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Antiviral optical techniques as a possible novel approach to COVID-19 treatment

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Journal of Innovative Optical Health Sciences 2021年第3期4卷 1-18页

作者： Fereshteh Moshfegh Farshad Khosraviani Negar Moghaddasi Seyedeh Fatemeh Seyed Javadi Limoodi Ebrahim Boluki Department of dentistry New Vision University 1a Evgeni Mikeladze StreetTbilisi 0159Georgia School of dentistry University of California Los Angeles10833 Le Conte CHSCA 90095USA School of dentistry Shiraz University of Medical Sciences Zand Street P.O. School of dentistry Tehran University of Medical Sciences North Karegar Street P.O. Blood Transfusion Research Center High institute for Research&Education in Transfusion Medicine TehranIran

The current pandemic SARS-CoV-2(also known as 2019-nCoV and COVID-19)viral infection is growing globally and has created a disastrous situation all over the *** of the biggest challenges is that no drugs are available to treat this life-threatening *** no drugs are available for definitive treatment of this disease and the mortality rate is very high,there is an utmost need to cure the infection using novel *** study will point out some new antimicrobial technologies that have great potentials for eradicating and preventing emerging *** can be considered as treatments of choice for viral infections in the future.

关键词： SARS-CoV-2 COVID-19 light therapy photodynamic therapy photocatalysis ARDS

Characterization of the osteogenic potential of mesenchymal stem cells from human periodontal ligament based on cell surface markers

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International Journal of Oral Science 2015年第4期7卷 213-219页

作者： Ruth Alvarez Hye-Lim Lee Cun-Yu Wang Christine Hong Division of Oral Biology and Medicine School of DentistryUniversity of California at Los Angeles Section of Orthodontics School of DentistryUniversity of California at Los Angeles

Mesenchymal stem cell （MSC）-mediated therapy has been shown to be clinically effective in regenerating tissue defects. For improved regenerative therapy, it is critical to isolate homogenous populations of MSCs with high capacity to differentiate into appropriate tissues. The utilization of stem cell surface antigens provides a means to identify MSCs from various tissues. However, few surface markers that consistently isolate highly regenerative MSCs have been validated, making it challenging for routine clinical applications and making it all the more imperative to identify reliable surface markers. In this study, we used three surface marker combinations： CD51/CD140a, CD271, and STRO-1/CD146 for the isolation of homogenous populations of dental mesenchymal stem cells （DMSCs） from heterogeneous periodontal ligament cells （PDLCs）. Fluorescence-activated cell sorting analysis revealed that 24% of PDLCs were CD51＋/CD140a＋, 0.8% were CD271＋, and 2.4% were STRO-1＋/CD146＋. Sorted cell populations were further assessed for their multipotent properties by inducing osteogenic and chondrogenic differentiation. All three subsets of isolated DMSCs exhibited differentiation capacity into osteogenic and chondrogenic lineages but with varying degrees. CD271＋ DMSCs demonstrated the greatest osteogenic potential with strong induction of osteogenic markers such as DLX5, RUNX2, and BGLAP. Our study provides evidence that surface marker combinations used in this study are sufficient markers for the isolation of DMSCs from PDLCs. These results provide important insight into using specific surface markers for identifying homogenous populations of DMSCs for their improved utilization in regenerative medicine.

关键词： cell surface markers dental mesenchymal stem cells periodontal ligament

Cardiac sympathetic nerve terminal function in congestive heart failure

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Acta Pharmacologica Sinica 2007年第7期28卷 921-927页

作者： Chang-seng LIANG School of Medicine and dentistry,University of Rochester,Rochester,New York 14642,USA School of Medicine and dentistry University of Rochester Rochester USA

Increased cardiac release of norepinephrine (NE) and depleted cardiac stores ofNE are two salient features of the human failing *** from my labo-ratory have shown that these changes are accompanied by a functional defect ofNE uptake in the cardiac sympathetic nerve *** studies have shownthat the decrease of NE uptake is caused by reduction of NE transporter density inthe sympathetic nerve endings,and this change is responsible,at least in part,forthe increased myocardial interstitial NE,decreased myocardial adrenoceptordensity,and increased myocyte apoptosis in experimental *** also provided evidence in both intact animals and cultured PC12 cells thatthe decrease of NE transporter is induced by the actions of oxidative metabolitesof exogenous NE,involving endoplasmic reticulum stress and impairedN-glycosylation of the NE *** change in the cardiac sympathetic NEuptake function,as demonstrated by [123I] metaiodobenzylguanidine in humanstudies,may not only serve as an important prognostic variable in patients withcongestive heart failure,but also be used as a surrogate for the efficacies ofvarious therapeutic interventions for heart ***,increasing evidencesuggests and further studies are needed to show that the cardiac sympatheticnerve terminal function may be a direct target for pharmacologic treatment ofcongestive heart failure.

