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human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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On the laboratory rearing of green dock leaf beetles Gastrophysa viridula （Coleoptera： Chrysomelidae）

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Insect Science 2011年第3期18卷 379-384页

作者： Dagmar Voigt Naoe Hosoda Jan Schuppert Stanislav Gorb Evolutionary Biomaterials Group Department of Thin-Films and Biological Systems Max Planck Institute for Metals Research Stuttgart Department of Functional morphology and Biomechanics Zoological Institute Christian Albrechts University of Kiel Kiel Germany Advanced Nano Materials Laboratory Interconnect Design Group National Institute for Materials Tsukuba Ibaraki Japan

Leaf beetles Gastrophysa viridula have attracted recently increased research interest from various points of view, since they are：（i） pest insects in rhubarb crops; （ii） potential biocontrol agents of dock plants Rumex spp. in grasslands; and （iii） a model species in ecological studies on insect population dynamics, biochemistry, behavior, biomechanics and biomimetics. The continuous rearing of beetles at standardized conditions may help to unify the fitness state of different individuals, allowing a better comparison of experimental results. The present communication suggests a modular space- and time-saving rearing method ofG. viridula in stackable faunariums under laboratory conditions, which has been successfully established and continuously used over the last 5 years. Several developmental stages were kept in separate boxes, and multiple generations were kept simultaneously, depending on the required number of beetles.

关键词： Chrysomelidae standardisation Rumex obtusifolius

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SCIENCE OF WINNING SOCCER:EMERGENT PATTERN-FORMING DYNAMICS IN ASSOCIATION FOOTBALL

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Journal of Systems Science & Complexity 2013年第1期26卷 73-84页

作者： VILAR Luís ARAUJO Duarte DAVIDS Keith BAR-YAM Yaneer Faculty of Physical Education and Sports Lusofona University of Humanities and Technologies Faculty of human Kinetics Technical University of Lisbon SpertLab CIPERFaculty of Human KineticsTechnical University of Lisbon School of human Movement Studies Queensland University of Technologies New England Complex Systems institute

Quantitative analysis is increasingly being used in team sports to better understand performance in these stylized,delineated,complex social ***,the authors provide a first step toward understanding the pattern-forming dynamics that emerge from collective offensive and defensive behavior in team *** authors propose a novel method of analysis that captures how teams occupy sub-areas of the field as the ball changes *** authors use this method to analyze a game of association football(soccer) based upon a hypothesis that local player numerical dominance is key to defensive stability and offensive *** authors find that the teams consistently allocated more players than their opponents in sub-areas of play closer to their own *** is consistent with a predominantly defensive strategy intended to prevent yielding even a single *** authors also find differences between the two teams' strategies:while both adopted the same distribution of defensive,midfield,and attacking players(a 4:3:3 system of play),one team was significantly more effective in maintaining both defensive and offensive numerical dominance for defensive stability and offensive *** team indeed won the match with an advantage of one goal(2 to 1) but the analysis shows the advantage in play was more pervasive than the single goal victory would *** proposed focus on the local dynamics of team collective behavior is distinct from the traditional focus on individual player *** supports a broader view in which specific player abilities contribute within the context of the dynamics of multiplayer team coordination and coaching *** applying this complex system analysis to association football,the authors can understand how players' and teams' strategies result in successful and unsuccessful relationships between teammates and opponents in the area of play.

关键词： Collective behavior performance analysis team sports.

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Seminal concentrations of trace elements in various animalsand their correlations

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Asian Journal of Andrology 2003年第2期5卷 101-104页

作者： P.Massányi J.Trandzik P.Nad R.Toman M.Skalická B.Koréneková Department of Animal morphology Slovak University of Agriculture SK-94976 Nitra Slovak Republic State Breeding institute SK-94992 Nitra Slovak Republic Research institute of Veterinary Medicine University of Veterinary Medicine SK-040 01 Kosice Slovak Republic

