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Toxicity of the disinfectant benzalkonium chloride(C_(14))towards cyanobacterium Microcystis results from its impact on the photosynthetic apparatus and cell metabolism

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Journal of Environmental Sciences 2024年第1期135卷 198-209页

作者： Yunlu Jia Yi Huang Jin Ma Shangwei Zhang Jin Liu Tianli Li Lirong Song institute of Hydrobiology Chinese Academy of SciencesWuhan 430072China School of Environmental studies China University of GeosciencesWuhan 430074China Advanced Interdisciplinary institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087China

Quaternary ammonium compounds(QACs)are commonly used in a variety of consumer and commercial products,typically as a component of *** the COVID-19 pandemic,QACs became one of the primary agents utilized to inactivate the SARS CoV-2 virus on ***,the ecotoxicological effects of QACs upon aquatic organisms have not been fully *** this study,we examined the effects of a widely used QAC(benzalkonium chloride-C_(14),BAC-14)on two toxigenic Microcystis strains and one non-toxigenic freshwater Microcystis strain and carried out an analysis focused on primary,adaptive and compensatory stress responses at apical(growth and photosynthesis)and metabolic *** analysis revealed that the two toxic Microcystis strains were more tolerant than the non-toxic strain,with 96 hr-EC_(50)values of 0.70,0.76,and 0.38 mg/L BAC-14 for toxigenic *** FACHB-905,toxigenic *** FACHB-469,and non-toxigenic *** FACHB-908,*** photosynthetic activities of the Microcystis,assessed via F_(v)/F_(m) values,were significantly suppressed under 0.4 mg/L ***,this analysis revealed that BAC-14 altered 14,12,and 8 metabolic pathways in *** FACHB-905,*** FACHB-469,and *** FACHB-908,*** is noteworthy that BAC-14 enhanced the level of extracellular microcystin production in the toxigenic Microcystis strains,although cell growth was not significantly ***,these data show that BAC-14 disrupted the physiological and metabolic status of Microcystis cells and stimulated the production and release of microcystin,which could result in damage to aquatic systems.

关键词： Disinfectants Quaternary ammonium compounds Microcystis Cyanotoxin Metabolomics Chlorophyll fluorescence

Impact of lifestyle interventions on pathogenesis of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第20期30卷 2633-2637页

作者： Wafaa Mohamed Ezzat Department of Internal Medicine Medical Research and Clinical Studies InstituteNational Research CenterGiza 12311Egypt

This editorial builds on the article titled“Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease”by Zeng et *** carried out a critical examination of nonalcoholic fatty liver disease(NAFLD)pathogenesis and how lifestyle interventions could facilitate disease resolution,particularly highlighting that non-alcoholic steatohepatitis(NASH)is a severe form of *** discussion details that weight loss is a pivotal factor in disease outcomes:A 3%-5%reduction is enough for resolution in 50%of non-obese individuals,while a 7%-10%reduction achieves similar benefits in obese individuals,as demonstrated by magnetic resonance ***,the editorial underscores that such lifestyle changes are instrumental not only in resolving NAFLD but also in reversing hepatic steatosis and *** insights,derived from the research,emphasize the critical role of personalized lifestyle modifications in halting the progression of NAFLD to NASH and even reversing fibrosis,thus offering a template for effective patient management.

关键词： Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Diet Physical activity Life style

Multi-Objective Rule System Based Control Model with Tunable Parameters for Swarm Robotic Control in Confined Environment

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Complex System Modeling and Simulation 2024年第1期4卷 33-49页

作者： Yuan Wang Lining Xing Junde Wang Tao Xie Lidong Chen Beijing institute of Advanced studies College of Advanced Interdisciplinary StudiesNational University of Defense TechnologyBeijing 100084China Key Laboratory of Collaborative Intelligence Systems Ministry of EducationXidian UniversityXi’an 710071China

Enhancing the adaptability of Unmanned Aerial Vehicle(UAV)swarm control models to cope with different complex working scenarios is an important issue in this research *** achieve this goal,control model with tunable parameters is a widely adopted *** this article,an improved UAV swarm control model with tunable parameters namely Multi-Objective O-Flocking(MO O-Flocking)is *** MO O-Flocking model is a combination of a multi rule control system and a virtual-physical-law based control model with tunable *** achieve multi-objective parameter tuning,a multi-objective parameter tuning method namely Improved Strength Pareto Evolutionary Algorithm 2(ISPEA2)is *** experiment scenarios include six target orientation scenarios with different kinds of *** results show that both the ISPEA2 algorithm and MO O-Flocking control model have good performance in their experiment scenarios.

