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Clinical features of abnormalα-fetoprotein in 15 patients with chronic viral hepatitis B after treatment with antiviral drugs

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World Journal of Hepatology 2025年第1期17卷 47-54页

作者： Man-Lei Jiang Fei Xu Jin-Long Li Jia-Yu Luo Jiang-Ling Hu Xian-Qiang Zeng Ganzhou institute of liver disease Department of HepatologyGanzhou Fifth People's HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUND liver function of chronic hepatitis B(CHB)patients is essentially normal after treatment with antiviral *** rare cases,persistently abnormally elevatedα-fetoprotein(AFP)is seen in CHB patients following long-term antiviral ***,in the absence of imaging evidence of liver cancer,a reasonable expla-nation for this phenomenon is still *** To explore the causes of abnormal AFP in patients with CHB who were not diag-nosed with liver *** From November 2019 to May 2023,15 patients with CHB after antiviral treatment and elevated AFP were *** data and quality indicators related to laboratory testing,imaging data,and pathological data were obtained through inpatient medical *** All patients had increased AFP and significantly elevated *** was excluded by imaging *** four patients had elevated alanine ami-notransferase,10 had elevated aspartate aminotransferase,nine had elevated total bilirubin,and two had antinuclear *** liver biopsy and histopatho-logical examination indicated that 14 patients had rosette,moderate,or higher interfacial inflammation,lymphocyte infiltration,and severe hepatic fibers(11 cases),which was consistent with the pathological features of autoimmune hepa-titis(AIH).After 8-12 week of hormone therapy,the levels of AFP and IgG,and liver function returned to normal(P<0.05).CONCLUSION For patients with CHB and elevated AFP after antiviral treatment,autoimmune hepatitis should be *** with AIH is clinically insidious and difficult to detect,and prone to progression to *** puncture pathological examination should be performed when necessary to confirm diagnosis.

关键词： Abnormalα-fetoprotein Chronic viral hepatitis B Antiviral treatment Autoimmune hepatitis Hepatic pathology

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Multicenter analysis on the correlation between the anatomical characteristics of hepatic veins and hepatic venous wedge pressure

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World Journal of gastroenterology 2025年第9期31卷 43-53页

作者： Qiu-Xia Ye Ming-Ming Meng Yi-Fan Wu Cheng-Bin Dong Yu Zhang Bo-Wen Liu Yi-Fan Lv Shao-Li You Sa Lv Hui-Guo Ding Ying Han Yong-Ping Yang Bing Zhu Fu-Quan Liu liver disease Minimally Invasive Diagnosis and Treatment Center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China liver Vascular disease Diagnosis and Treatment Center The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100039China Department of gastroenterology and Hepatology Beijing You’an HospitalCapital Medical UniversityBeijing 100069China

BACKGROUND Wedged hepatic venous pressure(WHVP)is a crucial variable for accurately assessing the hepatic venous pressure gradient(HVPG)and is vital for the diagnosis and prognostic evaluation of patients with portal hypertension(PH).AIM To investigate the anatomical characteristics of balloon-occluded hepatic venous angiography in patients with PH and analyze the relationship between the WHVP and portal venous pressure(PVP).METHODS This retrospective study included 877 patients with PH who met the inclusion criteria from January 2020 to June *** and innovative hepatic venous angiography was performed during transjugular intrahepatic portosystemic shunt procedures to measure hepatic venous and *** patients'angiographic images were collected for *** associations between WHVP and PVP in each group were analyzed via linear regression analysis,and a predictive model was *** The 877 patients had a mean age of 52.6±13.0 years,with 582 males and 295 *** were categorized into four groups on the basis of their anatomical *** groups showed strong correlations between WHVP and *** regression coefficient between the WHVP and PVP in the hepatic right vein-portal venous angiography group was 0.884(P<0.05);in the hepatic right vein-accessory hepatic venous angiography group,it was 0.721(P<0.05);in the hepatic right vein-middle hepatic venous angiography group,it was 0.344(P<0.05);and in the hepatic right vein-nonangiography group,it was 0.293(P<0.05).CONCLUSION The presence and anatomical classification of hepatic venous collaterals are key factors influencing the relationship between WHVP with and *** on the different anatomical classifications of hepatic veins,WHVP can be used to estimate PVP,improving the accuracy of PVP prediction.

