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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of endemic and Ethnic diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for disease control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and control of endemic and Ethnic Regional diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Advancements in Mpox Vaccine Development:A Comprehensive Review of Global Progress and Recent Data

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Biomedical and Environmental Sciences 2025年第2期38卷 248-254页

作者： Yuqian Zhai Yize Han Wenling Wang Wenjie Tan NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Since May 2022,a severe global Mpox epidemic has underscored the urgent need for a preventative *** September 16,2022,the mainland of China reported its first case of imported Mpox,which was subsequently followed by a significant rise in domestic infections commencing from June *** alarming trend has escalated the likelihood of localized outbreaks and covert transmission,posing a heightened risk to public ***,the United States,many European countries,and Japan have approved the use of smallpox vaccines for Mpox prevention and emergency vaccination post-exposure,based on their cross-protection *** recent years,virology research has broadened its scope to include investigations into various novel vaccine approaches,such as nucleic acid-based vaccines,protein subunit vaccines,and epitope peptide vaccines,and other related *** review offers a thorough examination of the current global landscape of Mpox prevalence,delves into the advancements in Mpox vaccine development,and highlights the progress achieved in Mpox vaccine research,serving as a valuable resource and providing technical insights essential for the effective prevention and control of Mpox.

关键词： Mpox vaccine Vaccinia virus Mpox virus Smallpox vaccine

Separate and Combained Associations of PM_(2.5) Exposure and Smoking with Dementia and Cognitive Impairment

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Biomedical and Environmental Sciences 2025年第2期38卷 194-205页

作者： Lu Cui Zhihui Wang Yuhong Liu Linlin Ma Shige Qi Ran An Xi Chen Haoyan Guo Yuxiang Yan Department of Epidemiology and Biostatistics School of Public HealthCapital Medical UniversityBeijing 100069China National Center for Chronic and Noncommunicable disease control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100050China National institute for Nutrition and Health Control and PreventionChinese Center for Disease Control and PreventionBeijing 100050China

Objective The results of limited studies on the relationship between environmental pollution and dementia have been *** analyzed the combined effects of PM_(2.5)and smoking on the prevalence of dementia and cognitive impairment in an elderly community-dwelling Chinese *** We assessed 24,117 individuals along with the annual average PM_(2.5)concentrations from 2012 to *** was confirmed in the baseline survey at a qualified clinical facility,and newly suspected dementia was assessed in 2017,after excluding cases of suspected dementia in *** census data were used to weight the sample data to reflect the entire population in China,with multiple logistic regression performed to analyze the combined effects of PM_(2.5)and smoking frequency on dementia and cognitive *** Individuals exposed to the highest PM_(2.5)concentration and smoked daily were at higher risk of dementia than those in the lowest PM_(2.5)concentration group(OR,1.603;95%CI[1.626−1.635],P<0.0001)and in the nonsmoking group(OR,1.248;95%CI[1.244−1.252];P<0.0001).Moderate PM_(2.5)exposure and occasional smoking together increased the short-term risk of cognitive *** PM_(2.5)exposure and smoking were associated with an increased risk of dementia,so more efforts are needed to reduce this risk through environmental protection and antismoking *** High-level PM_(2.5)exposure and smoking were associated with an increased risk of *** the ambient PM_(2.5),and smoking cessation are recommended to promote health.

关键词： PM_(2.5) exposure Smoking Dementia Cognitive impairment Environmental protection Smoking cessation

Exposure of individuals aged 18-44 years to personal care products in Beijing,China:Exposure profiles,possible influencing factors,and risk assessment

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Journal of Environmental Sciences 2025年第2期148卷 691-701页

作者： Xu Zhang Linxue Han Qi Sun Xiaochen Wang Xiaojian Hu Xiao Lin Ying Zhu China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China The Bureau for Health Inspection and Supervision of Haidian District Beijing 100037China

Personal care products(PCPs)are a class of emerging pollutants that have attracted public concern owing to their harmful effects on humans and the *** data is valuable for insight the levels of PCPs in the human body and can be crucial for identifying potential health *** gain a better understanding of timely exposure profiles and health risk of reproductive-age population to PCPs,we determined six parabens,six benzophenone-type ultraviolet filters,and three disinfectants in 256 urine samples collected from young adults aged 18-44 years in Beijing,*** urinary levels of benzophenone-3(BP-3)and 4-hydroxybenzophenone(4-OHBP)were significantly higher in summer compared to winter,suggesting these compounds have different seasonal usage ***,the total concentration of 15 PCPs in female was 430 ng/mL,approximately two times higher than that in male.P-chloro-m-xylenol(PCMX),as a new type of antibacterial agent,has the greatest level among all target analytes,indicating the increasingly use of this antibacterial alternative *** potential influencing factors that lead to the elevated exposure level of PCPs were *** 19%of the target population had a high hazard index value(greater than 1)which was attributed to exposure to propyl paraben(PrP),benzophenone-1(BP-1),BP-3 and PCMX,indicating that PCPs may pose a relatively high exposure risk at environmental levels that should be a cause for concern.

