activate the photochemical afterglow system to determine the alpha-fetoprotein(AFP)levels in clinical serum samples.Without the use of a real-time excitation source,the interference of autofluorescence and scattering from blood can be avoided.The demonstrated limit of detection(LOD)for AFP was as low as 0.12 ng·mL^(−1).This covalently connected dissolution-enhanced luminescent bioassay(DELBA)and novel afterglow system shows tremendous potential for ultrasensitive and rapid clinical diagnosis.

关键词： bioassay photochemical afterglow mesoporous SiO2 nanoparticles(MSNs) nanocomposites dissolution-enhanced

Multiscale analysis of friction behavior at fretting interfaces

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Friction 2021年第1期9卷 119-131页

作者： Zhinan ZHANG Shuaihang PAN Nian YIN Bin SHEN Jie SONG State Key Laboratory of Mechanical Systems and Vibrations Shanghai Jiao Tong UniversityShanghai 200240China School of Mechanical&Aerospace engineering University of California Los AngelesLos Angeles 90095USA Institute of Nano Biomedicine and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Friction behavior at fretting interfaces is of fundamental interest in tribology and is important in material applications.However,friction has contact intervals,which can accurately determine the friction characteristics of a material;however,this has not been thoroughly investigated.Moreover,the fretting process with regard to different interfacial configurations have also not been systematically evaluated.To bridge these research gaps,molecular dynamics(MD)simulations on Al–Al,diamond–diamond,and diamond–silicon fretting interfaces were performed while considering bidirectional forces.This paper also proposes new energy theories,bonding principles,nanoscale friction laws,and wear rate analyses.With these models,semi-quantitative analyses of coefficient of friction(CoF)were made and simulation outcomes were examined.The results show that the differences in the hardness,stiffness modulus,and the material configuration have a considerable influence on the fretting process.This can potentially lead to the force generated during friction contact intervals along with changes in the CoF.The effect of surface separation can be of great significance in predicting the fretting process,selecting the material,and for optimization.

关键词： molecular dynamics simulation friction wear fretting

Artificial optical microfingerprints for advanced anticounterfeiting

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nano Research 2024年第5期17卷 4371-4378页

作者： Xueke Pang Qiang Zhang Jingyang Wang Xin Jiang Menglin Wu Mingyue Cui Zhixia Feng Wenxin Xu Bin Song Yao He Suzhou Key Laboratory of nanotechnology and biomedicine Institute of Functional Nano&Soft Materials&Collaborative Innovation Center of Suzhou Nano Science and Technology(NANO-CIC)Soochow UniversitySuzhou 215123China School of Sensing Science and engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Artificial optical microfingerprints,known as physically unclonable functions(PUFs)offer a groundbreaking approach for anti-counterfeiting.However,these PUFs artificial optical microfingerprints suffer from a limited number of challenge-response pairs,making them vulnerable to machine learning(ML)attacks when additional error-correcting units are introduced.This study presents a pioneering demonstration of artificial optical microfingerprints that combine the advantages of PUFs,a large encoding capacity algorithm,and reliable deep learning authentication against ML attacks.Our approach utilizes the triple-mode PUFs,incorporating bright-field,multicolor fluorescence wrinkles,and the topography of surface enhanced Raman scattering in the mechanical and optical layers.Notably,the quaternary encoding of these PUFs artificial microfingerprints allows for an encoding capacity of 6.43×10^(24082) and achieves 100%deep learning recognition accuracy.Furthermore,the PUFs artificial optical microfingerprints exhibit high resilience against ML attacks,facilitated by generative adversarial networks(GAN)(with mean prediction accuracy of~85.0%).The results of this study highlight the potential of utilizing up to three PUFs in conjunction with a GAN training system,paving the way for achieving encoded information that remains resilient to ML attacks.

关键词： artificial microfingerprints physically unclonable functions deep learning anti-counterfeiting