Aim: To determine the seminal concentrations of copper, zinc, iron, cadmium, lead and nickel in bulls, rams, boars, stallions and foxes and study their correlations. Methods: Semen samples were obtained, digested and analyzed by means of the atomic absorption spectrophotometer. Data were analyzed statistically with the Student's t-test and Scheffe's test using PC programs SAS and Excel. Results: The seminal copper concentration was significantly higher in ram [(2.49±0.18) mg/kg] and fox [(2.16±0.53) mg/kg] than that in bull [(1.64±0.21) mg/kg], boar [(1.64±0.28) mg/kg] and stallion (0.86 mg/kg). In boar a significantly higher seminal zinc concentration (171.74±65.72) mg/kg] was found in comparison with stallion [(86.20±45.88) mg/kg], bull [(83.15±61.61) mg/kg], ram [( 60.46±35.37) mg/kg] and fox (13.09±5.22) mg/kg]. The iron concentration in semen was significantly higher in ram [(40.32±10.81) mg/kg), bull [(38.04±22.07) mg/kg] and fox [(33.16±24.36) mg/kg] than that in boar [(16.14±10.35) mg/kg] and stallion (12.68 mg/kg). The seminal cadmium concentration was relatively low [(0.05-0.12) mg/kg] in all studied species. The seminal lead concentration was the highest in ram [(0.35±0.68) mg/kg], which was much higher than in fox [(0.08±0.06) mg/kg], bull [(0.06±0.04) mg/kg], stallion [(0.05±0.05) mg/kg] and boar [0.02±0.03) mg/kg]. The level of seminal nickel was significantly higher in fox [(0.35±0.24) mg/kg] and ram [(0.31±0.19) mg/ kg] in comparison with bull [(0.12±0.07) mg/kg] and boar [(0.06±0.08) mg/kg]. The concentration of nickel in the semen of stallion was (0.20±0.24) mg/kg. There was a high positive correlation between seminal iron and zinc in bull (r=0.723) and stallion (r=0.723), between cadmium and lead in ram (r=0.976) and boar (r=0.973) and between iron and cadmium (r=0.783) and iron and lead (r=0.791) in boar. A high negative correlation between seminal nickel and copper in ram (r=-0.709) and between seminal copper and lead in fox (r=-0.854) was found

关键词： semen copper zinc iron cadmium lead nickel

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The Role of Vanes in the Damping of Bird Feathers

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Journal of Bionic Engineering 2023年第4期20卷 1646-1655页

作者： Kai Deng Hamed Rajabi Alexander Kovalev Clemens F.Schaber Zhendong Dai Stanislav N.Gorb Functional morphology and Biomechanics Institute of ZoologyKiel University24098KielGermany School of Engineering London South Bank UniversityLondonSE10AAUK institute of Bioinspired Structure and Surface Engineering Nanjing University of Aeronautics and AstronauticsNanjing210026People’s Republic of China

Bird feathers sustain bending and vibrations during *** unwanted vibrations could potentially cause noise and flight *** could alter the system response,resulting in improving quiet flight,stability,and *** of feathers are known to be indispensable for supporting the aerodynamic function of the *** relationship between the hierarchical structures of vanes and the mechanical properties of the feather has been previously ***,still little is known about their relationship with feathers’damping ***,the role of vanes in feathers’damping properties was *** vibrations of the feathers with vanes and the bare shaft without vanes after step deflections in the plane of the vanes and perpendicular to it were measured using high-speed video *** presence of several main natural vibration modes was observed in the feathers with *** trimming vanes,more vibration modes were observed,the fundamental frequencies increased by 51-70%,and the damping ratio decreased by 38-60%.Therefore,we suggest that vanes largely increase feather damping *** mechanisms based on the morphology of feather vanes are *** aerodynamic damping is connected with the planar vane surface,the structural damping is related to the interlocking between barbules and barbs,and the material damping is caused by the foamy medulla inside barbs.

