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Journal of Traffic and Transportation Engineering 2024年第3期12卷 130-140页

作者： Su Min Hong Oek Seok Jeon Young Soo Na Metro research institute Seoul MetroSeoul 04806Korea Department of Transportation Engineering University of SeoulSeoul 02504Korea

Seoul Metro is Seoul’s leading metro company, transporting up to 3 billion people annually. However, future ridership is expected to plummet due to an aging and shrinking population with one of the fastest declining total fertility rates in the world. The COVID-19 pandemic in 2019 accelerated this phenomenon. On the contrary, the e-commerce and home delivery industries have developed significantly since COVID-19. Seoul’s current logistics infrastructure cannot handle it. Under the inflection point of declining passenger transportation demand and increasing urban logistics demand, urban rail operators need new growth engines. Therefore, it is necessary to consider the introduction of an UULS (underground urban logistics system) that transports parcels instead of passengers through urban railways. If the UULS becomes a reality, it can be expected to secure scarce logistics land in cities, protect the environment and prevent traffic congestion by operating eco-friendly mass urban transportation, and acquire new revenue sources for urban rail operators. The UULS’s B/C ratio is 1.32. The sensitivity analysis shows that the ratio is above 1 in most cases where the unit cost of transportation is not significantly reduced.

关键词： UULS metro new growth engines COVID-19 traffic congestion environment.

Programmable synthetic receptors:the next-generation of cell and gene therapies

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Signal Transduction and Targeted Therapy 2024年第2期9卷 376-400页

作者： Fei Teng Tongtong Cui Li Zhou Qingqin Gao Qi Zhou Wei Li University of Chinese Academy of Sciences Beijing 101408China State Key Laboratory of Stem Cell and Regenerative Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing institute for Stem Cell and Regenerative Medicine Beijing 100101China

Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat ***,concerns over the safety and efficacy require to be further addressed in order to realize their full *** receptors,a synthetic biology tool that can precisely control the function of therapeutic cells and genetic modules,have been rapidly developed and applied as a powerful *** designed and engineered,they can be applied to finetune the therapeutic activities,i.e.,to regulate production of dosed,bioactive payloads by sensing and processing user-defined signals or *** review provides an overview of diverse synthetic receptor systems being used to reprogram therapeutic cells and their wide applications in biomedical *** a special focus on four synthetic receptor systems at the forefront,including chimeric antigen receptors(CARs)and synthetic Notch(synNotch)receptors,we address the generalized strategies to design,construct and improve synthetic ***,we also highlight the expanding landscape of therapeutic applications of the synthetic receptor systems as well as current challenges in their clinical translation.

关键词： synthetic landscape payload

Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis

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Zoological research 2024年第2期45卷 398-414页

作者： Poornima D.E.Weerasinghe-Mudiyanselage Sohi Kang Joong-Sun Kim Sung-Ho Kim Hongbing Wang Taekyun Shin Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR ProgramChonnam National UniversityGwangju 61186Republic of Korea Department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju 52727Republic of Korea Department of Physiology and Neuroscience Program Michigan State UniversityEast LansingMI 48824USA Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJeju 63243Republic of Korea

Structural plasticity is critical for the functional diversity of neurons in the *** autoimmune encephalomyelitis(EAE)is the most commonly used model for multiple sclerosis(MS),successfully mimicking its key pathological features(inflammation,demyelination,axonal loss,and gliosis)and clinical symptoms(motor and non-motordysfunctions).Recentstudieshave demonstrated the importance of synaptic plasticity in EAE *** the present study,we investigated the features of behavioral alteration and hippocampal structural plasticity in EAE-affected mice in the early phase(11 days post-immunization,DPI)and chronic phase(28DPI).EAE-affected mice exhibited hippocampus-related behavioral dysfunction in the open field test during both early and chronic *** complexity was largely affected in the cornu ammonis 1(CA1)and CA3 apical and dentate gyrus(DG)subregions of the hippocampus during the chronic phase,while this effect was only noted in the CA1 apical subregion in the early ***,dendritic spine density was reduced in the hippocampal CA1 and CA3 apical/basal and DG subregions in the early phase of EAE,but only reduced in the DG subregion during the chronic ***,mRNA levels of proinflammatory cytokines(Il1β,Tnfα,and Ifnγ)and glial cell markers(Gfap and Cd68)were significantly increased,whereas the expression of activity-regulated cytoskeletonassociated protein(ARC)was reduced during the chronic ***,exposure to the aforementioned cytokines in primary cultures of hippocampal neurons reduced dendritic complexity and ARC *** cultures of hippocampal neurons also showed significantly reduced extracellular signal-regulated kinase(ERK)phosphorylation upon treatment with proinflammatory ***,these results suggest that autoimmune neuroinflammation alters structural plasticity in the hippocampus,possibly through the ERK-ARC pathway,indicating that this alteration may be associated with hi

