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Metal-polyphenol-network coated CaCO_(3)as pH-responsive nanocarriers to enable effective intratumoral penetration and reversal of multidrug resistance for augmented cancer treatments

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nano Research 2020年第11期13卷 3057-3067页

作者： Ziliang Dong Yu Hao Quguang Li Zhijuan Yang Yujie Zhu Zhuang Liu Liangzhu Feng institute of functional nano&soft materials Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China

Construction of multifunctional stimuli-responsive nanotherapeutics enabling improved intratumoral penetration of therapeutics and reversal of multiple-drug resistance(MDR)is potent to achieve effective cancer ***,we report a general method to synthesize pH-dissociable calcium carbonate(CaCO_(3))hollow nanoparticles with amorphous CaCO_(3)as the template,gallic acid(GA)as the organic ligand,and ferrous ions as the metallic center via a one-pot coordination *** obtained GA–Fe@CaCO_(3)exhibits high loading efficiencies to both oxidized cisplatin prodrug and doxorubicin,yielding drug loaded GA-Fe@CaCO_(3)nanotherapeutics featured in pH-responsive size shrinkage,drug release,and Fenton catalytic *** to nonresponsive GA-Fe@silica nanoparticles prepared with silica nanoparticles as the template,such GA-Fe@CaCO_(3)confers significantly improved intratumoral penetration ***,both types of drug-loaded GA–Fe@CaCO_(3)nanotherapeutics exhibit synergistic therapeutic efficacies to corresponding MDR cancer cells because of the GA–Fe mediated intracellular oxidative stress amplification that could reduce the efflux of engulfed drugs by impairing the mitochondrial-mediated production of adenosine triphosphate(ATP).As a result,it is found that the doxorubicin loaded GA-Fe@CaCO_(3)exhibits superior therapeutic effect towards doxorubicin-resistant 4T1 breast tumors via combined chemodynamic and *** work highlights the preparation of pH-dissociable CaCO_(3)-based nanotherapeutics to enable effective tumor penetration for enhanced treatment of drug-resistant tumors.

关键词： self-templated synthesis gallic acid(GA)–Fe@calcium carbonate(CaCO_(3))hollow nanoparticles reactive oxygen species(ROS)generation and chemodynamic therapy improved intratumoral penetration reversal of multi-drug resistance

Photostable and Biocompatible Fluorescent Silicon nanoparticles for Imaging-Guided Co-Delivery of siRNA and Doxorubicin to Drug-Resistant Cancer Cells

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nano-Micro Letters 2019年第2期11卷 127-139页

作者： Daoxia Guo Xiaoyuan Ji Fei Peng Yiling Zhong Binbin Chu Yuanyuan Su Yao He Laboratory of nanoscale Biochemical Analysis Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesInstitute of Functional Nano and Soft Materials (FUNSOM)Soochow University

The development of effective and safe vehicles to deliver small interfering RNA(siRNA) and chemotherapeutics remains a major challenge in RNA interference-based combination therapy with chemotherapeutics,which has emerged as a powerful platform to treat drug-resistant cancer ***,we describe the development of novel all-in-one fluorescent silicon nanoparticles(SiNPs)-based nanomedicine platform for imaging-guided co-delivery of siRNA and doxorubicin(DOX).This approach enhanced therapeutic efficacy in multidrug-resistant breast cancer cells(i.e.,MCF-7/ADR cells).Typically,the SiNP-based nanocarriers enhanced the stability of siRNA in a biological environment(i.e.,medium or RNase A) and imparted the responsive release behavior of siRNA,resulting in approximately 80% down-regulation of P-glycoprotein ***-delivery of P-glycoprotein siRNA and DOX led to>35-fold decrease in the half maximal inhibitory concentration of DOX in comparison with free DOX,indicating the pronounced therapeutic efficiency of the resultant nanocomposites for drug-resistant breast cancer *** intracellular time-dependent release behaviors of siRNA and DOX were revealed through tracking the strong and stable fluorescence of *** data provide valuable information for designing effective RNA interference-based co-delivery carriers.

