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Gas fiber lasers may represent a breakthrough in creating powerful radiation sources in the mid-IR

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Light(Science & Applications) 2022年第2期11卷 153-155页

作者： Andrey Pryamikov Prokhorov General physics institute of the russian academy of sciences 38 Vavilov streetMoscowRussia

Continuous wave fiber laser created on the basis of silica glass negative curvature hollow core fiber filled with HBr make it possible to obtain efficient narrow linewidth mid-IR emission with a maximum laser power of about 500mW at wavelength of 4200 *** is for the first time that emission from a continuous wave fiber laser have been achieved at a wavelength of 4496 nm with the largest tuning range of 686 nm.

关键词： fiber tuning breakthrough

Anomalous Josephson Effect in Topological Insulator-Based Josephson Trijunction

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Chinese physics Letters 2022年第1期39卷 31-35页

作者：张祥吕昭征杨光李冰侯延亮乐天王翔王安琪孙晓培卓恩娜刘广同沈洁屈凡明吕力 Beijing National Laboratory for Condensed Matter physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical sciences University of Chinese Academy of SciencesBeijing 100049China Huairou division Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

We studied anomalous Josephson effect(AJE) in Josephson trijunctions fabricated on Bi_(2)Se_(3), and found that the AJE in T-shaped trijunctions significantly alters the Majorana phase diagram of the trijunctions, when an in-plane magnetic field is applied parallel to two of the three single junctions. Such a phenomenon in topological insulator-based Josephson trijunction provides unambiguous evidence for the existence of AJE in the system, and may provide an additional knob for controlling the Majorana bound states in the Fu–Kane scheme of topological quantum computation.

关键词： computation Josephson topological

Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2

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Science China Life sciences 2024年

作者： Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li Innovation Center for AI and Drug Discovery East China Normal University Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&Technology Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine (Ministry of Education)Shanghai Jiao Tong University Lingang Laboratory Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of Pharmacy and School of Chemical Science and TechnologyYunnan University CAS Key Laboratory of Separation sciences for Analytical Chemistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of Sciences Department of Cardiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical University Department of Medicine University of Massachusetts Chan Medical School Department of Pathophysiology School of Basic Medical SciencesAcademy of Medical ScienceCollege of MedicineZhengzhou University

Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy. Here, we identify a natural pentacyclic triterpenoid, Pygenic Acid A(PA), as a PD-1 signaling inhibitor. PA exerts anti-tumor activity in hPD-1 knock-in C57BL/6 mice and enhances effector functions of T cells to promote immune responses by disrupting the PD-1 signaling transduction. Furthermore, we identify SHP-2 as the direct molecular target of PA for inhibiting the PD-1 signaling transduction. Subsequently, mechanistic studies suggest that PA binds to a new druggable site in the phosphorylated PD-1 ITSM recognition site of SHP-2, inhibiting the recruitment of SHP-2 by PD-1. Taken together, our findings demonstrate that PA has a potential application in cancer immunotherapy and occupying the phosphorylated ITSM recognition site of SHP-2 may serve as an alternative strategy to develop PD-1 signaling inhibitors. In addition, our success in target recognition provides a paradigm of target identification and confirmation for natural products.

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Shock-wave impact on the knee joint affected with osteoarthritis and after arthroplasty

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Defence Technology（防务技术） 2023年第2期20卷 1-10页

作者： Galina Eremina Alexey Smolin institute of Strength physics and Materials Science of Siberian Branch of russian academy of sciences 2/4pr.AkademicheskiiTomsk634055Russia

Degenerative diseases significantly reduce the quality of human ***-invasive treatments are used in the initial stages of osteoarthritis(OA).Total knee arthroplasty is used in the late stages of osteoarthritis of the knee ***-invasive methods based on mechanical action are also used for the rehabilitation of a patient after *** paper presents numerical models of the knee joint with degenerative OA changes and *** these models,a computational study was made of the influence of the intensity of shock-wave exposure on the conditioning for the regeneration of bone and cartilage *** on the modeling results,it was found that in the knee joint with degenerative OA changes,conditions for the regeneration of cartilage and meniscus tissues were fulfilled under medium and highintensity *** high-intensity loading(up to 0.9 m J/mm^(2)),the stress level was significantly below the ultimate value required for *** knee arthroplasty,the conditions for bone tissue regeneration around the tibia component are fulfilled only under high-intensity loading.