关键词： Wedged hepatic venous pressure Portal venous pressure Portal hypertension Collateral branches of the hepatic vein Transjugular intrahepatic portosystemic shunt

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Internal transcribed spacer sequencing to explore the intrinsic composition of fungal communities in fungal esophagitis

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World Journal of gastroenterology 2025年第7期31卷 26-38页

作者： Yi-Kang Song Lin Zheng Ai-Xin Liu Jun-Ji Ma Department of gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000Hebei ProvinceChina

BACKGROUND Fungal esophagitis(FE)is caused by fungal invasion of the esophageal *** endoscopy,the esophageal mucosa shows edema,congestion,erosion,and ulceration,and bleeds easily when touched,and the surface of the mucosa is covered with small white spots like"bean curd residue".Clinical cases showing typical FE under endoscopic imaging but negative esophageal mucosal brush(referred to as suspected FE)have increased the difficulty and challenge of clinical diagnosis and *** present,the esophageal fungal flora of suspected case has not been thoroughly *** To characterize the fungal flora in FE,suspected FE,and the esophageal normal controls(NCs),and to identify marker species to improve detection of *** This was a case-control study.A total of 19 patients with FE,16 with suspected FE,and 10 NCs were selected by *** esophageal cell brush samples of each group were sequenced by internal transcribed spacer(ITS)1 and analyzed by *** In FE and suspected FE patients,species richness,species diversity and species evenness,as measured by the Chao1 index,Shannon index and Pielou index,were lower than in the NCs,and the comparison between the FE and NCs was the most significant(P<0.05).Compared with the NCs,the relative abundance of Candida in FE and suspected FE patients was significantly increased(P<0.001),while the relative abundance of Yarrowia was significantly decreased(P<0.05).Moreover,Yarrowia abundance in the FE group was significantly lower than in the NCs and suspected FE groups(P<0.001).The area under the curve for Candida in FE and suspected FE patients was 99.5%(P<0.05)and 81.3%(P<0.05),***,compared with FE patients,the relative abundance of Ascomycota and Candida in the esophageal flora of suspected FE patients was decreased,while the relative abundance of Yarrowia,Thermomyces and Pichia was *** ITS showed that composition of the fungal community was similar in the F

关键词： Fungal microbiota Esophagitis Candida Yarrowia Biomarker

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Endoscopic ultrasound-guided liver biopsy in liver transplant recipients: A preliminary experience

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Hepatobiliary & Pancreatic diseases International 2025年第1期24卷 108-110页

作者： Wei Rao Yue-Ping Jiang Jin-Zhen Cai Man Xie Division of Hepatology Liver Disease Centerthe Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Organ Transplantation the Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of gastroenterology the Affiliated Hospital of Qingdao UniversityQingdao 266000China

To the Editor:With the popularity of liver transplantation(LT)and the inspiration for long-time survival,issues related to evaluating the liver allograft have increased in recent years[1-3].Although there has been renewed interest in non-invasive methods to evaluate diffuse liver disease,liver biopsy is still the golden standard in clinical practice,particularly for liver transplant recipients(LTRs).The liver biopsy has always been performed in LTRs as a part of standard procedure in cases whose liver function was normal,named as protocol liver biopsy,or to identify histological abnormalities for abnormal liver function and provide guidance for the adjustment of immunosuppressive regimen[4,5].Percutaneous liver biopsy(PLB)has been frequently conducted in LTRs;however,the clinical implementation of protocol liver biopsy by PLB in LTRs is challenging due to their suboptimal compliance,particularly in China[6].Besides,the PLB procedure has been associated with discomfort and potentially life-threatening complications in the general population,as reported in the literature[7,8].

