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Crosstalk among canonical Wnt and Hippo pathway members in skeletal muscle and at the neuromuscular junction

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Neural Regeneration Research 2025年第9期20卷 2464-2479页

作者： Said Hashemolhosseini Lea Gessler institute of Biochemistry Medical FacultyFriedrich-Alexander-University of Erlangen-NürnbergErlangenGermany

Skeletal muscles are essential for locomotion,posture,and metabolic *** understand physiological processes,exercise adaptation,and muscle-related disorders,it is critical to understand the molecular pathways that underlie skeletal muscle *** process of muscle contra ction,orchestrated by a complex interplay of molecular events,is at the core of skeletal muscle *** contraction is initiated by an action potential and neuromuscular transmission requiring a neuromuscular *** muscle fibers,calcium ions play a critical role in mediating the interaction between actin and myosin filaments that generate *** of calcium release from the sarcoplasmic reticulum plays a key role in excitation-contraction *** development and growth of skeletal muscle are regulated by a network of molecular pathways collectively known as *** regulators coordinate the diffe rentiation of myoblasts into mature muscle *** pathways regulate muscle protein synthesis and hypertrophy in response to mechanical stimuli and nutrient *** ral muscle-related diseases,including congenital myasthenic disorders,sarcopenia,muscular dystrophies,and metabolic myopathies,are underpinned by dys regulated molecular pathways in skeletal *** interventions aimed at preserving muscle mass and function,enhancing regeneration,and improving metabolic health hold promise by targeting specific molecular *** molecular signaling pathways in skeletal muscle include the canonical Wnt signaling pathway,a critical regulator of myogenesis,muscle regeneration,and metabolic function,and the Hippo signaling *** recent years,more details have been uncovered about the role of these two pathways during myogenesis and in developing and adult skeletal muscle fibers,and at the neuromuscular *** fact,research in the last few years now suggests that these two signaling pathways are interconnected and

关键词： canonical Wnt"Wingless-related integration site"pathway beta-catenin(CTNNB1) Hippo pathway myogenesis myotube neuromuscular junction satellite cell skeletal muscle fiber transcriptional co-activator with PDZ-binding motif(TAZ) T-cell-specific transcription factor/lymphoid enhancer-binding factor(TCF/LEF) TEA domain family member(TEAD) transducin-like enhancer of split(TLE) yes-associated protein 1(YAP1)

A Comparative Study of Thyroid Hormone and Lipid Status of Patient with and without Diabetes in Adults

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Open Journal of Endocrine and metabolic Diseases 2013年第2期3卷 113-119页

作者： Hasi Rani Saha Habiba Khan Bidhan Chandra Sarkar Shahidul Alam Khan Niranjan Kumar Sana Akira Sugawara Subhagata Choudhury Bangladesh institute of Research & Rehabilitation in Diabetes Endocrine and Metabolic Disorders Dhaka Bangladesh

Introduction: Lipid and thyroid function abnormalities are common in IDDM and NIDDM. Very few studies have addressed this issue in Bangladesh though Bangladeshi population is very much susceptible to patient with diabetes. Aims: To study on lipid profile and thyroid function in IDDM and NIDDM and the effect of glycemic control on it. Patients and Methods: This was a retrospective study carried out in the Dept. of Endocrinology, BIRDEM, Dhaka, Bangladesh during the period of January, 2012 to May, 2012. In this study, population consisted of 120 subjects (Age between 40 - 72 years;and Sex matched) divided into two groups: patient with diabetes 60 subjects (male-30, female-30) and patient without diabetes 60 subjects (male-30, female-30). Plasma glucose, HbA1c and serum lipids were measured by enzymatic method. Thyroid hormones were measured by a Chemiluminescent Micro particle Immunoassay (CMIA).Results: The statistical significance was evaluated by Student’s t-test, Correlation-Coefficient test. All Values are given as mean ± SD. The level of serum TSH in patient with diabetes (3.43 ± 2.71) was significantly (p 0.05) increased compared to patient without diabetes subjects (1.98 ± 1.72). TSH levels were positively correlated with fasting plasma glucose (r = 0.240, p 0.05), serum cholesterol (r = 0.290, p 0.020) and triglyceride concentration (r = 0.246, p 0.05). On the other hand, free T4 levels were inversely correlated with postprandial blood glucose (r =-0.256, p 0.046). Conclusions: It may be concluded that the lipid and thyroid function abnormalities with others socio-demographic and biophysical risk factors were more common in patient with diabetes cases rather than patient without diabetes cases. Therefore, further prospective studies with larger number of patients are required to strengthen the observations of the present study.

