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health benefits from the rapid reduction in ambient exposure to air pollutants after China's clean air actions:progress in efficacy and geographic equality

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National Science Review 2024年第2期11卷 103-113页

作者： Tao Xue Ruohan Wang Meng Wang Yanying Wang Dan Tong Xia Meng Conghong Huang Siqi Ai Fangzhou Li Jingyuan Cao Mingkun Tong Xueqiu Ni Hengyi Liu Jianyu Deng Hong Lu Wei Wan Jicheng Gong Shiqiu Zhang Tong Zhu institute of Reproductive and Child health National Health Commission Key Laboratory of Reproductive Health/Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Epidemiology of Major Diseases(PKU) School of Public Health Peking University Health Science Centre State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management and Center for Environment and Health Peking University Advanced institute of Information Technology Peking University Department of epidemiology and Environmental health School of Public Health and Health ProfessionsUniversity at Buffalo State Key Joint Laboratory of Environment Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking University Department of Earth System Science Tsinghua University School of Public health Key Laboratory of Public Health Safety of the Ministry of Education and Key Laboratory of Health Technology Assessment of the Ministry of HealthFudan University College of Land Management Nanjing Agricultural University National&Local Joint Engineering Research Center for Rural Land Resources Use and Consolidation Clean Air Asia

Clean air actions （CAAs） in China have been linked to considerable benefits in public ***,whether the beneficial effects of CAAs are equally distributed geographically is *** high-resolution maps of the distributions of major air pollutants (fine particulate matter[PM2.5]and ozone[O3]) and population,we aimed to track spatiotemporal changes in health impacts from,and geographic inequality embedded in,the reduced exposures to PM2.5and O3from 2013 to *** used a method established by the Global Burden of Diseases *** analyzing the changes in loss of life expectancy（LLE） attributable to PM2.5and O3,we calculated the gain of life expectancy （GLE） to quantify the health benefits of the air-quality ***,we assessed the geographic inequality embedded in the GLE using the Gini index （GI）.Based on risk assessments of PM2.5and O3,during the first stage of CAAs（2013 to 2017）,the mean GLE was 1.87 *** of the sum of the GLE was disproportionally distributed in about one quarter of the population exposed （GI 0.44）.During the second stage of CAAs（2017 to 2020）,the mean GLE increased to 3.94 months and geographic inequality decreased （GI 0.18）.According to our assessments,CAAs were enhanced,from the first to second stages,in terms of not only preventing premature mortality but also ameliorating health *** enhancements were related to increased sensitivity to the health effects of air pollution and synergic control of PM2.5and *** findings will contribute to optimizing future CAAs.

关键词： clean air action public health inequality fine particulate matter ozone

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health-oriented strategies are needed to optimize China’s 2025 clean air action plan

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Science Bulletin 2024年第13期69卷 2007-2008页

作者： Tao Xue Ning Kang Wei Wan Tong Zhu institute of Reproductive and Child health/National health Commission Key Laboratory of Reproductive health and Department of epidemiology and Biostatistics/Ministry of Education Key Laboratory of epidemiology of Major Diseases(PKU) School of Public HealthPeking University Health Science CentreBeijing 100191China State Environmental Protection Key Laboratory of Atmospheric Exposure and health Risk Management Center for Environment and HealthPeking UniversityBeijing 100871China Advanced institute of Information Technology Peking UniversityHangzhou 311215China Clean Air Asia Beijing 100600China College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China

Recently,China’s State Council issued the Continuous Improvement of Air Quality Action Plan(hereafter,the third action plan),which follows the Air Pollution Prevention and Control Action Plan(2013–2017)(hereafter,the first action plan)and the Three-Year Action Plan for Winning the Blue Sky Defense Battle(2018–2020)(hereafter the second action plan).The first two action plans yielded nationwide health benefits[1–3],from improving lung function[4]to saving medical expenditures[5].Based on our previous estimates[6],due to reductions in the fine particulate matter(PM2.5)level,implementation of the first and second action plans was expected to increase life expectancy by 2.11 and 3.68 months.