关键词： Knee joint Total knee replacement Shock-wave therapy Computer simulation Method of movable cellular automata

Mathematical Modeling of Biological Fluid Flow Through a Cylindrical Layer with Due Account for Barodiffusion

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Communications on Applied Mathematics and Computation 2023年第4期5卷 1365-1384页

作者： N.N.Nazarenko A.G.Knyazeva institute of Strength physics and Materials Science Siberian Branch of the Russian Academy of SciencesTomsk634021Russia

The work proposes a model of biological fluid flow in a steady mode through a cylindrical layer taking into account convection and *** model considers finite compressibility and concentration expansion connected with both barodiffusion and additional mechanism of pressure change in the pore volume due to the concentration ***,the model is entirely *** paper highlights the complexes composed of scales of physical quantities of different *** iteration algorithm for the numerical solution of the problem was developed for the coupled *** work involves numerical studies of the considered effects on the characteristics of the flow that can be convective or diffusive,depending on the relation between the dimensionless *** is demonstrated that the distribution of velocity and concentration for different cylinder wall thicknesses is *** is established that the barodiffusion has a considerable impact on the process in the convective mode or in the case of reduced cylinder wall thickness.

关键词： Filtration Diffusion Convective and diffusive flow regimes Barodiffusion

Integrated modeling of fracturing-flowback-production dynamics and calibration on field data:Optimum well startup scenarios

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Petroleum Science 2023年第4期20卷 2202-2231页

作者： S.A.Boronin K.I.Tolmacheva I.A.Garagash I.R.Abdrakhmanov G.Yu Fisher A.L.Vainshtein P.K.Kabanova E.V.Shel G.V.Paderin A.A.Osiptsov Skolkovo institute of Science and Technology(Skoltech) Russia LLC Gazpromneft Science and Technology Center Russia The Schmidt institute of physics of the Earth of the russian academy of sciences MoscowRussia

We aim at the development of a general modelling workflow for design and optimization of the well flowback and startup operation on hydraulically fractured *** flowback model developed earlier by the authors is extended to take into account several new fluid mechanics factors accompanying flowback,namely,viscoplastic rheology of unbroken cross-linked gel and coupled“fracture-reservoir”numerical submodel for influx from rock *** also developed models and implemented new geomechanical factors,namely,(i)fracture closure in gaps between proppant pillars and in proppant-free cavity in the vicinity of the well taking into account formation creep;(ii)propagation of plastic deformations due to tensile rock failure from the fracture face into the fluid-saturated *** carried out parametric calculations to study the dynamics of fracture conductivity during flowback and its effect on well production for the set of parameters typical of oil wells in Achimov formation of Western Siberia,*** first set of calculations is carried out using the flowback model in the reservoir linear flow *** is obtained that the typical length of hydraulic fracture zone,in which tensile rock failure at the fracture walls occurs,is *** the range of rock permeability in between 0.01 mD and 1 D,we studied the effect of non-dimensional governing parameters as well as bottomhole pressure drop dynamics on oil *** obtained a map of pressure drop regimes(fast,moderate or slow)leading to maximum cumulative oil *** second set of parametric calculations is carried out using integrated well production modelling workflow,in which the flowback model acts as a missing link in between hydraulic fracturing and reservoir commercial *** evaluated quantitatively effects of initial fracture aperture,proppant diameter,yield stress of fracturing fluid,pressure drop rate and proppant material type(ceramic and sand)on long-term well product

关键词： Fracture cleanup Flowback Tensile rock failure Fracture closure Proppant embedment Proppant pack compaction

Experimental study on start-up characteristics of loop heat pipes

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Science China(Technological sciences) 2005年第2期48卷 131-144页

作者： R.G. Sudakov Yu. F. Maidanik institute of Thermal physics ural Branch of the russian academy of sciences Ekaterinburg 620219Russia Institute of Thermal Physics Ural Branch of the Russian Academy of Sciences Ekaterinburg 620219Russia

This paper presents results of ground-experimental study on the start-up characteristics of a Loop Heat Pipe. The physical process of start-up is described, and the explanation that “Pressure Transfer” leads to the saturated temperature rise in compensation chamber during start-up is first discussed. Start-up behaviors as a function of various parameters including vapor/liquid distribution in the evaporator, adverse elevation, start-up heat load, sink temperature are described and explained. A peculiar start-up phenomenon composed of two start-up scenarios was first observed at adverse elevations and is described.

