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Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

四川生理科学杂志 2021年第1期43卷 138-138页

作者： Peter Horby The affiliations of the members of the writing committee are as follows: the Centre for Tropical Medicine and Global Health Nuffield Department of Medicine (P.H. J.T. J.A.W. N.J.W.) Nuffield Department of Population Health (M.M. L.L. J.L.B. N.S. J.R.E. E.J. R.H. M.J.L.) the Medical Research Council (MRC) Population Health Research Unit (N.S. J.R.E. R.H. M.J.L.) University of Oxford the Oxford University Hospitals NHS Foundation Trust (K.J. M.J.L.) and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (M.J.L.) Oxford University Hospitals of Leicester NHS Trust and University of Leicester Leicester (M.W.) the Regional Infectious Diseases Unit North Manchester General Hospital (A.U.) University of Manchester (A.U. T.F.) and Manchester University NHS Foundation Trust (T.F.) Manchester the Research and Development Department Northampton General Hospital Northampton (E.E.) the Department of Respiratory Medicine North Tees and Hartlepool NHS Foundation Trust Stockton-on-Tees (B.P.) University Hospitals Birmingham NHS Foundation Trust and Institute of Microbiology and Infection University of Birmingham Birmingham (T.W.) James Cook University Hospital Middlesbrough (J.W.) North West Anglia NHS Foundation Trust Peterborough (J.F.) the Department of Infectious Diseases Cardiff and Vale University Health Board and the Division of Infection and Immunity Cardiff University Cardiff (J.U.) Roslin Institute University of Edinburgh Edinburgh (J.K.B.) the School of Life Course Sciences King’s College London (L.C.C.) and the Intensive Care National Audit and Research Centre (K.R.) London the NIHR Southampton Clinical Research Facility and Biomedical Research Centre University Hospital Southampton NHS Foundation Trust and University of Southampton Southampton (S.N.F.) the Department of Mathematics and Statistics Lancaster University Lancaster (T.J.) the MRC Biostatistics Unit University of Cambridge Cambridge (T.J.) and the Respiratory M

Background:Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019(Covid-19)on the basis of in vitro activity and data from uncontrolled studies and small,randomized ***:In this randomized,controlled,open-label platform trial comparing a range of possible treatments with usual care in patients hospitalized with Covid-19,we randomly assigned 1561 patients to receive hydroxychloroquine and 3155 to receive usual *** primary outcome was 28-day mortality.

关键词： mortality patients Patients

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Neglected interstitial space in malaria recurrence and treatment

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Nano Research 2020年第10期13卷 2869-2878页

作者： Qiang Zhang Zhuo Ao Nan Hu Yuting Zhu Fulong Liao Dong Han CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China Unriversity of Chinese Academy of Sciences Beijing 100049China Department of Traditional Chinese Medicine Chengde Medical UniversityChengde 066000China Artemisinin Research Center and the institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100049China

The interstitial space, a widespread fluid-filled compartment throughout the body, is related to many pathophysiological alterations and diseases, attracting increasing attention. The vital role of interstitial space in malaria infection and treatment has been neglected current research efforts. We confirmed the reinfection capacity of parasites sequestrated in interstitial space, which replenish the mechanism of recurrence. Malaria parasite-infected mice were treated with artemisinin-loaded liposomes through the interstitial space and exhibited a better therapeutic response. Notably, compared with oral administration, interstitial administration showed an unexpectedly high activation and recruitment of immune cells, and resulted in better clearance of sequestered parasites from organs, and enhanced pathological recovery. The interstitial route of administration prolongs the blood circulation time of artemisinin and increases its plasma concentration, and may compensate for the inefficiency of oral administration and the nanotoxicity of intravenous administration, providing a potential strategy for infectious disease therapy.