关键词： NIDDM IDDM Glycosylated Hemoglobin Lipid Profile Hypo and Hyperthyroidism

CMT1A current gene therapy approaches and promising biomarkers

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Neural Regeneration Research 2023年第7期18卷 1434-1440页

作者： Marina Stavrou Kleopas AKleopa Neuroscience Department The Cyprus Institute of Neurology and GeneticsNicosiaCyprus Center for Neuromuscular disorders The Cyprus Institute of Neurology and GeneticsNicosiaCyprus

Charcot-Marie-Tooth neuropathies(CMT)constitute a group of common but highly heterogeneous,non-syndromic genetic disorders affecting predominantly the peripheral nervous *** type 1A(CMT1A)is the most frequent type and accounts for almost~50%of all diagnosed CMT ***1A results from the duplication of the peripheral myelin protein 22(PMP22)*** of PMP22 protein overloads the protein folding apparatus in Schwann cells and activates the unfolded protein *** leads to Schwann cell apoptosis,dys-and de-myelination and secondary axonal degeneration,ultimately causing neurological *** the last decades,several different gene therapies have been developed to treat *** all of them remain at the pre-clinical stage using CMT1A animal models overexpressing *** therapeutic goal is to achieve gene silencing,directly or indirectly,thereby reversing the CMT1A genetic mechanism allowing the recovery of myelination and prevention of axonal *** promising treatments are rapidly emerging,treatment-responsive and clinically relevant biomarkers are becoming *** biomarkers and sensitive clinical evaluation tools will facilitate the design and successful completion of future clinical trials for CMT1A.

关键词： axonal degeneration biomarkers Charcot-Marie-Tooth disease gene therapy inherited neuropathy mouse models

Serum Alanine Aminotransferase Is Associated with metabolic Syndrome and 10-year Risk of Cardiovascular Disease

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Biomedical and Environmental Sciences 2019年第2期32卷 121-125页

作者： MA Li Na DU Rui CHENG Di LIN Lin WU Xue Yan HU Chun Yan DAI Meng XU Yu XU Min JIANG Lei LI Mian LU Jie Li BI Yu Fang WANG Wei Qing NING Guang Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai institute of Endocrine and metabolic Diseases

metabolic syndrome(MetS) is a cluster of metabolic disorders including obesity, hypertension, hyperglycemia, elevated triglyceride levels, and low high-density lipoprotein cholesterol(HDL-C) levels. In recent years, t... 详细信息

关键词： ALT HDL CVD LDL SBP BMI

Non-invasive diagnosis of H pylori infection: Evaluation of serological tests with and without current infection marker CIM

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World Journal of Gastroenterology 2008年第8期14卷 1231-1236页

作者： Sufi HZ Rahman M Golam Azam M Anisur Rahman MS Arfin M Mahbub Alam Tareq M Bhuiyan Nasim Ahmed Motiur Rahman Shamsun Nahar MS Hassan Department of Immunology Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders Dhaka Bangladesh Department of Gastrointestinal Hepatobiliary and Pancreatic Diseases Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders Dhaka Bangladesh Department of Pathology Ibrahim MedicalCollege Dhaka Bangladesh Laboratory Sciences Division International Centre for Diarrhoeal Diseases Research Bangladesh Dhaka Bangladesh

AIM:To evaluate the performance of commercially available immunochromatographic (ICT) and immunoblot tests covering the current infection marker CIM and conventional ELISA for the diagnosis of H pylori infection in adult dyspeptic patients. METHODS:Consecutive non-treated dyspeptic patients undergoing diagnostic endoscopy were tested for H pylori infection by culture, rapid urease test, and histology of gastric biopsy specimens. Serum from 61 H pylori infected and 21 non-infected patients were tested for anti-H pylori IgG antibodies by commercial ELISA (AccuBindTM ELISA, Monobind, USA), ICT (Assure H pylori Rapid Test, Genelabs Diagnostics, Singapore), and immunoblot (Helico Blot 2.1, Genelabs Diagnostics, Singapore) assays. ICT and immunoblot kits cover CIM among other parameters and their performance with and without CIM was evaluated separately. RESULTS:Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of ELISA were 96.7%, 42.8%, 83.1%, 81.8%, and 82.9%, of ICT were 90.1%, 80.9%, 93.2%, 73.9%, and 87.8%, of ICT with CIM were 88.5%, 90.4%, 96.4%, 73.0%, and 89.0%, of immunoblot were 98.3%, 80.9%, 93.7%, 94.4%, and 93.9%, and of immunoblot with CIM were 98.3%, 90.4%, 96.7%, 95.0%, and 96.3%, respectively. CONCLUSION:Immunoblot with CIM had the best performance. ICT with CIM was found to be more specific and accurate than the conventional ELISA and may be useful for non-invasive diagnosis of H pylori infection.