关键词： loop heat pipe, start-up, experiment.

Graphene/MoS_(2-x)O_(x)/graphene photomemristor with tunable non-volatile responsivities for neuromorphic vision processing

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Light(Science & Applications) 2023年第2期12卷 284-293页

作者： Xiao Fu Tangxin Li Bin Cai Jinshui Miao Gennady NPanin Xinyu Ma jinjin Wang Xiaoyong Jiang Qing Li Yi Dong Chunhui Hao Juyi Sun Hangyu Xu Qixiao Zhao Mengjia Xia Bo Song Fansheng Chen Xiaoshuang Chen Wei Lu Weida Hu School of physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Infrared physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China University of Chinese academy of sciences 100049 BeijingChina institute of Intelligent Machines HFiPSChinese Academy of SciencesHefei 230031China Jianghuai Frontier Technology Coordination and Innovation Center Hefei 230088China institute of Microelectronics Technology and High-Purity Materials Russian Academy of SciencesChernogolovkaMoscow district142432Russia

Conventional artificial intelligence(Al)machine vision technology,based on the von Neumann architecture,uses separate sensing,computing,and storage units to process huge amounts of vision data generated in sensory *** frequent movement of redundant data between sensors,processors and memory,however,results in high-power consumption and latency.A more efficient approach is to offload some of the memory and computational tasks to sensor elements that can perceive and process the optical signal ***,we proposed a non-volatile photomemristor,in which the reconfigurable responsivity can be modulated by the charge and/or photon flux through it and further stored in the *** non-volatile photomemristor has a simple two-terminal architecture,in which photoexcited carriers and oxygen-related ions are coupled,leading to a displaced and pinched hysteresis in the current-voltage *** the frst time,non-volatile photomemristors implement computationally complete logic with photoresponse-stateful operations,for which the same photomemristor serves as both a logic gate and memory,using photoresponse as a physical state variable instead of light,voltage and *** polarity reversal of photomemristors shows great potential for in-memory sensing and computing with feature extraction and image recognition for neuromorphic vision.

关键词： tunable operations hysteresis

Evolution of stress fields during the supercontinent cycle

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Geodesy and Geodynamics 2022年第4期13卷 363-375页

作者： Alexander Bobrov Alexey Baranov Robert Tenzer Schmidt institute of physics of the Earth Russian Academy of SciencesMoscowRussia institute of Earthquake Prediction Theory and Mathematical Geophysics Russian Academy of SciencesMoscowRussia Department of Land Surveying and Geo-Informatics Hong Kong Polytechnic UniversityHong KongChina

We investigate the evolution of stress fields during the supercontinent cycle using the 2D Cartesian geometry model of thermochemical convection with the non-Newtonian rheology in the presence of floating deformable *** the course of the simulation,the supercontinent cycle is implemented several *** number of continents considered in our model as a function of time oscillates around *** lifetime of a supercontinent depends on its *** results suggest that immediately before a supercontinent breakup,the over-lithostatic horizontal stresses in it(referring to the mean value by the computational area)are tensile and can reach-250 *** the same time,a vast area beneath a supercontinent with an upward flow exhibits clearly the over-lithostatic compressive horizontal stresses of 50-100 МРа.The reason for the difference in stresses in the supercontinent and the underlying mantle is a sharp difference in their *** large parts of the mantle,the over-lithostatic horizontal stresses are in the range of±25 MPa,while the horizontal stresses along subduction zones and continental margins are significantly *** the process of continent-to-continent collisions,the compressive stresses can approximately reach 130 MPa,while within the subcontinental mantle,the tensile over-lithostatic stresses are about-50 *** dynamic topography reflects the main features of the su-percontinent cycle and correlates with real *** the breakup and immediately after the disin-tegration of the supercontinent,continents experience maximum *** the supercontinent cycle,topographic heights of continents typically vary within the interval of about±1.5 km,relatively to a mean *** maxima of orogenic formations to about 2-4 km are detected along continent-to-continent collisions as well as when adjacent subduction zones interact with continental margins.

关键词： Supercontinent cycle Floating deformable continents Thermochemical convection Horizontal stresses Dynamic topography