关键词： Personal care products Hazard quotient Risk assessment Exposure patterns Urine

Impulsive thrust strategy for orbital pursuit-evasion games based on impulse-like constraint

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Chinese Journal of Aeronautics 2025年第1期38卷 520-536页

作者： Hongbo WANG Yao ZHANG Hao LIU Kunpeng ZHANG School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Space Intelligent control Beijing Institute of Control EngineeringBeijing 100094China

This paper proposes a novel impulsive thrust strategy guided by optimal continuous thrust strategy to address two-player orbital pursuit-evasion game under impulsive thrust *** strategy seeks to enhance the interpretability of impulsive thrust strategy by integrating it within the framework of differential game in traditional continuous ***,this paper introduces an impulse-like constraint,with periodical changes in thrust amplitude,to characterize the impulsive thrust ***,the game with the impulse-like constraint is converted into the two-point boundary value problem,which is solved by the combined shooting and deep learning method proposed in this *** learning and numerical optimization are employed to obtain the guesses for unknown terminal adjoint variables and the game terminal ***,the accurate values are solved by the shooting method to yield the optimal continuous thrust strategy with the impulse-like ***,the shooting method is iteratively employed at each impulse decision moment to derive the impulsive thrust strategy guided by the optimal continuous thrust *** examples demonstrate the convergence of the combined shooting and deep learning method,even if the strongly nonlinear impulse-like constraint is *** effect of the impulsive thrust strategy guided by the optimal continuous thrust strategy is also discussed.

关键词： Orbital pursuit-evasion game Differential game Impulsive thrust Deep learning Shooting method

Advances on ALV-J in China over the past two decades

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Journal of Integrative Agriculture 2025年第2期24卷 429-440页

作者： Wenrui Fan Yuntong Chen Mengmeng Yu Yongzhen Liu Yulong Gao Avian Immunosuppressive diseases Division State Key Laboratory for Animal Disease Control and PreventinonHarbin Veterinary Research InstituteChinese Academy of Agricultural Sciences Jiangsu Co-Innovation Center for the Prevention and control of Important Animal Infectious disease and Zoonose Yangzhou University

Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus(ALV) in poultry. ALVs belong to the retroviral family and are classified into 11 subgroups(ALV-A to ALV-K). Among them, ALV-J was first introduced into China in 1999, spreading widely and evolving from infecting meat-type chickens to layer chickens and Chinese local chickens. ALV-J typically induces myeloid leukosis in infected chickens, but also induces a high proportion of hemangiomas in infected layer chickens, posing a serious threat to poultry breeds in China. As a retrovirus, the genome of ALV-J has undergone significant mutations, which may be related to the expansion of the infection host range and increased pathogenicity of ALV-J. Over the last two decades, the introduction and spread of ALV-J in China have caused substantial losses to the poultry industry. Specialized detection assays have been developed to combat ALV-J infections in China. Additionally, ongoing research aims to employ gene-editing technology as a novel antiviral strategy to control the spread of ALV infections. This review highlights the importance of understanding the impact of ALV-J on the Chinese poultry industry and emphasizes the need for ongoing research and innovation to safeguard poultry health and promote sustainable poultry farming practices in China.