关键词： biopsy preliminary comfort

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New perspectives and prospects for the next generation of combination therapy in inflammatory bowel disease

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World Journal of gastroenterology 2025年第5期31卷 124-128页

作者： Wen-Ting Xie Hui Yang Lan Bai Feng-Fei Wu Guangdong Provincial Key Laboratory of gastroenterology Institute of Gastroenterology of Guangdong ProvinceDepartment of GastroenterologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

This article comments on the letter by Lowell et al,which addresses the next generation of combination therapy for inflammatory bowel disease(IBD).As the understanding of the pathogenesis of IBD continues to improve,treatment strategies are evolving *** letter examines the current status and future directions of combination therapy for IBD,focusing on approaches that combine biologics with immunomodulators and the emerging dual-biologic therapy(DBT).The traditional combination of biologics and immunomodulators has demonstra-ted preliminary efficacy by enhancing the effects of biologics through ***,concerns regarding long-term safety warrant careful *** trials,including DUET-Crohn's disease and DUET-ulcerative colitis,have shown promising potential for the broader adoption of ***,comprehensive data on efficacy and safety,as well as the effective integration of supportive treatments,remain essential to establish new paradigms for the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Dual-biologic therapy Supportive treatment The next generation of combination therapy

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Patient and physician factors contributing to delays in inflammatory bowel diseases:Enhancing timely diagnosis

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World Journal of gastroenterology 2025年第6期31卷 115-120页

作者： Horia Minea Ana-Maria Singeap Laura Huiban Cristina Maria Muzica Carol Stanciu Anca Trifan Department of gastroenterology Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania institute of gastroenterology and Hepatology “St.Spiridon”University HospitalIasi 700111Romania

In this article,we comment on the article by Blüthner et *** article provides a comprehensive analysis of the factors contributing to the late detection of Crohn’s disease and ulcerative colitis within a German *** highlights the conse-quences on patient outcomes,particularly disease progression and the increased risk of developing *** study identifies specific predictors asso-ciated with both patient-related and physician-related delays,offering a detailed exploration of the initial ***,the article delves into the distinct patterns observed in the German population,stressing the unique aspects of diagnostic delays that may differ from those reported in other *** detailed examination offers valuable insights into the specific challenges faced within the German healthcare system and underscores the necessity of targeted interventions to facilitate early *** importance of improved screening tools,patient education,and better healthcare infrastructure is emphasized as crucial steps toward improving patient care in inflammatory bowel disease.

关键词： Inflammatory bowel disease Diagnostic delay disease awareness Healthcare system Screening tools

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Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway

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World Journal of gastroenterology 2025年第7期31卷 88-97页

作者： Qian Chen Ya-Li Zhang Yong-Quan Shi Lie Zheng institute of Digestive disease Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of gastroenterology Xijing Hospital affiliated to Air Force Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of gastroenterology Traditional Chinese Medicine Hospital of Shaanxi ProvinceXi’an 710003Shaanxi ProvinceChina