关键词： neurotransmitter transporter norepinephrine congestive heart failure nerve growth factors antioxidants

Oral Microbiology:Past,Present and Future

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International Journal of Oral Science 2009年第2期1卷 47-58页

作者： Xue-song He Wen-yuan Shi School of dentistry the University of California Los Angeles USA

Since the initial observations of oral bacteria within dental plaque by van Leeuwenhoek using his primitive microscopes in 1680, an event that is generally recognized as the advent of oral microbiological investigation, oral microbiology has gone through phases of ＂reductionism＂ and ＂holism＂. From the small beginnings of the Miller and Black period, in which microbiologists followed Koch＇s postulates, took the reductionist approach to try to study the complex oral microbial community by analyzing individual species; to the modem era when oral researchers embrace ＂holism＂ or ＂system thinking＂, adopt new concepts such as interspecies interaction, microbial community, biofilms, poly-microbial diseases, oral microbiological knowledge has burgeoned and our ability to identify the resident organisms in dental plaque and decipher the interactions between key components has rapidly increased, such knowledge has greatly changed our view of the oral microbial flora, provided invaluable insight into the etiology of dental and periodontal diseases, opened the door to new approaches and techniques for developing new therapeutic and preventive tools for combating oral polymicrobial diseases.

关键词： oral microbiology biofilms dental caries oral pathogenesis

The effect of platform switching on the levels of metal ion release from different implant–abutment couples

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International Journal of Oral Science 2016年第2期8卷 117-125页

作者： Ghada O Alrabeah Jonathan C Knowles Haralampos Petridis Division of Biomaterials and Tissue Engineering UCL Eastman Dental Institute University College London London UK Prosthodontic Unit Department of Restorative Dentistry UCL Eastman Dental Institute University College London London UK

The improved peri-implant bone response demonstrated by platform switching may be the result of reduced amounts of metal ions released to the surrounding tissues. The aim of this study was to compare the levels of metal ions released from platform-matched and platform-switched implant-abutment couples as a result of accelerated corrosion. Thirty-six titanium alloy （Ti-6AI-4V） and cobalt-chrome alloy abutments were coupled with titanium cylinders forming either platform-switched or platform-matched groups （n = 6）. In addition, 18 unconnected samples served as controls. The specimens were subjected to accelerated corrosion by static immersion in 1% lactic acid for 1 week. The amount of metal ions ion of each test tube was measured using inductively coupled plasma mass spectrometry. Scanning electron microscope （SEM） images and energy dispersive spectroscopy X-ray analyses were performed pre- and post-immersion to assess corrosion at the interface. The platform-matched groups demonstrated higher ion release for vanadium, aluminium, cobalt, chrome, and molybdenum compared with the platform-switched groups （P〈 0.05）. Titanium was the highest element to be released regardless of abutment size or connection （P〈0.05）. SEM images showed pitting corrosion prominent on the outer borders of the implant and abutment platform surfaces. In conclusion, implant-abutment couples underwent an active corrosion process resulting in metal ions release into the surrounding environment. The highest amount of metal ions released was recorded for the platform-matched groups, suggesting that platform-switching concept has a positive effect in reducing the levels of metal ion release from the implant-abutment couples.

关键词： corrosion dental implants ion release peri-implant bone loss platform-switching titanium

Magnesium/Nano-hydroxyapatite Composite for Bone Reconstruction: The Effect of Processing Method

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Journal of Bionic Engineering 2020年第1期17卷 92-99页

作者： Mohammad Khodaei Farahnaz Nejatidanesh Mohammad Javad Shirani Srinivasan Iyengar Hossein Sina Omid Savabi Department of Materials Science and Engineering Golpayegan University of TechnologyGolpayegan ***Iran Dental Materials Research Center Dental Research InstituteSchool of DentistryIsfahan University of Medical SciencesIsfahan ***Iran Post graduate student of Prosthodontics Student Research CommitteeSchool of DentistryIsfahan University of Medical SciencesIsfahan ***Iran Materials Engineering Division Faculty of EngineeringLund UniversityLund 11822100Sweden European Spallation Source ERIC Lund 17622100Sweden Dental Research Center Dental Research InstituteSchool of DentistryIsfahan University of Medical SciencesIsfahan ***Iran

Nano-ceramic particles can serve as reinforcing agents for metallic materials to improve their mechanical ***,it is important to ensure chemical compatibility between the matrix and *** the present study,magnesium composites with and without nano-hydroxyapatite(nHA)particles were fabricated for bone reconstruction *** different techniques were used,Conventional Sintering(CS)of powder compacts and Spark Plasma Sintering(SPS)of pre-compacted *** showed that a 10 wt%addition of nHA particles to magnesium,followed by SPS improved the compression strength by 27%.CS did not lead to any significant improvement compared to SPS processing.X-ray diffraction data after CS revealed the formation of unfavorable phases due to chemical reactions between nHA particles and the magnesium matrix,while these phases were absent after SPS *** mechanical properties of the specimens fabricated by CS were much inferior to those processed using *** shorter processing time associated with SPS leaded to reduced interaction between nHA particles and the Mg-matrix,compared to CS.

关键词： magnesium nano-hydroxyapatite composite materials in situ reaction biomedical-materials

Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report

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International Journal of Oral Science 2018年第1期10卷 7-13页

作者： Astrid Truschnegg Stephan Acham Lumnije Kqiku Norbert Jakse Alfred Beham Department of Dental Medicine and Oral Health Division of Oral Surgery and OrthodonticsMedical University Graz Department of Dental Medicine and Oral Health Division of Preventive an Operative DentistryEndodonticsPeriodontologyProsthodonticsRestorative Dentistry and ImplantologyMedical University Graz IMAH Institute of Morphological Analytics and Human Genetics

Prompted by a unique case of an ectomesenchymal chondromyxoid tumor(ECT) of the palate in a 54-year-old female, we reviewed the English and German literature on this entity until the end of 2016 using Pub Med. The search produced 74 lingual cases with a nearly equal sex distribution and a mean age of 39.3 years, and two extra-lingual cases sharing histological and immunohistological features including nodular growth, round, fusiform or spindle-shaped cellular architecture, and chondromyxoid *** showed the majority of cases to be positive for glial fibrillary acidic protein(GFAP), S-100 protein,glycoprotein CD57, pancytokeratin (AE1/AE3), and smooth muscle actin(SMA); in isolated cases there was molecular-genetic rearrangement or gain of Ewing sarcoma breakpoint region 1 (EWSR1) but no rearrangement of pleomorphic adenoma gene 1 (PLAG1). At present, ectomesenchymal cells that migrate from the neural crest are considered to play a pivotal role in tumor *** cases had a benign course, although there were three recurrences. Because of the rarity of this tumor and the need for differential diagnostic differentiation from myoepithelioma and pleomorphic adenoma, both oral surgeons and pathologists should be aware of this entity.

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Tumor suppressor p53:new functions of an old protein

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Frontiers in Biology 2011年第1期6卷 58-68页

作者： Zhaohui FENG Rui WU Meihua LIN Wenwei HU Department of Radiation Oncology The Cancer Institute of New JerseyUniversity of Medicine and Dentistry of New JerseyNew BrunswickNJ 08903USA Department of Pediatrics and Department of Obstetrics and Gynecology The Cancer Institute of New JerseyUniversity of Medicine and Dentistry of New JerseyNew BrunswickNJ 08903USA

p53 was discovered 30 years *** studies have been done on p53 since then,which makes p53 one of the most extensively studied genes.p53 has long been recognized as a key tumor *** cycle arrest,apoptosis and senescence have been traditionally recognized as the main functions of p53 in tumor ***,some novel functions of p53 have been identified,including the regulation of energy metabolism,antioxidant defense,and microRNA expression and maturation,which all contribute to the role of p53 in tumor ***,the contribution of p53 to normal biologic processes(*** and aging)and some other aspects of diseases(*** diseases)is only now being *** we will review recent advances in the study of some new functions of p53.

关键词： p53 tumor suppressor energy metabolism oxidative stress microRNAs reproduction

Carbon Nanotube Coating on Titanium Substrate Modified with TiO_2 Nanotubes

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Journal of Wuhan University of Technology(Materials Science) 2011年第5期26卷 867-871页

作者：白玉 PARK Ilsong BAE Taesung KIM Kyounga WATARI Fumio UO Motohiro LEE Minho Department of Dental Biomaterials School of Dentistry and Institute of Oral BioscienceBrain Korea 21 ProjectChonbuk National University School of Materials Science and Engineering Inner Mongolia University of Technology Department of Conservative dentistry Institute of Oral Bioscience and BK 21 ProjectSchool of DentistryChonbuk National University Biomedical Dental Materials and EngineeringDepartment of Oral Health ScienceGraduate School of Dental MedicineHokkaido University Advanced Biomaterials Section Graduate School of Medical and Dental SciencesTokyo Medical and Dental University

A combination of carbon nanotubes （CNTs） and titanium （Ti） modified with TiO2 nanotubes （TiO2 NTs） was fulfilled with the aim of improving bioactivity of Ti ***,well-ordered TiO2 NTs were prepared by the electrochemical anodization of Ti in an ethylene glycol electrolyte containing 1 wt% NH4F and 10 wt% H2O at 20 V for 50 min,followed by ***,the carboxylated CNTs were coated onto the TiO2 NTs using electrophoretic deposition （EPD） *** growth of hydroxyapatite （HA） on the samples was investigated by soaking them in simulated body fluid （SBF）.The result showed the CNTs-coated Ti with the modification of TiO2 NTs （CNTs-TiO2 NTs） was more efficient to induce HA formation than the CNTs-coated smooth Ti （CNTs-Ti）.The vitro cell response was evaluated using osteoblast cells （MC3T3-E1）.The good cell proliferation and strong cell adhesion could be obtained on the CNTs-TiO2 *** results indicated that CNT coating on the Ti modified with TiO2 NTs could be potentially useful for the periodontal ligament combination on dental implants.

关键词： carbon nanotubes TiO2 nanotubes apatite-forming ability cell adhesion