关键词： swarm robotics flocking model parameter tuning multi-objective optimization heuristics

Hydro-uvarovite from Mantle Peridotites of Naga Hills Ophiolite: A Mineral Tracer for Neo-Tethyan Mantle Wedge Metasomatism

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 867-877页

作者： Anisha VERENCAR Abhishek SAHA Nilanjana SORCAR Sohini GANGULY Pankaj KUMAR Atul Kumar SINGH CSIR-National institute of Oceanography Dona PaulaGoa 403004India School of Earth Ocean and Atmospheric SciencesGoa UniversityTaleigao PlateauGoa 403206India National Centre for Earth Science studies ThiruvananthapuramKeralaIndia Inter University Accelerator Centre(IUAC) New Delhi 110067India North-eastern Hill University ShillongMeghalaya 793022India

Hydrous Cr-bearing uvarovite garnets are rare in natural occurrences and belong to the ugrandite series and exist in binary solid solutions with grossular and andradite garnets. Here, we report the occurrence of hydrous uvarovite garnet having Cr_(2)O_(3) upto 19.66 wt% and CaO of 32.12–35.14 wt% in the serpentinized mantle peridotites of Naga Hills Ophiolite(NHO), India. They occur in association with low-Cr diopsides. They are enriched in LILE(Ba, Sr), LREEs, with fractionating LREE-MREE [avg.(La/Sm)_(N) = 2.16] with flat MREE/HREE patterns [avg.(Sm/Yb)_(N) = 0.95]. Raman spectra indicate the presence of hydroxyl(OH^(–)) peaks from 3500 to 3700 cm^(-1). Relative abundances in fluid mobile elements and their close association with clinopyroxenes are suggestive of the formation of uvarovite garnets through low temperature metasomatic alteration of low-Cr diopsides by hydrothermal slab fluids. The high LREE concentration and absence of Eu anomaly in the garnet further attest to alkaline nature of the transporting slab dehydrated fluid rather the involvement of low-p H solution. The chemical characteristics of the hydroxyl bearing uvarovite hosted by the mantle peridotite of NHO deviate from the classical features of uvarovite garnet, and their origin is attributed to the fluid-induced metasomatism of the sub arc mantle wedge in a suprasubduction zone regime.

关键词： uvarovite hydroxyl metasomatic alteration low-Cr diopsides serpentinization mantle peridotite

Exploring Sequential Feature Selection in Deep Bi-LSTM Models for Speech Emotion Recognition

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Computers, Materials & Continua 2024年第2期78卷 2689-2719页

作者： Fatma Harby Mansor Alohali Adel Thaljaoui Amira Samy Talaat Computer Science Department Future Academy-Higher Future Institute for Specialized Technological StudiesCairo12622Egypt Department of Computer Science and Information College of Science at Zulfi Majmaah UniversityP.O.Box 66Al-Majmaah11952Saudi Arabia Preparatory institute for Engineering studies of Gafsa ZarrougGafsa2112Tunisia Computers and Systems Department Electronics Research InstituteCairo12622Egypt

Machine Learning(ML)algorithms play a pivotal role in Speech Emotion Recognition(SER),although they encounter a formidable obstacle in accurately discerning a speaker’s emotional *** examination of the emotional states of speakers holds significant importance in a range of real-time applications,including but not limited to virtual reality,human-robot interaction,emergency centers,and human behavior *** identifying emotions in the SER process relies on extracting relevant information from audio *** studies on SER have predominantly utilized short-time characteristics such as Mel Frequency Cepstral Coefficients(MFCCs)due to their ability to capture the periodic nature of audio signals *** these traits may improve their ability to perceive and interpret emotional depictions appropriately,MFCCS has some *** this study aims to tackle the aforementioned issue by systematically picking multiple audio cues,enhancing the classifier model’s efficacy in accurately discerning human *** utilized dataset is taken from the EMO-DB database,preprocessing input speech is done using a 2D Convolution Neural Network(CNN)involves applying convolutional operations to spectrograms as they afford a visual representation of the way the audio signal frequency content changes over *** next step is the spectrogram data normalization which is crucial for Neural Network(NN)training as it aids in faster *** the five auditory features MFCCs,Chroma,Mel-Spectrogram,Contrast,and Tonnetz are extracted from the spectrogram *** attitude of feature selection is to retain only dominant features by excluding the irrelevant *** this paper,the Sequential Forward Selection(SFS)and Sequential Backward Selection(SBS)techniques were employed for multiple audio cues features ***,the feature sets composed from the hybrid feature extraction methods are fed into the deep Bidirectional Long Short

关键词： Artificial intelligence application multi features sequential selection speech emotion recognition deep Bi-LSTM

An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning

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National Science Review 2024年第5期11卷 186-201页

作者： Mingyue Lv Ruyi Cai Renzimo Zhang Xiju Xia Xuelin Li Yipan Wang Huan Wang Jianzhi Zeng Yifei Xue Lanqun Mao Yulong Li State Key Laboratory of Membrane Biology School of Life SciencesPeking University State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences PKU-IDG/Mc Govern institute for Brain Research Yuanpei College Peking University Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University Peking University–Tsinghua University–National institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary Studies Peking University institute of Molecular Physiology Shenzhen Bay Laboratory College of Chemistry Beijing Normal University Chinese institute for Brain Research