关键词： Bird Feather Vibrations Damping Bionic

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EFFECTS OF CHANGES IN PATTERN OF LHRH PULSE ON LH SECRETION BY PERFUSED ANTERIOR PITUITARY CELLS OF MALE RATS

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Science China Chemistry 1991年第2期34卷 161-170页

作者：屈智超喻晶华郭景郭建 Sichuan Family Planning Research institute WHO Collaborating Centre for Research in Human Reproduction

In the present study, a perfusion system of dispersed cells was used to investigate theeffects of LHRH pulse amplitude and frequency, and LHRH continuous stimulation on LHsecretion by anterior pituitary cells of adult male rats. The results have shown that, in therange of LHRH concentrations from 1×10^(-10) to 1 ×10^(-6) mol/L, the dose-response curve of LHsecretion was linear. LHRH pulse frequency generated a biphasic LH response: increasingLHRH pulse frequency increased the basal LH secretion and decreased LH/pulse. When1 ×10^(-9), mol/L or greater LHRH was given at frequencies of 3 pulses/h or higher, it wasobserved that a maximal LH peak was induced and then the LH release declined progres-sively to its LH basal level, i.e. LHRH self-priming effect and LH desensitization occurred.Enhancement of amplitude of LHRH pulses could reduce pulse frequency required for prim-ing. Increases in frequency of LHRH pulses with high amplitude would provoke the prim-ing effect more quickly. In addition, continuous perfusion of LHRH with different con-centrations could also elicit the LHRH self-priming effect and LH desensitization. LHRHwith low concentration (1×10^(-10) mol/L) would take much longer to evoke a self-primingeffect. These results indicate that the LH secretion pattern is dependent on LHRH pulsatileamplitude and frequency, and will help to clarify the kinetics mechanisms by which LHpulses fluctuate in vivo.

关键词： LHRH pulses pituitary cells LH secretion

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Immune and non-immune responses to hepatitis C virus infection

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World Journal of Gastroenterology 2015年第38期21卷 10739-10748页

作者： Jiaren Sun Ricardo Rajsbaum Min Kyung Yi Department of Microbiology and Immunology Institute for Human Infections and ImmunityUniversity of Texas Medical Branch

The host innate and adaptive immune systems are involved in nearly every step of hepatitis C virus(HCV) infection. In patients,the outcome is determined by a series of complex host-virus interactions,whether it is a natural infection or results from clinical intervention. Strong and persistent CD8+ and CD4+ T-cell responses are critical in HCV clearance,as well as cytokineinduced factors that can directly inhibit virus replication. Newly available direct-acting antivirals(DAAs) are very effective in viral clearance in patients. DAA treatment may further result in the down-regulation of programmed death-1,leading to rapid restoration of HCV-specific CD8+ T cell functions. In this review,we focus on recent studies that address the host responses critical for viral clearance and disease resolution. Additional discussion is devoted to the prophylactic vaccine development as well as to current efforts aimed at understanding the host innate responses against HCV infection. Current theories on how the ubiquitin system and interferon-stimulated genes may affect HCV replication are also discussed.

关键词： Hepatitis C virus Hepatitis T cell Direct-acting a

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A Middle Triassic stem-neopterygian fish from China sheds new light on the peltopleuriform phylogeny and internal fertilization

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Science Bulletin 2016年第22期61卷 1766-1774页

作者： Guang-Hui Xu Xin-Ying Ma Key Laboratory of Vertebrate Evolution and human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences

Internal fertilization and viviparity are easily observed and well studied in living neopterygian fishes(14teleostean families), but they are difficult to identify in extinct taxa due to the limitation of the fossil record. The Peltopleuriformes from the Middle to Late Triassic of Europe and South China are a stem group of Neopterygii that may have first evolved internal fertilization and viviparity in this clade because they show a highly modified anal fin in presumed males resembling the intromittent organ in living viviparous teleosts. Until recently, Peltopleurus lissocephalus and P. rugosus from the Ladinian/Anisian boundary(*242 Ma) of Monte San Giorgio area in Switzerland and Italy represent the oldest record of Peltopleuriformes, and the phylogenetic interrelationships of this group remain controversial. Here, we report the discovery of a new peltopleuriform, Peltopleurus nitidus sp. nov., based on eleven well-preserved specimens from the early Middle Triassic(Pelsonian, Anisian, *244 Ma)of Luoping, eastern Yunnan, China. The discovery documents the oldest convincing peltopleuriform, extending the geological range of this clade by proximately two million years. Results of the phylogenetic analysis recover *** at the base of Peltopleuridae, and provide robust support for the sister-group relationships of Peltopleuridae with Thoracopteridae within the Peltopleuriformes. The male anal fin of P. nitidus shows a primitive condition unknown in other peltopleuriforms. Comparative studies of the male anal fin in P. nitidus and other peltopleuriforms shed new light on the internal fertilization in this group.

