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Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy

nano Research 2025年第1期18卷 628-641页

作者： Min Han Zishan Chen Shiying Zhou Zunde Liao Xiangting Yi Yao He Yiling Zhong Kam W.Leong College of Pharmacy State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 511443China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA institute of functional nano and soft materials(FUNSOM) Soochow UniversitySuzhou 215123China

Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and ***,metalorganic frameworks(MOFs)have emerged as promising candidates for biomedicine,characterized by adjustable chemical composition,high porosity,and ***,the combination of silicon with MOFs to create silicon-based MOF nanostructures(SiMOFs)remains ***,we establish a diverse library of SiMOFs with various nanostructures,including flower-like,capsule-like,hexagonal snowflake-like,and necklace-like morphologies via microwave-assisted *** SiMOFs,with their spacious interiors,are ideal for drug *** are used to load drugs and create drug-loaded SiMOFs(e.g.,SiFeO).SiFeO exhibits excellent photothermal effects and high reactive oxygen species(ROS)generation capacity,enabling synergistic treatments involving chemochemodynamic-photothermal *** approach efficiently triggers immunogenic cell death(ICD)and demonstrates excellent antitumor efficacy in *** staining reveals that the synergistic therapy can modulate the tumor microenvironment(TME)by reducing M2-phenotype macrophages,increasing the activation of antigen-presenting cells(APCs),enhancing the infiltration of CD4^(+)and CD8^(+)T cells,elevating Granzyme B production,and decreasing the presence of immunosuppressive regulatory T cells(Tregs).Consequently,drug-loaded SiMOFs-mediated combination therapy effectively reverses the immunosuppressive TME and activates robust antitumor immune responses by inducing ICD in tumor cells,ultimately achieving superior anticancer efficacy.

关键词： silicon-based nanomaterials nanocarriers immunogenic cell death antitumor immune responses

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Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing Dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of nanophotonic materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz institute Ulm (HIU) Karlsruhe institute of Technology (KIT) School of materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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Constructing robust all-inorganic contacts enable stable perovskite solar cells with efficiencies over 20%

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Science China materials 2018年第1期61卷 125-126页

作者： Zhongwei Wu Baoquan Sun institute of functional nano & soft materials (FUNSOM) Soochow University

Developing photovoltaic(PV)cells for harvesting renewable and clean solar energy is a promising strategy to meet the growing energy *** solar cells(PSCs),as a new player in the photovoltaic field,exhibit rapid development with an original power conversion efficiency(PCE)of 3.81%in 2009,a promising PCE of over 20%in 2014 and a record PCE of 22.1%in

关键词： SCN PCE Constructing robust all-inorganic contacts enable stable perovskite solar cells with efficiencies over 20

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Perovskite-Inspired Lead-Free Ag2BiI5 for Self-Powered NIR-Blind Visible Light Photodetection

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nano-Micro Letters 2020年第2期12卷 199-210页

作者： Vincenzo Pecunia Yue Yuan Jing Zhao Kai Xia Yan Wang Steffen Duhm Luis Portilla Fengzhu Li institute of functional nano & soft materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University

In recent years,solution-processible semiconductors with perovskite or perovskite-inspired structures have been extensively investigated for optoelectronic *** particular,silver-bismuth-halides have been identified as especially promising because of their bulk properties and lack of heavily toxic *** study investigates the potential of Ag2BiI5 for near-infrared(NIR)-blind visible light photodetection,which is critical to emerging applications(e.g.,wearable optoelectronics and the Internet of Things).Self-powered photodetectors were realized and provided a near-constant≈100 mA W−1 responsivity through the visible,a NIR rejection ratio of>250,a long-wavelength responsivity onset matching standard colorimetric functions,and a linear photoresponse of>5 orders of *** optoelectronic characterization of Ag2BiI5 photodetectors additionally revealed consistency with one-center models and the role of the carrier collection distance in self-powered *** study provides a positive outlook of Ag2BiI5 toward emerging applications on low-cost and low-power NIR-blind visible light photodetector.