Octopamine（OA）,analogous to norepinephrine in vertebrates,is an essential monoamine neurotransmitter in invertebrates that plays a significant role in various biological functions,including olfactory associative ***,the spatial and temporal dynamics of OA in vivo remain poorly understood due to limitations associated with the currently available methods used to detect *** overcome these limitations,we developed a genetically encoded GPCR activation-based（GRAB） OA sensor called *** sensor is highly selective for OA and exhibits a robust and rapid increase in fluorescence in response to extracellular *** GRABOA1.0,we monitored OA release in the Drosophila mushroom body（MB）,the fly's learning center,and found that OA is released in response to both odor and shock stimuli in an aversive learning *** OA release requires acetylcholine（ACh） released from Kenyon cells,signaling via nicotinic ACh ***,we discovered that OA amplifies aversive learning behavior by augmenting dopamine-mediated punishment signals via Octβ1R in dopaminergic neurons,leading to alterations in synaptic plasticity within the ***,our new GRABOA1.0sensor can be used to monitor OA release in real time under physiological conditions,providing valuable insights into the cellular and circuit mechanisms that underlie OA signaling.

关键词： octopamine dopamine GRAB sensor learning and memory

Cholesky GAS models for large time-varying covariance matrices

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Journal of Management Science and Engineering 2024年第1期9卷 115-142页

作者： Tingguo Zheng Shiqi Ye Department of Statistics and Data Science School of EconomicsXiamen UniversityXiamen361005China Wang Yanan institute for studies in Economics Xiamen UniversityXiamen361005China Paula and Gregory Chow institute for studies in Economics Xiamen UniversityXiamen361005China

This paper develops a new class of multivariate models for large-dimensional time-varying covariance matrices,called Cholesky generalized autoregressive score(GAS)models,which are based on the Cholesky decomposition of the covariance matrix and assume that the parameters are ***,two types of score-driven updates are considered:one is closer to the GARCH family,and the other is inspired by the stochastic volatility *** demonstrate that the models can be estimated equation-wise and are computationally feasible for high-dimensional ***,we design an equationwise dynamic model averaging or selection algorithm which simultaneously extracts model and parameter uncertainties,equipped with dynamically estimated model *** simulation results illustrate the superiority of the proposed ***,using a sizeable daily return dataset that includes 124 sectors in the Chinese stock market,two empirical studies with a small sample and a full sample are conducted to verify the advantages of our *** full sample analysis by a dynamic correlation network documents significant structural changes in the Chinese stock market before and after COVID-19.

关键词： Cholesky decomposition GAS Dynamic conditional correlations Dynamic model averaging

Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy(PAR-SIM)

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Light(Science & Applications) 2024年第6期13卷 1140-1158页

作者： Xinzhu Xu Wenyi Wang Liang Qiao Yunzhe Fu Xichuan Ge Kun Zhao Karl Zhanghao Meiling Guan Xin Chen Meiqi Li Dayong Jin Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace H.Coulter Dept.of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China Department of Biomedical Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy Technologies Co. Ltd.Beijing100086China eastern institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315200China School of Life Science Peking UniversityBeijing100871China institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

Structured illumination microscopy(SIM)has emerged as a promising super-resolution fluorescence imaging technique,offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological *** efforts to enhance system frame rates have concentrated on processing algorithms,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOS cameras with accelerated row readout *** this article,we introduce an approach to elevate SIM frame rates and region of interest(ROI)coverage at the hardware level,without necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout SIM(PAR-SIM)achieves the highest imaging speed for fluorescence imaging at currently available detector *** using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process,we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold that of the latest techniques,with the lowest SNR of−2.11 dB and 100 nm ***-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-short exposure ***,mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell,recorded with PAR-SIM at an impressive 408 *** posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

关键词： hardware illumination resolution

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土耳其国家安全战略:演变、特征与实践

Contemporary International Relations 2024年第3期34卷 52-78页

作者：李亚男 the institute of middle East studies at China institutes of Contemporary International Relations

Over the past century since the Republic of Türkiye was founded,its national security mechanisms have undergone a process of transformation from military-dominated to civilian government-dominated,and the ideology guiding its national security strategy has gradually transitioned from Kemalism to Erdo?*** the present stage,Türkiye's national security strategy is prominently characterized by its geographical and cultural duality,the expansivity deep-rooted in its history and religion,and an enterprising response to its geopolitical *** a strategy will comprehensively shape Türkiye's practice of preserving national security and guide the future of its security policies,prompting the country to seek a balance between its differentiated perceptions of identity and generalized national interests.

关键词： diverse identity national security strategy Turkiye