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An NIR-II-emissive Ru(II) metallacycle for efficient and safe immunotherapy

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Science China Chemistry 2024年

作者： Chonglu Li Jianbo Zhan Biao Dong institute of health inspection and testing Hubei Provincial Center for Disease Control and Prevention State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University

Immunotherapy, as a groundbreaking cancer treatment, has gained considerable attention for its utilization of the body’s immune system to combat tumors [1]. This therapy induces tumor cell apoptosis, triggering a sustained anti-tumor immune response and effectively preventing tumor recurrence and metastasis [2]. The fundamental principle lies in inducing tumor cell death through specific treatment modalities,leading to the release of a cascade of signaling molecules and antigens, thereby mobilizing the immune system to actively identify and attack tumor cells [3].

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Modularized and Parametric Modeling Technology for Finite Element Simulations of Underground Engineering under Complicated Geological Conditions

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 621-645页

作者： Jiaqi Wu Li Zhuo Jianliang Pei Yao Li Hongqiang Xie Jiaming Wu Huaizhong Liu State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China Research institute of testing and inspection Sinohydro Bureau 7 Co.Ltd.Chengdu610213China

The surrounding geological conditions and supporting structures of underground engineering are often updated during construction,and these updates require repeated numerical *** improve the numerical modeling efficiency of underground engineering,a modularized and parametric modeling cloud server is developed by using Python *** basic framework of the cloud server is as follows:input the modeling parameters into the web platform,implement Rhino software and FLAC3D software to model and run simulations in the cloud server,and return the simulation results to the web *** modeling program can automatically generate instructions that can run the modeling process in Rhino based on the input modeling *** main modules of the modeling program include modeling the 3D geological structures,the underground engineering structures,and the supporting structures as well as meshing the geometric *** particular,various cross-sections of underground caverns are crafted as parametricmodules in themodeling *** and parametric modeling program is used for a finite element simulation of the underground powerhouse of the Shuangjiangkou Hydropower *** complicatedmodel is rapidly generated for the simulation,and the simulation results are ***,this modularized and parametric modeling program is applicable for three-dimensional finite element simulations and analyses.

关键词： Underground engineering modularized and parametric modeling finite element method complex geological structure cloud modeling

A novel low molecular weight compound polysaccharides from Chinese herbal medicines: purification， characterization and anti-tumor activities in vitro and in vivo

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Food Science and Human Wellness 2024年

作者： Xu Yang Dongli Cao Haiyu Ji Huijing Xu Mengjie Xu Anjun Liu Key Laboratory of Food Nutrition and Safety， Ministry of Education， School of Food Science and Engineering， Tianjin University of Science and Technology National Center of inspection and testing for Processed Food Quality， Tianjin institute for Food Safety inspection Technology

A novel low molecular weight polysaccharide (LMW-CPS) was identified from a specific combination of Chinese herb ingredients. The monosaccharide composition of LMW-CPS was consisted of single arabinose， which had an α-L-furanose configuration with an average molecular weight of 2.06 kDa. NMR spectra and monosaccharide constitution analyses revealed that it had a backbone of →5)-α-L-Araf-(1→ with α-L-Araf-(1→ as the terminal residue. In vitro experiments found that it could lead to apoptosis and inhibit hepatocellular carcinoma cell proliferation by arresting them in the S phase. In vivo experiments showed that it protected immune organs such as the thymus and spleen， enhanced immune cell activities， stimulated cytokine release， augmented the abundance of CD8， CD3， CD4， and CD19 positive lymphocytes， and markedly impeded solid hepatocellular carcinoma progression in mice. H&E staining and cell cycle examination also indicated that LMW-CPS arrested hepatocellular carcinoma cells at the S phase to induce apoptosis. These findings indicated its promising potential for the treatment of hepatocellular carcinoma.

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Penetration Study of Key Technologies for Cybersecurity Risk Assessment

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Journal of Electronic Research and Application 2024年第4期8卷 81-87页

作者： Lin Ma Zhejiang testing&inspection institute for Mechanical and Electrical Products Quality Hangzhou 310051China

In recent years,with the frequent occurrence of cyber security incidents,people have paid more attention to *** security risk assessment is a very important research *** paper gives a brief overview of the theory of cybersecurity risk assessment,focuses on the description of the current mainstream cybersecurity risk assessment methods,classifies and compares the existing methods according to the nature of the methods,and analyses the advantages,disadvantages,and application scope of each ***,the main factors affecting the evaluation results are summarized and refined,and future research hotspots in this field are *** the empirical analysis of the three factors,the influence of the correlation of the three factors,the uncertainty of the evaluation indexes,and the timeliness of the evaluation on the evaluation results are concluded,which provides a reference for future research on evaluation methods.