关键词： action hereafter nationwide

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Intertwined depressive and cognitive trajectories and the risk of dementia and death in older adults:a competing risk analysis

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General Psychiatry 2024年第2期37卷 207-215页

作者： Ziyang Ren Lirong Nie Yushan Du Jufen Liu institute of Reproductive and Child health/National health Commission Key Laboratory of Reproductive health Peking UniversityBeijingChina Department of epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina

Background Depressive symptoms and cognitive impairment often interact,rendering their associations *** date,their joint trajectories and associations with dementia and death remain *** To explore the interactions between depressive symptoms and cognitive function,their developmental trajectories and the associations with all-cause dementia,Alzheimer’s disease(AD)and all-cause death in older *** Data were from the health and Retirement *** symptoms and cognitive function were measured using the 8-item Centre for Epidemiologic Studies Depression Scale and the Telephone Interview of Cognitive Status,***-cause dementia and AD were defined by self-reported or proxy-reported physician ***-cause death was determined by *** restricted cubic spline,group-based trajectory modelling and subdistribution hazard regression were *** Significant interactions between depressive symptoms and cognitive function in 2010 in their association with new-onset all-cause dementia and AD from 2010 to 2020 were found,especially in women(p for interaction<0.05).Independent trajectory analysis showed that emerging or high(vs no)depressive trajectories and poor or rapidly decreased cognitive trajectories(vs very good)from 1996 to 2010 were at significantly higher risk of subsequent all-cause dementia,AD and all-cause death.15 joint trajectories of depressive symptoms and cognitive function from 1996 to 2010 were determined,where rapidly decreased cognitive function was more common in those with no depressive *** with older adults with the trajectory of no depressive symptoms and very good cognitive function,those with the trajectory of no depressive symptoms but rapidly decreased cognitive function were much more likely to develop new-onset all-cause dementia and death,with subdistribution hazard ratios(95%confidence intervals)of 4.47(2.99 to 6.67)and 1.84(1.43 to 2.36),especially in wome

关键词： death analysis rendering

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Preliminary assessment of the data appropriateness of electronic health records for real-world studies:A survey of hospitals in a developing region in China

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Chinese Medical Journal 2024年第9期137卷 1130-1131页

作者： Yuelin Yu Lin Zhuo Ruogu Meng Wanqian Guo Yuanyuan Chen Yunjing Zhang Ying Chen Hongjing Shi Zhi Lin Siyan Zhan Shengfeng Wang Department of epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Research Center of Clinical epidemiology Peking University Third HospitalBeijing 100191China National institute of health Data Science Peking UniversityBeijing 100191China health Science Center Peking UniversityBeijing 100191China

To the Editor:Assessment of data appropriateness is a process to answer whether electronic health records(EHRs)from routine healthcare practices couldt intended study purposes,for example,available to be proceeded,with enough individual records,with relevant information able to be extracted from records,etc.[1-3]This has been increasingly underscored as a prerequisite when using EHRs(one important type of real-world data[RWD])for scientic purposes.[4-6]Although controversies remain on the denitions,types and assessment methods of the dimensions of RWD appropriateness,the latest ofcial guidelines(i.e.,from the *** and Drug Administration[FDA][4]and China National Medical Products Administration[NMPA][6])suggest that the assessment start from a preliminary stage on variable existence,and subsequently deepen into the issue of data value(such as missing value,outliers,etc.),as the preliminary assessment is the foundation of the overall RWD appropriateness.[7]Little is known about the appropriateness of EHRs in developing regions,which feature high visit volumes and a great number of ***,this study aimed to preliminarily investigate RWD appropriateness from hospitals in developing regions from the perspective of core variables’comparison.

关键词： electronic dimensions records

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Variations in the Prevalence of Anemia of Varying Severity Among Urban Non-Pregnant Women—China,2021

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China CDC weekly 2024年第10期6卷 175-180页

作者： Xiaoxi Liu Bo Wang Sailimai Man Heling Bao Yuanyuan Huang Canqing Yu Jun Lyu Linhong Wang Liming Li Hui Liu institute of Medical Information Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Peking University health Science Center Meinian Public health institute BeijingChina Meinian institute of health BeijingChina Peking University Center for Public health and Epidemic Preparedness&Response BeijingChina Department of epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Key Laboratory of epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Anemia is a significant public health issue affecting women *** studies in China predominantly concentrated on anemia in pregnant or reproductiveage women,leaving a gap i... 详细信息

关键词： Anemia anemia China.