关键词： subgroup J avian leucosis epidemiology molecular variation pathogenicity prevention and control

Deletion of Salmonella pathogenicity islands SPI-1, 2 and 3 induces substantial morphological and metabolic alternation and protective immune potential

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Journal of Integrative Agriculture 2025年第1期24卷 272-289页

作者： Gaosong Liu Xuelian Lü Qiufeng Tian Wanjiang Zhang Fei Yi Yueling Zhang Shenye Yu State Key Laboratory for Animal disease control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China

The Salmonella pathogenicity islands(SPIs) play crucial roles in the progression of Salmonella infection. In this study, we constructed an improved λ Red homologous recombination system to prepare single and triple deletion mutants of 3 prominent SPIs(SPI-1, 2, and 3), aiming at the impact of deletion on morphology, carbon source metabolism, adhesion and invasion capacity, in vivo colonization, and immune efficacy in chicks. Our examination revealed that the surface of the single deletion mutants(SM6ΔSPI1, ΔSPI2, and ΔSPI3) exhibited a more rugged texture and appeared to be enveloped in a layer of transparent colloid, whereas the morphology of the triple deletion mutant(SM6ΔSPI1&2&3) remained unaltered when compared to the parent strain. The carbon metabolic spectrum of the SPI mutants underwent profound alterations, with a notable and statistically significant modification observed in 30 out of 95 carbon sources, primarily carbohydrates(17 out of 30). Furthermore, the adhesion capacity of the 4 mutants to Caco-2 cells was significantly reduced when compared to that of the parent strain. Moreover,the invasion capacity of mutants SM6ΔSPI1 and SM6ΔSPI1&2&3 exhibited a substantial decrease, while it was enhanced to varying degrees for SM6ΔSPI3 and SM6ΔSPI2. Importantly, none of the 4 mutants induced any clinical symptoms in the chicks. However, they did transiently colonize the spleen and liver. Notably, the SM6ΔSPI1&2&3mutant was rapidly cleared from both the spleen and liver within 8 days post-infection and no notable pathological changes were observed in the organs. Additionally, when challenged, the mutants immunized groups displayed a significant increase in antibody levels and alterations in the CD3+CD4+ and CD3+CD8+ subpopulations, and the levels of IL-4 and IFN-γ cytokines in the SM6ΔSPI1&2&3 immunized chicken serum surpassed those of other *** summary, the successful construction of the 4 SPI mutants lays the groundwork for further exploration into the p

关键词： Salmonella pathogenicity islands(SPls) morphology carbon source metabolism pathogenicity immunogenicity live attenuated vaccine

Optimizing Nutrition to Reduce Cardiometabolic disease Burden:Strategies for a Healthier China

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Biomedical and Environmental Sciences 2025年第1期38卷 1-2页

作者： Gangqiang Ding Key-Laboratory of Public Health Nutrition and Health National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China

China faces a significant challenge with increasing cardiovascular disease(CVD)incidence and mortality rates,imposing a heavy disease *** of 2020,approximately 330 million individuals in China suffer from CVD,including 245 million with hypertension and 13 million with stroke,not accounting for those with cardiometabolic risk factors[1].Given this context,shifting from a diseasecentered approach to a population health-centered strategy,as outlined in the“Healthy China Action(2019-2030)”,is critical.

关键词： mortality cardiovascular shifting

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China(Life Sciences) 2025年第1期68卷 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gastroenterology Gansu Wuwei Tumor HospitalWuwei 730000China Cixian Cancer institute Handan 056500China Linzhou Cancer Hospital Linzhou 456550China Center for disease control and Prevention of Sheyang County Yancheng 224499China Department of Cancer Prevention and control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410029China Luoshan Center for disease control and Prevention Xinyang 464299China Office for Cancer control and Research Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150081China

Surveillance recommendations for gastric cancer(GC)in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline *** aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool,and assessed whether mild-precursor-lesion patients can be safely exempt from *** the multicenter communitybased cohort,75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until *** incidence rates(CIRs)of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank *** Cox regression models were used to detect potential factors for progression towards GC.A risk score was calculated as counts of selected *** independent cohort,including 26,586 participants was used for external *** a median follow-up of 6.25 years,CIRs of GC were 0.302%,0.436%,and 4.756%for normal group,non-neoplastic(atrophic gastritis/intestinal metaplasia)and neoplastic lesions(low-grade/high-grade dysplasia),respectively(Ptrend<0.001).Four predictors,including male,≥60 years,smoking,and limited vegetable consumption,were selected for ***-risk patients(≥3 risk factors)with non-neoplastic lesions showed higher GC risks(adjusted HR=7.73,95%CI:4.29–13.92),and their four-year CIR reached the one-year CIR of neoplastic *** categorizing non-neoplastic lesions by histological grade,both patients with moderate-to-severe lesions(aHR=3.07,95%CI:1.67–5.64)and high-risk patients with mild lesions(aHR=7.29,95%CI:3.58–14.86)showed higher *** trends were observed in validation ***-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline *** study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification