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Ignition of Hydrocarbon-Air Supersonic Flow by Volumetric Ionization

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Journal of Thermal Science 2015年第6期24卷 583-590页

作者： Marat A.Goldfeld George A.Pozdnyakov Khristianovich institute of Theoretical and Applied Mechanics sb ras

The paper describes the results of the electron-beam initiation of the combustion in the mixtures of hydrogen,natural gas or kerosene vapors with *** beam characteristics were studied in closed volume with immobile *** researches included definition of an integrated current of an electronic beam,distribution of a current density and an estimation of average energy of *** of fuel mixtures ignition by means of this approach in the combustor at high velocity at the entrance was *** were carried out at Mach numbers of 4 and *** of ignition and combustion under electron beam action was *** was revealed that ignition of mixture occurs after completion of electron gun *** obtained have confirmed effectiveness of electron beam application for ignition of hydrogen and natural *** numerical simulation of the combustion of mixture in channel was carried out by means of ANSYS CFD 12.0 instrumentation on the basis of Reynolds averaged Navier-Stokes equation using SST/k-ωturbulence *** combustion modeling,a detailed kinetic scheme with 38 reactions of 8 species was implemented taking into account finite rate *** have shown that the developed model allow to predict ignition of a mixture and flame propagation even at low flow temperatures.

关键词： supersonic flow combustor electron bean ignition delay numerical simulation.

Geochemistry and petrology of superpure quartzites from East Sayan Mountains, Russia

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Acta Geochimica 2019年第1期38卷 22-39页

作者： A.M.Fedorov V.A.Makrygina A.I.Nepomnyaschikh A.P.Zhaboedov A.V.Parshin V.F.Posokhov Yu.V.Sokolnikova A.P.Vinogradov institute of Geochemistry sb ras Irkutsk National Research Technical University Irkutsk Scientific Center sb ras Irkutsk State University Geological institute sb ras

Quartzites are widespread within Earth's lithosphere, but their highly pure varieties occur quite infrequently. With the development of alternative energy sources, including solar, and with increasing demand for high-purity quartz for optics, interest has risen in highpurity silicon-bearing materials. The quartzites discovered in the southeast part of the Eastern Sayan Mountains are particularly attractive for exploration in terms of their raw material quality and feasibility to be enriched. For this reason, their genesis also merits study. Available geochemical data show that chemogenic(d^(18)O>29.2%)siliceous-carbonate sediments of the Irkut Formation are fairly pure(impurity elements 0.9% impurities, but later, under the action of sliding slabs of ophiolite dynamothermal treatment reduced impurities to < 100 ppm, resulting in ‘‘superquartzites' '(highly pure quartzites). The presence of only minor structural impurities is due to the enrichment capacity of superquartzites to 10.1 ppm(7.2 ppm under special conditions) of 10 elements: Fe, Al, Ti, Ca, Mg, Cu,Mn, Na, K, and Li.

关键词： High-purity quartz Superquartzite Gravitational sliding Dynamic metamorphism Recrystallization

Development of Genetic Engineering Tools for p75ngfr Methylation and Expression Modulation

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Journal of Biosciences and Medicines 2020年第11期8卷 197-207页

作者： D. A. Lanshakov E. V. Sukhareva Postgenomic Neurobiology Laboratory Institute of Cytology and Genetics SB RAS Novosibirsk Russia Functional Neurogenomics Laboratory Institute of Cytology and Genetics SB RAS Novosibirsk Russia

Neurotrophic factors, as well as their receptors are key players in the formation and development of the central nervous system. Like the sculptor’s incisor, they form the neural networks and circuits of the future organism. The neurotrophic growth factor receptor p75ngfr interacts with sortilin, serves as a receptor for proform of neurotrophic factors and exhibits a proapoptotic effect in developing neurons—dorsal root ganglia neurons and brainstem norepinephrine neurons. p75ngfr is highly expressed in Locus Coeruleus norepinephrine neurons. Therefore, an important task for developing further methods of CNS gene therapy is the development of tools and molecular methods for suppressing p75ngfr expression in norepinephrine neurons. For this purpose, we’ve developed improved dCas9 vectors with Suntag system to suppress gene expression and enhance methylation of CpG islands. We used 10 times repetitive GCN peptide that were fused to dCas9. Single chain antibody against GCN peptide was fused to KRAB repressor or Dnmt3a catalytic domain. Expression specificity was achieved by using a promoter consisting of 8 repeated phox2a/2b binding sites. In this work, we’ve tested a set of guide RNAs targeting p75ngfr cpg island in the promoter. Usage of Suntag system led us to the conclusion that topological orientation and length of the final complex could influence on p75ngfr antisense transcript expression, and that sequence was established in the rat P3 brainstem.