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Weight change and all-cause and cause-specific mortality:A 25-year follow-up study

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Chinese Medical Journal 2024年第10期137卷 1169-1178页

作者： Huan Yang Jianbing Wang Xiaokun Wang Wanyi Sun Chenyunhao Tong Jinhu Fan Youlin Qiao Christian *** Department of Cancer epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Public health Zhejiang University School of MedicineNational Clinical Research Center for Children’s HealthHangzhouZhejiang 310058China Metabolic epidemiology Branch Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleMD 20850USA

Background:Whether the dynamic weight change is an independent risk factor for mortality remains *** study aimed to examine the association between weight change and risk of all-cause and cause-specific mortality based on the Linxian Nutrition Intervention Trial(NIT)***:Body weight of 21,028 healthy residents of Linxian,Henan province,aged 40-69 years was measured two times from 1986 to *** events were prospectively collected up to *** maintenance group(weight change<2 kg)or stable normal weight group was treated as the *** proportional hazard model was performed to calculate hazard ratios(HRs)and 95%confidence intervals(95%CIs)to estimate the risk of ***:A total of 21,028 subjects were included in the final *** with the weight maintenance group,subjects with weight loss≥2 kg had an increased risk of death from all-cause(HR_(All-cause)=1.14,95%CI:1.09-1.19,P<0.001),cancer(HR_(Cancer)=1.12,95%CI:1.03-1.21,P=0.009),and heart disease(HR_(Heart diseases)=1.21,95%CI:1.11-1.31,P<0.001),whereas subjects with weight gain≥5 kg had 11%(HR_(Cancer)=0.89,95%CI:0.79-0.99,P=0.033)lower risk of cancer mortality and 23%higher risk of stroke mortality(HR_(Stroke)=1.23,95%CI:1.12-1.34,P<0.001).For the change of weight status,both going from overweight to normal weight and becoming underweight within 5 years could increase the risk of total death(HR_(Overweight to normal)=1.18,95%CI:1.09-1.27;HR_(Becoming underweight)=1.35,95%CI:1.25-1.46)and cancer death(HR_(Overweight to normal)=1.20,95%CI:1.04-1.39;HR_(Becoming underweight)=1.44,95%CI:1.24-1.67),while stable overweight could increase the risk of total death(HR_(Stable overweight)=1.11,95%CI:1.05-1.17)and death from stroke(HR_(Stable overweight)=1.44,95%CI:1.33-1.56).Interaction effects were observed between age and weight change on cancer mortality,as well as between baseline BMI and weight change on all-cause,heart disease,and stroke mortality(all P_(

关键词： Weight change All-cause mortality Cancer Stroke Heart diseases Body mass index

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Developing fertility control for rodents: a framework for researchers and practitioners

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Integrative Zoology 2024年第1期19卷 87-107页

作者： Giovanna MASSEI Jens JACOB Lyn A.HINDS Botstiber institute for Wildlife Fertility Control Department of Environment and GeographyUniversity of YorkHeslingtonYorkUK Rodent Research Institute for Epidemiology and Pathogen DiagnosticsJulius Kühn–Institute(JKI)Federal Research Institute for Cultivated PlantsMünsterGermany CSIRO health and Biosecurity CanberraACTAustralia

Fertility control is often heralded as a humane and effective technique for management of overabundant wildlife,including *** intention is to reduce the use of lethal and inhumane methods,increase farm productivity and food security as well as reduce disease transmission,particularly of *** developed a framework to guide researchers and stakeholders planning to assess the effectiveness of a potential contraceptive agent for a particular *** guidelines describe the overarching research questions which must be sequentially addressed to ensure adequate data are collected so that a contraceptive can be registered for use in broad-scale rodent *** framework indicates that studies should be undertaken iteratively and,at times,in parallel,with initial research being conducted on(1)laboratory-based captive assessments of contraceptive effects in individuals;(2)simulation of contraceptive delivery using bait markers and/or surgical sterilization of different proportions of afield-based or enclosure population to determine how population dynamics are affected;(3)development of mathematical models which predict the outcomes of different fertility control scenarios;and(4)implementation of large-scale,replicated trials to validate contraceptive efficacy under various management-scalefield *** some circumstances,fertility control may be most effective when integrated with other methods(*** culling).Assessment of non-target effects,direct and indirect,and the environmental fate of the contraceptive must also be *** fertility control for a species is a resource-intensive commitment but will likely be less costly than the ongoing environmental and economic impacts by rodents and rodenticides in many contexts.