BACKGROUND Excessive endoplasmic reticulum(ER)stress in intestinal epithelial cells can lead to damage to the intestinal mucosal barrier,activate the signal transducer and activator of transcription 3(STAT3)/nuclear factor kappa B(NF-κB)signaling pathway,and exacerbate the inflammatory response,thus participating in the pathogenesis of ulcerative colitis(UC).Mesalazine is a commonly used drug in the clinical treatment of ***,further studies are needed to determine whether mesalazine regulates the ER stress of intestinal epithelial cells,downregulates the STAT3/NF-κB pathway to play a role in the treatment of *** To study the therapeutic effects of mesalazine on spontaneous colitis in interleukin-10(IL-10)-/-*** The 24-week-old IL-10-/-mice with spontaneous colitis were divided into the model group and the 5-amino salicylic acid *** of wild-type mice of the same age group served as the *** were eight mice in each group,four males and four *** severity of symptoms of spontaneous colitis in IL-10-/-mice was assessed using disease activity index *** day 15,the mice were *** colon length was measured,and the histopathological changes and ultrastructure of colonic epithelial cells were *** protein expressions of STAT3,p-STAT3,NF-κB,IκB,p-IκB,and glucoseregulated protein 78 were identified using Western *** STAT3 and NF-κB mRNA expressions were identified using real-time polymerase chain *** glucose-regulated protein 78 and C/EBP homologous protein expressions in colon sections were detected using *** Mesalazine reduced the symptoms of spontaneous colitis in IL-10 knockout mice and the histopathological damage of colonic tissues,and alleviated the ER stress in epithelial cells of colitis *** blotting and quantitative real-time polymerase chain reaction results showed that the STAT3/NF-κB pathway in the colon tissue of model mice was activated,sugge

关键词： Mesalazine Ulcerative colitis Interleukin-10-/-mice Signal transducer and activator of transcription 3/nuclear factor kappa B signaling pathway Endoplasmic reticulum stress Inflammatory bowel disease

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Clinicopathological and radiological characteristics and prediction of survival in colon cancer

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 41-44页

作者： Ashok Kumar Payal Kaw Department of Surgical gastroenterology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

There are various histological characteristics which have been proposed to predict the survival rate in colon ***,there is no definitive model to accurately predict the ***,it is important to find out one model for the prediction of survival in colon cancer which may also include the preoperative,and operative factors in addition to histopathology.

关键词： Colon cancer Survival Predictors Clinicopathological Radiological

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Effect of Modulen vs budesonide on clinical response and mucosal healing in Crohn’s patients

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World Journal of gastroenterology 2025年第5期31卷 84-93页

作者： Baruch Ovadia Eva Niv Sara Stern Katie Elisabeth Mahajna Oren Gal Yael Kopelman Department of gastroenterology Hillel Yaffe Medical CenterHadera 38100HaifaIsrael Faculty of Medicine Technion-Israel Institute of TechnologyHadera 38100HaifaIsrael Department of gastroenterology Meuhedet Health ServicesHadera 38100HaifaIsrael

BACKGROUND Mucosal healing has become an important goal of Crohn’s disease(CD)***,enriched with transforming growth factor-beta 2,and budeso-nide are commonly accepted treatments for mild-moderate ***,their effects on the small bowel(SB)mucosa remain *** To prospectively assess clinical and mucosal responses to Modulen vs budesonide in adults with CD,using SB capsule *** Thirty patients were divided into two groups:Modulen+home-based diet(21 patients)and budesonide(9 patients)for an eight-week intervention followed by four weeks of ***,laboratory,and endoscopic responses were *** mucosal changes were assessed through SB capsule *** Results indicated significant clinical improvement in the Modulen group with reduced CD activity index(P=0.041)and improved inflammatory bowel disease questionnaire score(P=0.016).Moreover,Modulen was associated with a signifi-cant SB mucosal improvement,evidenced by a decrease in Lewis score(P=0.027).No significant changes were observed in calprotectin or other laboratory ***,budesonide exhibited more modest clinical effects,but it improved calprotectin,hemoglobin,and C-reactive protein levels(P=0.051,P=0.014,and P=0.038,respectively).The capsule endoscopy did not reveal a significant mucosal response in the budesonide *** Both interventions have a role in CD ***,their effects differ and may complement each other:Modulen yields clinical and mucosal improvements,while budesonide primarily leads mainly to laboratory improvements.

关键词： Crohn’s disease Modulen oral polymeric diet Transforming growth factor-beta 2 Budesonide Mucosal healing Clinical response Capsule endoscopy Small bowel capsule

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-Yu Ye Jun-Ji Ma Department of gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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