关键词： Fluorescent silicon nanoparticles Drug resistance Gene therapy Bioimaging

In situ surface-confined fabrication of single atomic Fe-N_(4) on N-doped carbon nanoleaves for oxygen reduction reaction

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Journal of Energy Chemistry 2021年第8期30卷 482-491,I0011页

作者： Xiaojing Jiang Jianian Chen Fenglei Lyu Chen Cheng Qixuan Zhong Xuchun Wang Ayaz Mahsud Liang Zhang Qiao Zhang institute of functional nano&soft materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China

Controllable fabrication of Fe-N-C based single-atom catalysts(SACs)for enhanced electrocatalytic performance is highly desirable but still ***,an in situ surface-confined strategy was demonstrated for the synthesis of single atomic Fe-N_(4))on N-doped carbon nanoleaves(L-FeNC).The in situ generated Zn3[Fe(CN)6]2 could not only serve as a protection layer against collapse of nanoleaves but also provide abundant Fe source for the formation of Fe-N moieties during pyrolysis,leading to high surface area and high graphitization degree of L-FeNC *** from abundant Fe-N_(4))active sites,enhanced mass and charge transfer,the as-prepared L-FeNC manifested a half-wave potential of 0.89 V for oxygen reduction reaction(ORR)in 0.1 M KOH.A maximum power density of 140 m W cm^(-2)and stable discharge voltage even after operation for 50,000 s have been demonstrated when the L-FeNC was used as air cathode for Zn-air *** work not only provided a unique surfaceconfined strategy for the synthesis of two-dimensional nanocarbons,but also demonstrated the significant benefit from rational design and engineering of Fe-N-C SACs,thus offering great opportunities for fabrication of efficient energy conversion and storage devices.

关键词： Single atom catalyst Iron-nitrogen-carbon Surface confine Oxygen reduction reaction Metal-organic frameworks

On-surface Synthesis of Graphene nanoribbons

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Chinese Journal of Structural Chemistry 2020年第8期39卷 1377-1384,1357页

作者： TANG Yan-Ning SUN Ke-Wei LI Xue-Chao ZHANG Hai-Ming CHI Li-Feng institute of functional nano&soft materials(FUNSOM) Soochow UniversitySuzhou 215123China

On-surface synthesis never fails to fascinate chemists by producing new functional polymers which can hardly been prepared via traditional solution *** those newly prepared polymers,graphene nanoribbons(GNRs),featured with tunable band gap,have attracted substantial attention because they are considered as promising candidates for next generation carbon-based ***,we summarize the recent advances of GNRs prepared on single crystal surfaces with emphasis on the structural tuning and electronic properties of ***,critical developments toward the application of GNRs have also been reviewed including the mass fabrication and the performance of GNRs as field effect transistors.

关键词： graphene nanoribbons(GNRs) on-surface reactions scanning tunneling microscopy(STM) scanning tunneling spectroscopy(STS)

nanoparticle accumulation in liver may induce resistance to immune checkpoint blockade therapy

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nano Research 2023年第4期16卷 5237-5246页

作者： Huaxing Dai Qianyu Yang Rong Sun Yue Zhang Qingle Ma Yifan Shen Beilei Wang Yitong Chen Jialu Xu Bo Tian Fang Xu Chao Wang institute of functional nano&soft materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China

Despite immune checkpoint blockade(ICB)therapy has transformed cancer treatment,only 20.2%of these patients achieved a *** resistance mechanisms to ICB is important for the treatment of a wider *** this work,we occasionally found that the silica nanoparticles(SiO_(2)NPs)accumulated in the liver can induce resistance to following ICB therapy to a subcutaneous tumor in *** analysis of T cells frequency,we uncovered that SiO_(2)NPs in the liver resulted in a siphoning of T cells from circulation to the liver by produced *** addition,liver immunosuppressive cells further inhibit the function and induce apoptosis of recruited T cells,leading to a systemic loss and reduced tumor infiltration of T cells,which contributes to poor responses to ICB ***,such effect is not observed in poly(lactic-co-glycolic acid)(PLGA)NPs treated mice under the same conditions,likely due to their much lower immunogenicity in perturbing the liver immune microenvironment,indicating that cancer is not a local disease but an ecosystem that is linked to the distal *** further provide a new mechanism insight into ICB resistance induced by liver accumulation of nanoparticles.

