检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2024年第7期14卷 3286-3290页

作者： Miao Zheng Bo Feng Yumin Zhang Xin Liu NaZhao Hui Liu Zichao Xu Xinheng He Zhiyan Qu ShizhaoChen Zhidong Jiang Xi Cheng Hong Liu Yi Zang Linxiang Zhao Jie Zheng Leike Zhang Jia Li Yu Zhou Key Laboratory of Structure-Based Drugs Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China School of Life sciences and Biopharmaceuticals Shenyang Pharmaceutical UniversityShenyang 110016China Shanghai institute of Materia Medica Chinese Academy of SciencesShanghai 201203and University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203and University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Lingang Laboratory Shanghai 200031China School of Pharmaceutical science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Hubei Jiangxia Laboratory Wuhan 430200China

To the Editor:The papain-like protease(PL^(pro)),as one of the most important proteases of SARS-CoV-2,has emerged as a highly promising target protein,its inhibitor probably holds dual potentials,namely blocking the cleavage of viral polyprotein and intercepting the deubiquitination and deISGylation functions to restore antiviral immunity1.

关键词： Non-covalent PL^(pro)inhibitors Antiviral activity Structural-based drug design Imidazo[4,5-b]pyridine scaffold

Construction of a Metallacyclopentadiene Ring through the Attack of Carbanions to M≡C Bond Followed by C—H Activation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第3期42卷 235-242页

作者： Chun Tang Shengjie Zhang Zhengyu Lu Qian Li Ming Luo Dafa Chen Haiping Xia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringCollaborative Innovation Center of Chemistry for Energy MaterialsXiamen UniversityXiamenFujian361005 China Shenzhen Grubbs institute and Guangdong Provincial Key Laboratory of Catalysis Department of ChemistrySouthern University of Science and TechnologyShenzhenGuangdong518055 China

Metallacyclopentadienes are important metallacycles and regarded as intermediates in many reactions,therefore,new methods to achieve them are *** this study,a formal[3+2]method,through the reactions of an osmapentalyne with benzyl carbanions,was *** reactions underwent a nucleophilic attack of carbanions to the Os≡C bond,followed by C—H activation to form the five-membered osmacyclopentadiene *** of the reactions were carried out at room temperature,the substituents on the aromatic rings of benzyl carbanions are diverse,and the resulting products contain an Os—H bond,representing a novel type of 10C-carbolong *** work provides a new convenient route to construct metallacyclopentadienes,which is expected to further promote the development of such a type of substances.

关键词： Metallacyclopentadiene Carbolong chemistry Osmium C–H activation Nucleophilic addition

Supported Cu/Ni Bimetallic Cluster Electrocatalysts Boost CO_(2) Reduction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Precision Chemistry 2024年第3期2卷 96-102页

作者： Depeng Wang Jiazhi Wang Zhi Wang Ning Zhang Jianrong Zeng Haixia Zhong Xinbo Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Supported metal clusters with the integrated advantages of single-atom catalysts and conventional nanoparticles held great promise in the electrocatalytic carbon dioxide reduction(ECO_(2)R)operated at low overpotential and high current ***,its precise synthesis and the understanding of synergisti-cally catalytic effects remain ***,we report a facile method to synthesize the bimetallic Cu and Ni clusters anchored on porous carbon(Cu/Ni-NC)and achieve an enhanced ECO_(2)*** aberration-corrected high-angle annular dark-field scanning transmission electron microscopy and synchrotron X-ray absorption spectroscopy were employed to verify the metal dispersion and the coordination of Cu/Ni clusters on *** a result of this route,the target Cu/Ni-NC exhibits excellent electrocatalytic performance including a stable 30 h electrolysis at 200 mA cm^(-2) with carbon monoxide Faradaic efficiency of∼95.1%using a membrane electrode assembly electrolysis *** with the in situ analysis of the surface-enhanced Fourier transform infrared spectroelectrochemistry,we propose that the synergistic effects between Ni and Cu can effectively promote the H_(2)O dissociation,thereby accelerate the hydrogenation of CO_(2)to*COOH and the overall reaction process.