关键词： dCas9 Suntag System CRISPRi Dnmt3a p75ngfr

Quercetin Attenuates Benzo(α)pyrene-induced CYP1A Expression

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Biomedical and Environmental Sciences 2017年第4期30卷 308-313页

作者： Perepechaeva ML Seredina TA Sidorova YA Pivovarova EN Markel AL Lyakhovich VV Grishanova AY institute of Molecular Biologv and Biophysics Novosibirsk 630117Russia Federal research center institute of cytology and genetics Siberian Branch of Russian Academy of Sciences(SB RAS)Novosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia

We studied effects of nutrient quercetin on cytochromes＇ Р450 1А （CYP1A） activities （measured spectrofluorimetrically using 7-ethoxy-resorufin for CYP1A1 and 7-methoxy-resorufin for CYP1A2 as substrates）, on m RNA levels （measured by RT-PCR）, and on DNA-binding activities （evaluated by an electrophoretic mobility shift assay） of proteins regulating CYP1A expression in untreated and benzo（α）pyrene （Ba P）-treated rats. Wistar rats received quercetin, Ba P, or both once daily for 1-3 days. Quercetin did not influence CYP1A1 in untreated rats but inhibited Ba P-mediated CYP1A induction on the transcriptional level decreasing positive input （Ah R functional activity） and increasing negative input （Ah RR/ARNT expression and Oct-1 and C/EBP functional activities）.

关键词： CYP pyrene-induced CYP1A Expression Quercetin Attenuates Benzo

Finding Symmetry Groups of Some Quadratic Programming Problems

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Numerical Mathematics(Theory,Methods and Applications) 2023年第2期16卷 370-392页

作者： Anton V.Eremeev Alexander S.Yurkov Sobolev institute of Mathematics sb ras Omsk DepartmentOmskRussia Omsk Scientific Center sb ras(institute of Radiophysics and Physical Electronics) OmskRussia

Solution and analysis of mathematical programming problems may be simplified when these problems are symmetric under appropriate linear *** particular,a knowledge of the symmetries may help decrease the problem dimension,reduce the size of the search space by means of linear *** the previous studies of symmetries in the mathematical programming usually dealt with permutations of coordinates of the solutions space,the present paper considers a larger group of invertible linear *** study a special case of the quadratic programming problem,where the objective function and constraints are given by quadratic *** formulate conditions,which allow us to transform the original problem to a new system of coordinates,such that the symmetries may be sought only among orthogonal *** particular,these conditions are satisfied if the sum of all matrices of quadratic forms,involved in the constraints,is a positive definite *** describe the structure and some useful properties of the group of symmetries of the *** that,the methods of detection of such symmetries are outlined for different special cases as well as for the general case.

关键词： Non-convex programming orthogonal transformation symmetry group Lie group

The Sytykanskaya kimberlite pipe:Evidence from deep-seated xenoliths and xenocrysts for the evolution of the mantle beneath Alakit,Yakutia,Russia

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Geoscience Frontiers 2015年第5期6卷 687-714页

作者： I.V.Ashchepkov A.M.Logvinova L.F.Reimers T.Ntaflos Z.V.Spetsius N.V.Vladykin H.Downes D.S.Yudin A.V.Travin L.V.Makovchuk V.S.Palesskiy O.S.Khmel'nikova institute of Geology and Mineralogy sb ras Vienna University Alrosa Stock Company institute of Geochemistry sb ras Birkbeck College University of LondonUKMalet Street

Mantle xenoliths（>150） and concentrates from late autolithic breccia and porphyritic kimberlite from the Sytykanskaya pipe of the Alakit field（Yakutia） were analyzed by EPMA and LAM ICP *** P-TX-f（O2） diagrams minerals from xenoliths show widest variations,the trends P-Fe#-CaO,f（O2）for minerals from porphyric kimberlites are more stepped than for xenocrysts from *** PTX points mark moving for protokimberlites from the lithosphere base（7.5 GPa） to pyroxenite lens（5-3.5 GPa） accompanied by Cr increase by AFC and creation of two trends P-Fe#OI10-12%and13-15%.The Opx-Gar-based mantle geotherm in Alakit field is close to 35 mW/m2 at 65 GPa and 600 C near Moho was *** oxidation state for the megacrystalline ilmenites is lower for the metasomatic associations due to reduction of protokimberlites on peridotites than for uncontaminated varieties at the lithosphere *** inclined linear REE patterns with deep HFSE troughs for the parental melts of clinopyroxene and garnet xenocrysts from breccia were influenced by differentiated *** for metasomatic xenoliths reveal less inclined slopes without deep troughs in spider *** reveal S-shaped REE *** clinopyroxenes from graphite bearing Cr-websterites show inclined and inflected in Gd spectrums with LREE variations due to AFC *** for garnets display less inclined patterns and Ba-Sr troughs but enrichment in ***40Ar/39Ar ages for micas from the Alakit mantle xenoliths for disseminated phlogopites reveal Proterozoic（1154 Ma） age of metasomatism in early Rodinia *** glimmerites with richterite- like amphiboles mark1015 Ma plume event in Rodinia ***600-550 Ma stage manifests final Rodinia *** last 385 Ma metasomatism is protokimberlite-related.