关键词： H pylori ELISA Immunochromatographic test Immunoblot Current infection marker

Dubin-Johnson syndrome coinciding with colon cancer and atherosclerosis

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World Journal of Gastroenterology 2013年第6期19卷 946-950页

作者： Eva Sticova Milan Elleder Helena Hulkova Ondrej Luksan Martin Sauer Irena Wunschova-Moudra Jan Novotny Milan Jirsa Center for Experimental Medicine Institute for Clinical and Experimental Medicine14021 Prague 4Czech Republic Third Faculty of Medicine Charles University10000 Prague 10Czech Republic institute of inherited metabolic disorders First Faculty of MedicineCharles University and VFN12808 Prague 2Czech Republic Department of Surgery IPVZ Masaryk Hospital40113 Usti nad LabemCzech Republic Department of Thoracic Surgery Masaryk Hospital40113 Usti nad LabemCzech Republic Gastroenterology Department Masaryk Hospital40113 Usti nad LabemCzech Republic

Hyperbilirubinemia has been presumed to prevent the process of atherogenesis and cancerogenesis mainly by decreasing oxidative ***-Johnson syndrome is a rare,autosomal recessive,inherited disorder characterized by biphasic,predominantly conjugatedhyperbilirubinemia with no progression to end-stage liver *** molecular basis in Dubin-Johnson syndrome is absence or deficiency of human canalicular multispecific organic anion transporter MRP2/cMOAT caused by homozygous or compound heterozygous mutation(s) in ABCC2 located on chromosome *** onset of the syndrome is most often seen in the late teens or early *** this report,we describe a case of previously unrecognized Dubin-Johnson syndrome caused by two novel pathogenic mutations (c.2360_2366delCCCTGTC and c.3258+1G>A),coinciding with cholestatic liver disease in an 82-year-old male *** patient,suffering from advanced atherosclerosis with serious involvement of coronary arteries,developed colorectal cancer with nodal *** subsequent findings do not support the protective role of Dubin-Johnson type hyperbilirubinemia.

关键词： Dubin-Johnson syndrome ABCC2 Hyperbilirubinemia Oxidative stress Atherosclerosis Cancer

The injury effect of oxygen free radicals in vitro on cultured pulmonary artery endothelial cells from broiler

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The injury effect of oxygen free radicals in vitro on cultur...

Effects of Electroacupuncture on metabolic Changes in Motor Cortex and Striatum of 6-Hydroxydopamine-Induced Parkinsonian Rats

中国畜牧兽医学会家畜内科学分会2009年学术研讨会

作者：潘家强 institute of Nutritional and metabolic disorders in Domestic Animals and Fowls Nanjing Agricultural University

Pulmonary artery endothelial cells(PAEC) of broiler were isolated by the method of tissue *** of the cells were performed with the morphological feature and immunocytochemical stain using specific antiserum against factorⅧrelated ***/Xanthine oxidase(X/XO) served as the oxygen free radical(OFR) generating *** vitro model of oxidative injury of PAEC was established based on the X/XO *** effect of OFR on the growth and viability of PAEC was determined with methylthiazol tetrazolium(MTT) colorimetric *** (MDA,a product of lipid peroxidation) in culture medium of PAEC was detected by a thiobarbituric acid colorimetric *** result showed that PAEC could be survived in vitro and had been subcultured for 5-6 *** and immunohistochemical observing of cultured cells demonstrated specific characteristics of endothelial *** were severely damaged by *** viability of cells was inhibited by X/XO system and dose-dependent decrease of cell viability was found with increased XO *** promoted the lipid peroxidation of PAEC and increased the MDA concentration in culture *** results suggest that OFR had an injury effect on the endothelial cells of pulmonary artery in broiler,which was consistent with the result in vivo,and may play an important role in the pathogenesis of pulmonary hypertension syndrome in broiler.