关键词： interstitial space malaria infection recurrence treatment

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A Combinative Assembly Strategy Inspired Reversibly Borate-Bridged Polymeric Micelles for Lesion-Specific Rapid Release of Anti-Coccidial Drugs

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Nano-Micro Letters 2020年第11期12卷 168-186页

作者： Hao Cheng Huaqing Zhang Gujun Xu Jin Peng Zhen Wang Bo Sun Djamila Aouameur Zhechen Fan Wenxin Jiang Jianping Zhou Yang Ding State Key Laboratory of Natural Medicines Department of PharmaceuticsChina Pharmaceutical University24 TongjiaxiangNanjing 210009People’s Republic of China Department of Radiation Oncology Lineberger Comprehensive Cancer CenterCarolina Center for Cancer Nanotechnology ExcellenceCarolina Institute of NanomedicineUniversity of North Carolina at Chapel HillChapel HillNC 27599USA

Stimuli-triggered drug delivery systems hold vast promise in local infection treatment for the site-specific targeting and shuttling of ***,chitosan conjugates(SPCS)installed with sialic acid(SA)and phenylboronic acid(PBA)were synthesized,of which SA served as targeting ligand for coccidium and reversible-binding bridge for *** enhanced drug-loading capacity of SPCS micelles was attributed to a combination assembly from hydrophobicity-driving and reversible borate *** drug-loaded SPCS micelles shared superior biostability in upper gastrointestinal *** reaching the lesions,the borate bridges were snipped by carbohydrates under a higher pH followed by accelerated drug release,while SA exposure on micellar surface facilitated drug cellular internalization to eliminate parasites *** drugmicelles revealed an enhanced anti-coccidial capacity with a higher index of 185.72 compared with commercial *** dual-responsive combination of physicochemical assembly could provide an efficient strategy for the exploitation of stable,safe and flexible anti-infectious drug delivery systems.

关键词： Combinative assembly strategy Borate-bridged micelles Dual-stimuli-triggered release Lesion-specific location Coccidiosis control

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Mutual interaction of microbiota and host immunity during health and diseases

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Biophysics Reports 2021年第4期7卷 326-340页

作者： Di Wu Yinlian Zhang Suwei Dong Chao Zhong institute of Systems Biomedicine Department of ImmunologyBeijing Key Laboratory of Tumor Systems BiologyPeking University Health Science Center State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical BiologySchool of Pharmaceutical SciencesPeking University

Microbiota–host interaction has attracted more and more attentions in recent years. The association between microbiota and host health is largely attributed to its influence on host immune ***-derived antigens and metabolites play a critical role in shaping the host immune system,including regulating its development, activation, and function. However, during various diseases the microbiota–host communication is frequently found to be disordered. In particular, gut microbiota dysbiosis associated with or led to the occurrence and progression of infectious diseases, autoimmune diseases, metabolic diseases, and neurological diseases. Pathogenic microbes and their metabolites disturb the protective function of immune system, and lead to disordered immune responses that usually correlate with disease exacerbation. In the other hand, the immune system also regulates microbiota composition to keep host homeostasis. Here, we will discuss the current advances of our knowledge about the interactions between microbiota and host immune system during health and diseases.

关键词： Microbiota Microbial-derived antigens and metabolites Immune system Composition of microbiota Host health and diseases

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Computation of sensitivities of IC interconnect parasitic capacitances to the process variation with dual discrete geometric methods

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Journal of Semiconductors 2016年第8期37卷 90-96页

作者：高展任但闫帅徐小宇任卓翔 institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China University of Chinese Academy of Sciences Beijing 100049 China Beijing Key Laboratory of 3D & Nano IC Electronic Design Automatic Technologies Beijing 100029 China

Sensitivity analysis methods help to deal with the challenges of process variation in extraction of para- sitic capacitances in an integrated circuit. The dual discrete geometric methods （DGMs）, which have been recently utilized to extract parasitic capacitances, are reviewed. The computation method based on the dual DGMs for sen- sitivities of capacitances with respect to the given process parameters is presented. As the dual DGMs utilize scalar electric potential is unknown, the capacitances are obtained effectively, and then the sensitivities are calculated conveniently.

关键词： capacitance extraction dual discrete geometric methods (DGMs) process variation sensitivity ana- lysis

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A cellular and proteomic approach to assess proteins extracted from cryopreserved human amnion in the cultivation of corneal stromal keratocytes for stromal cell therapy

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Eye and Vision 2019年第1期6卷 247-260页