关键词： Risk assessment Correlation Real-time analysis Uncertainty analysis Quantitative analysis

Ellagic Acid Enhances Antioxidant System Activity and Maintains the Quality of Strawberry Fruit during Storage

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Phyton-International Journal of Experimental Botany 2024年第1期93卷 15-28页

作者： Jian Chen Jing Zhang Gang Pan Dandan Huang Shuhua Zhu College of Chemistry and Material Science Shandong Agricultural UniversityTaian271018China Agriculture and Rural Bureau of Penglai District Yantai265699China Laiyang inspection and testing Center Yantai265299China

Ellagic acid(EA)is a natural antioxidant,widely present in a lot of forms’soft fruits,nuts,and other plant tissues,and helpful for promoting human health;however,its protective effect on postharvest fruit and improving the quality index of postharvest fruit have rarely been *** this experiment,the strawberries were soaked in 0,100,200,300,400,and 500 mg L^(−1) EA,respectively,and the influential EA on fruit quality and the antioxidant system of strawberries were *** with the control,EA treatment can reduce the browning degree and rotting rate of strawberry fruit during storage and augment the soluble solid content(SSC).EA treatment can also increase the content of related stuff and enzyme activity in antioxidant systems;the gene expression level of polyphenol oxidase(PPO)in strawberries treated with EA was always down-regulated,correspondingly,the expression of other antioxidant enzyme genes was *** the strawberry fruits treated with EA of different concentrations,300 mg L^(−1) EA had the best effect in the process of strawberry *** results suggested that the proper concentration of exogenous EA at 300 mg L−1 could maintain strawberries’quality and enhance the antioxidant system by improving the activities of antioxidative enzymes and the ascorbateglutathione(AsA-GSH)cycle during storage.

关键词： Strawberry ellagic acid antioxidative enzyme AsA-GSH cycle storage

An Improved Thermal Conductivity Measurement Scheme for Macroscopic Graphitic Films Using the Laser Flash Method

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Journal of Thermal Science 2024年第4期33卷 1480-1490页

作者： ZHANG Peijuan MING Xin LIU Yingjun WANG Xuelong SHI Hang HAO Yuanyuan LU Jiahao LIU Zheng LAI Haiwen ZHANG Ying GAO Weiwei XU Zhen GAO Chao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceZhejiang UniversityHangzhou310027China Shanxi-Zheda institute of Advanced Materials and Chemical Engineering Taiyuan030032China Special Equipment Safety Supervision and inspection institute of Jiangsu Province National Graphene Products Quality Inspection and Testing Center(Jiangsu)Wuxi214174China Hangzhou Gaoxi Technol Co. LtdHangzhou311113China China Academy of Aerospace Aerodynamics Beijing100074China

Achieving efficient thermal management urges to exploit high-thermal-conductivity materials to satisfy the boosted demand of heat *** is critical to adopt standardized characterization protocols to evaluate the intrinsic thermal conductivity of thermal management ***,for the most representative laser flash method,the lack of standard measurement methodology and systematic description on the thermal diffusivity and influencing factors has led to significant deviations and confusion of the thermal conduction performance in the emerging thermal management ***,the measurement error factors of thermal diffusivity by the common laser flash analyzer(LFA)are *** high-thermal-conductivity graphitic film(GF)as a typical case,the key factors are analyzed to guide the measurement protocol of related carbon-based thermal management *** basic principle of the LFA measurement,actual pre-processing conditions,instrument parameters setting,and data analysis are elaborated for accurate ***,the graphene thick films and common isotropic materials are also extended to meet various thermal measurement *** on the existing practical problems,we propose a feasible test flow to achieve a unified and standardized thermal conductivity measurement,which is beneficial to the rapid development of carbon-based thermal management materials.

关键词： thermal management graphitic film laser flash method thermal conductivity thermal diffusivity

Advancing ophthalmic delivery of flurbiprofen via synergistic chiral resolution and ion-pairing strategies

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 177-189页

作者： Zhining Ma Yuequan Wang Huiyang He Tong Liu Qikun Jiang Xiaohong Hou School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Liaoning Provincial institute of Drug inspection and testing Shenyang 110036China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang 110016China