关键词： Activity-regulated cytoskeleton-associated protein Anxiety-like behavior Experimental autoimmune encephalomyelitis Hippocampal dysfunction Neuroinflammation

Effect of Gum Arabic from Acacia senegal var. kerensis as an Improver on the Rheological Properties of Wheat Flour Dough

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Food and Nutrition Sciences 2024年第4期15卷 298-312页

作者： Roseline Mwihaki Kiama Mary Omwamba George Wafula Wanjala Symon Maina Mahungu Department of Dairy and Food Science and Technology Egerton University Nakuru Kenya Kenya Industrial research and Development institute Nairobi Kenya

Dough improvers are substances with functional characteristics used in baking industry to enhance dough properties. Currently, the baking industry is faced with increasing demand for natural ingredients owing to increasing consumer awareness, thus contributing to the rising demand for natural hydrocolloids. Gum Arabic from Acacia senegal var. kerensis is a natural gum exhibiting excellent water binding and emulsification capacity. However, very little is reported on how it affects the rheological properties of wheat dough. The aim of this study was therefore, to determine the rheological properties of wheat dough with partial additions of gum Arabic as an improver. Six treatments were analyzed comprising of: flour-gum blends prepared by adding gum Arabic to wheat flour at different levels (1%, 2% and 3%), plain wheat flour (negative control), commercial bread flour and commercial chapati flour (positive controls). The rheological properties were determined using Brabender Farinograph, Brabender Extensograph and Brabender Viscograph. Results showed that addition of gum Arabic significantly (p chapati. These findings support the need to utilize gum Arabic from Acacia senegal var. kerensis as a dough improver.

关键词： Gum Arabic Improver Rheology Hydrocolloids Wheat Dough

Overall Selection Design Based on the Mega Highway Bridge Project

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Journal of World Architecture 2024年第4期8卷 27-32页

作者： Rongpeng Xu China Merchants Chongqing Communications Technology research&Design institute Co. LTD.Chongqing 400067China

In the continuous development of the modern highway and bridge engineering industry,the reasonable selection of mega highway bridges and their design is *** on this,this paper takes the actual bridge project as an example,and analyses the overall selection design of such highway bridges,including the basic overview of the project,the basic selection principle of mega highway bridge project structure and its design strategy,etc.,to provide scientific reference for its selection design.

关键词： Mega highway bridge Selection principle Selection design for railway crossing Selection design for road crossing

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地球大数据及其推动可持续发展的作用

Science Bulletin 2024年第11期69卷 1623-1627页

作者：郭华东梁栋 International research Center of Big Data for Sustainable Development Goals Beijing 100094China Aerospace Information research institute Chinese Academy of SciencesBeijing 100094China University of Chinese Academy of Sciences Beijing 100049China

The information age has been a product of, and has been fueled by, the process of decades-long digitization aided by digital technologies that progressed rapidly, consequently transforming human societies globally.