作者： Beau J.Fenner Nur Zahirah B.M.Yusoff Matthias Fuest Lei Zhou Francisco Bandeira Howard ***-Uy H.K.Tan Jodhbir S.Mehta Gary H.F.Yam Tissue Engineering and Stem Cell Group Singapore Eye Research Institute20 College RoadThe AcademiaDiscovery Tower Level 6Singapore 169856Singapore Singapore National Eye Centre SingaporeSingapore Department of Ophthalmology RWTH Aachen UniversityAachenGermany Eye-Academic Clinical Programme Duke-NUS Graduate Medical SchoolSingaporeSingapore Proteomics Platform Singapore Eye Research InstituteSingaporeSingapore Federal University of São Paulo Sao PauloBrazil Singapore Eye Bank SingaporeSingapore Department of Obstetrics and Gynaecology Singapore General HospitalSingaporeSingapore

Background:Human corneal stromal keratocytes propagated in culture media supplemented with human amnion extract(AME)can correct early corneal haze in an animal *** application of cultivated keratocytes is limited by infectious disease screening before amnion products can be used in *** remains unclear if AME from cryopreserved versus fresh human amnion can support human keratocyte propagation,and which components of the extract promote keratocyte ***:Three placentas were collected for the preparation of fresh and cryopreserved amnion tissues followed by homogenization and protein *** protein profiles were studied using isobaric tagging for relative and absolute quantitation(iTRAQ)*** gene ontology(GO)terms and functional classes were *** human keratocytes from 4 donor corneas were cultured in media supplemented with fresh AME(F-AME)or cryopreserved AME(C-AME).Cell viability,proliferation and keratocyte marker expression were examined by confocal immunofluorescence and flow ***:AME proteomics revealed 1385 proteins with similar expression levels(between 0.5-and 2-fold)between Fand C-AME,while 286 proteins were reduced(less than 0.5-fold)in *** GO term and biological pathway analysis showed that those proteins with comparable expression between F-AME and C-AME were involved in cell metabolism,epithelial-mesenchymal transition,focal adhesion,cell-extracellular matrix interaction,cell stress regulation and complement *** corneal stromal keratocytes cultured with F-AME or C-AME showed similar morphology and viability,while cell proliferation was mildly suppressed with C-AME(P>0.05).Expression of aldehyde dehydrogenase 3A1(ALDH3A1)and CD34 was similar in both ***:AME from cryopreserved amnion had limited influence on keratocyte *** is feasible to use protein extract from cryopreserved amnion to propagate human keratocytes for potential translati

关键词： Amnion extract Proteomics Corneal stromal keratocytes Marker expression

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Polar, catalytic, and conductive CoSe2/C frameworks for performance enhanced S cathode in Li–S batteries

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Journal of Energy Chemistry 2020年第9期29卷 128-135,I0004页

作者： Bo Yuan Di Hua Xingxing Gu Yu Shen Li-Chun Xu Xiuyan Li Bing Zheng Jiansheng Wu Weina Zhang Sheng Li Fengwei Huo Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)Nanjing Tech UniversityNanjing 211816JiangsuChina Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China College of Physics and Optoelectronics Taiyuan University of TechnologyTaiyuan 030024ShanxiChina

Lithium-sulfur battery(Li-S)is considered as one of the new-generation rechargeable batteries with high performance because of its extremely high theoretical capacity,energy density,environmental harmony and low ***,low electrical and ionic conductivity of sulfur,safety concerns and parasitic reaction generated by the dissolved polysulfide species in electrolyte hinder the commercialization of Li-S ***,we report a polyhedral porous structure comprising of carbon coating metal selenide nanoparticles(CoSe2/C),which could not only host sulfur for Li-S battery owing to its porous and conductive structure,but also mitigate the shuttle phenomenon by polysulfides adsorption and catalytic acceleration of redox *** a result,a performance enhanced CoSe2/C-S electrode for Li-S battery is achieved.

关键词： Catalytic Polar Conductive Sulfur cathode Cobalt Selenides

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The Importance of Reducing Smoking in China: To Achieve Healthy China 2030 While Reducing the Severity of the COVID-19 Pandemic

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China CDC weekly 2020年第22期2卷 404-406页

作者： Geoffrey T.Fong Yuan Jiang Department of Psychology and School of Public Health and Health Systems University of WaterlooWaterlooOntarioCanada Ontario institute for Cancer Research TorontoOntarioCanada Former Director Tobacco Control OfficeChina CDCBeijingChina

The coronavirus disease 2019(COVID-19)pandemic is the most devastating threat to global health since the 1918 influenza *** of May 22,2020,there have been 5.1 million cases confirmed,with over 333,000 *** we are just at the beginning of a long *** is a connection between COVID-19—the greatest infectious disease outbreak in a century—and the greatest chronic disease threat in the world today—tobacco *** has been identified by the World Health Organization(WHO)as the“single greatest preventable cause of death in the world”(1).Tobacco smoking kills 7.1 million people a year(2),with an additional 1.2 million dying from secondhand smoke(2).

