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Edible films based on milk proteins release effectively active immunoglobulins

Food Quality and Safety 2019年第1期3卷 23-34页

作者： Pirjo Rantamäki Vuokko Loimaranta Erkki Vasara Jari Latva-Koivisto Hannu Korhonen Jorma Tenovuo Pertti Marnila Natural Resources institute Finland FI-31600 JokioinenFinland institute of dentistry University of TurkuFI-20014 Turun yliopistoFinland

Objectives:The goal of this study was to develop novel compositions of edible protein coatings based on immunoglobulin(Ig)fraction from bovine *** coatings can be used to protect foods against microbial,chemical,and physical *** developed novel compositions of edible protein coatings based on immunoglobulin(Ig)fraction from bovine milk.A lot of Ig could be obtained from under-utilized side streams of dairy *** the best of our knowledge,such use of the Ig fraction has not been published *** and Methods:Bovine colostral Ig’s were incorporated in edible films based on various milk proteins and investigated the characteristics of the films including solubility of Ig’s and nisin and on technological properties of ***’s specific to cariogenic bacteria Streptococcus mutans and Streptococcus sobrinus were produced to colostrums by hyperimmunizing cows before ***:The milk Ig rich fraction suited well as a component of milk protein *** Ig’s dissolved from the films very ***,commoly used for food protection,was used as a model of antimicrobial *** was released biologically active from bothβ-lactoglobulin(β-lg)andβ-lg/Ig *** exerted its bactericidal effect at clearly lower concentrations in theβ-lg/Ig films when compared withβ-lg *** also retained its activity better in film containing Ig-enriched *** Ig-enriched whey into films enhanced adhesion and tensile strength of the *** Ig-enriched whey also affected strongly on the appearance of films based on commercial whey protein concentrate in a dose-dependent way by making the films more smooth,transparent,and clear which are all favoured properties in most food and pharmaceutical ***:Biologically active Ig’s can be successfully incorporated in and released from milk protein based edible *** content of Igs in films affected considerably technological properties of these ***

关键词： edible films immunoglobulins whey proteins β-lactoglobulin caseinates nisin dental caries

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A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

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International Journal of Oral Science 2024年第2期16卷 265-279页

作者： Alfredo Torres M.Angélica Michea Ákos Végvári Marion Arce Valentina Pérez Marcela Alcota Alicia Morales Rolando Vernal Mauricio Budini Roman A.Zubarev Fermín E.González Laboratory of Experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and Molecular Pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RNA sequencing(scRNA-seq)dataset(GSE164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including SNCA,CA1,HBB,SLC4A1,and ANK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(SNCA,FTH1,HSPB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRNA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

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Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages

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International Journal of Oral Science 2018年第3期10卷 190-196页

作者： Yuri Song Hee Sam Na Eunjoo Park Mi Hee Park Hyun Ah Lee Jin Chung Department of Oral Microbiology School of Dentistry Pusan National University institute of Translational Dental Sciences Pusan National University

Streptococcus mutans(S. mutans), a major aetiologic agent of dental caries, is involved in systemic diseases, such as bacterial endocarditis, if it enters the bloodstream through temporary bacteraemia. Interleukin(IL)-1β, a proinflammatory cytokine, is related to the host defences against pathogens, and its synthesis, maturation, and secretion are tightly regulated by the activation of the inflammasome, an inflammatory signalling complex. This study examined the signalling mechanism of IL-1β secretion and the inflammasome pathway induced by S. mutans to explain the molecular mechanism through which systemic infection by oral streptococci can occur. After infection of THP-1 cells with S. mutans, the expression of inflammasome components was detected using various methods. S. mutans induced IL-1β secretion via caspase-1 activation, and S. mutans-induced IL-1β secretion required absent in melanoma(AIM2), NLR family pyrin domain-containing 3(NLRP3) and NLR family CARD domain-containing 4(NLRC4)inflammasome activation. In particular, the S. mutans-induced NLRP3 inflammasome was mediated by adenosine triphosphate(ATP) release, potassium depletion and lysosomal damage. Our study provides novel insight into the innate immune response against S. mutans infection.

关键词： NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages THP Streptococcus mutans activates the AIM2 AIM

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Is ATP a key player in conditioning neurons to support axonal regeneration?

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Neural Regeneration Research 2018年第12期13卷 2077-2079页

作者： Xuenong Bo Centre for Neuroscience and Trauma Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London

Neurons in the central nervous system （CNS） of adult mammals have a weak intrinsic regenerative capacity, which is one contributing factor to the failure of axonal regeneration. Finding the means to elevate the regenerative capacity of axotomised neurons is one requirement for successful regeneration. Forty-five years ago, it was reported that crushing of the sciatic nerves of adult mice two weeks before cutting the nerves accelerated the regrowth of their axons （McQuarrie and Grafstein, 1973）. The nerve injury two weeks before triggered the regeneration machinery in the injured neurons, leading to faster axonal regrowth after a subsequent lesion. Later it was found that a lesion to a peripheral nerve also strongly enhanced the regeneration of the central branches of the appropriate primary sensory neurons （Richardson and Issa, 1984）. This phenomenon is termed preconditioning lesion （or conditioning lesion if the central branches of the sensory neurons are injured after a concomitant in- jury to their peripheral branches）.

关键词： ATP

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Targeting oral-gut microbial transmission in diabetic coronary heart disease:unveiling key pathogenic mechanisms

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Science China(Life Sciences) 2024年第10期67卷 2287-2288页

作者： Ismail Cimen Aab Cardiovascular Research institute Department of MedicineUniversity of Rochester School of Medicine and DentistryRochester 14642USA

Diabetes significantly exacerbates the occurrence and adverse prognosis of coronary heart disease(CHD),emphasizing the importance of focusing on the prevention and management of diabetesrelated *** study identifies and verifies for the first time a distinctive oral-gut microbiota profile in patients with diabetic coronary heart disease(DCHD),marked by an increased abundance of oral Fusobacterium nucleatum and gut Lactobacillus.

关键词： coronary prevention diabetic

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TGF-β2 downregulates osteogenesis under inflammatory conditions in dental follicle stem cells

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International Journal of Oral Science 2018年第4期10卷 232-243页

作者： Soyoun Um Joo-Hee Lee Byoung-Moo Seo Biotooth Engineering Lab Dental Research InstituteDental Regenerative BiotechnologyDepartment of Dental ScienceSchool of DentistrySeoul National University Biotooth Engineering Lab Department of Oral and Maxillofacial Surgery and Craniomaxillofacial Life ScienceDental Research InstituteSchool of DentistrySeoul ational University

Bone formation is important for the reconstruction of bone-related structures in areas that have been damaged by *** conditions such as those that occur in patients with rheumatoid arthritis, cystic fibrosis, and periodontitis have been shown to inhibit osteoblastic differentiation. This study focussed on dental follicle stem cells(DFSCs), which are found in developing tooth germ and participate in the reconstruction of alveolar bone and periodontal tissue in periodontal disease. After bacterial infection of inflamed dental tissue, the destruction of bone was observed. Currently, little is known about the relationship between the inflammatory environment and bone formation. Osteogenic differentiation of inflamed DFSCs resulted in decreased alkaline phosphatase(ALP) activity and alizarin red S staining compared to normal DFSCs. Additionally, in vivo transplantation of inflamed and normal DFSCs demonstrated severe impairment of osteogenesis by inflamed DFSCs. Protein profile analysis via liquid chromatography coupled with tandem mass spectrometry was performed to analyse the differences in protein expression in inflamed and normal tissue. Comparison of inflamed and normal DFSCs showed significant changes in the level of expression of transforming growth factor(TGF)-β2. Porphyromonas gingivalis(P.g.)-derived lipopolysaccharide(LPS) was used to create in vitro inflammatory conditions similar to periodontitis. The osteogenic differentiation of LPS-treated DFSCs was suppressed, and the cells displayed low levels of TGF-β1 and high levels of TGF-β2. DFSCs treated with TGF-β2 inhibitors showed significant increases in alizarin red S staining and ALP activity. TGF-β1 expression was also increased after inhibition of TGF-β2. By examining inflamed DFSCs and LPS-triggered DFSCs, these studies showed both clinically and experimentally that the increase in TGF-β2 levels that occurs under inflammatory conditions inhibits bone formation.

关键词： TGF downregulates osteogenesis under inflammatory conditions in dental follicle stem cells

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Role of third molars in orthodontics

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World Journal of Clinical Cases 2015年第2期3卷 132-140页

作者： Konstantinia Almpani Olga-Elpis Kolokitha Forsyth institute Department of Orthodontics Faculty of DentistrySchool of Health SciencesAristotle University

The role of third molars in the oral cavity has been extensively studied over the years. Literature includes numerous diagnostic and treatment alternatives regarding the third molars. However, an issue that has not been discussed at the same level is their involvement in orthodontic therapy. The aim of this study is to present a review of the contemporary literature regarding the most broadly discussed aspects of the multifactorial role of third molars in orthodontics and which are of general dental interest too.

关键词： Crowding Extraction Eruption Third molar Orthodontics Impaction

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Evaluation of Oral Health-Related Quality of Life among Institutionalized Orphan Children

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Journal of Forensic Science and Medicine 2021年第4期7卷 117-122页

作者： KL Girish Babu Gururaj Hebbar Kavyashree Department of dentistry Hassan Institute of Medical SciencesHassanKarnatakaIndia

Introduction:Children residing in orphanages are a disadvantaged section of the *** care can impair the quality of life of orphan ***:The aim of this study was to assess the oral health-related quality of life and dental caries status among institutionalized orphan *** and Methods:Children without parents,aged 6-14 years,were selected from government-run *** who were willing to participate were *** on oral health-related quality of life were collected by personal interviews by a single ***,intraoral examination of each child was carried out in an adequate natural light using a sterilized mouth mirror and *** caries was assessed according to the World Health Organization *** data obtained were subjected to statistical ***:The Decayed,Missed and Filled teeth(DMFT)score of males was 0.41士0.86 and females was 0.97士1.44,and the difference was statistically *** mean of oral symptoms,functional limitation,emotional well-being,and social well-being was 26.49±4.48,37.75士3.63,33.31±4.1&and 47.92士3.37,***:The prevalence of dental caries was low among these orphan *** quality of life of these children was not affected by their dental caries status.

关键词： Dental caries oral health related quality of life orphans

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Growth inhibitory response and ultrastructural modification of oral-associated candidal reference strains (ATCC) by Piper betle L. extract

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International Journal of Oral Science 2014年第1期6卷 15-21页

作者： Mohd-Al-Faisal Nordin Wan Himratul-Aznita Wan Harun Fathilah Abdul Razak Md Yusoff Musa Department of Oral Biology and Biomedical Sciences Faculty of Dentistry University of Malaya institute of Biological Sciences Faculty of ScienceUniversity of Malaya

Candida species have been associated with the emergence of strains resistant to selected antifungal agents. Plant products have been used traditionally as alternative medicine to ease mucosal fungal infections. This study aimed to investigate the effects of Piper betle extract on the growth profile and the ultrastructure of commonly isolated oral candidal cells. The major component of Po betle was identified using liquid chromatography-mass spectrophotometry （LC-MS/MS）. Seven ATCC control strains of Candida species were cultured in yeast peptone dextrose broth under four different growth environments：（i） in the absence of P. betle extract; and in the presence of P. beUeextract at respective concentrations of （ii） 1 ***-1; （iii） 3 ***-1; and （iv） 6 ***- 1 The growth inhibitory responses of the candidal cells were determined based on changes in the specific growth rates （μ）. Scanning electron microscopy （SEM） was used to observe any ultrastructural alterations in the candida colonies. LC-MS/MS was performed to validate the presence of bioactive compounds in the extract. Following treatment, it was observed that the p-values of the treated cells were significantly different than those of the untreated cells （P〈0.05）, indicating the fungistatic properties of the P. beUe extract. The candidal population was also reduced from an average of 13.44× 10^6 to 1.78×10^6 viable cell counts （CFU）.mL-1, SEM examination exhibited physical damage and considerable morphological alterations of the treated cells. The compound profile from LC-MS/MS indicated the presence of hydroxybenzoic acid, chavibetol and hydroxychavicol in P. betle extract. The effects of P. betle on candida cells could potentiate its antifungal activity.

关键词： antifungal activity Candida cell morphology growth inhibitory effect Piperbetle L.

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Kinetic study of all-or-none hemolysis induced by cationic amphiphilic polymethacrylates with antimicrobial activity

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Chinese Chemical Letters 2015年第4期26卷 479-484页

作者： Kazuma Yasuhara Kenichi Kuroda Graduate School of Materials Science Nara Institute of Science and Technology Department of Biologic and Materials Sciences University of Michigan School of Dentistry

To gain an understanding of the toxicity of antimicrobial polymers to human cells, their hemolytic action was investigated using human red blood cells （RBCs）. We examined the hemolysis induced by cationic amphiphilic methacrylate random copolymers, which have amino ethyl sidechains as cationic units and either butyl or methyl methacpjlate as hydrophobic units. The polymer with 30 tool% butyl sidechains （B3o） displayed higher hemolytic toxicity than the polymer with 59 tool% methyl sidechains （Ms9）. B3o also induced faster release of hemoglobin from RBCs than lVlsg. A new theoretical model is proposed based on two consecutive steps to form active polymer species on the RBC membranes, which are associated to RBC lysis. This model takes the all-or-none release of hemoglobin by the rupture of RBCs into account, providing new insight into the polymer-induced hemolysis regarding how individual or collective ceils respond to the polymers.

关键词： HemolysisAntimicrobial polymerAmphiphilic polymethacrylateKinetic analysisMembrane disruption

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