关键词： Kimberlites Mantle lithosphere Mantle xenoliths Th

Unravelling-based (auto)control of back-action in atomic Bose–Einstein condensate

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Frontiers of physics 2024年第4期19卷 287-295页

作者： V.A.Tomilin L.V.Il’ichov institute of Automation and Electrometry sb ras 630090 NovosibirskRussia

We present a novel feedback control method for quantum *** does not affect the controlled system ***,it controls the unravelling of the quantum channel of interaction between the system and its *** interaction can be represented as a history of *** their informational content is changed,their back-action on the system is also *** action is trigged by the events,thus granting the system the degree of control over its own *** efficiency of the proposed scheme is demonstrated on the example of two-mode atomic Bose-Einstein condensate,with one of its modes subject to phase-contrast imaging in a Mach–Zehnder *** histories of photocounts in the output channels of the interferometer are used for *** capabilities of state engineering are studied for different settings of the feedback loop and different numbers of events in the recorded histories.

关键词： quantum feedback control quantum measurements twomode Bose-Einstein condensates

Development of Genetic Engineering Tools for p75ngfr Methylation and Expression Modulation

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Development of Genetic Engineering Tools for p75ngfr Methyla...

Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice

作者： D.A.Lanshakov E.V.Sukhareva Postgenomic Neurobiology Laboratory Institute of Cytology and Genetics SB RAS Functional Neurogenomics Laboratory Institute of Cytology and Genetics SB RAS

Neurotrophic factors, as well as their receptors are key players in the formation and development of the central nervous system. Like the sculptor’s incisor, they form the neural networks and circuits of the future organism. The neurotrophic growth factor receptor p75 ngfr interacts with sortilin, serves as a receptor for proform of neurotrophic factors and exhibits a proapoptotic effect in developing neurons—dorsal root ganglia neurons and brainstem norepinephrine neurons. p75 ngfr is highly expressed in Locus Coeruleus norepinephrine neurons. Therefore, an important task for developing further methods of CNS gene therapy is the development of tools and molecular methods for suppressing p75 ngfr expression in norepinephrine neurons. For this purpose, we’ve developed improved dCas9 vectors with Suntag system to suppress gene expression and enhance methylation of CpG islands. We used 10 times repetitive GCN peptide that were fused to dCas9. Single chain antibody against GCN peptide was fused to KRAB repressor or Dnmt3 a catalytic domain. Expression specificity was achieved by using a promoter consisting of 8 repeated phox2 a/2 b binding sites. In this work, we’ve tested a set of guide RNAs targeting p75 ngfr cpg island in the promoter. Usage of Suntag system led us to the conclusion that topological orientation and length of the final complex could influence on p75 ngfr antisense transcript expression, and that sequence was established in the rat P3 brainstem.

关键词： dCas9 Suntag System CRISPRi Dnmt3a p75ngfr

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World Journal of Diabetes 2020年第12期11卷 596-610页

作者： Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein Laboratory of Endocrinology Research Institute of Clinical and Experimental Lymphology–Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of Sciences(RICEL–Branch of IC&G SB RAS)Novosibirsk 630060Russia Laboratory of Ultrastructural Research Research Institute of Clinical and Experimental Lymphology–Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of Sciences(RICEL–Branch of IC&G SB RAS)Novosibirsk 630060Russia Laboratory of Clinical Immunogenetics Research Institute of Clinical and Experimental Lymphology–Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of Sciences(RICEL–Branch of IC&G SB RAS)Novosibirsk 630060Russia Center for Genetic Resources of Laboratory Animals Institute of Cytology and GeneticsSiberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia Department of Cardiometabolic Diseases Research Boehringer Ingelheim Pharma GmbHBiberach 88397Germany

BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney ***,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully *** of podocytes and nephrin expression in glomeruli in db/db diabetic *** We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 ***-matched male db/+mice were included as non-diabetic *** of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were *** evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,*** nephrin and transforming growth factor beta(TGF-β)were assessed by *** Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were *** expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated *** was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were *** decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of *** These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney *** anti-albuminuric effect of EMPA could be attributed to mitigation o

关键词： Diabetes Chronic kidney disease Albuminuria Podocyte Sodium-glucose transporter 2 inhibitors Empagliflozin