关键词： electrocatalytic CO_(2)reduction bimetallic cluster synergistic catalysis membrane electrode assembly electrolysis cell in situ surface-enhanced infrared absorption spectroscopy

Acoustic Purcell effect induced by quasibound state in the continuum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fundamental Research 2024年第1期4卷 57-62页

作者： Sibo Huang Shuhuan Xie He Gao Tong Hao Shuang Zhang Tuo Liu Yong Li Jie Zhu institute of Acoustics School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China College of Surveying and Geo-Informatics Tongji UniversityShanghai 200092China Department of Physics The University of Hong KongHong Kong 999077China Key Laboratory of Noise and Vibration Research Institute of AcousticsChinese Academy of SciencesBeijing 100190China The Hong Kong Polytechnic University Shenzhen Research institute Shenzhen 518057China

We study theoretically and experimentally the acoustic Purcell effect induced by quasi-bound states in the continuum(quasiBICs).A theoretical framework describing the acoustic Purcell effect of a resonant system is developed based on the system’s radiative and dissipative factors,which reveals the critical emission condition for achieving optimum Purcell *** show that the quasiBICs contribute to highly confined acoustic field and bring about greatly enhanced acoustic emission,leading to strong Purcell *** concept is demonstrated via two coupled resonators supporting a Friedrich-Wintgen quasiBIC,and the theoretical results are validated by the experiments observing emission enhancement of the sound source by nearly two orders of *** work bridges the gap between the acoustic Purcell effect and acoustic BICs essential for enhanced wave-matter interaction and acoustic emission,which may contribute to the research of high-intensity sound sources,high-quality-factor acoustic devices and nonlinear acoustics.

关键词： Acoustic Purcell effect Bound state in the continuum Mode coupling Sound emission enhancement High-quality-factor acoustic device

Reliable intracavity reflection for self-injection locking lasers and microcomb generation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonics Research 2024年第5期12卷 I0001-I0010页

作者： BITAO SHEN XUGUANG ZHANG YIMENG WANG ZIHAN TAO HAOWEN SHU HUAJIN CHANG WENCAN LI YAN ZHOU Zhangfeng Ge RUIXUAN CHEN BOWEN BAI LIN CHANG XINGJUN WANG State Key Laboratory of Advanced Optical Communications System and Networks School of ElectronicsPeking UniversityBeijing 100871China Peng Cheng Laboratory Shenzhen 518055China Peking University Yangtze Delta institute of Optoelectronics Nantong 226010China Frontiers science Center for Nano-optoelectronics Peking UniversityBeijing 100871China

Self-injection locking has emerged as a crucial technique for coherent optical sources,spanning from narrow linewidth lasers to the generation of localized *** technique involves key components,namely a laser diode and a high-quality cavity that induces narrow-band reflection back into the laser ***,in prior studies,the reflection mainly relied on the random intracavity Rayleigh backscattering,rendering it unpredictable and unsuitable for large-scale production and wide-band *** this work,we present a simple approach to achieve reliable intracavity reflection for self-injection locking to address this challenge by introducing a Sagnac loop into the *** method guarantees robust reflection for every resonance within a wide operational band without compromising the quality factor or adding complexity to the fabrication *** a proof of concept,we showcase the robust generation of narrow linewidth lasers and localized microcombs locked to different resonances within a normal-dispersion ***,the existence and generation of localized patterns in a normal-dispersion cavity with broadband forward–backward field coupling is first proved,as far as we know,both in simulation and in *** research offers a transformative approach to self-injection locking and holds great potential for large-scale production.

关键词： intracavity injection locking

同方期刊数据库

Effect of Aqueous Extract of Boscia senegalensis on Hyperglycemia, Hyperlipidemia and Oxidative Stress Induced in Rats

在线全文

学校读者我要写书评

暂无评论

Journal of Diabetes Mellitus 2024年第1期14卷 49-68页

作者： Faustin Dongmo Elie Baudelaire Djantou Alcherif Hamid Mahamat Selestin Sokeng Dongmo Nicolas Njintang Yanou Department of Biological sciences Faculty of Science University of Ngaoundere Ngaoundere Cameroon Department of Food science and Nutrition ENSAI University of Ngaoundere Ngaoundere Cameroon Department of Biomedical and Pharmacetical sciences National Higher Institute of Science and Techniques of Abeche Abeche Chad

Boscia aqueous extract. senegalensis on hyperglycemia, hyperlipidemia and oxidative stress induced in rats. The aqueous extract was prepared from B. senegalensis seed powders under the extraction conditions: time (10 min), temperature (55˚C) and the ratio of mass of flour/volume of water (3/10 g/mL). Male wistar rats aged 6 to 8 weeks were acclimated and divided into 8 groups of 5 rats each: two normal control groups which received a normal standard diet (3810 kcal/kg), and six test groups which were subjected to a hyperlipidemic diet (5310 Kcal/kg). All groups of animals were fed in this manner for 8 weeks to induce hyperglycemia, hyperlipidemia and oxidative stress. After induction the animals were treated either with distilled water for the normal and negative control groups or with atorvastatin for the positive control group or with the extract of B. senegalensis. (125, 250 and 500 mg/kg) for the test groups. Fasting blood glucose was taken every 7 days during induction. After sacrifice, biochemical and oxidative stress parameters were measured. The aqueous extract of B. senegalensis significantly decreased (p B. senegalensis at a dose of 500 mg/kg has the capacity to reduce blood sugar, improve the quality of the lipid profile and reduce oxidative stress. Thus, the results reveal that the aqueous extract of B. senegalensis has powerful hypoglycemic, hypolipidemic and antioxidant properties.

关键词： Boscia Senegalensis Hypoglycemic Hypolipidemic Hyperlipidemic Diet An-tioxidant

Larval development and voracity of Eupeodes americanus (Diptera: Syrphidae): comparison of the focal prey Aphis gossypi (Hemiptera: Aphididae) and the banker prey Rhopalosiphum padi (Hemiptera: Aphididae)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect science 2024年第2期31卷 575-586页

作者： Arlette Fauteux Antonio Onofre Soares Eric Lucas Laboratoire de lutte biologique Departement des sciences biologiquesUniversite du Quebec a Montreal(UQAM)MontrealQuebecCanada Faculty of science and Technology Center for Ecology Evolution and Environmental ChangesAzorean Biodiversity Group(cE3c-ABG)&CHANGE-Global Change and Sustainability InstitutePonta DelgadaPortugal

Unlike European species,the potential of Nearctic syrphids as biological control agents is still poorly ***,the American hoverfly,Eupeodes americanus(Wiedemann),has recently demonstrated promising traits as a biocontrol agent,notably against the foxglove aphid,Aulacorthum solani Kaltenbach,on *** present study aims to extend our knowledge of the American hoverfly by evaluating its potential as a biocontrol agent in a banker plant system against the melon aphid,Aphis gossypi Glover,in a greenhouse cucumber *** preimaginal development and voracity of *** were compared when preying upon the focal prey/pest(***)or the banker prey(bird cherry-oat aphid,Rhopalosiphum padi L.)by daily observations of larvae from egg to *** development time,survival rate,and occurrence of deformation were similar on both prey *** weight of third instar and pupae,however,was higher for larvae that fed on the banker *** ad libitum voracity of the syrphid larvae was generally very high and did not significantly differ between prey species,except for the third-instar larvae which consumed more focal *** suggest that a banker plant system involving the bird cherry-oat aphid may be a promising tactic for utilizing *** for melon aphid biocontrol.

关键词： american hoverfly banker plant system biological control bird cherry-oat aphid greenhouse cucumber melon aphid

Improving the Forecasts of Coastal Wind Speeds in Tianjin,China Based on the WRF Model with Machine Learning Algorithms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2024年第3期38卷 570-585页

作者： Weihang ZHANG Meng TIAN Shangfei HAI Fei WANG Xiadong AN Wanju LI Xiaodong LI Lifang SHENG College of Oceanic and Atmospheric sciences Ocean University of ChinaQingdao266100China Tianjin Key Laboratory for Oceanic Meteorology Tianjin Institute of Meteorological ScienceTianjin300074China CMA Earth System Modeling and Prediction Centre China Meteorological Administration(CMA)Beijing100081China Qingdao Meteorological Bureau Qingdao266003China

Characterized by sudden changes in strength,complex influencing factors,and significant impacts,the wind speed in the circum-Bohai Sea area is relatively challenging to *** the western side of Bohai Bay,as the economic center of the circum-Bohai Sea,Tianjin exhibits a high demand for accurate wind *** this study,three machine learning algorithms were employed and compared as post-processing methods to correct wind speed forecasts by the Weather Research and Forecast(WRF)model for *** results showed that the random forest(RF)achieved better performance in improving the forecasts because it substantially reduced the model bias at a lower computing cost,while the support vector machine(SVM)performed slightly worse(especially for stronger winds),but it required an approximately 15 times longer computing *** back propagation(BP)neural network produced an average forecast significantly closer to the observed forecast but insufficiently reduced the *** regard to wind speed frequency forecasting,the RF method commendably corrected the forecasts of the frequency of moderate(force 3)wind speeds,while the BP method showed a desirable capability for correcting the forecasts of stronger(force>6)*** addition,the 10-m u and v components of wind(u_(10)and v_(10)),2-m relative humidity(RH_(2))and temperature(T_(2)),925-hPa u(u925),sea level pressure(SLP),and 500-hPa temperature(T_(500))were identified as the main factors leading to bias in wind speed forecasting by the WRF model in Tianjin,indicating the importance of local dynamical/thermodynamic processes in regulating the wind *** study demonstrates that the combination of numerical models and machine learning techniques has important implications for refined local wind forecasting.

关键词： machine learning Weather Research and Forecast(WRF)model wind speed forecasting coastal region

A synthesis of the Cretaceous wildfire record related to atmospheric oxygen levels?

在线全文

学校读者我要写书评

暂无评论

Journal of Palaeogeography 2024年第1期13卷 149-164页

作者： Da-Wei Lü Wen-Xu Du Zhi-Hui Zhang Yuan Gao Tian-Tian Wang Jin-Cheng Xu Ao-Cong Zhang Cheng-Shan Wang Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Minerals College of Earth Sciences and EngineeringShandong University of Science and TechnologyQingdao 266590Shandong ProvinceChina School of Earth sciences and Resources China University of GeosciencesBejing 100083China institute of Earth sciences China University of Geosciences(Bejing)Beijing 100083China

The Cretaceous was a significant greenhouse period in Earth's history with higher atmospheric CO_(2) levels and temperatures than today. Although evidence of combustion has been widely described from the Cretaceous deposits, our understanding of the spatiotemporal diversification pattern and process of the Cretaceous wildfires is still limited. In this study, we comprehensively synthesize a total of 271 published Cretaceous wildfire occurrences based on the by-products of burning, including fossil charcoal, pyrogenic inertinite(fossil charcoal in coal), and pyrogenic polycyclic aromatic hydrocarbons(PAHs). Spatially, the dataset shows a distinctive distribution of reported wildfire evidence characterized by high concentration in the middle latitudinal areas of the Northern Hemisphere(30°N-60°N) over the Cretaceous. Temporally, an overall increasing trend of the reported wildfire data from the Early Cretaceous to the Late Cretaceous is coincident with higher atmospheric O_(2) levels. However, the spatial and temporal patterns may result from many types of factors, such as taphonomy, preservation, and researcher biases, instead of a real picture of the Cretaceous wildfire evolution. To better understand the spatiotemporal diversification of the Cretaceous wildfire, more investigations on the record of wildfire occurrences during this period would be necessary in the future.

关键词： Wildfire Cretaceous Atmospheric oxygen Taphonomy Charcoal

Tracing Sources of Geochemical Anomalies in a Deeply Buried Volcanic-Related Hydrothermal Uranium Deposit:the Daguanchang Deposit,Northern Hebei Province,North China Craton

在线全文

学校读者我要写书评

暂无评论

Journal of Earth science 2024年第4期35卷 1186-1195页

作者： Yangyang Zhang Yuelong Chen Dapeng Li Huan Kang Mingliang Fang Yunliang Xu School of Earth science and Resources China University of GeosciencesBeijing100083China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing100083China Jinchuan Group Company Limited Jinchang737104China China-Explo Tian Cheng(Beijing)Technology Company Limited Beijing100093China

Radon(Rn)and helium(He)gases from uranium decay form distinct anomalies related to buried uranium *** order to trace the geochemical anomalous sources from the volcanic-related uranium deposits in deeply buried areas,systematical Rn contents and He isotope ratios were analyzed from the Daguanchang uranium *** soil gas Rn concentrations above the deep uranium are ten times higher than those in barren areas,indicating that instantaneous Rn content measurements can be used to detect deeply buried *** helium isotope ratios(^(3)He/^(4)He)of the unmineralized samples from the mineralized drill hole(ZK1)are relatively lower and uniform compared to those of the samples from no-mineral drill hole(ZK2).However,the Th and U contents of the drill core samples from ZK1 are slightly lower than those of the samples from ZK2,indicating that the lower 3He/4He ratios in ZK1 are most likely due to the addition of 4He from underlying uranium *** differences in the instantaneous Rn contents are consistent with the variations in the He isotope ratios of the drill core *** results demonstrate that soil gas Rn and ^(3)He/^(4)He ratios are useful tracers and can indicate the existence of deeply buried volcanic-related hydrothermal uranium ores.

关键词： tracers radon helium ^(3)He/^(4)He ratio uranium deposits Daguanchang deposit