关键词： Broiler Pulmonary artery endothelial cells In vitro culture Oxygen free radical

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Chinese Journal of Integrative Medicine 2020年第9期26卷 701-708页

作者： LI Min WANG Ke SU Wen-ting JIA Jun WANG Xiao-min Departments of Neurobiology and Physiology Key Laboratory for Neurodegenerative Disorders of the Ministry of EducationBeijing Key Laboratory for Parkinson's DiseaseCapital Medical UniversityBeijing Institute for Brain DisordersBeijing(100069)China

Objective:To explore the possible underlying mechanism by investigating the effect of electroacupuncture(EA)treatment on the primary motor cortex and striatum in a unilateral 6-hydroxydopamine(6-0HDA)induced rat Parkinson's disease(PD)***:Male Sprague-Dawley rats were randomly divided into sham group(n=16),model group(n=14),and EA group(n=14).EA stimulation at Dazhui(GV 14)and Baihui(GV20)was applied to PD rats in the EA group for 4 *** tests were conducted to evaluate the effectiveness of EA *** were detected by 7.0 T proton nuclear magnetic ***:Following 4 weeks of EA treatment in PD model rats,the abnormal behavioral impairment induced by 6-0HDA was *** monitoring changes in metabolic activity,ratios of myoinositol/creatine(Cr)and N-acetyl aspartate(NAA)/Cr in the primary motor cortex were significantly lower at the injected side than the non-injected side in PD rats(P=0.024 and 0.020).The ratios of glutamate+glutamine(Glx)/Cr and NAA/Cr in the striatum were higher and lower,respectively,at the injected side than the non-injected side(P=0.046 and 0.008).EA treatment restored the balance of metabolic activity in the primary motor cortex and *** addition,the taurine/Cr ratio and GIx/Cr ratio were elevated in the striatum of PD model rats compared to sham-lesioned rats(P=0.026 and 0.000).EA treatment alleviated the excessive glutamatergic transmission by down-regulating the striatal Glx/Cr ratio(P=0.001).The Glx/Cr ratio was negatively correlated with floor plane spontaneous locomotion in PD rats(P=0.027 and P=0.0007).Conclusions:EA treatment is able to normalize the metabolic balance in the primary motor cortex and striatum of PD rats,which may contribute to its therapeutic effect on motor *** striatal GIx/Cr ratio may serve as a potential indicator of PD and a therapeutic target of EA treatment.

关键词： electroacupuncture magnetic resonance spectroscopy motor cortex striatum Parkinson's disease

metabolic regulation of microglial phagocytosis:Implications for Alzheimer’s disease therapeutics

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Translational Neurodegeneration 2023年第1期12卷 205-224页

作者： Izabela Lepiarz-Raba Ismail Gbadamosi Roberta Florea Rosa Chiara Paolicelli Ali Jawaid Laboratory for Translational Research in Neuropsychiatric disorders(TREND) BRAINCITY:Center of Excellence for Neural Plasticity and Brain DisordersNencki Institute of Experimental BiologyWarsawPoland Swiss Federal institute of Technology(ETH) ZurichSwitzerland Department of Biomedical Sciences University of LausanneLausanneSwitzerland

Microglia,the resident immune cells of the brain,are increasingly implicated in the regulation of brain health and *** perform multiple functions in the central nervous system,including surveillance,phagocytosis and release of a variety of soluble ***,a majority of their functions are closely related to changes in their *** natural inter-dependency between core microglial properties and metabolism offers a unique opportunity to modulate microglial activities via nutritional or metabolic *** this review,we examine the existing scientific literature to synthesize the hypothesis that microglial phagocytosis of amyloid beta(Aβ)aggregates in Alzheimer’s disease(AD)can be selectively enhanced via metabolic *** first review the basics of microglial metabolism and the effects of common metabolites,such as glucose,lipids,ketone bodies,glutamine,pyruvate and lactate,on microglial inflammatory and phagocytic ***,we examine the evidence for dysregulation of microglial metabolism in *** is followed by a review of in vivo studies on metabolic manipulation of microglial functions to ascertain their therapeutic potential in ***,we discuss the effects of metabolic factors on microglial phagocytosis of healthy synapses,a pathological process that also contributes to the progression of *** conclude by enlisting the current challenges that need to be addressed before strategies to harness microglial phagocytosis to clear pathological protein deposits in AD and other neurodegenerative disorders can be widely adopted.

关键词： Microglia Metabolism Alzheimer’s disease Neurodegeneration Inflammation Phagocytosis