关键词： Perovskite-inspired semiconductor Silver bismuth iodide Self-powered photodetector NIR-blind photodetector Visible light photodetector

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Recent advances in the development of nanomaterials for DC-based immunotherapy

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Science Bulletin 2016年第7期61卷 514-523页

作者： Ligeng Xu Jian Xiang Rui Peng Zhuang Liu institute of functional nano and soft materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University

As professional antigen presenting cells, dendritic cells(DCs) greatly determine the quality of the innate and adaptive immunities. Therefore, DC-based immunotherapy has been one of the hotspots in cancer immunotherapy in recent years. Although this unique therapeutic strategy has been approved by U.S. Food and Drug Administration for prostate cancer treatment, the efficacy of DC-based immunotherapy remains to be further improved. Moreover, it is still not completely clear about the immunological basis of DCs, which is another hurdle for the progress of DC-based immunotherapy. Due to their unique physicochemical properties, nanomaterials have shown potentials in addressing these above mentioned problems and have provided important guidelines for optimizing DC-based immunotherapy. However, it is still at the starting stage for this emerging field and there are many critical questions in the rational design of this therapeutic strategy to be answered. Therefore, it is greatly necessary to review and analyze recent progresses in this field. In this review, we mainly focus on the development of various types nanoparticles for DC-based immunotherapy. The existed challenges in this field are also discussed.

关键词： Dendritic cells Immunotherapy Cancer vaccine Tracking nanomaterials

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The acidic tumor microenvironment: a target for smart cancer nano-theranostics

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National Science Review 2018年第2期5卷 269-286页

作者： Liangzhu Feng Ziliang Dong Danlei Tao Yicheng Zhang Zhuang Liu institute of functional nano & soft materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University

The acidic tumor microenvironment(TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article,we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards.

关键词： tumor microenvironment cancer targeting nanomedicine theranostics

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Cobalt atoms dispersed on hierarchical carbon nitride support as the cathode electrocatalyst for high-performance lithium-polysulfide batteries

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Science Bulletin 2019年第24期64卷 1875-1880页

作者： Jialing Wu Junmei Chen Yang Huang Kun Feng Jun Deng Wei Huang Yunling Wu Jun Zhong Yanguang Li institute of functional nano & soft materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University

Lithium-sulfur batteries are promising candidates for next-generation energy storage but are confronted with several challenges. One of the possible solutions is to design proper cathode electrocatalysts to accelerate the redox interconversion of solvated polysulfide intermediates. Herein, we report cobalt atoms dispersed on hierarchical carbon nitride support as an effective cathode electrocatalyst for lithium-polysulfide batteries. The electrocatalyst material is prepared from the simple reaction between melamine and cyanuric acid in the presence of Co^2+, followed by the Ar annealing. The product has a unique hierarchical structure consisting of many thin and porous C3 N4 nanosheets finely dispersed with Co atoms. The atomic dispersion of Co species is confirmed by X-ray absorption *** measurements reveal that it can promote the interconversion of polysulfides. As a result,batteries using this cathode electrocatalyst achieve large capacity($1400 mAh/g at 1.6 mA/cm^2), good rate performance($800 mAh/g at 12.8 mA/cm^2) and impressive cycling stability under different current densities and different sulfur loadings.

关键词： Li-polysulfide battery Cathode electrocatalyst Carbon nitride Cobalt single atom

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Selective electrocatalytic CO2 reduction enabled by SnO2 nanoclusters

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Journal of Energy Chemistry 2019年第10期28卷 93-96页

作者： Hui Yang Yang Huang Jun Deng Yunling Wu Na Han Chenyang Zha Leigang Li Yanguang Li Jiangsu Key Laboratory for Carbon-Based functional materials and Devices Institute of Functional Nano & Soft Materials (FUNSOM) Soochow University