关键词： smoke threat greatest

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Optimum Threshold Estimation of Thorax CT Scan for COVID-19 Diagnosis in a Single Center in Cameroon

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Advances in infectious diseases 2023年第1期13卷 12-20页

作者： Anne Esther Njom Nlend Landry Bonyomo Serges Abogo Serges Nga Nomo Luc Meka Moise Nna Beatrice Meva’a Arsene Brunelle Sandie Christiane Nsahlai Essos Hospital Center Yaoundé Cameroon Health Ebene consulting Research Department Yaoundé Cameroon Higher institute of Medical Technology Yaoundé Cameroon Ministry of Public Health Yaoundé Cameroon Faculty of Medicine and Biomedical Sciences Yaoundé Cameroon African Population and Health Research Center Yaoundé Cameroon

Objective: To evaluate the lung CT scan as a possible predictive diagnostic method for COVID-19 in the Cameroonian context. Methods: We designed a cross sectional study. Suspected cases of COVID-19 during the first wave at the national social insurance fund (NSIF) hospital were screened with both COVID-19 with lung CT scan and a PCR test. Univariate analysis was performed for sample description and multivariate analysis to assess the correlation between positive results for the PCR and other parameters. We estimated the optimum threshold of sensitivity/specificity, and area under curve using the empirical method and package. Results: A total of 62 suspected COVID-19 cases were recorded, predominantly males (Sex Ratio = 2.2) with a median age of 58.5 (IQR = 19.7). Among our 62 patients, 29 (46.8%) were confirmed COVID-19 cases with positive PCR results. All the patients had a thorax CT scan with a median impairment of 40% (IQR = 20%). The optimum threshold estimate for CT scan for COVID-19 infection diagnosis was 60% (95% CI = 25% - 80%). Overall, the sensitivity and specificity estimates were 0.30 (95% CI = 0.15 - 0.49) and 0.87 (95% CI = 0.70 - 0.96), respectively, leading to an Area Under Curve (AUC) estimate of 0.59 (95% CI = 0.46, 0.71). Conclusion: In this setting, lung CT scan was neither sensitive nor specific to predict COVID-19 disease.

关键词： COVID-19 CT Scan Lung Diagnosis

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Comprehensive profiling of lysine acetylome in Staphylococcus aureus

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Science China Chemistry 2014年第5期57卷 732-738页

作者： ZHANG Yi WU ZhiXiang WAN XueLian LIU Ping ZHANG JiBao YE Yang ZHAO YingMing TAN MinJia Chemical Proteomics Center & State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences Natural Products Chemistry Department & State Key Laboratory of Drug Research Shanghai Instituteof Materia Medica Chinese Academy of Sciences Ben May Department for Cancer Research University of Chicago

The Gram-positive bacterium Staphylococcus aureus(***)is a wide spread common opportunistic pathogen that causes a wide variety of infectious diseases,from benign skin infections to life-threatening diseases such as the methicillin-resistant Staphylococcus aureus(MRSA)*** emerging evidence suggests that lysine acetylation may play critical roles in bacterial physiology,the atlas of acetylome in *** has not been *** comprehensively profile protein lysine acetylation in ***,we used an integrated approach that combined immune affinity peptide enrichment using anti-lysine acetylation antibody,high-pH HPLC fractionation,and HPLC/mass spectrometry *** study led to the identification of 1361 non-redundant acetylation sites on 412 proteins found in a search of *** protein database extracted from the Swiss-Prot *** further performed bioinformatic analysis to characterize this modification,including gene ontology annotation,protein-protein interaction,and domain analysis of the acetylation *** found that the acetylated proteins were enriched in multiple biological pathways,such as ribosomal function and energy *** data provides a rich source for functional studies of lysine acetylation in ***.

关键词：金黄色葡萄球菌赖氨酸蛋白质数据库革兰氏阳性细菌色谱质谱分析蛋白质相互作用皮肤感染乙酰化

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