关键词： liver induce resistance

A photoactive process cascaded electrocatalysis for enhanced methanol oxidation over Pt-MXene-TiO2 composite

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nano Research 2020年第10期13卷 2683-2690页

作者： Yue Sun Yunjie Zhou Yan Liu Qingyao Wu Mengmeng Zhu Hui Huang Yang Liu Mingwang Shao Zhenhui Kang institute of functional nano and soft materials Laboratory(FUNSOM) Jiangsu Key Laboratory for Carbon Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China

Highly efficient photo-assisted electrocatalysis for methanol oxidation reaction(MOR)realizes the conversion of solar and chemical energy into electric energy *** we report a Pt-MXene-TiO2 composite for highly efficient MOR via a photoactive cascaded electro-catalytic *** light(UV and visible light)irradiation,MXene-TiO2 serves as the photo active centre(photoinduced hole)to activate the methanol molecules,while Pt particles are the active centre for the following electro-catalytic oxidation of those activated methanol ***-MXene-TiO2 catalyst exhibits a lower onset potential(0.33 V)and an impressive mass activity of 2,750.42 mA·mg^−1 Pt under light *** represents the highest MOR activity ever reported for photo-assisted ***-MXene-TiO2 also shows excellent CO tolerance ability and stability,in which,after long-term(5,000 s)reaction,still keeps a high mass activity of 1,269.81 mA·mg−1Pt(62.66%of its initial activity).The photo-electro-catalytic system proposed in this work offers novel opportunities for exploiting photo-assisted enhancement of highly efficient and stable catalysts for MOR.

关键词： photoactive process electrocatalysis cascade photoelectrochemistry methanol oxidation reaction

External-force-driven solution epitaxy of large-area 2D organic single crystals for high-performance field-effect transistors

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nano Research 2019年第11期12卷 2796-2801页

作者： Jinwen Wang Wei Deng Wei Wang Ruofei Jia Xiuzhen Xu Yanling Xiao Xiujuan Zhang Jiansheng Jie Xiaohong Zhang institute of functional nano&soft materials(FUNSOM) jilngsu Key Laboratory for Carbon Based Functional Materials&DevicesSoochow UniversitSuzhou 215123China

Growth of two-dimensional(2D)organic single crystals(2DOSCs)on water surface has attracted increasing attention,because it can serve as a molecularly flat and defect-free ***,large-area growth of 2DOSCs with controllable crystal orientation on water surface remains a key ***,we develop a simple method,***-force-driven solution epitaxy(EFDSE),for the large-area growth of 2DOSCs at air/water *** 2,7-didecylbenzothienobenzothiophene(C1o-BTBT)as an example,high-quality 2D C10-BTBT crystals on centimeter scale are generated by directionally controlling the spreading of organic solution on water surface with external *** from the controllable crystal orientation with optimal charge transport,the corresponding 2DOSC-based organic field-effect transistors(OFETs)exhibit a high carrier mobility of 13.5 cm^2·V^-1·s^-1(effective mobility=5.4 cm^2·V^-1·s^-1 according to a reliability factor of 40%),which represents the best result achieved for water-surface-assembled 2DOSC based ***,by transterring the C1o-BTBT 2DOSCs to flexible substrates,devices with excellent bending stability are *** is anticipated that our method will provide new insight into the controllable growth of large-area 2DOSCs for high-performance organic devices.

关键词： external-force-driven solution epitaxy two-dimensional organic single crystals high mobility organic field-effecet transistors

Recent Advances in Fibrous materials for Hydroelectricity Generation

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nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China institute of functional nano&soft materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

Fluorescent silicon nanoparticle-based gene carriers featuring strong photostability and feeble cytotoxicity

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nano Research 2016年第10期9卷 3027-3037页

作者： Jingyang Pang Yuanyuan Su Yiling Zhong Fei Peng Bin Song Yao He Jiangsu Key Laboratory for Carbon-Based functional materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM)Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 China

Safe fluorescent gene-transfection vectors are in great demand for basic biological applications and for gene-therapy research. Here, we introduce a new type of luminescent silicon nanoparticle （SiNP）-based gene carrier suitable for determining the intracellular fate of the gene vehicle in a long-term and real-time manner. The presented SiNP-based nanocarriers simultaneously feature strong and stable fluorescence, high DNA-loading capacity and gene-transfection efficienc35 as well as favorable biocompafibility. Taking advantage of these unique benefits, we were able to readily observe the behavior of the gene carriers in live cells （e.g. cellular uptake, intracellular trafficking, and endosomal escape） in a long-term and real- time manner. The results demonstrate the potential usability of these fluorescent SiNP-based gene vectors as powerful tools in the field of gene therapy, and provide invaluable information for understanding the intracellular behavior of gene carriers.

关键词： fluorescent silicon nanoparficles gene delivery biocompatibility long-term and real-time tracking