关键词：大数据 globally digit

Detection and Identification of Phytoplasma of Cleome rutidosperma in Areca Palm Yellow Leaf Disease Field

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Plant Diseases and Pests 2024年第4期15卷 7-12页

作者： Zhaowei LIN Xiaoqing NIU Shida LONG Qinghua TANG Dejie YANG Weiwei SONG Coconut research institute of Chinese Academy of Tropical Agricultural Sciences/Hainan Innovation Center of Academician Team Wenchang 571339China

[Objectives]The paper was to detect and identify the phytoplasma of Cleome rutidosperma in areca palm yellow leaf disease(YLD)field in Wenchang City,Hainan Province,China.[Methods]The nested PCR technique was employed to amplify the phytoplasma 16S rDNA of *** samples,followed by sequence ***,this study examined *** in YLD field,collecting symptomatic leaves for phytoplasma detection.[Results]The 16S rDNA sequence of the *** witches'-broom phytoplasma was found to be identical to that of the HNWC5 strain associated with areca palm yellows phytoplasma,leading to the identification of this phytoplasma as belonging to the 16SrII-A *** investigations revealed a higher incidence of *** in areca palm fields,with symptoms of leaf yellows observed in six of these *** PCR(qPCR)analysis confirmed the presence of phytoplasma infection in these instances.[Conclusions]Through the analysis of geographical distribution,sequence alignment,and field occurrence data,a significant correlation has been identified between witches'broom disease and *** is proposed that the former may act as an intermediate host for the areca palm yellows phytoplasma.

关键词： Areca palm yellow leaf disease Phytoplasma Cleome rutidosperma Identification Detection

A Review of the Key Points in the Design of Small-Radius Curved Ramp Bridges

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Journal of World Architecture 2024年第1期8卷 97-102页

作者： Yuxiao Zhang China Merchants Chongqing Communications Technology research&Design institute Co. Ltd.Chongqing 400067China

This article explores the fundamentals of small-radius curved ramp *** covers the selection of box girder spans,support methods,and forms,along with design optimization techniques for this type of bridge *** purpose of this paper is to provide robust support for enhancing the design quality of these bridges and ensuring their efficacy in real-world applications.

关键词： Bridge design Small-radius curve ramp Box girder span Support method Support form

Application of Intelligent Technology in Building Electrical Lighting Project

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Journal of Electronic research and Application 2024年第3期8卷 112-117页

作者： Yingling Dai Qinghua Zhao China Merchants Chongqing Communications Technology research&Design institute Co. LTD.Chongqing 400067China

The rapid development of intelligent technology has led to its introduction into the field of electrical lighting in *** provides more technical support for system design,use,and management,and creates a comfortable and safe living *** adoption of intelligent technology enables the creation of an intelligent management system,where controllers and sensors are used to adjust the light source within the building,monitor and manage the lighting system in real time,monitor the energy consumption and safety of the system,and achieve the goal of energy saving and emission *** paper briefly discusses the application and significance of intelligent technology in electrical lighting and puts forward design ideas to optimize electrical lighting and measures for lighting system management.

关键词： Intelligent technology Buildings Electric lighting

Static and Thermal Analysis of Aluminium (413,390,384 and 332) Piston Using Finite Element Method

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Modeling and Numerical Simulation of Material Science 2024年第1期14卷 1-38页

作者： Offei David Inusah Jacob Kwaku Nkrumah Vincent Akolbire Atindana Automotive Engineering Department Tamale Technical University Tamale Ghana Automotive Engineering research institute Jiangsu University Zhenjiang China

The main objective of this research was to examine the suitability of aluminium alloy to design a piston of an internal combustion engine for improvement in weight and cost reduction. The piston was modelled using Autodesk Inventor 2017 software. The modelled piston was then imported into Ansys for further analysis. Static structural and thermal analysis were carried out on the pistons of the four different materials namely: Al 413 alloy, Al 384 alloy, Al 390 alloy and Al332 alloy to determine the total deformation, equivalent Von Mises stress, maximum shear stress, and the safety factor. The results of the study revealed that, aluminium 332 alloy piston deformed less compared to the deformations of aluminium 390 alloy piston, aluminium 384 alloy piston and aluminium 413 alloy piston. The induced Von Mises stresses in the pistons of the four different materials were found to be far lower than the yield strengths of all the materials. Hence, all the selected materials including the implementing material have equal properties to withstand the maximum gas load. All the selected materials were observed to have high thermal conductivity enough to be able to withstand the operating temperature in the engine cylinders.

关键词： Von Mise stress Total deformation Aluminium alloy Thermal analysis. Piston Static structural Heat fux