关键词： captive studies field applications modeling oral contraceptive delivery population management rodents

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Predictors of Global Disparities in COVID-19 Vaccination Coverage — 219 Countries and Territories, December 2020–July 2022

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China CDC weekly 2024年第15期6卷 318-323,I0006,I0007页

作者： Ying Zhang Shujie Zang Xu Zhang Zhiqiang Qu Xinyu Zhou Leesa Lin Zhiyuan Hou School of Public health and Global Health InstituteFudan UniversityShanghaiChina Department of Infectious Disease epidemiology London School of Hygiene&Tropical MedicineLondonUnited Kingdom Laboratory of Data Discovery for health(D24H) Hong Kong Science ParkHong Kong Special Administrative RegionChina

What is already known about this topic?The significant disparities in global coronavirus disease 2019(COVID-19)vaccine coverage hamper the pace of epidemic *** is a need to better understand the factors contributing to disparities in COVID-19 vaccination rates across *** is added by this report?This report revealed significant associations between vaccination coverage and various country-level *** pandemic preparedness,higher levels of trust,and a lower proportion of young population aged 0–14 were strongly correlated with higher COVID-19 vaccination *** are the implications for public health practices?Our findings emphasize the need for enhanced pandemic preparedness and governance,coupled with building trust in government and healthcare *** also needs to address the hesitancy of vaccinating children and adolescents aged 0–14 as the vaccination campaign progresses.

关键词： vaccination vaccine COV

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Epidemiological Characteristics of Fracture Among Children Aged 6-17 Years-China,2019-2021

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China CDC weekly 2024年第32期6卷 799-803,I0001页

作者： Lu Cui Qian Gan Juan Xu Peipei Xu Titi Yang Wei Cao Hongliang Wang Haoyan Guo Ruihe Luo Jianfen Zhang Hui Pan Wenhua Zhao Zhenyu Yang Yuxiang Yan Qian Zhang Department of epidemiology and Biostatistics School of Public HealthCapital Medical UniversityBeijingChina National institute for Nutrition and health Chinese Center for Disease Control and PreventionBeijingChina Key Laboratory of Public Nutrition and health National Health Commission of the People’s Republic of ChinaBeijingChina

Summary What is already known about this topic?Fractures are a common and serious injury among *** many studies have utilized clinical data,there is a lack of large-scale community-based research in *** is added by this report?This cross-sectional study provides national and regionally representative data on the prevalence of fractures among Chinese children aged 6–17 years(6.93%),with higher rates observed in males than in females(8.13%vs.5.71%)and in rural areas compared to urban areas(7.22%vs.6.62%).The most common site of fracture was the upper limbs(4.24%,accounting for 63.0%of fractures).What are the implications for public health practice?The need to enhance awareness of fracture prevention is critical,particularly for children in rural areas and males in middle *** recommend that local authorities increase investments in educational programs and child safety ***,promoting balanced diets for children,training in proper exercise techniques,and reinforcing participation in outdoor sports are essential.

关键词： prevention utilized children

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Small mammal community composition impacts bank vole (Clethrionomys glareolus) population dynamics and associated seroprevalence of Puumala orthohantavirus

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Integrative Zoology 2024年第1期19卷 52-65页

作者： Felicitas Maria BUJNOCH Daniela REIL Stephan DREWES Ulrike MROSENFELD Rainer G.ULRICH Jens JACOB Christian IMHOLT Julius Kühn-institute Federal Research Centre for Cultivated PlantsInstitute for Epidemiology and Pathogen DiagnosticsRodent ResearchMünsterGermany University of Münster Institute for Evolution and BiodiversityMünsterGermany Friedrich-Loeffler-Institut Federal Research Institute for Animal HealthInstitute of Novel and Emerging Infectious DiseasesGreifswald-Insel RiemsGermany

Rodents are important reservoirs for zoonotic pathogens that cause diseases in *** is hypoth-esized to be closely related to pathogen prevalence through multiple direct and indirect *** example,the presence of non-host species can reduce contact rates of the main reservoir host and thus reduce the risk of transmission(“dilution effect”).In addition,an overlap in ecological niches between two species could lead to increased interspecific competition,potentially limiting host densities and reducing density-dependent pathogen transmission *** this study,we investigated the relative impact of population-level regulation of direct and indirect drivers of the prevalence of Puumala orthohantavirus(PUUV)in bank voles(Clethrionomys glareolus)during years with high *** compiled data on small mammal community composition from four regions in Germany between 2010 and *** equation modeling revealed a strong seasonality in PUUV control mechanisms in bank *** abundance of shrews tended to have a negative relationship with host abundance,and host abundance positively influenced PUUV seroprevalence,while at the same time increasing the abundance of competing non-hosts like the wood mouse(Apodemus sylvaticus)and the yellow-neckedfield mouse(Apodemusflavicollis)were associated with reduced PUUV seroprevalence in the *** results indicate that for PUUV in bank voles,dilution is associated with increased interspecific *** pressures leading to the decline of Apodemus *** a specific habitat could lead to the amplification of mechanisms promoting PUUV transmission within the host populations.

关键词： bank vole biodiversity Puumala orthohantavirus small mammals

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