关键词： Sexual dimorphism Viviparity Peltopleuridae Thoracopteridae Triassic

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Structure and electrochemical performance of delafossite AgFeO_(2)nanoparticles for supercapacitor electrodes

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 201-213页

作者： Choulong Veann Thongsuk Sichumsaeng Ornuma Kalawa Narong Chanlek Pinit Kidkhunthod Santi Maensiri School of Physics Institute of ScienceSuranaree University of TechnologyNakhon Ratchasima 30000Thailand SUT Center of Excellence on Advanced Functional Materials Suranaree University of TechnologyNakhon Ratchasima 30000Thailand Synchrotron Light Research institute Nakhon Ratchasima 30000Thailand Department of Physics Universitas Negeri MalangMalang 65145Indonesia

Delafossite AgFeO_(2)nanoparticles with a mixture of 2H and 3R phases were successfully fabricated by using a simple co-precipitation *** resulting precursor was calcined at temperatures of 100,200,300,400,and 500℃to obtain the delafossite AgFe0_(2)*** morphology and microstructure of the prepared AgFeO_(2)samples were characterized by using field emission scanning electron microscopy(FESEM),transmission electron microscopy(TEM),N_(2) adsorption/desorption,X-ray absorption spectroscopy(XAS),and Xray photoelectron spectroscopy(XPS)techniques.A three-electrode system was employed to investigate the electrochemical properties of the delafossite AgFeO_(2)nanoparticles in a 3 M KOH *** delafossite AgFeO_(2)nanoparticles calcined at 100℃(AFO100)exhibited the highest surface area of 28.02 m^(2)·g^(-1)and outstanding electrochemical performance with specific capacitances of 229.71 F·g^(-1)at a current density of 1 A·g^(-1)and 358.32 F·g^(-1)at a scan rate of 2 mV·s^(-1).This sample also demonstrated the capacitance retention of 82.99% after 1000 charge/discharge cycles,along with superior specific power and specific energy values of 797.46 W·kg^(-1)and 72.74Wh·kg^(-1),*** findings indicate that delafossite AgFeO_(2)has great potential as an electrode material for supercapacitor applications.

关键词： nanoparticles delafossite electrochemical properties X-ray absorption spectroscopy co-precipitation supercapacitor

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Protein Product Encoded by a human Novel Gene E9730 Enhances AP-1 Activity through Interacting with Jab1

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Acta Biochimica et Biophysica Sinica 2004年第1期36卷 11-15页

作者： Zhao-Qing WANG, Han-Dong WEI, and Fu-Chu HE(Department of System Biology, Beijing institute of Radiation Medicine, Chinese human National Center at Beijing, Beijing 100850, China) Department of System Biology Beijing Institute of Radiation Medicine Chinese Human National Center at Beijing Beijing 100850 China

A novel human gene, named E9730 (a clone number of fetal liver cDNA library), has been identified from more than 14,000 expressed sequence tags (ESTs) based on our large scale sequencing of human fetal liver cDNA libraries. Although sequencing of this novel human gene indicates that it is a leucine zipper protein, the function of E9730 and its homologous genes among species is unknown yet. To find out physiological functional clue of E9730, the yeast two-hybrid system was used to screen the E9730-interac-ting protein(s), and one clone containing a cDNA insert with almost the entire coding sequence (amino acids 39-335) of human Jabl (Jun-activating domain binding protein 1) that interacted specifically with E9730 was identified. A specific association between Jabl and E9730 was shown by co-immunoprecipitation and co-localization experiments. Furthermore, E9730 appeared to enhance Jab 1 -induced AP-1 activity in a concentration-dependent manner and Jabl may be involved in the intracellular signaling trans

关键词： human E9730 gene CSN5/Jabl protein-protein interaction signaling transduction

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