The development of high-performance electrocatalysts holds the decisive key to the electrochemical CO2 reduction toward value-added products. Formic acid or formate is a desirable reduction product, but its selective production is often challenging. Tin based-materials have attracted great attention for formate production, and yet their performances are far from satisfactory. In this study, we reported the preparation of SnO2 nanoclusters from the controlled self-polymerization of dopamine together with SnO32-, followed by the mild-temperature calcination. The final product consisted of large primary particles that were further made of small secondary SnO2 nanocrystals. When evaluated as the electrocatalyst for CO2 reduction in 0.5 M NaHCO3, our material exhibited impressive activity, selectivity and stability for the selective CO2 reduction to formate. A peak formate Faradaic efficiency of^73% and large partial current density of 16.3 mA/cm2 was achieved at -0.92 V versus reversible hydrogen electrode.

关键词： CO2 reduction reaction Electrocatalysts Formate Tin oxide Selectivity

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Direct Synthesis of Co-doped Graphene on Dielectric Substrates Using Solid Carbon Sources

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nano-Micro Letters 2015年第4期7卷 368-373页

作者： Qi Wang Pingping Zhang Qiqi Zhuo Xiaoxin Lv Jiwei Wang Xuhui Sun Jiangsu Key Laboratory for Carbon-Based functional materials and Devices Institute of Functional Nano & Soft Materials Soochow University

Direct synthesis of high-quality doped graphene on dielectric substrates without transfer is highly desired for simplified device processing in electronic ***,graphene synthesis directly on substrates suitable for device applications,though highly demanded,remains unattainable and ***,a simple and transfer-free synthesis of high-quality doped graphene on the dielectric substrate has been developed using a thin Cu layer as the top catalyst and polycyclic aromatic hydrocarbons as both carbon precursors and doping sources.N-doped and N,F-co-doped graphene have been achieved using TPB and F16Cu Pc as solid carbon sources,*** growth conditions were systematically optimized and the as-grown doped graphene were well *** growth strategy provides a controllable transfer-free route for high-quality doped graphene synthesis,which will facilitate the practical applications of graphene.

关键词： Graphene Solid carbon sources Transfer-free Doping and co-doping

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High-mobility air-stable n-type field-effect transistors based on large-area solution-processed organic single- crystal arrays

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nano Research 2018年第2期11卷 882-891页

作者： Liang Wang Xiujuan Zhang Gaole Dai Wei Deng Jiansheng Jie Xiaohong Zhang institute of functional nano & soft materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Suzhou China

Solution-processed n-type organic semiconductor micro/nanocrystals （OSMCs） are fundamental elements for developing low-cost, large-area, and all organic logic/complementary circuits. However, the development of air-stable, highly aligned n-channel OSMC arrays for realizing high-performance devices lags far behind their p-channel counterparts. Herein, we present a simple one-step slope-coating method for the large-scale, solution-processed fabrication of highly aligned, air-stable, n-channel ribbon-shaped single-crystalline N,N＇-bis（2- phenylethyl）-perylene-3,4：9,10-tetracarboxylic diimide （BPE-PTCDI） arrays. The slope and pattemed photoresist （PR） stripes on the substrate are found to be crucial for the formation of large-area submicron ribbon arrays. The width and thickness of the BPE-PTCDI submicron ribbons can be finely tuned by controlling the solution concentration as well as the slope angle. The resulting BPE-PTCDI submicron ribbon arrays possess an optimum electron mobility up to 2.67 cm2.V-l.s-1 （with an average mobility of 1.13 cm2.V-l-s-1）, which is remarkably higher than that of thin film counterparts and better than the performance reported previously for single-crystalline BPE-PTCDI-based devices. Moreover, the devices exhibit robust air stability and remain stable after exposing in air over 50 days. Our study facilitates the development of air-stable, n-channel organic field-effect transistors （OFETs） and paves the way towards the fabrication of high-performance, organic single crystal-based integrated circuits.

关键词： n-type organic singlecrystals submicron ribbon arrays slope-coating method air-stable organic field-effecttransistors

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