Flurbiprofen(FB),a nonsteroidal anti-inflammatory drug,is widely employed in treating ocular inflammation owing to its remarkable anti-inflammatory ***,the racemic nature of its commercially available formulation(Ocufen^(R))limits the full potential of its therapeutic activity,as the(S)-enantiomer is responsible for the desired antiinflammatory ***,the limited corneal permeability of FB significantly restricts its *** this study,we successfully separated the chiral isomers of FB to obtain the highly active(S)-***,utilizing ion-pairing technology,we coupled(S)-FB with various counter-ions,such as sodium,diethylamine,trimethamine(TMA),and l-arginine,to enhance its ocular bioavailability.A comprehensive evaluation encompassed balanced solubility,octanol-water partition coefficient,corneal permeability,ocular pharmacokinetics,tissue distribution,and in vivo ocular anti-inflammatory activity of each chiral isomer *** the various formulations,S-FBTMA exhibited superior water solubility(about 1–12 mg/ml),lipid solubility(1

关键词： Flurbiprofen Anti-inflammatory Ophthalmic delivery Chiral resolution Ion-pairing

Development and Validation of an Impedimetric Sensor Modified with Molecularly Imprinted Polymer for Direct Determination of Bisphenol A in Bioanalytics

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Journal of Analysis and testing 2024年第2期8卷 228-236页

作者： Wenjing Song Yingyi Guo Pengyu Liu Xiucong Pei School of Public health Shenyang Medical CollegeShenyang110034China Shenyang institute for Food and Drug Control Shenyang110021China Key Laboratory of Food Pollutant inspection and Risk Assessment in Liaoning Province Shenyang110021China

There is a strong correlation between bisphenol A(BPA)and the risks of endocrine disruption in ***,the mechanism behind this correlation is still unknown due to the challenge of accurately assessing BPA levels in biological ***,we demonstrate a molecularly imprinted polymer(MIP)modified impedimetric sensor treated with bovine serum albumin(BSA)not only reduces the impact of protein interference but also maintains both specificity and sensitivity for the precise analysis of *** platinum disc electrode was coated with MIP via electrochemical polymerization of o-phenylenediamine(o-PD)in the presence of BPA as a template,and free sites were then blocked with 1%*** impedance spectroscopy(EIS)was utilized for the detection of *** linear range for detection was between 1.0 pg/L and 10.0 ng/L,with a detection limit(LOD)of 0.28 pg/*** sensor presented a good selectivity over structurally similar steroid hormones and BPA *** validate the performance of the proposed sensor in the presence of possible interfering proteins,it was used to quantify BPA in real samples without any prior *** findings indicate that such an impedimetric sensor can be used to measure BPA in complex matrices.

关键词： Bisphenol A Molecularly imprinted polymers Impedimetric sensor Bovine serum albumin Biological matrices

Terpyridine-based metallo-cuboctahedron nanomaterials for efficient photocatalytic degradation of persistent organic pollutants

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Nano Research 2024年第8期17卷 6833-6840页

作者： Qixia Bai Yan Huang Zhihong Chen Yilin Pan Xiaohan Zhang Qingwu Long Qiaoan Yang Tun Wu Ting-Zheng Xie Mingjian Wang Hongguang Luo Chun Hu Pingshan Wang Zhe Zhang Key Laboratory for Water Quality and Conservation of the Pearl River Delta(Ministry of Education) Institute of Environmental Research at Greater Bay AreaGuangzhou UniversityGuangzhou 510006China College of Light Chemical Industry and Materials Engineering Shunde PolytechnicFoshan 528333China Guangdong Guangye inspection&testing Group Co. Ltd.Guangzhou 510006China

Metal–organic cage photocatalysts with nanoscale dimensions have received wide attention in the field of photocatalytic environmental pollutant treatment due to their large cavities,easy modification,high tunability,and enriched active ***,we prepared a series of dihydroanthracene-cored terpyridine-based metallo-cuboctahedron nanomaterials through a selfassembly method,which exhibited satisfactory degradation performance for persistent organic pollutants under visible light *** particular,under light conditions,S1-Zn,one of the prepared nanomaterials,produced photogenerated holes oxidizing water molecules to∙OH,which attacked ibuprofen(IBU)for up to 95% ***,the corresponding photogenerated electrons reduced the dissolved oxygen in water,producing 66.2μmol/L hydrogen *** obtained supramolecular photocatalytic materials have a stable structure with non-precious metals and do not require a sacrificial *** metal sites of metallo-cuboctahedrons adsorb pollutants and transfer captured holes to them,accelerating degradation and promoting simultaneous H_(2)O_(2) *** work not only proposes a simple and efficient synthesis method for supramolecular photocatalysts but also opens up opportunities for efficient,low-cost,and multifunctional materials for environmental persistent organic pollutants treatment.

关键词： supramolecular cages self-assembly photocatalytic pollutant degradation H2O2 production